DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hml and MUC6

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	NP_005952.2	Gene:	MUC6 / 4588	HGNCID:	7517	Length:	2439	Species:	Homo sapiens

Alignment Length:	1295	Identity:	376/1295 - (29%)
Similarity:	559/1295 - (43%)	Gaps:	201/1295 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   467 YQSNNLDIVIDK---TPRPALCTTWGGINMKTFDGLVFKAPLSCSHTLIT--DKVSGTFDIILKA 526
            |.|..|..:.|.   .|....|:|||..:..|||..|:....:|::....  .....||.:.|:.
Human    24 YTSPGLQRLKDSPQTAPDKGQCSTWGAGHFSTFDHHVYDFSGTCNYIFAATCKDAFPTFSVQLRR 88

  Fly   527 CPYGSGYGCAHTLKILWQSVLYTFENLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESV 591
            .|.||   .:..:..|..||:...|.:.....    |..:.:|....|:::.|..|.|::..:.:
Human    89 GPDGS---ISRIIVELGASVVTVSEAIISVKD----IGVISLPYTSNGLQITPFGQSVRLVAKQL 146

  Fly   592 GLKLD--WDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRS 654
            .|:|:  |....::.|....:..|::.||||..||....:..|..||.|...| ||...:::|..
Human   147 ELELEVVWGPDSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEPHK-FAALQKLDDPG 210

  Fly   655 ELCQVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKP---FNYDALIRTCMADYCNC 716
            |:|..::       :.|....:.|.| .:|.:||.      .:.|   .:.:..:.:|.||.. .
Human   211 EICTFQD-------IPSTHVRQAQHA-RICTQLLT------LVAPECSVSKEPFVLSCQADVA-A 260

  Fly   717 ANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPI-SCGFGRVYQACGPNVEPTCDSDLA 780
            |.:..|::.:|..::..:::|:..|..:.. ||:..:|.: .|...:|||.||.....||.:
Human   261 APQPGPQNSSCATLSEYSRQCSMVGQPVRR-WRSPGLCSVGQCPANQVYQECGSACVKTCSN--- 321

  Fly   781 LP--ASKGACNEGCFCPEGTV----QYKEACITRELCPCSLRGKEFKPESTVKKNCNTCTCKNGQ 839
             |  :...:|..|||||||||    .....|:....|||.|.|..:.|.......|.||.|..|:
Human   322 -PQHSCSSSCTFGCFCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVTIAACQTCRCTLGR 385

  Fly   840 WRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQNTSVEAENVAC--SGAVSESMNF 902
            |.|||..|...|...|.....|||.:.|.|.|.|:|.||::.....:...:|.  ...||.|.
Human   386 WVCTERPCPGHCSLEGGSFVTTFDARPYRFHGTCTYILLQSPQLPEDGALMAVYDKSGVSHSE-- 448

  Fly   903 AAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFLTV 967
                    |..|.:.::.|. ...||..|:   .:.|:.....||  .....:.:.|.:||.|.:
Human   449 --------TSLVAVVYLSRQ-DKIVISQDE---VVTNNGEAKWLP--YKTRNITVFRQTSTHLQM 499

  Fly   968 EFADGIR--VWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRT 1030
            ..:.|:.  |....:.:.|:...|..||||:||||.||.:|.|||.|..|..|.....|.|.||.
Human   500 ATSFGLELVVQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDTTDDFTTSMGIAEGTASLFVDSWRA 564

  Fly  1031 KDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWILQ--DIFQDCHFLVEPEQFYEDCLYDTCACK 1093
             ..|  .|...:...||:::...|..||..|..:|:  .:|:.||..|.|..||:.|:|..|. .
Human   565 -GNC--PAALERETDPCSMSQLNKVCAETHCSMLLRTGTVFERCHATVNPAPFYKRCVYQACN-Y 625

  Fly  1094 DEMSKCFCPILSAYGTECMRQGVKT-GWRMSVKECAVKCPLGQVFDECGDGCALSCDDLPSKGSC 1157
            :|.....|..|..|...|..:||.. |||.||..|.:.|.....|......|..:|..|..:.:
Human   626 EETFPHICAALGDYVHACSLRGVLLWGWRSSVDNCTIPCTGNTTFSYNSQACERTCLSLSDRAT- 689

  Fly  1158 KREC------VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFL---DLCTC 1213
              ||      |:||.||.|.|:|:.||||.|..|.|..:      |||.:...:..:   ..|.|
Human   690 --ECHHSAVPVDGCNCPDGTYLNQKGECVRKAQCPCILE------GYKFILAEQSTVINGITCHC 746

  Fly  1214 TDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTKC-APKEPKTC--KNMDKYVAD------ 1269
            .:|                     |..|.::|......| |||..|:|  .:.:|:.|.
Human   747 ING---------------------RLSCPQRPQMFLASCQAPKTFKSCSQSSENKFGAACAPTCQ 790

  Fly  1270 ---------SSDCLPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAG 1325
                     .:.|.|||||.|| :|:.:...||.|..|.|..:|.||..|.::..||..|.|..|
Human   791 MLATGVACVPTKCEPGCVCAEG-LYENADGQCVPPEECPCEFSGVSYPGGAELHTDCRTCSCSRG 854

  Fly  1326 NWKCSK-NGCESTCSVWGDSHFTTFDGHDFDFQGACDYVLAK---GVFDNGDGFSITIQNVLCGT 1386
            .|.|.: ..|.|||:::|:.|..||||..|.|.|.|:|:||.   ||.|:...|.|..:||:||.
Human   855 RWACQQGTHCPSTCTLYGEGHVITFDGQRFVFDGNCEYILATDVCGVNDSQPTFKILTENVICGN 919

  Fly  1387 MGVTCSKSLEIALTGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVE 1451
            .|||||::::|.|.|.:    ::.||..|:.             ...:.|....:....:.:||:
Human   920 SGVTCSRAIKIFLGGLS----VVLADRNYTV-------------TGEEPHVQLGVTPGALSLVVD 967

  Fly  1452 V-IP--LKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWK 1513
            : ||  ..|.:.|:....:.:::....:..:.|||||:|||..||.:|.|..:.:|.:...::||
Human   968 ISIPGRYNLTLIWNRHMTILIRIARASQDPLCGLCGNFNGNMKDDFETRSRYVASSELELVNSWK 1032

  Fly  1514 LQPHCSAPVAPIDACKKHPERETWAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGD 1578
            ..|.|.......|.|..:..|.:||:.||..:.|..|..||::|....:::.|:.|.|.||.|||
Human  1033 ESPLCGDVSFVTDPCSLNAFRRSWAERKCSVINSQTFATCHSKVYHLPYYEACVRDACGCDSGGD 1097

  Fly  1579 CECLCTAVAAYADACAQKGINIRWRSQHFCPMQC---DPHCSDYKACTPACAVETCDNFLDQGIA 1640
            |||||.||||||.||..||:.:.||:..|||:.|   :.|..|                   |..
Human  1098 CECLCDAVAAYAQACLDKGVCVDWRTPAFCPIYCGFYNTHTQD-------------------GHG 1143

  Fly  1641 ERMCNRE-NCLEGCHIKPC--------------EDGFIYLNDTYRD-----CVPKAECKP 1680
            |....:| ||.  .|.:||              |..:....|.|.|     |||   |.|
Human  1144 EYQYTQEANCT--WHYQPCLCPSQPQSVPGSNIEGCYNCSQDEYFDHEEGVCVP---CMP 1198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339	37/154 (24%)
		C8	680..754	CDD:285899	15/76 (20%)
		TIL	758..811	CDD:280072	20/58 (34%)
		VWD	840..1015	CDD:214566	53/178 (30%)
		C8	1054..1121	CDD:214843	23/69 (33%)
		TIL	1131..1185	CDD:280072	20/59 (34%)
		TIL	1245..1298	CDD:280072	21/70 (30%)
		VWD	1327..1498	CDD:214566	57/177 (32%)
		C8	1535..1609	CDD:214843	35/73 (48%)
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
MUC6	NP_005952.2	VWD	40..192	CDD:214566	38/158 (24%)
		C8	228..297	CDD:285899	15/77 (19%)
		TIL	302..357	CDD:280072	20/58 (34%)
		VWC_out	359..>403	CDD:214565	16/43 (37%)
		VWD	386..549	CDD:214566	53/178 (30%)
		C8	588..660	CDD:285899	26/72 (36%)
		TIL	664..721	CDD:280072	20/59 (34%)
		TIL	782..827	CDD:280072	13/45 (29%)
		VWC	829..886	CDD:302663	23/56 (41%)
		VWD	868..1017	CDD:278521	52/165 (32%)
		C8	1057..1127	CDD:285899	33/69 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1455
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1471..1626
		1, truncated	1561..1738
		Approximate repeats	1607..1953
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1642..1834
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1868..1983
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2033..2077
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2090..2196
		PHA03255	2188..>2343	CDD:165513
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2233..2278
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2348
		CT	2351..2434	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7243
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12226at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100854
Panther	1	1.100	-	-	O	PTHR11339
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820