DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8745 and AGXT2

DIOPT Version :9

Sequence 1:	NP_648665.1	Gene:	CG8745 / 39530	FlyBaseID:	FBgn0036381	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_114106.1	Gene:	AGXT2 / 64902	HGNCID:	14412	Length:	514	Species:	Homo sapiens

Alignment Length:	469	Identity:	169/469 - (36%)
Similarity:	259/469 - (55%)	Gaps:	43/469 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EQLSKTETIKLRNQHIGQACQLFYRSDPLKIVRGQGQYMFDEEGTRYLDCINNV--AHVGHCHPE 76
            :.|.....:::..:|:......:::. ||.:.:|..:::||.||:||||..:.:  ..||||||:
Human    59 QSLGYNRVLEIHKEHLSPVVTAYFQK-PLLLHQGHMEWLFDAEGSRYLDFFSGIVTVSVGHCHPK 122

  Fly    77 VVRAGALQMATI-STNNRFLHDELVQCARTLTSKMPEPLSVCFFVNSGSEANDLALRLARNFTKR 140
            |......|:..: .|:..|.|..:.:.|..|.:.:||||.|.|.||||||||:||:.:||..:..
Human   123 VNAVAQKQLGRLWHTSTVFFHPPMHEYAEKLAALLPEPLKVIFLVNSGSEANELAMLMARAHSNN 187

  Fly   141 QDVITLDHAYHG---HLQSVMEVSPYKFNQPGGE-AKPDYVHVAPCPDVYGGKFTDKMYPDADMG 201
            .|:|:...||||   :...:..|..||...|||. .:|     ..||||:.|.:......|:.:.
Human   188 IDIISFRGAYHGCSPYTLGLTNVGTYKMELPGGTGCQP-----TMCPDVFRGPWGGSHCRDSPVQ 247

  Fly   202 AL---------------YAQPIEEICQKQLAKGQGVAAFIAESLQSCGGQILPPAGYFQAVYDAV 251
            .:               |.:..::.....:||  .:|.|.||.:|...|.:..|.|:.:..::.|
Human   248 TIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAK--SIAGFFAEPIQGVNGVVQYPKGFLKEAFELV 310

  Fly   252 RSAGGVCIADEVQVGFGRVGSHYWAFETQNVIPDIVCVAKPMGNGHPVGAVVTTPEIAQAFHATG 316
            |:.||||||||||.||||:|||:|.|:|.:|:||||.:||.:|||.|:.||:||||||::. |..
Human   311 RARGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAAVITTPEIAKSL-AKC 374

  Fly   317 VAYFNTYGGNPVSCAIANAVMRVIEEEGLQQKALVLGDYLLEECNRLKQEFECIGDVRGAGLFVG 381
            :.:|||:||||::|||.:||:.||:||.||:.:..:|.|:|.:..:|:.|||.:|||||.||.:|
Human   375 LQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLKFAKLRDEFEIVGDVRGKGLMIG 439

  Fly   382 IELVQDRKERIPDKKAAHWVVNRMKQLHR------VLVSSDGPNDNVIKLKPPMCFNRENADEFL 440
            ||:|||:....|..:      ..:.|:|.      :||..........::.|.||..:...|..:
Human   440 IEMVQDKISCRPLPR------EEVNQIHEDCKHMGLLVGRGSIFSQTFRIAPSMCITKPEVDFAV 498

  Fly   441 LGFRECLTAVMQER 454
            ..||..||..|:.|
Human   499 EVFRSALTQHMERR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8745	NP_648665.1	GabT	20..450	CDD:223238	166/457 (36%)
CG8745	NP_648665.1	OAT_like	37..447	CDD:99735	163/437 (37%)
AGXT2	NP_114106.1	GabT	65..508	CDD:223238	166/457 (36%)
AGXT2	NP_114106.1	OAT_like	70..505	CDD:99735	164/449 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63788
OrthoDB	1	1.010	-	-		D145181at2759
OrthoFinder	1	1.000	-	-		FOG0000701
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830