DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hml and VIT

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	NP_444506.2	Gene:	VIT / 5212	HGNCID:	12697	Length:	693	Species:	Homo sapiens

Alignment Length:	216	Identity:	55/216 - (25%)
Similarity:	80/216 - (37%)	Gaps:	62/216 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   897 SESMNFAAPDDPSCTKAVTIRFILRDGTPSVIK----------------LDQG------------ 933
            ::|:...:..||:|  .:.:.|:: ||:.|:.|                ||.|
Human   292 TQSLEPVSLGDPNC--KIDLSFLI-DGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYG 353

  Fly   934 --------LTTIVNDK----PIAKLPKMLGLGEVLIRRASSTFLTVEF---ADGIRVWWDGVSRV 983
                    |.|..|.:    .|.|:.:..||..|  .||.| |:|..|   |:|.|.....|..|
Human   354 DNPATHFNLKTHTNSRDLKTAIEKITQRGGLSNV--GRAIS-FVTKNFFSKANGNRSGAPNVVVV 415

  Fly   984 YIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVET----AVEP-FADK--WRTKDTCQFKAETH 1041
            .:|..|:.:.:....... .|.....|:|.||..|.    .||| ||:|  .||........::.
Human   416 MVDGWPTDKVEEASRLAR-ESGINIFFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSW 479

  Fly  1042 QGPHPCTLNPEKKAQAEKFCD 1062
            .|.|. ||.|..|    :.||
Human   480 FGLHK-TLQPLVK----RVCD 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566	36/160 (23%)
		C8	1054..1121	CDD:214843	3/9 (33%)
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
VIT	NP_444506.2	LCCL	44..133	CDD:281766
		vWFA	308..471	CDD:294047	43/167 (26%)
		vWA_collagen	509..669	CDD:238749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900