DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8745 and PHYKPL

DIOPT Version :9

Sequence 1:	NP_648665.1	Gene:	CG8745 / 39530	FlyBaseID:	FBgn0036381	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_011532971.1	Gene:	PHYKPL / 85007	HGNCID:	28249	Length:	460	Species:	Homo sapiens

Alignment Length:	459	Identity:	227/459 - (49%)
Similarity:	319/459 - (69%)	Gaps:	19/459 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VASEQLSKTETIKLRNQHIGQACQLFYRSDPLKIVRGQGQYMFDEEGTRYLDCINNVAHVGHCHP 75
            :|::|..|.:|:.||.:.|..:|:||:..||:||||.|||||:||:|..|:|||:||||||||||
Human     1 MAADQRPKADTLALRQRLISSSCRLFFPEDPVKIVRAQGQYMYDEQGAEYIDCISNVAHVGHCHP 65

  Fly    76 EVVRAGALQMATISTNNRFLHDELVQCARTLTSKMPEPLSVCFFVNSGSEANDLALRLARNFTKR 140
            .||:|...|...::||:|:|||.:|..|:.|:..:||.|.|.:|:|||||||||||||||::|..
Human    66 LVVQAAHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEQLCVFYFLNSGSEANDLALRLARHYTGH 130

  Fly   141 QDVITLDHAYHGHLQSVMEVSPYKFNQPGGEAKPDYVHVAPCPDVYGGKFTDKMYPDADMGALYA 205
            |||:.|||||||||.|::::|||||....|:  .::|||||.||.|.|.:.:. :|:..|.  ||
Human   131 QDVVVLDHAYHGHLSSLIDISPYKFRNLDGQ--KEWVHVAPLPDTYRGPYRED-HPNPAMA--YA 190

  Fly   206 QPIEEICQKQLAKGQGVAAFIAESLQSCGGQILPPAGYFQAVYDA----------VRSAGGVCIA 260
            ..::.:......||:.:|||.||||.|.||||:||||||..|.|.          :|.||||.:|
Human   191 NEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFSQVADPRVSHLLCHRHIRKAGGVFVA 255

  Fly   261 DEVQVGFGRVGSHYWAFETQ--NVIPDIVCVAKPMGNGHPVGAVVTTPEIAQAFHATGVAYFNTY 323
            ||:||||||||.|:|||:.|  :.:||||.:.|.:||||||..|..|..:|:||.||||.||||:
Human   256 DEIQVGFGRVGKHFWAFQLQGKDFVPDIVTMGKSIGNGHPVACVAATQPVARAFEATGVEYFNTF 320

  Fly   324 GGNPVSCAIANAVMRVIEEEGLQQKALVLGDYLLEECNRLKQEFECIGDVRGAGLFVGIELVQDR 388
            ||:|||||:..||:.|:|:|.||..|..:|.:|::...:.|.:...:|||||.|||:|::|::|.
Human   321 GGSPVSCAVGLAVLNVLEKEQLQDHATSVGSFLMQLLGQQKIKHPIVGDVRGVGLFIGVDLIKDE 385

  Fly   389 KERIPDKKAAHWVVNRMKQLHRVLVSSDGPNDNVIKLKPPMCFNRENADEFLLGFRECLTAVMQE 453
            ..|.|..:.|.::|:|:|: :.||:|:|||..|::|.||||||:.:||.:.:......||. |:|
Human   386 ATRTPATEEAAYLVSRLKE-NYVLLSTDGPGRNILKFKPPMCFSLDNARQVVAKLDAILTD-MEE 448

  Fly   454 RLAS 457
            ::.|
Human   449 KVRS 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8745	NP_648665.1	GabT	20..450	CDD:223238	221/441 (50%)
CG8745	NP_648665.1	OAT_like	37..447	CDD:99735	212/421 (50%)
PHYKPL	XP_011532971.1	GabT	7..445	CDD:223238	221/443 (50%)
PHYKPL	XP_011532971.1	OAT_like	30..443	CDD:99735	212/418 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	478	1.000	Domainoid score	I425
eggNOG	1	0.900	-	-		E1_COG0160
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1314
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63788
OrthoDB	1	1.010	-	-		D145181at2759
OrthoFinder	1	1.000	-	-		FOG0000701
OrthoInspector	1	1.000	-	-		otm40649
orthoMCL	1	0.900	-	-		OOG6_103965
Panther	1	1.100	-	-	O	PTHR45688
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1960
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840