Protein Alignment Hml and FCGBP

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: NP_003881.2
• Gene: FCGBP / 8857
• HGNCID: 13572
• Length: 5405
• Species: Homo sapiens
• Alignment Length: 4365
• Identity: 962/4365 - (22%)
• Similarity: 1404/4365 - (32%)
• Gaps: 1455/4365 - (33%)

  Fly    97 YGGIKT----SHAAGGLLTK-TLGFLGMGGQG-------SQGNF--YGGGGHFLA--AFG----- 140
            |.|:.|    ||:..  ||: .:||:.:..|.       |:|..  |..|...:.  .||
Human   527 YVGLVTVRAYSHSVS--LTRGEVGFVLVDNQRSRLPVSLSEGRLRVYQSGPRAVVELVFGLVVTY 589

  Fly   141 --KCS-ALQLPSNVQSE-CHNGRCKVFCPTGYSFAQDVSVLEMFCSNDGWIIGNSV-FA---EVP 197
              .|. ||.||:..|.: |  |.|.       ::..|.:  :.|.:.||.:..::| ||   ::.
Human   590 DWDCQLALSLPARFQDQVC--GLCG-------NYNGDPA--DDFLTPDGALAPDAVEFASSWKLD 643

  Fly   198 PCQAQCTPPCQNNGICISAGVCQCPENYYGP-LCQQKKSICASFPKAPKNSKVSCKNNMCH---- 257
            .....|...||||....:.|..|   :|.|. ||.....:...|.             :||
Human   644 DGDYLCEDGCQNNCPACTPGQAQ---HYEGDRLCGMLTKLDGPFA-------------VCHDTLD 692

  Fly   258 -----AECMRGFQFPDGSGITNIECRN---------------GQWVHTKTGLSKTPDCAPTCAPA 302
                 .:|:.......|..::  .||.               |.|        ::|...|...||
Human   693 PRPFLEQCVYDLCVVGGERLS--LCRGLSAYAQACLELGISVGDW--------RSPANCPLSCPA 747

  Fly   303 CQNGGQCISFNVCQCSKMFRGDHCQYNIDRCN--VTNTNFNGNYKCAYEMDDARCTFSCPQVPGL 365
            ...      :.:|       |..|..:   ||  ...:|.:|.          .|...|..:||.
Human   748 NSR------YELC-------GPACPTS---CNGAAAPSNCSGR----------PCVEGCVCLPGF 786

  Fly   366 KIQGRIDIEYKCNYLQGQYLPAPLPKCIF-----PPGYTVRSTSSMQ------GVTHQNGVYHRG 419
            ...|            |..:||....|.|     .||..|.:....|      |.|||  |..|.
Human   787 VASG------------GACVPASSCGCTFQGLQLAPGQEVWADELCQRRCTCNGATHQ--VTCRD 837

  Fly   420 MSGEMAYELQTERQKLLALLAKYRDLERRSEWWSSEETVVTMSSYSLYQSNNLDIVIDKTPRPAL 484
            .....|.|..:.:.   .||..|.|                                    |...
Human   838 KQSCPAGERCSVQN---GLLGCYPD------------------------------------RFGT 863

  Fly   485 CTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGTFDIILKACPYGSGYGCAHTLKILWQSVLYT 549
            |...|..:..:|||..|....:|::.|:                 ||   |.....:....||..
Human   864 CQGSGDPHYVSFDGRRFDFMGTCTYLLV-----------------GS---CGQNAALPAFRVLVE 908

  Fly   550 FENLNG-TMQLTTPIKKLPMPVQVMGMKVM------------PVAQHV-------QIDLESVG-- 592
            .|:... |:..|..::     |:..|:||.            .|.|::       |:.:...|
Human   909 NEHRGSQTVSYTRAVR-----VEARGVKVAVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQGRD 968

  Fly   593 ----------LKLDWDHRQYVSVQAGPQMWGK-VGGLCGTLDGDPNTDLTSRTGKKLATVKAFAD 646
                      :..||:.|....|   |..:.: :.||||..:|||..||..|.|.:.|...||.:
Human   969 AVVRTDFGLTVTYDWNARVTAKV---PSSYAEALCGLCGNFNGDPADDLALRGGGQAANALAFGN 1030

  Fly   647 AWRVEDRSELCQVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEK--LGDCIKPFNYDALIRTC 709
            :|:.|.|.. |......:.. .:||....:|| :.:.| .:||:.|  ..:|....:....:|.|
Human  1031 SWQEETRPG-CGATEPGDCP-KLDSLVAQQLQ-SKNEC-GILADPKGPFRECHSKLDPQGAVRDC 1091

  Fly   710 MADYCNCANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVEPT 774
            :.|.|....:..|   .|||:|..|..|...|..: |.||:.|:||:||.....|:||......:
Human  1092 VYDRCLLPGQSGP---LCDALATYAAACQAAGATV-HPWRSEELCPLSCPPHSHYEACSYGCPLS 1152

  Fly   775 CDSDLALPASKGA-CNEGCFCPEGTVQYKEACITRELCPCSLRGKEFKPESTV--KKNCNT-CTC 835
            | .||.:|...|: |:|||.|.||.....|:|:....|.|..:|....|..|.  ...|:: |.|
Human  1153 C-GDLPVPGGCGSECHEGCVCDEGFALSGESCLPLASCGCVHQGTYHPPGQTFYPGPGCDSLCHC 1216

  Fly   836 KNGQW-RCTEDKCG-------------------ARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKT 880
            :.|.. .|....||                   :.|.|.|||||.||||:|:||||.|.|.|.:|
Human  1217 QEGGLVSCESSSCGPHEACQPSGGSLGCVAVGSSTCQASGDPHYTTFDGRRFDFMGTCVYVLAQT 1281

  Fly   881 QNT-------SVEAENVAC-SGAVSESMNFAAPDDPSCTKAVTIR---FILRDGTPSVIKLDQGL 934
            ..|       :|..||||. :|.|            |.|:.:|::   |.||        |:|..
Human  1282 CGTRPGLHRFAVLQENVAWGNGRV------------SVTRVITVQVANFTLR--------LEQRQ 1326

  Fly   935 TTIVNDKPIAKLPKMLGLGEVLIRRAS--STFLTVEFADGIRVWWDGVSRVYIDAPPSLRGQTQG 997
            ..:..:....|||.:|..|::   |||  .:.:.:|...|:||.:|.|..|.:..|.:...|..|
Human  1327 WKVTVNGVDMKLPVVLANGQI---RASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCG 1388

  Fly   998 LCGTFNSNTQDDFLTPEGDVETAVEPFADKWR--TKDT-------CQFKAETHQGPHPCTLNPEK 1053
            |||.:|.:.:|||..|.|........|.:.|.  ..|:       |...:|.....|.|....||
Human  1389 LCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEK 1453

  Fly  1054 KAQAEKFCDWILQDI--FQDCHFLVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQGV 1116
            |.|.|:||..:....  ...||.||:|:...:||::|.|.....:| ..|..:.||.:.|...|.
Human  1454 KYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLS-ILCSNIHAYVSACQAAGG 1517

  Fly  1117 KT-GWRMSVKECAVKCPLGQVFDECGDGCALSCDDLPSKGSCKRECVEGCRCPHGEYVNEDGECV 1180
            .. .||... .|.::||....::.|.|.|:|.|..|.:...|:..|.|||:|..|...|... ||
Human  1518 HVEPWRTET-FCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGCAEGCQCDSGFLYNGQA-CV 1580

  Fly  1181 PKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQP 1245
            |.:.|.|..:|:.:.|        |:.:.:..|                        |.:|
Human  1581 PIQQCGCYHNGVYYEP--------EQTVLIDNC------------------------RQQC---- 1609

  Fly  1246 YAEFTKCAPKEPKTCKNMDKYVADSSDCLPGCVCM-EGYVYDTSRLACVLPANCSCHHAGKSYDD 1309
                         ||......|.....|.||.||. .|.:     |:||  ....||  |.:...
Human  1610 -------------TCHAGKGMVCQEHSCKPGQVCQPSGGI-----LSCV--TKDPCH--GVTCRP 1652

  Fly  1310 GEKIKEDCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFDFQGACDYVLA----KGVFD 1370
            .|..||       :.|...|..| .|:||.:|||.|:.:|||..|||||.|:||||    .||..
Human  1653 QETCKE-------QGGQGVCLPN-YEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVST 1709

  Fly  1371 NG-DGFSITIQNVLCGTMGVTCSKSLEIALTG-----HAEESLLLSADSAYSTDPNKTPIKKLRD 1429
            .| ..|::|.:|...|...|:..:.:.:|..|     |.:|...:..:...:..|  ..:...|.
Human  1710 QGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALP--VSVADGRI 1772

  Fly  1430 SVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDM 1494
            ||......|..:...|           |||.:|...||.|.|.:.:...|.|||||.:.|..:|.
Human  1773 SVTQGASKALLVADFG-----------LQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQ 1826

  Fly  1495 QTPSMGLETSPMLFGHAWKL---QPHC------SAPVAPIDACKKHPERETWAQLKCGALKSDL- 1549
            ..|:..|..|..::|.:|:.   .|.|      |.|..|.|..::: |...:    ||.|....
Human  1827 VFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQY-EGPGF----CGPLAPGTG 1886

  Fly  1550 --FKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIR-WRSQHFCPMQ 1611
              |..|||.||.|.|:|.|:.|.|.  .|||.:.||.|:|:|..||...|:.|. ||:|..|.:.
Human  1887 GPFTTCHAHVPPESFFKGCVLDVCM--GGGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEIT 1949

  Fly  1612 CDPHCSDYKACTPACAVETCDN---FLDQGIAERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCV 1673
            | |..|.|:.|...|.. :|.:   .....:.|     ..|:|||.   |:.||:...|.   ||
Human  1950 C-PENSHYEVCGSPCPA-SCPSPAPLTTPAVCE-----GPCVEGCQ---CDAGFVLSADR---CV 2001

  Fly  1674 PKAECKPVCMVRDGKTFYEGDITF--TDSCAT-CRCSK--RKEICSGVKCDVPATTGLPAPLVEG 1733
            |   ....|......|::|....|  ..:|:. |||..  ...:|:...|.:....||   |..|
Human  2002 P---LNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGL---LPSG 2060

  Fly  1734 TTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRME----NVYGTCLKQYMT 1794
            .....|::|   .:|    ..|.|                  |.|..::    |..|||  :|:.
Human  2061 QHGCQPVST---AEC----QAWGD------------------PHYVTLDGHRFNFQGTC--EYLL 2098

  Fly  1795 KVECR------------VKDTHEA--------------------------------------PEQ 1809
            ...|.            |.:.|..                                      |.|
Human  2099 SAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQ 2163

  Fly  1810 MDE---------NVVCSLEEGLR---------------------CIGKCHDY------ELRAF-- 1836
            :|.         :||.:...||.                     | |.|.:|      :|:|.
Human  2164 LDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAGSLC-GLCGNYNQDPADDLKAVGG 2227

  Fly  1837 ------------C-QCDEELEPELPKPTEKPQLGLACDAAVVEYKEFP-GDCHKFL--------- 1878
                        | :|..:..|....|.::...|......|:...:.| ..||..:
Human  2228 KPAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGC 2292

  Fly  1879 ---HCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCG--LKPEPEPEFEPIKQC 1938
               .||.:|..||                   :|..:||........|  |:....|:|.|. ||
Human  2293 LLDACQVQGHPGG-------------------LCPAVATYVAACQAAGAQLREWRRPDFCPF-QC 2337

  Fly  1939 PPGKIKSECANQCENTCHYYGSILKKRGLCQVGEHCKPGCVDELRPDCPKLGKFWRDEDTCVHAD 2003
            |.......|.:.|..:|   .|:....| |:  ..|:.|||.:        ..|....||||...
Human  2338 PAHSHYELCGDSCPGSC---PSLSAPEG-CE--SACREGCVCD--------AGFVLSGDTCVPVG 2388

  Fly  2004 ECPCMDKAEHYV--QPHKPVLGEFEVCQCIDNA-FTCVPNK--PEPVPKDEDDDLDLVSV----- 2058
            :|.|:....:|.  |...|..|...:|:|.:.. .:|.|:.  |....:.....|..|:|
Human  2389 QCGCLHDDRYYPLGQTFYPGPGCDSLCRCREGGEVSCEPSSCGPHETCRPSGGSLGCVAVGSTTC 2453

  Fly  2059 --------------------VPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEH 2103
                                ..:|.:..|...:....|.....||.|..      |....:....
Human  2454 QASGDPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWG------NGRVSVTRVI 2512

  Fly  2104 GPKMARLTKEQPRGSWSPSINDQMQYLELNFAKPEPFYGVVMAGSPEFDNYV-TLFKILHSHDGI 2167
            ..::|..|....:..|..::|.....|.:..|.     |.:.|.....|..: |.|.:..::|.:
Human  2513 TVQVANFTLRLEQRQWKVTVNGVDMKLPVVLAN-----GQIRASQHGSDVVIETDFGLRVAYDLV 2572

  Fly  2168 AY--------HYLV-------------DETEKPQMFNGPLDSRAPVQTLFKIPIEASSLRIYPLK 2211
            .|        :|.:             |:.:||   ||.               :|.:...:...
Human  2573 YYVRVTVPGNYYQLMCGLCGNYNGDPKDDFQKP---NGS---------------QAGNANEFGNS 2619

  Fly  2212 WHGSIAMRVELLICGDKEEPKPVPTVSTILPITERPARLVDLECIDLMGVDEGKMYQDQVQSSSL 2276
            |.                  :.||....:.|.|..|.             .||.:..::.
Human  2620 WE------------------EVVPDSPCLPPPTCPPG-------------SEGCIPSEEC----- 2648

  Fly  2277 WQQPNLGKKLQLLELL-KLSTPLAWRPLANSQNEFIEFDFLEPRN-----ISGFVTKGGPDGWVT 2335
              .|.|.||.|..|.. .||:|..  ||::...      .::|:.     |......||
Human  2649 --PPELEKKYQKEEFCGLLSSPTG--PLSSCHK------LVDPQGPLKDCIFDLCLGGG------ 2697

  Fly  2336 GYKVMFSKKKPTWNTVLSTDGQARIFEANHDAETERRHHFKNPILTQYIKIVPAYWEKNINMRIE 2400
            ...::.|......:...:..||         .|..|...|           .|....:|.:..:.
Human  2698 NLSILCSNIHAYVSACQAAGGQ---------VEPWRNETF-----------CPMECPQNSHYELC 2742

  Fly  2401 PLGCFLPYPEIQRQVPVEESKPTKCNICDGVSTSSSTTGCQCQDQLFWDGNTCVQHNLCPCIENY 2465
            ...|.|....:        |.|.:|.  ||.:     .||||.....::|..||....|.|..|.
Human  2743 ADTCSLGCSAL--------SAPLQCP--DGCA-----EGCQCDSGFLYNGQACVPIQQCGCYHNG 2792

  Fly  2466 VSY-PIGSKFENSACEDCVCVLGGHKNCKPKKCPPCLGGKLRPVITSDCFCKCEPCPKHQRLCPS 2529
            ..| |..:...::..:.|.|.:|....|:...|.|                        .::|..
Human  2793 AYYEPEQTVLIDNCRQQCTCHVGKVVVCQEHSCKP------------------------GQVCQP 2833

  Fly  2530 SGDCIPEILWCNGVQDCADDEDASCSDSFTVEPDVSREKNETEVITCPVPVCPPQMKIRITEKKS 2594
            ||          |:..|.:
Human  2834 SG----------GILSCVN---------------------------------------------- 2842

  Fly  2595 RKMSKMFTFSKQVSIVDDGTTITKTKFISSKEQILAMPNRELDFQLEEQCDEFTCVPIPSKQVDK 2659
                                                          ::.|...||.|
Human  2843 ----------------------------------------------KDPCHGVTCRP-------- 2853

  Fly  2660 NETVTCTEPKCPEKYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISG-KSFTTFDGTVFKY-GP 2722
            .||       |.|:         ...|.||       ||.:..|.:.| ..:.:|||..|.: |.
Human  2854 QET-------CKEQ---------GGQGVCL-------PNYEATCWLWGDPHYHSFDGRKFDFQGT 2895

  Fly  2723 CSHILARDIHSSSWSISVHQQCSD-ETRKVCHKVITIQDTEAGNELILLPHL------------- 2773
            |:::||.            ..|.. .|:.:....:|.::...||..:....:
Human  2896 CNYVLAT------------TGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIH 2948

  Fly  2774 -----KLKFNGYEFTVQQLINSPICKASFVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSKF 2833
                 |::.||    |...:...:......|:|.....|.|: .:|..|..|....|.|.:.|.:
Human  2949 KDEIGKVRVNG----VLTALPVSVADGRISVTQGASKALLVA-DFGLQVSYDWNWRVDVTLPSSY 3008

  Fly  2834 IRTVDGLCGYYNGNQKDDKRSPDGQIIPNTEKFGDSWYDKRIPK------DQCGDLKCP-----R 2887
            ...|.||||..:.|..:|:..|:|.:.|:...:|.||   |.|.      |:|.. .||     |
Human  3009 HGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSW---RAPGWDPLCWDECRG-SCPTCPEDR 3069

  Fly  2888 EMQAKALQLCNIIHHPT---FARCHKAVNYKQFLNNYCLEAACNCMMANNGDPAACKCNILESFV 2949
            ..|.:....|..:...|   |..||..|..:.|.....|:.   ||...:.|   ..|..|.|:|
Human  3070 LEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDV---CMGGGDRD---ILCKALASYV 3128

  Fly  2950 KKCLSVNPLVQLTTWRAVAQCEINCPSPLVHTDCYKRRCEPSCDNVHGDDCP---------VLPD 3005
            ..|.:...:::  .|||...|||.||.     :.:...|.|.|.    ..||         |...
Human  3129 AACQAAGVVIE--DWRAQVGCEITCPE-----NSHYEVCGPPCP----ASCPSPAPLTTPAVCEG 3182

  Fly  3006 ACFPGCYCPEGTVRKGPNCVPISECKDC------------------------------------- 3033
            .|..||.|..|.|.....|||::....|
Human  3183 PCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPA 3247

  Fly  3034 ------------------------VCNSLGASKYMTYDRKSFSFNGNCTYLLSRDVVLP--GVHT 3072
                                    .|.:.|...|:|.|...|.|.|.|.||||.....|  |...
Human  3248 SCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAEN 3312

  Fly  3073 FQVYVSMDDCKKLGQPTPVEGGSCAKS------LHILNGDHVIHVQRVPQKPKSLQVLVDGFEVK 3131
            |.|.|:.:           ..||.|.|      |.|.|  |.:.:.  .:.|:.||  |||..|
Human  3313 FTVTVANE-----------HRGSQAVSYTRSVTLQIYN--HSLTLS--ARWPRKLQ--VDGVFV- 3359

  Fly  3132 KIPYKDSWISLRQVVGKELVLSLPESHVELTASFE-DLIFSLGVPSIKYGSKMEGLCGDCNGNAG 3195
            .:|::...:....:.|.::|::....   |:.:|: |....|.||: .|...:.||||:.|.:..
Human  3360 TLPFQLDSLLHAHLSGADVVVTTTSG---LSLAFDGDSFVRLRVPA-AYAGSLCGLCGNYNQDPA 3420

  Fly  3196 NDLQPNPAKKKAGVDVIQSWQADEPKLGLVE---ECLSEDVPKEHCIPLPPEKDPCLQFYNAELF 3257
            :||:. ...|.||      ||     :|..:   ||:|:..|.    |..||:.        |.|
Human  3421 DDLKA-VGGKPAG------WQ-----VGGAQGCGECVSKPCPS----PCTPEQQ--------ESF 3461

  Fly  3258 G---KC--------PLA-----VDPIAYVSACQQDICKPGNTQQGVCVALAAYAKECNQHGI-CT 3305
            |   .|        |||     |.|..|...|..|.|:......|:|.|:|.|...|...|. ..
Human  3462 GGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLR 3526

  Fly  3306 NWRRPQLCPYECPSDMVYEPCG--CAKNCDTIKALSEFDAVSLKNEAVVHTVKTDEMCLSSERFE 3368
            .||||..||::||:...||.||  |..:|.::.|                    .|.|.|:.| |
Human  3527 EWRRPDFCPFQCPAHSHYELCGDSCPGSCPSLSA--------------------PEGCESACR-E 3570

  Fly  3369 GCFCPPGKVMDGGQCVPEIACTKCDDGLHLP--DEKWKKDKCTE-CQCDSKGKTTCVEKKCQVEE 3430
            ||.|..|.|:.|..|||...|....|..:.|  ...:....|.. |:|...|:.:|....|...|
Human  3571 GCVCDAGFVLSGDTCVPVGQCGCLHDDRYYPLGQTFYPGPGCDSLCRCREGGEVSCEPSSCGPHE 3635

  Fly  3431 NICAEGYRPETIVSVDECC-----PRYRCVPETKDPSKL-----CLAPLVPICG--PG------- 3476
            .....|.....:......|     |.|    .|.|..:.     |:..|...||  ||
Human  3636 TCRPSGGSLGCVAVGSTTCQASGDPHY----TTFDGHRFDFMGTCVYVLAQTCGTRPGLHRFAVL 3696

  Fly  3477 ----------------------------QFKKEKKDVNGCSQYICECIPKDQCE--------IIE 3505
                                        :.::.|..|||....:...:...|..        :||
Human  3697 QENVAWGNGRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIE 3761

  Fly  3506 --------------LRELLPG----------------------------------------EIIV 3516
                          :|..:||                                        |::
Human  3762 TDFGLRVAYDLVYYVRVTVPGNYYQLMCGLCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVV- 3825

  Fly  3517 NVEEGCCPTQKIECKPETCPKAPVNC---------QERFYEVK----TIKEP-GMCCSKHSCVPP 3567
             .:..|.|       |.|||.....|         .|:.|:.:    .:..| |...|.|..|.|
Human  3826 -PDSPCLP-------PPTCPPGSAGCIPSDKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDP 3882

  Fly  3568 K--------DLC-------IVQYELDEATKFTKTVG---DKW---THAKEVCKQ--------ETC 3603
            :        |||       |:...:.......:..|   :.|   |.....|.|        :||
Human  3883 QGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRNETFCPMECPQNSHYELCADTC 3947

  Fly  3604 SYG----------PDGNAQVVSTLEQCLTDCAPGFSYQNLDKTKCCGKCVQTSCIFEQKLYEVNA 3658
            |.|          |||.|      |.|  .|..||.|..    :.|....|..|......||...
Human  3948 SLGCSALSAPLQCPDGCA------EGC--QCDSGFLYNG----QACVPIQQCGCYHNGVYYEPEQ 4000

  Fly  3659 LWKSADNCTTYSCLKKDGQFLVTTSR-----EVCPDVGSCLSHLLYQDGC----CK---RCKSEP 3711
            . ...||| ...|....|:.:|....     :||...|..|| .:.:|.|    |:   .||.:
Human  4001 T-VLIDNC-RQQCTCHVGKVVVCQEHSCKPGQVCQPSGGILS-CVTKDPCHGVTCRPQETCKEQ- 4061

  Fly  3712 LVEDKSSCLPVSLA-------------ESRTKEILKFPVQGHGTCVNADPIQGFTDCEGACSSGS 3763
              ..:..|||...|             :.|     ||..|  |||   :.:...|.|.|..:.|.
Human  4062 --GGQGVCLPNYEATCWLWGDPHYHSFDGR-----KFDFQ--GTC---NYVLATTGCPGVSTQGL 4114

  Fly  3764 KYNTLTDMHE 3773
            ...|:|..::
Human  4115 TPFTVTTKNQ 4124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671	39/183 (21%)
		C8	684..754	CDD:462584	21/71 (30%)
		TIL	758..811	CDD:410995	18/53 (34%)
		VWD	840..1015	CDD:214566	65/207 (31%)
		C8	1054..1121	CDD:214843	20/69 (29%)
		TIL	1131..1185	CDD:410995	19/53 (36%)
		TIL	1245..1298	CDD:460351	12/53 (23%)
		VWD	1327..1498	CDD:214566	56/180 (31%)
		C8	1535..1609	CDD:214843	30/77 (39%)
		TIL	1938..2005	CDD:473303	17/66 (26%)
		FA58C	2089..2223	CDD:238014	22/155 (14%)
		FA58C	<2299..2403	CDD:238014	14/108 (13%)
		VWD	2703..2858	CDD:459671	37/175 (21%)
		TIL	2974..3030	CDD:460351	17/64 (27%)
		VWD	3035..3198	CDD:459671	48/171 (28%)
		C8	3248..3313	CDD:462584	24/81 (30%)
		VWC	3397..3451	CDD:450195	10/61 (16%)
		GHB_like	<3755..3813	CDD:473907	5/19 (26%)
FCGBP	NP_003881.2	IgGFc-binding	24..450
		IgGFc_binding	131..419	CDD:465430
		VWD	472..627	CDD:459671	27/112 (24%)
		C8	667..742	CDD:214843	14/97 (14%)
		TIL	745..799	CDD:460351	17/91 (19%)
		VWD	862..1014	CDD:214566	36/179 (20%)
		C8	1060..1133	CDD:214843	22/78 (28%)
		TIL	1136..1189	CDD:460351	18/53 (34%)
		VWC	1194..1245	CDD:450195	10/50 (20%)
		VWD	1249..1406	CDD:214566	62/179 (35%)
		C8	1454..1529	CDD:214843	22/76 (29%)
		TIL	1532..1585	CDD:460351	19/53 (36%)
		VWC	1587..1640	CDD:450195	17/106 (16%)
		VWD	1673..1832	CDD:459671	53/171 (31%)
		C8	1871..1946	CDD:214843	31/81 (38%)
		TIL	1950..2004	CDD:460351	19/69 (28%)
		VWD	2072..2222	CDD:459671	24/174 (14%)
		C8	2260..2334	CDD:214843	17/92 (18%)
		TIL	2337..2390	CDD:460351	17/66 (26%)
		VWC	2398..2446	CDD:450195	10/47 (21%)
		VWD	2450..2607	CDD:214566	24/170 (14%)
		C8	2655..2730	CDD:214843	18/108 (17%)
		TIL	2733..2786	CDD:460351	15/67 (22%)
		VWC	2788..2841	CDD:450195	14/86 (16%)
		VWD	2874..3033	CDD:459671	37/175 (21%)
		C8	3072..3147	CDD:214843	20/82 (24%)
		TIL	3151..3205	CDD:460351	17/62 (27%)
		VWD	3273..3423	CDD:459671	48/171 (28%)
		C8	3461..3535	CDD:214843	23/73 (32%)
		TIL	3538..3591	CDD:460351	23/73 (32%)
		VWC	3599..3647	CDD:450195	9/47 (19%)
		VWD	3651..3808	CDD:214566	21/160 (13%)
		C8	3856..3931	CDD:214843	14/74 (19%)
		TIL	3934..3987	CDD:460351	17/64 (27%)
		VWC	3989..4042	CDD:450195	14/55 (25%)
		VWD	4075..4234	CDD:459671	13/60 (22%)
		C8	4273..4348	CDD:214843
		TIL	4352..4406	CDD:460351
		VWD	4474..4624	CDD:459671
		C8	4662..4736	CDD:214843
		TIL	4739..4792	CDD:460351
		VWC	4797..4849	CDD:450195
		VWD	4856..5003	CDD:459671
		C8	5044..5118	CDD:214843
		TIL	5121..5174	CDD:460351
		VWD	5235..5382	CDD:459671