DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hml and CSS1

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	NP_012097.1	Gene:	CSS1 / 854637	SGDID:	S000001431	Length:	995	Species:	Saccharomyces cerevisiae

Alignment Length:	680	Identity:	119/680 - (17%)
Similarity:	183/680 - (26%)	Gaps:	270/680 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  2556 DSFTVEPDVSREK-----NETEVITCPVPVCPPQMKIRITEKKSRKMSKMFTFSKQVSIVD---- 2611
            |:||.:..|.:.:     :.||....|:||..                  :|...|::|..
Yeast   497 DTFTGQTVVFKGEGVLAVDPTETNATPIPVVG------------------YTGKNQIAITADITA 543

  Fly  2612 ---DGTT--ITKTKFISSKEQILAMPNRELDFQLEEQCDEFTCVPIPSKQVDKNETVTCTEPKCP 2671
               ||||  :|.|:           .||:..|.:......
Yeast   544 LSYDGTTGVLTATQ-----------GNRQFSFAIGTGFSS------------------------- 572

  Fly  2672 EKYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISGKSFTTFDGTVFKYGPCSHILARDIHSS-- 2734
            ..:.|...:.|......|.|:.|:..:.......||.|.:....|.|.........:....:|
Yeast   573 SDFSVSEGIFAGAYAYYLNYNGVVATSAASSSTASGASASVTGSTSFGASVTGSTASTSFGASVT 637

  Fly  2735 ------------SWSISVHQQCSDETRKVCHKVITIQDTEAGNELILLPHLKLKFNGYEFTVQQL 2787
                        :.|.||:....|........|::..:|...             ||..:|:...
Yeast   638 GSTASTSFGASVTGSTSVYTTTLDYVNATSTVVVSCSETTDS-------------NGNVYTITTT 689

  Fly  2788 INSPICKASFVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSKFIRTV------DGLCGYYNG 2846
            :  |....:..::...:|...|||..|        .:|...:|||...|.      |..|
Yeast   690 V--PCSSTTATITSCDETGCHVSTSTG--------AVVTETVSSKSYTTATVTHCDDNGC----- 739

  Fly  2847 NQKDDKRSPDGQIIPNTEKFGDSWYDKRIPKDQCGDLKCPREMQAKALQLCNIIHHPTFARCHKA 2911
                           ||         |.:..:      |.:|               |.|.....
Yeast   740 ---------------NT---------KTVTSE------CSKE---------------TSATTASP 759

  Fly  2912 VNYKQFLNNYCLEAACNCMMANNGDPAACKCNILESFVKKCLSVNPLVQLTTWRAVAQCEIN-CP 2975
            .:|......:|.:..||.....:..|.|.....:.|            |..|...|..|:.| |.
Yeast   760 KSYTTVTVTHCDDNGCNTKTVTSEAPEATTTTTVSS------------QSYTTATVTHCDDNGCK 812

  Fly  2976 ----------------SPLVHTDCYKRRCEPSCDNVHGDDCPVLPDACFPGC-------YCPEGT 3017
                            ||..:|.....:|:   ||               ||       .|||.|
Yeast   813 TKTVTSEAPEATTTTVSPKTYTTATVTQCD---DN---------------GCSTKTVTSECPEET 859

  Fly  3018 VR-----KGPNCVPISECKDCVCNSLGASKYMTYDRKSFSFNGNCTYLLSRDVVLPGVHTFQVYV 3077
            ..     |....|.::.|.|..||    :|.:|.:...          .:...|.|..:|.....
Yeast   860 SATTTSPKSYTTVTVTHCDDNGCN----TKTVTSEAPE----------ATTTTVSPKTYTTATVT 910

  Fly  3078 SMDD--C--KKLGQPTP------VEGGSCAKSLH----ILNGDHVIHVQRVPQKPKSLQVLVDGF 3128
            ..||  |  |.:....|      .|..:..|.:|    :||||.                  :|.
Yeast   911 QCDDNGCSTKTVTSEAPKETSETSETSAAPKDIHYCHWLLNGDD------------------NGC 957

  Fly  3129 EVK----KIPYKDSWISLRQVVGKELVLSL 3154
            .||    |||...|.::...::....:|||
Yeast   958 NVKIITSKIPEATSTVTQLVLLQSHTLLSL 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339	28/174 (16%)
		C8	2893..2970	CDD:285899	12/76 (16%)
		TIL	2974..3030	CDD:280072	15/83 (18%)
		VWD	3035..3198	CDD:295339	29/138 (21%)
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
CSS1	NP_012097.1	Hyphal_reg_CWP	313..596	CDD:371712	25/152 (16%)
CSS1	NP_012097.1	PRK12355	627..>977	CDD:237072	85/484 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900