DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and NEFM

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:NP_005373.2 Gene:NEFM / 4741 HGNCID:7734 Length:916 Species:Homo sapiens


Alignment Length:506 Identity:97/506 - (19%)
Similarity:156/506 - (30%) Gaps:181/506 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1767 VRLNDEEK--------------VPRYDRMENVYGTCLKQYMTKVE---------------CRVKD 1802
            :|.|.||:              |.|.|.::....|.||:..:::|               ||...
Human   234 LRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAK 298

  Fly  1803 THEAPEQMDENVVC---------------------------SLEEGLRCIGKCHDYELRAFCQCD 1840
            ..||.||..|.:..                           |||..|..|.:.|:::|.::....
Human   299 LTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTI 363

  Fly  1841 EELEPE-----------LPKPTEKPQLGLACDAAVVEYKE-FPGDCHKF---------------- 1877
            ::||.|           |.:..:...:.:|.|..:..|:: ..|:..:|                
Human   364 QQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRP 428

  Fly  1878 -----------------LHCQPKGVEGGWIYVEKTCGE---YMMFNPTMLICDHIA-TVTEIKPN 1921
                             |..|.|.||.   .:|:|..|   ..|......|.:.:| ::.|.|..
Human   429 PITISSKIQKPKVEAPKLKVQHKFVEE---IIEETKVEDEKSEMEEALTAITEELAVSMKEEKKE 490

  Fly  1922 CGLKPEPEPEFE---------PIKQCPPGKIKSE--------------------CANQC-ENTCH 1956
            ...:.|.|||.|         |:|...| ::|.|                    .::|. |....
Human   491 AAEEKEEEPEAEEEEVAAKKSPVKATAP-EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 554

  Fly  1957 YYGSILKKRGLCQVGEHCKPGCVDELRPDCPKLGKFWRDEDTCVHADECPCMDKAEHYVQPHKPV 2021
            ..||..|:.|..:.||.......:|......|  |.....:.....:|.....|.|      || 
Human   555 KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEK--KVEEKSEEVATKEELVADAKVE------KP- 610

  Fly  2022 LGEFEVCQCIDNAFTCVPNKP------EPVPKD--EDDDLDLVSVVPI-----YPVTLTP----- 2068
                      :.|.:.||..|      .||||.  |:.....|...|:     .||..:|     
Human   611 ----------EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 665

  Fly  2069 --PLQCSPERLIPKIENPAHSLPDSIFNASSQLAP-EHGPKMARLTKEQPR 2116
              |:..||  :..|.::|....|.....:.:::.. |...:..:..||.|:
Human   666 KSPVSKSP--VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843
TIL 1131..1185 CDD:280072
TIL 1245..1298 CDD:280072
VWD 1327..1498 CDD:214566
C8 1535..1609 CDD:214843
Mucin2_WxxW 1751..1837 CDD:290069 25/125 (20%)
TIL 1938..2005 CDD:280072 14/87 (16%)
FA58C 2089..2223 CDD:238014 5/29 (17%)
FA58C 2104..2225 CDD:214572 3/13 (23%)
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
NEFMNP_005373.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51
Head 2..104
Filament_head 10..78 CDD:282575
Filament 100..411 CDD:278467 33/176 (19%)
Coil 1A 105..136
Linker 1 137..149
Coil 1B 150..248 4/13 (31%)
Linker 12 249..265 3/15 (20%)
Coil 2A 266..287 4/20 (20%)
Linker 2 288..291 0/2 (0%)
Coil 2B 292..412 22/119 (18%)
Tail 413..916 63/327 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..851 52/252 (21%)
6 X 13 AA approximate tandem repeats of K-S-P-V-[PS]-K-S-P-V-E-E-[KA]-[GAK] 614..691 19/78 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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