Sequence 1: | NP_002294.2 | Gene: | LEPR / 3953 | HGNCID: | 6554 | Length: | 1165 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001284756.1 | Gene: | sdk / 31017 | FlyBaseID: | FBgn0021764 | Length: | 2265 | Species: | Drosophila melanogaster |
Alignment Length: | 1280 | Identity: | 240/1280 - (18%) |
---|---|---|---|
Similarity: | 419/1280 - (32%) | Gaps: | 468/1280 - (36%) |
- Green bases have known domain annotations that are detailed below.
Human 18 VITAFNLSYPITPWRFKLSCMPPN--STYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFS 80
Human 81 NLSKTTFHCCFRSEQDRNCSLCADNIEGK-TFVS--------------TVNSLVFQQIDANWNIQ 130
Human 131 CWLKGDLKLFICYVESLF-----KNLFRNYNYK--------------VHL-------LYVLPEVL 169
Human 170 EDSPLVPQKGSFQMVHCNC-----SVHECCECL-----VPVPTA----KLND----TLLM----- 211
Human 212 -------C-LKITSGGVIFQSPLMSVQPINMVKPDPPL-------------GLHMEITDD--GNL 253
Human 254 KISWSSPPLVPFPLQYQVKYSENSTTV----------------------------------IREA 284
Human 285 DKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIW-------------------SDWSTPRVFTT 330
Human 331 QDVIYFPPKILTSV-GSNVSFHCIYKKENKIV--PSKEIVWWMNLAEKIPQSQYDVVSDHVSKVT 392
Human 393 FFNLNETKPRGKFTYDA-VYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQS 456
Human 457 LAESTLQLRYHRSSLYC--SDIPSI-------------HPISEPKDCYLQSDGFYECIFQPIFLL 506
Human 507 SGYTMWIRINHSLGSLDSPPTCVLPD-----------SVVK-PLPPSSVKAE-------ITINIG 552
Human 553 LLKISWEKPVFPENNLQFQI-RYGLSGKEV-----------QWKMYEVYDAKSKSVSLPVPDLCA 605
Human 606 VYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKN 670
Human 671 DSLCSVQRYVINHHT--SCNGTWS-EDVGNHTKFTFL------WTEQAHTVTVLAINSIGASVAN 726
Human 727 FNLTFSWPMSKVNIVQSLSAYP--------LNSSCVIVSWILSPSDYKLM-----YFIIEWKNLN 778
Human 779 EDGEIKWLRISSSVKKYYIHDHFIP----------------IEKYQFSLYPIFM-------EGVG 820
Human 821 KPKIINSFTQDDIEKH--------QSDAGLYVI-VPVIISSSILLLGT----------------- 859
Human 860 ------LLISHQRMKKLFWEDVPNPKNCSWAQ-GLNFQKPETFEHLFIKHTASVTCG--PLLLEP 915
Human 916 ETISEDISVD------------------TSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSV 962
Human 963 NFSEAEGTEVTYEDESQRQPFVKY------ATLISNSKPSETGEE 1001 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
LEPR | NP_002294.2 | FN3 | 237..330 | CDD:238020 | 29/160 (18%) |
Lep_receptor_Ig | 333..420 | CDD:283889 | 17/90 (19%) | ||
Leptin-binding. /evidence=ECO:0000305|PubMed:22405007 | 467..484 | 7/31 (23%) | |||
FN3 | 537..627 | CDD:238020 | 25/108 (23%) | ||
WSXWS motif | 622..626 | 1/3 (33%) | |||
fn3 | 741..812 | CDD:278470 | 18/99 (18%) | ||
Box 1 motif | 871..879 | 1/7 (14%) | |||
Required for JAK2 activation. /evidence=ECO:0000250|UniProtKB:P48356 | 893..898 | 0/4 (0%) | |||
Required for STAT3 phosphorylation. /evidence=ECO:0000250|UniProtKB:P48356 | 898..906 | 2/7 (29%) | |||
sdk | NP_001284756.1 | Ig | 71..157 | CDD:299845 | 13/80 (16%) |
I-set | 72..150 | CDD:254352 | 11/64 (17%) | ||
Ig | 172..245 | CDD:299845 | 12/78 (15%) | ||
IG_like | 280..356 | CDD:214653 | 18/76 (24%) | ||
Ig | 280..343 | CDD:299845 | 14/63 (22%) | ||
IG_like | 375..450 | CDD:214653 | 16/88 (18%) | ||
Ig | 378..447 | CDD:143165 | 13/82 (16%) | ||
Ig | 506..587 | CDD:299845 | 20/109 (18%) | ||
IG_like | 506..587 | CDD:214653 | 20/109 (18%) | ||
I-set | 592..682 | CDD:254352 | 21/107 (20%) | ||
Ig | 595..682 | CDD:299845 | 20/104 (19%) | ||
FN3 | 686..789 | CDD:238020 | 27/113 (24%) | ||
FN3 | 798..893 | CDD:238020 | 20/106 (19%) | ||
FN3 | 901..1005 | CDD:238020 | 22/116 (19%) | ||
fn3 | 1011..1094 | CDD:278470 | 12/87 (14%) | ||
FN3 | 1108..1202 | CDD:238020 | 18/113 (16%) | ||
FN3 | 1210..1308 | CDD:238020 | |||
fn3 | 1317..1402 | CDD:278470 | |||
FN3 | 1415..1507 | CDD:238020 | |||
FN3 | 1513..1608 | CDD:238020 | |||
fn3 | 1617..1708 | CDD:278470 | |||
FN3 | 1722..1823 | CDD:238020 | |||
FN3 | 1828..1920 | CDD:238020 | |||
FN3 | 1927..2016 | CDD:238020 | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
1 | 0.910 |