DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hml and Crim1

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	NP_056615.1	Gene:	Crim1 / 50766	MGIID:	1354756	Length:	1037	Species:	Mus musculus

Alignment Length:	1094	Identity:	218/1094 - (19%)
Similarity:	325/1094 - (29%)	Gaps:	468/1094 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly  2880 CGDLKC--PREMQAKALQ-LCNIIHHPTFARCHKAVNYKQFLNNYC-----LEAACN----CMMA 2932
            |.:.||  ||......:| :|..        |:.....:   |..|     |..||:    |::.
Mouse    40 CDESKCEEPRSCPGSIVQGVCGC--------CYMCARQR---NESCGGAYGLHGACDRGLRCVIR 93

  Fly  2933 N--NGDP------AACK--------------CNILESFVKKCLSVNPLVQLTTWRAVAQCEINCP 2975
            .  |||.      ..|:              ||  |:.:..|..:|...:..|.|       .|.
Mouse    94 PPLNGDSITEYEVGVCEDEDWDDDQLIGFEPCN--ENLISGCNIINGKCECGTIR-------TCN 149

  Fly  2976 SPL-----------------VHTDCYKRRCE----PSCDNVHGDDCPVLPDACFPGCYCPEGTVR 3019
            :|.                 ...||.|.|||    |.|..          |:.....|.|.|
Mouse   150 NPFEFPRKDMCLSALKRIEEEKPDCSKARCEVRFSPRCPE----------DSILIEGYAPPG--- 201

  Fly  3020 KGPNCVPISECKDCVCNSLGASKYMTYDRKSFSFNGNCTYLLSRDVVLPGVHTFQVYVSMDDCKK 3084
               .|.|:.  ..|||:..|                 |.    |.|..||      |:::...|.
Mouse   202 ---ECCPLP--SRCVCDPAG-----------------CL----RKVCQPG------YLNILVSKA 234

  Fly  3085 LGQPTPVEGGSCAKSLHILNGDHVIHVQRVPQKPKSLQVLVDGFEVKKIPYKD-SWISLRQVVGK 3148
            .|:|     |.|.                            |.:|.|.:...| |.:....|...
Mouse   235 SGKP-----GECC----------------------------DLYECKPVFSVDCSTVECPPVQQA 266

  Fly  3149 ELVLSLPESHVELTAS--------FEDLIFSLGVPSIKYG------SKMEGLCGDCNGNAGNDLQ 3199
            ...|...|:.|.|||.        .|.|....|.|..:.|      |:.:|..|.|
Mouse   267 VCPLDSYETQVRLTADGCCTLPARCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKC--------- 322

  Fly  3200 PNPAKKKAGVDVIQSWQADEPKLGLVEECLSEDVPKEHCIPLPPEKDPCLQFYNAELFG------ 3258
                     .||.              ||::|..|.  |:      ...:::|:.::|.
Mouse   323 ---------CDVF--------------ECVNETKPA--CV------FNSVEYYDGDMFRMDNCRF 356

  Fly  3259 -KCPLAVDPIAYVSACQQDICKPGNTQQGVCVAL------------AAYAK-ECNQHGICTNWR- 3308
             :|...|. |.:.:.|.:..|:.....:|.|..:            ..||. :...||  ..||
Mouse   357 CRCQGGVS-ICFTAQCGELNCERYYVPEGECCPVCEDPIYPLNNPAGCYANGQIRAHG--DRWRE 418

  Fly  3309 -------------------------RPQLCPYEC------PSDMVYEP--CGCAKNCDTIKALSE 3340
                                     .|...|.||      |:.:..:|  ||...||
Mouse   419 DDCTFCQCINGEPHCVATACGQSCMHPVKVPGECCPVCEEPTYITIDPPACGELSNC-------- 475

  Fly  3341 FDAVSLKNEAVVHTVKTD-------------EMCLSSER----------------FEGC------ 3370
                |||.:..|:..|.|             |:||..:|                .|.|
Mouse   476 ----SLKEKDCVYGFKLDHNGCRTCQCKIREELCLGLKRACTLDCPFGFLTDVHNCELCQCRPRP 536

  Fly  3371 ----------FCPPGKVMDGGQC-------VPEIACTK---------------CD---------- 3393
                      |||.|.:.:...|       .||:.|:|               |.
Mouse   537 KKCRPTMCDKFCPLGFLKNKHGCDICRCKKCPELPCSKICPLGFQQDSHGCLICKCREVPPSAGP 601

  Fly  3394 ----------DGLHLPDEKWKKDKCTECQCDSKGKTTCVEKKCQVEENICAEGYRPETIVSVDEC 3448
                      ||.|..:|:...|.|.||.|.: ||..|....|.|.  .|..    .||.| .:|
Mouse   602 PVLSGTCLSMDGHHHKNEESWHDGCRECYCHN-GKEMCALITCPVP--ACGN----PTIRS-GQC 658

  Fly  3449 CPRYRCV-------PETKDPSKLCLAPLVPICGPGQF--KKEKKDVNGCSQYICECIPKDQCEII 3504
            ||  .|.       ||...|| :|.||      .|::  :.|..:::.|:|..|.
Mouse   659 CP--SCTDDFVVQKPELSTPS-ICHAP------GGEYFVEGETWNIDSCTQCTCH---------- 704

  Fly  3505 ELRELLPGEIIVNVEEGCCPTQKIECKPETCPKAPVNCQERFYEVKTIKEPGMCCSKHSCVPPKD 3569
                                :.::.|:.|.||  |:.||      ...:....||.:.:..||:
Mouse   705 --------------------SGRVLCETEVCP--PLLCQ------NPSRTQDSCCPQCTDDPPQ- 740

  Fly  3570 LCIVQYELDEATKFTKTV--------GDKWTHAKEVCKQETCSYGPDGNAQVVSTLEQCLTDCAP 3626
                     .:|...::|        ||.:. |.|..|.:.|:     :...|.:...|.::..|
Mouse   741 ---------PSTSHNESVPSYCRNDEGDIFL-AAESWKPDACT-----SCVCVDSAISCYSESCP 790

  Fly  3627 GFSYQN--LDKTKCCGKCVQTS------CIFEQKLYEVNALWKSADNCTTYSCLKKDGQFLVTTS 3683
            ..:.:.  |.|.:||..|::.:      |.|..|.|.....| ..|:||...||:  ||.|.:|.
Mouse   791 SVACERPVLRKGQCCPYCLEDTIPKKVVCHFSGKTYADEERW-DIDSCTHCYCLQ--GQTLCSTV 852

  Fly  3684 REVCPDVGSCLSHLLYQDGCCKRCKSEPLVEDKSSCLPVSLAESRTKEILKFPV 3737
            .  ||.: .|...:..:..||..| .|..|.:.:: :|:.....|.:..|:.|:
Mouse   853 S--CPPL-PCAEPIKVEGSCCPMC-PEMYVPEPTN-VPIEKKNHRGEIDLEVPM 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899	20/108 (19%)
		TIL	2974..3030	CDD:280072	16/76 (21%)
		VWD	3035..3198	CDD:295339	34/177 (19%)
		C8	3257..3313	CDD:285899	15/101 (15%)
		VWC	3397..3451	CDD:302663	18/53 (34%)
		GHB_like	<3755..3813	CDD:304424
Crim1	NP_056615.1	IB	37..>95	CDD:197525	14/65 (22%)
		Cell attachment site. /evidence=ECO:0000255	314..316		0/1 (0%)
		VWC	336..390	CDD:214564	10/60 (17%)
		VWC	403..456	CDD:214564	10/54 (19%)
		Antistasin	539..564	CDD:280912	5/24 (21%)
		Antistasin	567..592	CDD:280912	5/24 (21%)
		VWC	683..734	CDD:302663	14/88 (16%)
		VWC	758..808	CDD:302663	13/55 (24%)
		VWC	819..873	CDD:302663	19/59 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900