DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and FRAS1

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:NP_079350.5 Gene:FRAS1 / 80144 HGNCID:19185 Length:4012 Species:Homo sapiens


Alignment Length:1477 Identity:274/1477 - (18%)
Similarity:419/1477 - (28%) Gaps:634/1477 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly  2421 KPTKCNI--CDGVSTSSSTTGCQCQDQLFWDG-------NTCVQHNLCP---------CIENYVS 2467
            ||..|..  |.|.........|:.....|..|       |.|     ||         |......
Human    42 KPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQC-----CPECVLRTPGSCHHEKKI 101

  Fly  2468 YPIGSKFENSACEDCVCVLGGHKNCKPKKCPP--CLGGKLRPVITSDCFCKC----EPCPKHQRL 2526
            :..|:::.:|.|..|.| ..|...|.|:.|||  |...:|..:....|...|    :||.....:
Human   102 HEHGTEWASSPCSVCSC-NHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYEGHV 165

  Fly  2527 CPSSGD-----CIPEILWCNGVQDCADDEDASCSDSFTVEPDVSREKNETEVITCPVPVCPPQMK 2586
            .....|     | .:.|..|||..|.   .|.|...|.       .::|| |:..|...||    
Human   166 FQDGEDWRLSRC-AKCLCRNGVAQCF---TAQCQPLFC-------NQDET-VVRVPGKCCP---- 214

  Fly  2587 IRITEKKSRKMSKMFTFSKQVS-------IVDDGTTITKTKFISSKEQILAMPNRELDFQLEEQC 2644
             :.:.:......:::...:|.|       |.|.|                           |.:|
Human   215 -QCSARSCSAAGQVYEHGEQWSENACTTCICDRG---------------------------EVRC 251

  Fly  2645 DEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISGKS 2709
            .:..|:|:   :..|.::......:|.|:       ..|..|.| .|..|:| .:|::.:.|...
Human   252 HKQACLPL---RCGKGQSRARRHGQCCEE-------CVSPAGSC-SYDGVVR-YQDEMWKGSACE 304

  Fly  2710 FTTFDGTVFKYGPCSHILARDIHSSSWSISVHQQCSDETRKVCHKVITIQDTEAGNELILLPHLK 2774
            |...|                          |.|.:.:|.: |.||...:|.|       |.||.
Human   305 FCMCD--------------------------HGQVTCQTGE-CAKVECARDEE-------LIHLD 335

  Fly  2775 -------LKFNGYEFTVQQLINSPICKASFVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSK 2832
                   :..|||            |    |..:.|:                            
Human   336 GKCCPECISRNGY------------C----VYEETGE---------------------------- 356

  Fly  2833 FIRTVDGLCGYYNGNQKDDKRSPDGQIIPNTEKFGDSWYDK-------RIPKDQCGDLKCP---- 2886
                      :.:.|..:.||.|:          |:.|.|.       |..:..|.:..||    
Human   357 ----------FMSSNASEVKRIPE----------GEKWEDGPCKVCECRGAQVTCYEPSCPPCPV 401

  Fly  2887 ----REMQAKALQLCNIIH-HPTFARCHKAVNY--------KQFLNNYCLEAACNCMMANNGDPA 2938
                .|::.:....|..:| ||....|.::.::        |...|.:|:. :|.......|   
Human   402 GTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVH-SCGLGFYQAG--- 462

  Fly  2939 ACKCNILESFVKKCLSVNPLVQLTTWRAVAQCEINCPSPLV--HTDCYKRRCEPSC-DNVHGD-- 2998
                       ..||:..|  |.:|..:..:|. :|..||:  |     .:|.|:| |..:.|  
Human   463 -----------SLCLACQP--QCSTCTSGLECS-SCQPPLLMRH-----GQCVPTCGDGFYQDRH 508

  Fly  2999 DCPVLPDACFPGCY-------------------------CPEGTVRKGPNCVPISECKDCVCNSL 3038
            .|.|..::| .||:                         |.:|...:...|   |.| |..|:|.
Human   509 SCAVCHESC-AGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTC---SAC-DQSCDSC 568

  Fly  3039 GAS--KYMTYDRKSFSFNGNCTYLLSRDVVLPGVH----TFQVYVSMDDCKKLGQPTPVEGGSCA 3097
            |.|  :.:|...|:...:|.|   :|.   .||.:    |.:..|..:.|.....|||....:|:
Human   569 GPSSPRCLTCTEKTVLHDGKC---MSE---CPGGYYADATGRCKVCHNSCASCSGPTPSHCTACS 627

  Fly  3098 KSLHILNGDHVIHVQRVPQKPKSLQV------LVDGFEVKKIPYKDSWISLRQVVGKELVLSLPE 3156
                               .||:|:.      ..:||      |.|                   
Human   628 -------------------PPKALRQGHCLPRCGEGF------YSD------------------- 648

  Fly  3157 SHVELTASFEDLIFSLGVPSIKYGSKMEGLCGDCNGNAGNDLQPNPAK----KKAGVDVIQSWQA 3217
                                       .|:|..|:.:....:.|.|:.    ||           
Human   649 ---------------------------HGVCKACHSSCLACMGPAPSHCTGCKK----------- 675

  Fly  3218 DEPKLGLVEECLSE-DVPKEHCIPLPPEKDPCLQFYNAELFGKCPLAVDPIAYVSACQQDI---- 3277
              |:.||..|.||: .:|...|:.      .|...:..|..|.|          .||.|..    
Human   676 --PEEGLQVEQLSDVGIPSGECLA------QCRAHFYLESTGIC----------EACHQSCFRCA 722

  Fly  3278 ---------CKPGNT----------------QQGVC----------------------------- 3288
                     |.|.:.                |:|.|                             
Human   723 GKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTN 787

  Fly  3289 ------------VALAAYAKECN---QH---------GICTNWRRPQL------CPYECPSDMVY 3323
                        :.|..|..:|:   ||         .||...:....      |..:|||....
Human   788 GNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPDCPSGYYA 852

  Fly  3324 EPCGCAK---NCDTIKALSEFDAVSLKNEAVVHTVKTDEMCLSSERFEGCFCPPGKVMDG----- 3380
            |...|.|   :|.|.:....|...|.....|:....|   |.::     ||  ||..:|.     
Human   853 ERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGT---CSTT-----CF--PGHYLDDNHVCQ 907

  Fly  3381 ------GQCVPEIACTKCDDGLHLPDE------------------KWKKDKCTECQ-----CDSK 3416
                  |.|..:.:||.|.|    |::                  .:..:.|.||.     |...
Human   908 PCNTHCGSCDSQASCTSCRD----PNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGP 968

  Fly  3417 GKTTCVEKKCQVEENICAEGYRPETIVSVDEC-------------CPRY-----------RCVPE 3457
            .||.|::         |.:||..:....|::|             |..|           ||   
Human   969 LKTDCLQ---------CMDGYVLQDGACVEQCLSSFYQDSGLCKNCDSYCLQCQGPHECTRC--- 1021

  Fly  3458 TKDPSKLCLAPLVPICGPGQFKKE-KKDVNGCSQYICECIPKDQCEIIELRELLPGEIIVNVEEG 3521
             |.|..|..|..|..||.|.|... |.....|.|...:|..:|:|.:.:....|...:.|   ..
Human  1022 -KGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCV---YN 1082

  Fly  3522 CCPTQKIECKPETC------PKAPV-------------------NCQER--------FYEVKTIK 3553
            |.|...:....|||      |...|                   |.|::        |:.|.|..
Human  1083 CVPGFSVHTSNETCSGKIHTPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFHVVSTPT 1147

  Fly  3554 EPGMCCSKHSCVPPKDLCIVQYELDEATKFT-KTVGDK---WTHAKE 3596
            ...:..|::.         .:.:||:|.:|: |.|.:|   :.|:||
Human  1148 NGQLVLSRNG---------KEVQLDKAGRFSWKDVNEKKVRFVHSKE 1185

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843
TIL 1131..1185 CDD:280072
TIL 1245..1298 CDD:280072
VWD 1327..1498 CDD:214566
C8 1535..1609 CDD:214843
Mucin2_WxxW 1751..1837 CDD:290069
TIL 1938..2005 CDD:280072
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339 24/161 (15%)
C8 2893..2970 CDD:285899 15/85 (18%)
TIL 2974..3030 CDD:280072 18/85 (21%)
VWD 3035..3198 CDD:295339 28/174 (16%)
C8 3257..3313 CDD:285899 17/143 (12%)
VWC 3397..3451 CDD:302663 14/89 (16%)
GHB_like <3755..3813 CDD:304424
FRAS1NP_079350.5 VWC 28..87 CDD:214564 12/49 (24%)
VWC 95..152 CDD:278520 15/57 (26%)
VWC 159..216 CDD:278520 17/73 (23%)
VWC 221..278 CDD:278520 12/93 (13%)
VWC 285..342 CDD:214564 19/92 (21%)
VWC 367..416 CDD:214564 10/58 (17%)
FU 1 409..460 9/51 (18%)
Furin-like 462..620 CDD:279142 42/190 (22%)
FU 2 462..505 15/64 (23%)
FU 462..504 CDD:214589 15/63 (24%)
FU 3 507..553 7/46 (15%)
FU 507..552 CDD:214589 7/45 (16%)
FU 4 555..599 15/53 (28%)
FU 556..598 CDD:214589 15/51 (29%)
FU 5 602..647 12/69 (17%)
FU 608..653 CDD:238021 13/115 (11%)
FU 6 649..705 16/74 (22%)
FU 650..704 CDD:214589 16/72 (22%)
GF_recep_IV 655..777 CDD:291509 25/150 (17%)
FU 7 708..753 7/54 (13%)
FU 708..752 CDD:214589 7/53 (13%)
FU 8 755..800 2/44 (5%)
FU 755..799 CDD:214589 2/43 (5%)
FU 9 803..852 10/48 (21%)
FU 804..851 CDD:214589 10/46 (22%)
Furin-like 841..1056 CDD:279142 54/241 (22%)
FU 10 854..900 13/55 (24%)
FU 859..907 CDD:238021 13/57 (23%)
FU 11 903..948 7/48 (15%)
FU 12 952..997 12/53 (23%)
FU 952..996 CDD:214589 12/52 (23%)
FU 13 999..1042 12/46 (26%)
FU 999..1041 CDD:214589 12/45 (27%)
Furin-like_2 1009..1099 CDD:292535 24/96 (25%)
FU 14 1046..1089 10/45 (22%)
FU 1046..1087 CDD:214589 10/43 (23%)
Cadherin_3 <1101..1183 CDD:292802 15/90 (17%)
CSPG 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1102..1197 18/93 (19%)
Cadherin_3 1168..1310 CDD:292802 7/18 (39%)
CSPG 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1217..1308
Cadherin_3 1279..1438 CDD:292802
CSPG 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1329..1438
Cadherin_3 1409..1574 CDD:292802
CSPG 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1463..1559
Cadherin_3 1529..1691 CDD:292802
CSPG 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1595..1689
Cadherin_3 1660..1811 CDD:292802
CSPG 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1710..1810
Cadherin_3 1778..1938 CDD:292802
CSPG 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1833..1936
Cadherin_3 1904..2059 CDD:292802
CSPG 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1957..2057
Cadherin_3 2028..2179 CDD:292802
CSPG 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2078..2177
Cadherin_3 2147..2293 CDD:292802
CSPG 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2199..2291
Cadherin_3 2261..2406 CDD:292802
CSPG 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2311..2404
Cadherin_3 2375..2537 CDD:292802
CSPG 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2439..2536
Calx_beta 2555..2650 CDD:197594
Calx-beta 2675..2764 CDD:295344
Calx-beta 2798..2894 CDD:295344
Calx-beta 2920..3011 CDD:295344
Calx-beta 3039..3133 CDD:295344
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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