DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and fras1

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_005165392.1 Gene:fras1 / 563428 ZFINID:ZDB-GENE-060526-68 Length:4003 Species:Danio rerio


Alignment Length:1528 Identity:305/1528 - (19%)
Similarity:448/1528 - (29%) Gaps:627/1528 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly  2421 KPTKCN--ICDGVSTSSSTTGC---QCQ----DQLFWDGNTCVQHNLCP----CIENYVSYPIGS 2472
            ||..|.  ||.........|.|   ||.    ::|....|.|......|    |....:.|...|
Zfish    40 KPDTCQDCICYNDIVICKPTRCRNPQCDFPRGERLRIPPNKCCPECFAPSPGICHHEGLVYGHDS 104

  Fly  2473 KFENSACEDCVCVLGGHKNCKPKKCPPCLGGKLRPVITSDCFCKCEPCPKHQRLCPSSG-DCIPE 2536
            ::.||.|..|.|. .|...|.|:.|||...||.:.....|..|    ||    :|..:| .|..|
Zfish   105 QWSNSKCSVCTCA-HGKVTCGPRACPPLSCGKDQSPFIPDGNC----CP----VCAHNGVSCSWE 160

  Fly  2537 -------ILW---------C-NGVQDC--ADDEDASCSDSFTVEPDVSREKNETEVITCPVPVCP 2582
                   :.|         | ||..:|  |:.:..:|            :.||..|:. |...||
Zfish   161 GREYRDGLEWTSSPCTKCRCRNGHTECLVAECQPVTC------------KVNENLVVH-PGQCCP 212

  Fly  2583 -----PQMKIRITEKKSRKMSKMFTFSKQVSIVDDGTTITKTKFISSKEQILAMPNRELDFQLEE 2642
                 |.|:.....|...:..:.   |....:.|.|.:..:|                      |
Zfish   213 QCEPNPCMEAGNEYKHGEQWQRS---SCTTCVCDRGHSRCQT----------------------E 252

  Fly  2643 QCDEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISG 2707
            :|....|        ||.:|......:|.|      |.:.|| |.|| |..::|.:.|       
Zfish   253 KCPPLHC--------DKGQTKVKRADQCCE------DCATSK-GSCL-YEGIVRYHGD------- 294

  Fly  2708 KSFTTFDGTVFKYGPC--SHILARDIHSSSWSISVHQQCSDETRKVCHKVITIQDTEAGNELILL 2770
                .::||..::..|  ..:|.:.:           :||   |..|.:         |.:|:.|
Zfish   295 ----MWNGTGCEFCMCERGQVLCQRV-----------ECS---RSECPR---------GEKLVHL 332

  Fly  2771 PHLKLKFNGYEFTVQQLINSPICK---ASFVVSQPG-KTLLAVSTKYGFWVQLDDIGIVKVGISS 2831
            |..               ..|.||   :|...|||. |...|:.:    :.:|.::.||:     
Zfish   333 PGK---------------CCPECKTTTSSCTYSQPDQKGQKAIKS----FRRLSNLEIVR----- 373

  Fly  2832 KFIRTVDGLC-------GYYNGNQKDDKRSPDGQI-IPNTEKFGDSWYDKRIPKDQC-----GDL 2883
                  :|||       |:....|......|.|.: ||:              ::||     .::
Zfish   374 ------EGLCRECQCQEGHVTCYQHSCPTCPLGTLTIPH--------------REQCCPDCNPEV 418

  Fly  2884 KCPREMQAKALQLCNIIHHPTFARCHKAVNYKQFLNNYCLEAACNCMMANNGDPAACK--CNILE 2946
            ||..:    .|.......|....|...|:    .:|..||:|......|.....|||:  |...|
Zfish   419 KCHED----CLTCSGTPDHCASCRDPSAL----LMNGRCLQACPQGFFAQGKVCAACQPSCATCE 475

  Fly  2947 SFVKKCLSVNPLVQLTTWRAVAQCEINCPSPLVHTDCYKRRCEPSCDNVHG---DDCPVLPDA-- 3006
            :.. :|.:......|:..:.||.||.....  .||.|..  |...|.:..|   .||....|:  
Zfish   476 NDF-ECTACGGSFLLSGRQCVATCERGLFQ--AHTHCLS--CHDLCSSCQGAGPQDCLTCSDSSH 535

  Fly  3007 ----------CFPGCYCPEGTVRK-GPNCV---PIS-ECKDC---------VCNSLGASKYMTYD 3047
                      |.||.|..:|.... .|:|.   |.| .|..|         .|.....::|...|
Zfish   536 LLKDGYCVSDCGPGFYTSQGNCYACDPSCATCQPDSPSCMSCPAEHALHQGKCAPQCPAQYYKDD 600

  Fly  3048 RKSFSFNGNCTYLLSRDVVLPGVHTFQVYVSMDDCKKLGQPTPVEGGSCAKSLHILN-------- 3104
                  :|.|          ...|:        .|.....|......||:|:| |||        
Zfish   601 ------HGRC----------QACHS--------SCASCSGPAVSHCTSCSKAL-ILNQGQCVESC 640

  Fly  3105 GD---------HVIHVQRVPQKPKSLQVLVDGFEVKKIPYKDSWISLRQVVGKELVLSLPESHVE 3160
            |:         |..|        .|.:|.|.         .|| ....|.|..|.||.....|| 
Zfish   641 GEGLFSRAGHCHSCH--------SSCRVCVG---------PDS-SDCTQCVKMEEVLQPQNGHV- 686

  Fly  3161 LTASFEDLIFSLGVPSIKYGSKM-----------EGLCGDCNGNAGNDLQPNPAKKKAGVDVIQS 3214
                             .:||.|           :..|.:|:.:....:.               
Zfish   687 -----------------SHGSCMSACRPQHYLETDRTCRECHSSCSGCIG--------------- 719

  Fly  3215 WQADEPKLGLVEECLSEDVPKEHCIPLPPEKDPCLQ---FYNAELFGKCPLAVDPIAYVSACQQD 3276
                    |..:.|.|                 ||:   .:..:...|||.....|..:: ||  
Zfish   720 --------GSFQNCTS-----------------CLRPGVLHQGQCLSKCPNGFFHIQDLT-CQ-- 756

  Fly  3277 ICKPG-----NTQQGVCVALAAYAKECNQHGICTNWRRPQLCPYECPSDMVYEPCG----CAKNC 3332
            .|.|.     .|.|..|.|..|:|...|.:           |...||........|    |.:.|
Zfish   757 ACHPSCKECTGTSQADCSACPAHASLHNGY-----------CRTSCPEGQYLNSVGFCDECEEGC 810

  Fly  3333 DTIKALSEFDAVSLKNEAVVHTVKTDEMCLSSERFEGCFCP-PGKVMDGGQCVPEI--------- 3387
            .  :.:::..:.|            ..:||        :|. |..::.|..||||.         
Zfish   811 Q--RCVADLQSGS------------GTVCL--------WCKVPRMLLLGNHCVPECPHKHYRWHG 853

  Fly  3388 ACTKCDDGLHLPDEKWKKDKCTECQCDSKGKTTCVEKKCQVEENICAEGYRPETIVSVDECCPRY 3452
            ||.||            ...|.||..|  |..:|..                             
Zfish   854 ACKKC------------HSSCEECSAD--GPLSCTS----------------------------- 875

  Fly  3453 RCV-PETKDPSKLCLAPLVPICGPGQFKKEKKDVNGCSQYICECIPKDQCEIIELRELLPGEIIV 3516
             |: ||...||.||    .|.|..|.:..|.:....|..   :|:   .||            :.
Zfish   876 -CLAPEVLAPSGLC----SPRCPTGYYADENRVCQKCDS---QCL---SCE------------MA 917

  Fly  3517 NVEEGCCPTQKI----ECKPETCPKAPVNCQERFY---EVKTIKEPGMCCSKHSCVPPKDLCIVQ 3574
            .|...|....|:    ||:.|       :|..::|   ..:|.:|....|  ::|..|       
Zfish   918 GVCSSCRDPAKVLLFGECQYE-------SCAHQYYLNTSTRTCRECDWSC--NACRGP------- 966

  Fly  3575 YELDEATKFTKTVGDKWTHAKEVCKQETCSYG---PDGNAQVVSTLEQCLTDCAPGFSYQNLDKT 3636
                               .:..|.|  |..|   .||         .|:..|:||| ||:.::.
Zfish   967 -------------------LRSDCLQ--CMEGYVLQDG---------ICVPGCSPGF-YQDAERC 1000

  Fly  3637 KCC----------GKCVQTS---------CIFE-QKLYEVNALWKSADNCTTYS--CLK------ 3673
            ..|          |:|.:..         |:.| :|.|.::   .|...||..|  |::      
Zfish  1001 LSCEEHCEQCQAHGQCQRCQLPYASFNGHCVLECRKHYFLD---DSTRQCTACSAGCVECVSAGE 1062

  Fly  3674 ----------KDGQFLVTTSREVCPDVGSCLSHLLYQD----GCCKRCKSEPLVEDKSSCLPV-- 3722
                      |||:.:        ||.|    |..|.|    .|....::..|..:.|..:|:  
Zfish  1063 CRVCAENTFLKDGRCI--------PDCG----HGYYADLKTRACHANSRAPSLYINGSLLVPIGG 1115

  Fly  3723 ---------------SLAESRTKEILKFPVQGH 3740
                           |.:||...::|:.|..||
Zfish  1116 VKPLDPALLSIKDADSQSESMLLQLLQPPSNGH 1148

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843
TIL 1131..1185 CDD:280072
TIL 1245..1298 CDD:280072
VWD 1327..1498 CDD:214566
C8 1535..1609 CDD:214843
Mucin2_WxxW 1751..1837 CDD:290069
TIL 1938..2005 CDD:280072
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339 30/167 (18%)
C8 2893..2970 CDD:285899 18/78 (23%)
TIL 2974..3030 CDD:280072 18/75 (24%)
VWD 3035..3198 CDD:295339 35/190 (18%)
C8 3257..3313 CDD:285899 15/60 (25%)
VWC 3397..3451 CDD:302663 6/53 (11%)
GHB_like <3755..3813 CDD:304424
fras1XP_005165392.1 VWC 26..85 CDD:278520 12/44 (27%)
VWC 93..150 CDD:278520 20/65 (31%)
VWC 157..214 CDD:278520 15/69 (22%)
VWC 219..276 CDD:278520 14/95 (15%)
VWC 283..340 CDD:278520 18/106 (17%)
VWC 364..414 CDD:302663 14/74 (19%)
FU 419..465 CDD:238021 11/53 (21%)
Furin-like_2 424..512 CDD:292535 23/96 (24%)
FU 461..503 CDD:214589 11/42 (26%)
FU 507..551 CDD:214589 11/45 (24%)
GF_recep_IV 512..669 CDD:291509 40/199 (20%)
FU 555..597 CDD:214589 8/41 (20%)
Furin-like 588..762 CDD:279142 48/277 (17%)
FU 602..645 CDD:214589 13/61 (21%)
FU 648..700 CDD:214589 17/87 (20%)
FU 704..748 CDD:214589 10/83 (12%)
Furin-like 737..911 CDD:279142 53/260 (20%)
FU 754..796 CDD:214589 14/55 (25%)
FU 855..897 CDD:214589 19/89 (21%)
Furin-like 888..1054 CDD:279142 46/237 (19%)
FU 950..994 CDD:214589 16/83 (19%)
FU 1044..1086 CDD:214589 11/53 (21%)
Cadherin_3 <1097..1196 CDD:292802 10/52 (19%)
Cadherin_3 1166..1306 CDD:292802
Cadherin_3 1406..1538 CDD:292802
Cadherin_3 1526..1689 CDD:292802
Cadherin_3 1658..1811 CDD:292802
Cadherin_3 1777..1934 CDD:292802
Cadherin_3 1901..2056 CDD:292802
Cadherin_3 2025..2175 CDD:292802
Cadherin_3 2144..2290 CDD:292802
Cadherin_3 2258..2403 CDD:292802
Cadherin_3 2372..2534 CDD:292802
Calx-beta 2550..2647 CDD:295344
Calx-beta 2672..2771 CDD:295344
Calx-beta 2795..2891 CDD:295344
Calx-beta 2917..3008 CDD:295344
Calx-beta 3036..3130 CDD:295344
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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