DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and CRIM1

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_011531200.1 Gene:CRIM1 / 51232 HGNCID:2359 Length:1077 Species:Homo sapiens


Alignment Length:986 Identity:211/986 - (21%)
Similarity:310/986 - (31%) Gaps:378/986 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  2920 NYCLEAACNCMMANNGDPAACKCNILES------FVKK--CLSVNPLVQLTTWRAVAQCEINCPS 2976
            |..|.|.||.:   ||   .|:||.:.:      |..:  |||           |:.:.|...| 
Human   167 NENLIAGCNII---NG---KCECNTIRTCSNPFEFPSQDMCLS-----------ALKRIEEEKP- 213

  Fly  2977 PLVHTDCYKRRCE----PSCDNVHGDDCPVLPDACFPGCYCPEGTVRKGPNCVPISECKDCVCNS 3037
                 ||.|.|||    |.|..          |:.....|.|.|      .|.|:.  ..||||.
Human   214 -----DCSKARCEVQFSPRCPE----------DSVLIEGYAPPG------ECCPLP--SRCVCNP 255

  Fly  3038 LGASKYMTYDRKSFSFNGNCTYLLSRDVVLPGVHTFQVYVSMDDCKKLGQPTPVEGGSCAKSLHI 3102
            .|..:.:...       ||...|:|:....||           :|..|.:..||.|..|      
Human   256 AGCLRKVCQP-------GNLNILVSKASGKPG-----------ECCDLYECKPVFGVDC------ 296

  Fly  3103 LNGDHVIHVQRVPQKPKSLQVLVDGFEVKKIPYKDSWISLRQVVGKELVLSLPESHVELTAS--- 3164
                      |..:.|...|....         .||:                |:.|.|||.   
Human   297 ----------RTVECPPVQQTACP---------PDSY----------------ETQVRLTADGCC 326

  Fly  3165 -----FEDLIFSLGVPSIKYG------SKMEGLCGDCNG--NAGNDLQP---------------- 3200
                 .|.|....|.|..:.|      |:.:|..|.|..  ...||.:|                
Human   327 TLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFR 391

  Fly  3201 ----NPAKKKAGVDVIQSWQADEPKLGLVEECLSEDVPKEHCIPLPPEKDPCLQFYNAELFGKCP 3261
                ...:.:.||.:..:.|..|      ..|....||:..|.|:.  :||...|.|.   ..|.
Human   392 MDNCRFCRCQGGVAICFTAQCGE------INCERYYVPEGECCPVC--EDPVYPFNNP---AGCY 445

  Fly  3262 LAVDPIAYVSACQQDICKPGNTQQGV--CVALAAYAKECNQHGICTNWRRPQLCPYEC------P 3318
            .....:|:....::|.|.......|.  |||..     |.|  .|||   |...|.||      |
Human   446 ANGLILAHGDRWREDDCTFCQCVNGERHCVATV-----CGQ--TCTN---PVKVPGECCPVCEEP 500

  Fly  3319 SDMVYEP--CGCAKNCDTIKALSEFDAVS-LKNE----AVVHTVKTDEMCLSSERFEGCF--CPP 3374
            :.:..:|  ||...||    .|:..|.:: .|.:    .....:.|:|:|  |||.:||.  ||.
Human   501 TIITVDPPACGELSNC----TLTGKDCINGFKRDHNGCRTCQCINTEELC--SERKQGCTLNCPF 559

  Fly  3375 GKVMDGGQC---------------------------------------VPEIACTK--------- 3391
            |.:.|...|                                       .||::|:|         
Human   560 GFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQD 624

  Fly  3392 ------CD--------------------DGLHLPDEKWKKDKCTECQCDSKGKTTCVEKKCQVEE 3430
                  |.                    ||.|..:|:...|.|.||.| ..|:..|....|.|. 
Human   625 SHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYC-LNGREMCALITCPVP- 687

  Fly  3431 NICAEGYRPETIVSVDECCPRYRCV-------PETKDPSKLCLAPLVPICGPGQF--KKEKKDVN 3486
             .|.     ...:...:|||  .|.       ||...|| :|.||      .|::  :.|..:::
Human   688 -ACG-----NPTIHPGQCCP--SCADDFVVQKPELSTPS-ICHAP------GGEYFVEGETWNID 737

  Fly  3487 GCSQYICECIPKDQCEIIELRELLPGEIIVNVEEGCCPTQKIECKPETCPKAPVNCQERFYEVKT 3551
            .|:|..|.                              :.::.|:.|.||  |:.||      ..
Human   738 SCTQCTCH------------------------------SGRVLCETEVCP--PLLCQ------NP 764

  Fly  3552 IKEPGMCC------------SKHSCVPPKDLCIVQYELDEATKFTKTVGDKWTHAKEVCKQETCS 3604
            .:....||            |:::.||  :.|    :.||...|  ...:.|  ..:||....| 
Human   765 SRTQDSCCPQCTDQPFRPSLSRNNSVP--NYC----KNDEGDIF--LAAESW--KPDVCTSCIC- 818

  Fly  3605 YGPDGNAQVVSTLEQCLTDCAPGFSYQN--LDKTKCCGKCVQTS------CIFEQKLYEVNALWK 3661
                     :.::..|.::..|..|.:.  |.|.:||..|::.:      |.|..|.|.....| 
Human   819 ---------IDSVISCFSESCPSVSCERPVLRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERW- 873

  Fly  3662 SADNCTTYSCLKKDGQFLVTTSREVCPDVGSCLSHLLYQDGCCKRCKSEPLVEDKSSCLPVSLAE 3726
            ..|:||...||:  ||.|.:|..  ||.: .|:..:..:..||..| .|..|.:.:: :|:....
Human   874 DLDSCTHCYCLQ--GQTLCSTVS--CPPL-PCVEPINVEGSCCPMC-PEMYVPEPTN-IPIEKTN 931

  Fly  3727 SRTKEILKFPV 3737
            .|.:..|:.|:
Human   932 HRGEVDLEVPL 942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843
TIL 1131..1185 CDD:280072
TIL 1245..1298 CDD:280072
VWD 1327..1498 CDD:214566
C8 1535..1609 CDD:214843
Mucin2_WxxW 1751..1837 CDD:290069
TIL 1938..2005 CDD:280072
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899 15/57 (26%)
TIL 2974..3030 CDD:280072 15/59 (25%)
VWD 3035..3198 CDD:295339 35/178 (20%)
C8 3257..3313 CDD:285899 14/57 (25%)
VWC 3397..3451 CDD:302663 14/53 (26%)
GHB_like <3755..3813 CDD:304424
CRIM1XP_011531200.1 IGFBP 39..90 CDD:278641
VWC 377..431 CDD:214564 9/59 (15%)
VWC 444..497 CDD:214564 17/62 (27%)
Antistasin 608..633 CDD:280912 5/24 (21%)
VWC 653..703 CDD:302663 17/59 (29%)
VWC 724..775 CDD:302663 14/88 (16%)
VWC 799..849 CDD:214564 12/63 (19%)
VWC 860..914 CDD:302663 19/59 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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