Protein Alignment Hml and HPF1

DIOPT Version :9

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: NP_014487.1
• Gene: HPF1 / 854010
• SGDID: S000005515
• Length: 967
• Species: Saccharomyces cerevisiae
• Alignment Length: 491
• Identity: 89/491 - (18%)
• Similarity: 145/491 - (29%)
• Gaps: 160/491 - (32%)

  Fly    61 ILKAPAVSARYTYG-GSEGGRSGFGGGYGVGGGGGG---GYGGIKTSHA-------AGGLLTKTL 114
            :|.|...::::::. |:....|||....|...|...   .|||:..|.|       ..|....|.
Yeast   577 VLTATQGNSQFSFSIGTGFSSSGFNVSEGTFAGAYAYYLNYGGVVASSATPSSTSTTSGATNSTS 641

  Fly   115 GFLGMGGQ--GSQGNFYGGGGHFLAAFGKCSALQLPSNVQSECHNGRCKVFCPTGYSFAQDVSVL 177
            |....|..  ||..:         .:||    ..:..:..|...:|...|:..| .::|...|.:
Yeast   642 GSTSFGASVTGSTAS---------TSFG----ASVTGSTASTLISGSPSVYTTT-LTYATTTSTV 692

  Fly   178 EMFCSNDGWIIGN-----------SVFAEVPPC-QAQC-----------------------TPPC 207
            .:.||......||           |..|.:..| :..|                       ...|
Yeast   693 VVSCSETTDSNGNVYTITTTVPCSSTTATITSCDETGCHVTTSTGTVATETVSSKSYTTVTVTHC 757

  Fly   208 QNNGICISAGVCQCPENYYGPLCQQKKSICASFPKAPKNSKVS-CKNNMCHAECMRGFQFPDGSG 271
            .|||........:|||         :.|...:.||:.....|: |.:|.|
Yeast   758 DNNGCNTKTVTSECPE---------ETSATTTSPKSYTTVTVTHCDDNGC--------------- 798

  Fly   272 ITNIECRNGQWVHTKTGLSKTPDC-APTCAPACQNGGQCISFNVCQCSKMFRGDHCQYNIDRCNV 335
                        :|||..|:.|:. ..|.:|....     :..|.||..           :.|:.
Yeast   799 ------------NTKTVTSEAPEATTTTVSPKTYT-----TATVTQCDD-----------NGCST 835

  Fly   336 -TNTNFNGNYKCAYEMDDARCTFSCPQVPGLKIQGRIDIEYKCNYLQGQYLPAPLPKCIFPPGYT 399
             |.|:     :...|..:...|.:.|:........:.| :..||.   :.:.:.:|:.......|
Yeast   836 KTVTS-----EAPKETSETSETSAAPKTYTTATVTQCD-DNGCNV---KIITSQIPEATSTVTAT 891

  Fly   400 VRSTSSMQGVTHQNGVYHRGMSGEMAYELQTERQKLLALLAKYRDLERRSEWWSSEETVVTMSSY 464
            ..|..|...||.:         |..|..|.|...|..:.::.|          |.....:..|:.
Yeast   892 SASPKSYTTVTSE---------GSKATSLTTAISKASSAISTY----------SKSAAPIKTSTG 937

  Fly   465 SLYQSNNLDIVIDKTPRPALCTTWGGINMKTFDGLV 500
            .:.||..:.               .|:|..|.:.||
Yeast   938 IIVQSEGIA---------------AGLNANTLNALV 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339	5/16 (31%)
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
HPF1	NP_014487.1	Hyphal_reg_CWP	337..617	CDD:403079	8/39 (21%)
		Herpes_BLLF1	<643..937	CDD:282904	66/387 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900