DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hml and kcp

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	XP_697494.6	Gene:	kcp / 569039	ZFINID:	ZDB-GENE-070705-443	Length:	2200	Species:	Danio rerio

Alignment Length:	3123	Identity:	568/3123 - (18%)
Similarity:	876/3123 - (28%)	Gaps:	1360/3123 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 RGDHCQYN-IDRCNVTNTNFNGNYKCAYEMDDARCTFSCPQVPGLKIQGRIDIEYKCNYLQGQYL 385
            |||....| ::..|:|.:...          .::...|.|:.|..:::....:          .|
Zfish    32 RGDDTVINLLEALNITRSPHG----------VSKVKGSDPETPAWRLRSSTHL----------IL 76

  Fly   386 PAPLPKCIFPPGYTVRSTSSMQGVTHQNGVYHRGMSGEMAY----ELQTERQKLLALLAKYRDLE 446
            |..|.|.:|         |:.|||...:.:..:..:.|:..    ..|.||:.||.|::     .
Zfish    77 PQDLSKNLF---------STSQGVLGLHLLGRQTKNSEITLISVSNQQQERRPLLELIS-----N 127

  Fly   447 RRSEW----------------------------W----------------SSEETVVTMSS---- 463
            .:|:|                            |                ..:|.||....
Zfish   128 TQSDWLQMRFRSGDGLQTEVLKLPGGSPFTGGGWVRMALSVEPRQMLLFVDCQEAVVLKLKGGGR 192

  Fly   464 -YSLYQSNNLDIVIDKTPRPALCTT------W--GGINMKTFDGLVFKAPLSCSHTLITDKVSGT 519
             .||..::::.:...   |.|..||      |  ..::.:|::    :.|..|.:  |||.:..|
Zfish   193 ILSLDFTHDVQVTFS---RAAGNTTSKFSGSWQIAELSTRTYE----RRPWFCDN--ITDSLPDT 248

  Fly   520 FDIILKACP-----------YGSGYGCAHTLKILWQSVLY--TFENLNGTMQLTTPIKKLPMPVQ 571
            ....|...|           .|.|.|...|.......|.:  ...||:|.|.:...:|:....:|
Zfish   249 IHPTLSTVPAVPDLSMMRDEAGRGDGVLSTTGPSESDVRFGDLERNLHGIMTMLEMLKRQNTELQ 313

  Fly   572 VMGMKVMPVAQHVQI--DLESVGLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRT 634
            .          .|:.  ..|.:..|..|:.||   |..|......:..:|....|
Zfish   314 A----------RVEFLETCECIKRKCVWEGRQ---VDEGSHWSPDIRTVCSCSSG---------- 355

  Fly   635 GKKLATVKAFADAWRVE-DRSELCQVE---------------NSAEMEFG----------MDSCE 673
                          ||: :||..|..:               :..:.|:|          ..:||
Zfish   356 --------------RVQCNRSSECSFQSRIYSDGEVFSPDECSRCKCEYGRVECDVNPCPSQTCE 406

  Fly   674 QSKLQK-AVSVCERLLANEKLGDCIKPFNYDALIRT--CMADYCN---------------CAN-- 718
            :..:|: ..|||:..|..|..|. :....::.:.|:  |::..|:               |.|
Zfish   407 EPSVQRPCCSVCQTSLRCEHEGQ-VYENGHEFVSRSNPCLSCICSNSRVSCNTIQCPSTPCPNPY 470

  Fly   719 REHPESC-NCDAIAMLAKECAFKGIKLEHGWRNLEIC-PISCGFG--------RVYQACGPNVEP 773
            |...|.| .|.|       |...|......:..::.| ..:|..|        |..|.|...|:|
Zfish   471 RRPGECCPTCSA-------CDVDGRPYNGSFSTVDGCQTCTCQGGNQECVDVQRCPQTCQDGVKP 528

  Fly   774 ---TC---------DSDLALPA-----SKGACNEGCFCPEGTVQYKEACITRELC---PCSLR-- 816
               :|         |..:.|..     |...|.. |.|..|.:    .| ..|||   ||:|.
Zfish   529 PFGSCCRDCSRCYFDGQIVLDGVSFQDSSDPCKH-CVCSAGNI----VC-NPELCPELPCTLLET 587

  Fly   817 -GKEFKP--ESTVKKN---------------CNTCTCKNGQWRCTEDKCGARCGAVGDPHYQTFD 863
             |.:..|  .|.|::|               |:||||..|:.:|..::|...|.....|.    .
Zfish   588 VGGQCCPRCRSCVQENVWHLHGSQWRHPSDHCSTCTCTEGKIQCEHERCNVPCRNPASPP----P 648

  Fly   864 GKRYDFMGKCSYHLLKTQNTSVEAENVACSGAV----------------SESMNFAAPDD---PS 909
            |........|:.:.|...|.........|.|:.                :...|...|..   |.
Zfish   649 GSCCPVCEGCNLNGLDVPNGMPLPSGPVCEGSCRCENGNVICDRLPCPPTPCYNPVTPPGECCPR 713

  Fly   910 CTKAVTIRFILRDGTPSVIKLDQGLT------TIVNDKPIAKLPKMLGLGEVLIRRASSTFLTVE 968
            ||:.|....:..||...:.:.|..|.      .:..|.|.:..|
Zfish   714 CTECVYEGEVYEDGQTFISRQDPCLRCQCLGGQVSCDPPGSSCP--------------------- 757

  Fly   969 FADGIRVWWDGVSRVYIDAPPSLRGQTQ---GLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRT 1030
                               ||:....|:   ..|.|.|
Zfish   758 -------------------PPTCTHPTKPPTQCCATCN--------------------------- 776

  Fly  1031 KDTCQFKAETH--------QGPHPCTLNPEKKAQAEKFCDWILQDIFQDCHFLVEPEQFYEDCLY 1087
              ||:::...:        .|..||.|
Zfish   777 --TCEYEGRIYGDGEEFRPPGGGPCVL-------------------------------------- 801

  Fly  1088 DTCACKDEMSKCF--------CPI-LSAYGTEC-------------MRQGVKTGWRMSVKECAVK 1130
              |.||....:|.        ||: ..|...:|             ..:|  :.|....:.|:
Zfish   802 --CTCKGGNVRCHQERCPPTNCPVPTPAPPNQCCPACRGCVWNNNQYEEG--STWADGEQMCS-- 860

  Fly  1131 CPLGQVFDECGDGCALSCDDLPSKGSCKRECVEG--C-RCPHGEYVNEDGECV--PKKMCHCNFD 1190
            |..|||      .|.|:|   |:..||....|.|  | :|.:||||.|:|:..  |:..|
Zfish   861 CVAGQV------TCRLNC---PTPESCLEPIVTGGDCGQCQYGEYVYENGQSFQDPQDPC----- 911

  Fly  1191 GMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYPPSSELRSKC----AKQPYAEFTK 1251
                              ..|||.||...|                :...|    ...||....:
Zfish   912 ------------------VTCTCQDGQTRC----------------VLPACPAVTCVNPYTSPGE 942

  Fly  1252 CAPKEP--KTCK-------NMDKYVADSSDCLPGCVCMEGYVYDTSRLACVLPANCS-------- 1299
            |.|:.|  :.|:       |.|.:....:.|| .|||.:|:| |.....|..| ||:
Zfish   943 CCPRCPPVQDCEYDNRIITNGDTFPNPGNQCL-DCVCTDGHV-DCGNHECPKP-NCNYPRPGTCC 1004

  Fly  1300 ------CHHAGKSYDDGEKIK---EDCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFD 1355
                  |::||..|.:|.:..   ::|.:|.|..||.:|....|.   :|..|:.|..
Zfish  1005 QNNCNGCNYAGNEYPNGMEFPHPVDNCRMCRCTNGNVQCLMKRCP---AVHCDNSFVQ------- 1059

  Fly  1356 FQGAC---------DYVLAKGVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEESLLLSA 1411
             .|.|         |.::.:..:.:...||                         |       ..
Zfish  1060 -AGECCRQCPAPPADCIVEEQSYRHMQRFS-------------------------H-------PT 1091

  Fly  1412 DSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWR 1476
            ||..|
Zfish  1092 DSCQS------------------------------------------------------------ 1096

  Fly  1477 QKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPV-----APIDACKKHPERET 1536
                  |...||       |||......|         ...||.|:     ...|.|..|.....
Zfish  1097 ------CTCTNG-------TPSCRRRPCP---------SATCSHPIIQECCRTCDGCLYHGREHA 1139

  Fly  1537 WAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIR 1601
                 .||..:|....|.               ||.|..|        .|..:::.|.:..
Zfish  1140 -----NGATFADPSDSCR---------------TCVCRDG--------TVTCHSNQCQRIA---- 1172

  Fly  1602 WRSQHFCPM----QCDPHCSDYKACTPACAVETCDNFLDQGIAERM--CNRENCLEG---CHIKP 1657
                  ||.    ||.|||:       .|.....:....|..|:..  |....|..|   |:.||
Zfish  1173 ------CPFPVQDQCCPHCN-------GCMYAGVEYLNGQEFADPSDHCAHCICSNGHVTCNTKP 1224

  Fly  1658 CEDGFIYLNDTYRDCVPKAECKPVC--MVRDGKTFYEGDI--TFTDSCATCRCSKRKEICSGVKC 1718
            |.:.    ..||....|. :|.|||  ...:|:.:.:|::  :.|.||..||||:.:..||...|
Zfish  1225 CHNP----GCTYPTTRPD-QCCPVCDGCQFEGRVYVDGELFPSSTTSCEECRCSRGEVECSPKSC 1284

  Fly  1719 DVPATTGLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMEN 1783
                      |:|   :.|.|                   :||
Zfish  1285 ----------PIV---SCPHP-------------------ERD---------------------- 1295

  Fly  1784 VYGTCLKQYMTKVECRVKDTHEAPEQMDENVVCSLEEGLRCIGK-CHDYELRAFCQCDEELEPEL 1847
               .||                          |.:.||.:..|: |.:.|             ..
Zfish  1296 ---PCL--------------------------CPVCEGCQFNGRDCGNGE-------------RF 1318

  Fly  1848 PKPTEKPQLGLAC-DAAVVEYKEFPGDCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDH 1911
            |.|:: |....|| |.:|              .|.|           .:|.|        :.|.
Zfish  1319 PDPSD-PCRSCACLDGSV--------------SCSP-----------VSCPE--------VFCK- 1348

  Fly  1912 IATVTEIKPNCGLKPEPEPEFEPIKQCPPGKIKSECANQCENTCHYYGSILKKRG---------- 1966
                                 .|::  |||    ||...|..||.:.|.:.:...
Zfish  1349 ---------------------RPVR--PPG----ECCPVCSGTCEHLGQVYEDASTFIPADDRCS 1386

  Fly  1967 ---------LCQVGEHCKPGCVDELRPD--CPKLGKFWRDEDTCVHADECPCMDKAEHYVQPHKP 2020
                     ||: .:.|...|...:|..  ||..       |.|::.|:  .....|.::.|..|
Zfish  1387 TCTCLSGVVLCE-KKMCSKKCTHPVRTRLCCPVC-------DACLYEDK--KYRNTESFIDPWDP 1441

  Fly  2021 VLGEFEVCQCIDNAFTCVPNKPEPVPKDEDDDLDLVSVVPIYPVT----LTPPLQCSPERLI--- 2078
            .    ..|.|.|.:.:|                   |.:....|:    :||..:|.||..:
Zfish  1442 C----RTCVCRDGSVSC-------------------SAITCPAVSCQNPITPAGKCCPECRVCVQ 1483

  Fly  2079 ---PKIENPAHSLPDSIFNASSQLAPE---HGPKMARLT---KEQPRGSWSP----SINDQMQYL 2130
               ..::..:.:||.......:.:|.|   ..|:...|:   :....||..|    .|.|.::..
Zfish  1484 YDQQYVDGESLTLPADPCLKCTCVAGEVKCVSPRCKTLSCVHQLTDPGSCCPRCRGCIYDGVERQ 1548

  Fly  2131 ELNFAKPEPFYGVVMAGSPEFDNYVTLFKILHSHDGIA----YHYL---VDETEKPQ-------- 2180
            |               ||..|.: ..|.......||:.    .|.|   :::...|.
Zfish  1549 E---------------GSTWFAS-AGLCMSCMCVDGVTTCSEVHCLSTCINQITVPGECCPVCAD 1597

  Fly  2181 -MFNGPLDSRAPVQTLFKIPIEASSLRIY-PLKWHGSIAMRVELLICGDKEEPKPVP---TVSTI 2240
             :|.|                     |:| |                |:..:|...|   ....:
Zfish  1598 CVFEG---------------------RVYGP----------------GESFQPSEDPCQICTCEV 1625

  Fly  2241 LPITERPARLVDLECIDLMGVDEGKMYQDQVQSSSLWQQPNLGKKLQLLELLKLSTPLAWRPLAN 2305
            :|..|:..|....:|..|:...:..:......|                     ..|:..:||:|
Zfish  1626 MPDGEQHLRCYRKQCPSLVDCPKHNILHSSSDS---------------------CCPVCTQPLSN 1669

  Fly  2306 SQNEFIEFDFLEPRNISGFVTKGGPDGWVTGYKVMFSKKKPTWNTVLSTDGQARIFEANHDAETE 2370
            .....|                                    .|.||:||
Zfish  1670 CTATLI------------------------------------GNEVLATD--------------- 1683

  Fly  2371 RRHHFKNPILTQYIKIVPAYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKCNICDGVSTSS 2435
                                         :|  ||.
Zfish  1684 -----------------------------DP--CFT----------------------------- 1688

  Fly  2436 STTGCQCQDQLFWDGNTCVQHNLCP---CIENYVSYPIGSKFENSACEDC-VCVL--------GG 2488
                |||:| |.|   ||| |..||   |..:....|     .:|.|..| ||||        .|
Zfish  1689 ----CQCKD-LTW---TCV-HRGCPPLSCSPSDQHTP-----PDSCCPICDVCVLEGSNTRVPDG 1739

  Fly  2489 HK-NCKPKKCPPCLGGKLRPVITSDC-FCKCEP--CPKHQRLCPSSGDCIPEILWCNGVQDCADD 2549
            |: ..|..:|..|:..|..    .:| ..:|.|  ||.......:.|.|      |   |:|.:.
Zfish  1740 HRWTDKENECTTCICNKGH----IECDLQECAPLQCPDGSVKVKNPGKC------C---QECTEV 1791

  Fly  2550 ED-------ASCSDSFTVEPDVSREKNETEVITCPVPVCPPQMKIRITEKKSRKMSKMFTFSKQV 2607
            .|       |.|    ..|..:.|:.::.||
Zfish  1792 VDVVYIYPSAEC----VYEGQIYRDSDQWEV---------------------------------- 1818

  Fly  2608 SIVDDGTTITKTKFISSKEQILAMPNRELDFQLEEQCDEFTCVPIPSKQVDKNETVTCTEPKCPE 2672
                                              ::|...|||         |..|.|...:||.
Zfish  1819 ----------------------------------DECTTCTCV---------NGDVHCQTQRCPT 1840

  Fly  2673 KYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISG-KSFTTFDGTVFKY-GPCSHILARDIHSSS 2735
            ......:..|...|.|..: |:..|   ..|.:.| ..:.||||.:..: |.|:::||:|.....
Zfish  1841 LTCASDETPALVPGMCCPH-CIPHP---ATCVVFGDPHYRTFDGKMVHFQGTCTYVLAQDCEGGD 1901

  Fly  2736 WSISVHQQCSDETRKVCH--KVITIQDTEAGNELILLPHLKLKFNGYEFTVQQL----INSPICK 2794
            :  |||....|..||...  |.:|:   ..|:.:|.|         |:..:.::    ::.|..|
Zfish  1902 F--SVHVSNEDRGRKGVSWTKEVTV---FIGDVVIQL---------YQDWIVKVDYEPVSLPYLK 1952

  Fly  2795 ASFVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPDGQI 2859
            ..::..:.....:.::|..|..|..:....::|.:...:...:.||||.:|...:||.:..:|||
Zfish  1953 EPYIYLERKTNTILLNTNVGLKVLWNGRSHLEVSVPGTYKNHMCGLCGNFNNYPQDDMKLRNGQI 2017

  Fly  2860 IPNTEKFGDSWYDKRIPKD----QCGDLK----CPR---EMQAKALQLCNIIHHPTFARCHKAVN 2913
            ..:...||:||   ::...    ||.|::    |..   ..:..|...|.::..|.|.||||.|.
Zfish  2018 ATSEAAFGNSW---KVGNGNSSVQCPDVRNINPCKEAGYSARKTANSRCAVLKSPVFERCHKLVL 2079

  Fly  2914 YKQFLNNYCLEAACNCMMANNGDPAACKCNILESFVKKCLSVNPLVQLTTWRAVAQCEINCP--S 2976
            .:.|..: |:...|.|  .:|.|.  |.|::||.:..:|.....:||   ||....|.:.||  .
Zfish  2080 PEMFFAS-CVYDLCAC--GSNMDD--CLCDVLEVYASECREAGIIVQ---WRTPTLCAVGCPLDR 2136

  Fly  2977 PLVHTDCYKRRCEPSCDNVHGDDCP--VLPDACF----PGCYCPEGTVRKGPNCVPISECKDCVC 3035
            ..|..:| ...|..:|.|   .|.|  |:...||    |||.||.|.|....:|:...:|...:.
Zfish  2137 GYVFDEC-GPPCPKTCFN---KDVPLGVIEAHCFKPCVPGCQCPAGLVEHNAHCIAPEKCPKIIH 2197

  Fly  3036 NSL 3038
            ::|
Zfish  2198 DNL 2200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339	33/173 (19%)
		C8	680..754	CDD:285899	18/93 (19%)
		TIL	758..811	CDD:280072	17/77 (22%)
		VWD	840..1015	CDD:214566	29/202 (14%)
		C8	1054..1121	CDD:214843	9/88 (10%)
		TIL	1131..1185	CDD:280072	21/58 (36%)
		TIL	1245..1298	CDD:280072	18/61 (30%)
		VWD	1327..1498	CDD:214566	18/179 (10%)
		C8	1535..1609	CDD:214843	10/73 (14%)
		Mucin2_WxxW	1751..1837	CDD:290069	10/86 (12%)
		TIL	1938..2005	CDD:280072	19/87 (22%)
		FA58C	2089..2223	CDD:238014	25/160 (16%)
		FA58C	2104..2225	CDD:214572	22/144 (15%)
		FA58C	<2299..2404	CDD:214572	10/104 (10%)
		FA58C	<2299..2403	CDD:238014	10/103 (10%)
		VWD	2703..2858	CDD:295339	36/162 (22%)
		C8	2893..2970	CDD:285899	24/76 (32%)
		TIL	2974..3030	CDD:280072	20/63 (32%)
		VWD	3035..3198	CDD:295339	1/4 (25%)
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
kcp	XP_697494.6	LamG	38..>188	CDD:304605	28/183 (15%)
		VWC	365..418	CDD:302663	7/52 (13%)
		VWC	424..480	CDD:302663	10/56 (18%)
		VWC	540..596	CDD:302663	16/61 (26%)
		VWC	599..655	CDD:302663	13/59 (22%)
		VWC	<681..714	CDD:302663	3/32 (9%)
		VWC	778..836	CDD:302663	13/97 (13%)
		VWC	891..947	CDD:302663	20/94 (21%)
		VWC	1305..1361	CDD:302663	21/130 (16%)
		VWC	1422..1478	CDD:302663	15/80 (19%)
		VWC	1598..1663	CDD:302663	15/122 (12%)
		VWC	1803..1860	CDD:278520	17/138 (12%)
		VWD	1867..2016	CDD:278521	36/162 (22%)
		C8	2059..2128	CDD:285899	24/76 (32%)
		TIL	2139..2192	CDD:280072	18/56 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900