DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dysc and pdzd7a

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001177686.1	Gene:	pdzd7a / 100332580	ZFINID:	ZDB-GENE-090313-191	Length:	954	Species:	Danio rerio

Alignment Length:	1072	Identity:	214/1072 - (19%)
Similarity:	340/1072 - (31%)	Gaps:	464/1072 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 HYSNGGTRDRDRTGRRSPASSP-PSTTHQI--YRDRERERDRSV--------------------- 286
            |.|:  |..:|.|....|::.| ||.|..:  |..::::|.|.|
Zfish     3 HSSD--TARKDMTNGAHPSAQPGPSGTSTLPRYLHKKQQRQRGVRSSSPMGRVILINAPVDGGDD 65

  Fly   287 -PNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNG 350
             .:||.:|.       |:..|...|..|:||.:.|||:::|::|::|.||.|||..||.::||||
Zfish    66 SEDIHTITV-------DKSEDGHLGFSVRGGSEHGLGIFVSKVEDDSTAEMAGLCVGDKLVEVNG 123

  Fly   351 TPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQ 415
            ....||....|:|    :|..:.::.|.||..          |..|..|   |:
Zfish   124 ISLESITMSSAVK----VLTGNNRLRMVVRRV----------GKVPGIR---YS----------- 160

  Fly   416 AAAAAAAAAASGAGLPFRQTCSWMDR-HGRPASPPMEYGGR---RSERRDRIRRVELLIEPGQS- 475
                             ::..:|:|. |.|..   :|..||   .:.....:||:..|......
Zfish   161 -----------------KEKTTWVDLIHRRMV---VEESGRTPSEASSDGALRRIVHLYTTSDDY 205

  Fly   476 -LGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMS 539
             ||..||||.|:||||:|:.:|...:|:::|:.:||:||..||.||.|:||..||..||.|..:.
Zfish   206 CLGFNIRGGKEFGLGIYVSKLDPGGLAEQNGIKMGDQILAANGVSFEDITHSNAVEVLKSHTHVM 270

  Fly   540 LVIRDVGKVP-----------------------------HSCTS--------------------- 554
            |.|::.|:.|                             :|.||
Zfish   271 LTIKEAGRYPAYKEMVAEYSWLNKLANGGQPSSSQGSDSYSSTSSLSSGTPVSSLSGLSQVTFPP 335

  Fly   555 ----------------------------IEMEPWD------------------------------ 561
                                        |:.:|.|
Zfish   336 AFGSEMVDVCISTEDRSRRPSSERIETAIQTDPQDPDTISRTSRVMSTETSRMVGETVLLKDTVI 400

  Fly   562 ----AYSPTGT------------------------------------------------------ 568
                |:|.|.|
Zfish   401 RRGTAHSRTRTFSAGDKETLDSPKTAVLMALSKPRKAIRRSQSHITVSEFWFATERASCLCGCTS 465

  Fly   569 ----------RARRKGQIAT--------------------------------------------- 578
                      |..:||::.|
Zfish   466 RSRQEDKQKKRKHQKGKVETEGSTLQRSKTFVTLPFKSGRRRERSSSRDRKDTGREDGHKGRSKS 530

  Fly   579 -------------------------------------------MVEEKARSLLPRHHFASLSYYI 600
                                                       ::|:.||.||.....|::..:.
Zfish   531 PKHLDNEPGKERGRPIINLLSSPRETRAGLREQSPMPSPETMALLEDVARKLLNEDEVAAVMRHC 595

  Fly   601 AEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRH--- 662
            ..:....: ::..|..||.:||..||..|:.|:|.::...|..|:|.:|...|.:.|.:.:.
Zfish   596 KRFLVDRV-VEDLVRPLLAILDKPEKLLLLREVRMIIPATDLGRFDSMVLPFELEAYDILKSRSV 659

  Fly   663 --------RRKGDPARDL--------------PV--------TADDLEII----AATGR------ 687
                    |..|.|.|.|              ||        ..:|||.:    ..|||
Zfish   660 RSPVLRSPRHGGTPRRHLITPIPDYRGGFHLQPVQDLERERQLIEDLERMRLAGLPTGRLPPPRA 724

  Fly   688 -SPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSSLSPPQQQQQQQ 751
             :|..|..:...:||..:..:|.    |..:| ..|...|.|..:||.       ||     .::
Zfish   725 FTPLLDVPVDTYITDSLRNRSLS----PARSG-FSHSESPYSTERTGR-------SP-----LRR 772

  Fly   752 QHYQPHHASLRHLGGIGGNVGS-GRHHHHPLGPSQLKFRQTKDNQQQEYG-CDEHRTRRGSETLL 814
            .:..||.:    |...|.:|.. ||..:.  ...::|..::.:.::.:|. ...||..|
Zfish   773 DNGFPHDS----LSSRGDSVPERGRSPYR--NGHRMKTDKSLNGKEVKYTVMSAHRRSR------ 825

  Fly   815 PEYEPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGSTTEQTHEHNPNVVP 879
                        |.||:.|....|                |......||.|.::...|.:..:..
Zfish   826 ------------TPLSQVFAPSPE----------------QHWKEPVNGHSDSQDRTEQDYVLTT 862

  Fly   880 DHRGNLHITVKKTKPILGIAIEGGANTK-HPLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVE 943
                   :|:.|||..|||:|.||..:| .|:.:|..|...|||..:..|:.|..::.|||..::
Zfish   863 -------VTISKTKQSLGISISGGIESKVQPMVKIEKIFPGGAASTSDVLKAGFELVSVDGESLQ 920

  Fly   944 GLHHQEVARLIAECFANREKAEITFLVVEAKK 975
            |:.||.....|...|:|:.|..:.|:|...|:
Zfish   921 GVTHQHAVDAIRRAFSNKAKEPMEFIVKVPKR 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	29/85 (34%)
		PDZ_signaling	466..543	CDD:238492	33/78 (42%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	23/167 (14%)
		PDZ_signaling	886..971	CDD:238492	30/85 (35%)
pdzd7a	NP_001177686.1	PDZ_signaling	69..149	CDD:238492	32/90 (36%)
		PDZ_signaling	194..274	CDD:238492	34/79 (43%)
		HN_PDZD7_like	568..645	CDD:259824	20/77 (26%)
		PDZ_signaling	860..948	CDD:238492	30/94 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9773
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168224at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23116
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020