DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8745 and eppl-1

DIOPT Version :9

Sequence 1:	NP_648665.1	Gene:	CG8745 / 39530	FlyBaseID:	FBgn0036381	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001023346.1	Gene:	eppl-1 / 177646	WormBaseID:	WBGene00020139	Length:	467	Species:	Caenorhabditis elegans

Alignment Length:	443	Identity:	210/443 - (47%)
Similarity:	290/443 - (65%)	Gaps:	16/443 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SKTETIKLRNQHIGQACQLFYRSDPLKIVRGQGQYMFDEEGTRYLDCINNVAHVGHCHPEVVRAG 81
            ||.|.:|.|...||..||:||..||..:.|...||::||:..::||||:||.|||||||:||.|.
Worm    26 SKEEILKRRKDTIGSKCQIFYSDDPFMVSRASMQYLYDEKSNKFLDCISNVQHVGHCHPKVVEAI 90

  Fly    82 ALQMATISTNNRFLHDELVQCARTLTSKMPEPLSVCFFVNSGSEANDLALRLARNFTKRQDVITL 146
            :.|:||.:.|.||:..:|..||..:.|.:| .|....|.|||||||||||||||::||.:|.|.:
Worm    91 SKQLATSTCNVRFVSTQLTDCAEQILSTLP-GLDTVLFCNSGSEANDLALRLARDYTKHKDAIVI 154

  Fly   147 DHAYHGHLQSVMEVSPYKFNQPGGEAKPDYVHVAPCPDVYGGKF---------TDKMYPDADMGA 202
            :||||||:.:.||:|||||:.....::||:|||||||||:.||.         .||:|.   .|.
Worm   155 EHAYHGHVTTTMELSPYKFDHGSTVSQPDWVHVAPCPDVFRGKHRLADNELTNEDKLYA---AGK 216

  Fly   203 LYAQPIEEICQKQLAKGQGVAAFIAESLQSCGGQILPPAGYFQAVYDAVRSAGGVCIADEVQVGF 267
            .|:..::.|.....::..||||:.||:|||||||::||..||:.|...||:.||:.|.||||.||
Worm   217 QYSDDVKSILNDVESRQCGVAAYFAEALQSCGGQVIPPKDYFKDVATHVRNHGGLMIIDEVQTGF 281

  Fly   268 GRVGSHYWAFE--TQNVIPDIVCVAKPMGNGHPVGAVVTTPEIAQAFHATGVAYFNTYGGNPVSC 330
            ||:|..|||.:  ....:||||.:.||||||.||.||.|..|||.|.... |.||||||||||:|
Worm   282 GRIGRKYWAHQLYDDGFLPDIVTMGKPMGNGFPVSAVATRKEIADALGGE-VGYFNTYGGNPVAC 345

  Fly   331 AIANAVMRVIEEEGLQQKALVLGDYLLEECNRLKQEFECIGDVRGAGLFVGIELVQDRKERIPDK 395
            |...:||:|:::|.|.:.:..:|:.|......|:::.|||||:||.|||.||:||:||..|.||:
Worm   346 AAVISVMKVVKDENLLEHSQQMGEKLEVALRDLQKKHECIGDIRGVGLFWGIDLVKDRNTREPDQ 410

  Fly   396 KAAHWVVNRMKQLHRVLVSSDGPNDNVIKLKPPMCFNRENADEFLLGFRECLT 448
            |.|...:..:::.:.:|:::|||:.|::|:|||:|||..|..|.:....:.||
Worm   411 KLAIATILALRKSYGILLNADGPHTNILKIKPPLCFNENNILETVTALDQVLT 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8745	NP_648665.1	GabT	20..450	CDD:223238	208/440 (47%)
CG8745	NP_648665.1	OAT_like	37..447	CDD:99735	198/420 (47%)
eppl-1	NP_001023346.1	GabT	13..463	CDD:223238	208/441 (47%)
eppl-1	NP_001023346.1	OAT_like	49..462	CDD:99735	197/417 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167797
Domainoid	1	1.000	390	1.000	Domainoid score	I405
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69440
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1014
Isobase	1	0.950	-	0	Normalized mean entropy	S1443
OMA	1	1.010	-	-		QHG63788
OrthoDB	1	1.010	-	-		D145181at2759
OrthoFinder	1	1.000	-	-		FOG0000701
OrthoInspector	1	1.000	-	-		oto18290
orthoMCL	1	0.900	-	-		OOG6_103965
Panther	1	1.100	-	-	LDO	PTHR45688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2389
SonicParanoid	1	1.000	-	-		X1960
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890