DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8745 and ETNPPL

DIOPT Version :9

Sequence 1:	NP_648665.1	Gene:	CG8745 / 39530	FlyBaseID:	FBgn0036381	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_112569.2	Gene:	ETNPPL / 64850	HGNCID:	14404	Length:	499	Species:	Homo sapiens

Alignment Length:	474	Identity:	256/474 - (54%)
Similarity:	340/474 - (71%)	Gaps:	18/474 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EQLSKTETIKLRNQHIGQACQLFYRSDPLKIVRGQGQYMFDEEGTRYLDCINNVAHVGHCHPEVV 78
            |..||.:|:.||.:|||.:|::|:.|||:||||.|.||||||.|.:||||||||||||||||.||
Human     3 ELYSKRDTLGLRKKHIGPSCKVFFASDPIKIVRAQRQYMFDENGEQYLDCINNVAHVGHCHPGVV 67

  Fly    79 RAGALQMATISTNNRFLHDELVQCARTLTSKMPEPLSVCFFVNSGSEANDLALRLARNFTKRQDV 143
            :|...||..::||:|||||.:|:.|:.|::.:||.||||:|.|||||||||||||||.|...|||
Human    68 KAALKQMELLNTNSRFLHDNIVEYAKRLSATLPEKLSVCYFTNSGSEANDLALRLARQFRGHQDV 132

  Fly   144 ITLDHAYHGHLQSVMEVSPYKFNQPGGEAKPDYVHVAPCPDVYGGKFTDKMYPDADMGALYAQPI 208
            |||||||||||.|::|:||||| |.|.:.|.::|||||.||.|.||:.:   ..||..:.||..:
Human   133 ITLDHAYHGHLSSLIEISPYKF-QKGKDVKKEFVHVAPTPDTYRGKYRE---DHADSASAYADEV 193

  Fly   209 EEICQKQLAKGQGVAAFIAESLQSCGGQILPPAGYFQAVYDAVRSAGGVCIADEVQVGFGRVGSH 273
            ::|.:.....|:.:|||||||:|||||||:|||||||.|.:.|..||||.|||||||||||||.|
Human   194 KKIIEDAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVHGAGGVFIADEVQVGFGRVGKH 258

  Fly   274 YWAFET--QNVIPDIVCVAKPMGNGHPVGAVVTTPEIAQAFHATGVAYFNTYGGNPVSCAIANAV 336
            :|:|:.  ::.:||||.:.|||||||||..||||.|||:||.::|:.|||||||||||||:..||
Human   259 FWSFQMYGEDFVPDIVTMGKPMGNGHPVACVVTTKEIAEAFSSSGMEYFNTYGGNPVSCAVGLAV 323

  Fly   337 MRVIEEEGLQQKALVLGDYLLEECNRLKQEFECIGDVRGAGLFVGIELVQDRKERIPDKKAAHWV 401
            :.:||.|.||..|..:|:||.|...:.|.:...|||:||.|||:||:||:|..:|.|....|..:
Human   324 LDIIENEDLQGNAKRVGNYLTELLKKQKAKHTLIGDIRGIGLFIGIDLVKDHLKRTPATAEAQHI 388

  Fly   402 VNRMKQLHRVLVSSDGPNDNVIKLKPPMCFNRENADEFLLGFRECLTAVMQERLASATSAAMAAT 466
            :.:||: .|||:|:|||:.||:|:||||||..|:| :|::...:.:..|::|.:.:.|.
Human   389 IYKMKE-KRVLLSADGPHRNVLKIKPPMCFTEEDA-KFMVDQLDRILTVLEEAMGTKTE------ 445

  Fly   467 SGVIATATETLANKTKLFE 485
                :..:|....|||:.:
Human   446 ----SVTSENTPCKTKMLK 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8745	NP_648665.1	GabT	20..450	CDD:223238	246/431 (57%)
CG8745	NP_648665.1	OAT_like	37..447	CDD:99735	238/411 (58%)
ETNPPL	NP_112569.2	PRK06148	<6..441	CDD:180426	250/440 (57%)
ETNPPL	NP_112569.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	478	1.000	Domainoid score	I425
eggNOG	1	0.900	-	-		E1_COG0160
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69440
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1314
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63788
OrthoDB	1	1.010	-	-		D145181at2759
OrthoFinder	1	1.000	-	-		FOG0000701
OrthoInspector	1	1.000	-	-		otm40649
orthoMCL	1	0.900	-	-		OOG6_103965
Panther	1	1.100	-	-	LDO	PTHR45688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2389
SonicParanoid	1	1.000	-	-		X1960
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870