Protein Alignment Hml and crim1

DIOPT Version :9

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: NP_997986.1
• Gene: crim1 / 404210
• ZFINID: ZDB-GENE-040312-2
• Length: 1027
• Species: Danio rerio
• Alignment Length: 909
• Identity: 178/909 - (19%)
• Similarity: 269/909 - (29%)
• Gaps: 395/909 - (43%)

  Fly  3175 PSIKYGSKMEGLCGDCNGNAGND-----LQPNPAKKKAGVDVIQ------------------SWQ 3216
            |.:..||..:...|:|.....:|     .:|.......|.::|.                  |.:
Zfish    88 PPLNGGSITQYEVGNCEDENWDDDQLLGFEPCNENLVTGCNIIDGKCECDSVRTCNNPFEFASQE 152

  Fly  3217 ADEPKLGLVEECLSEDVPKEHC----IPLPPEKDPCLQFYNAELFGK-CPLAVDPIAYVSACQQD 3276
            |.:..|..:|| ...|..|..|    .|..||....::.|...  |: |||....:...:.|.:.
Zfish   153 ACQTALQKIEE-ERPDCSKARCEVQFSPRCPEDSILIEGYAPP--GECCPLPSRCVCSPAGCLRK 214

  Fly  3277 ICKPGNT---------QQGVCVALAAYAKECNQ--HGICTNWRRPQLCPYECPSDMVYEP----- 3325
            :|:||:.         :.|.|..|    .||..  ...|:....|.:.|.:||:|. ||.
Zfish   215 VCQPGHLNILVSKSSGKPGECCDL----YECKPVFSVDCSTVECPPVKPVQCPADS-YETQVRLT 274

  Fly  3326 ----CGCAKNCDTIKALSEFDAVSLKNEAVVHTVKTDEMCLSSERFEGCFCPPGKVMDGGQCVPE 3386
                |.....|:.:..|..|...|......|           ..|.:|   .||:..|..:||.|
Zfish   275 ADGCCTLPTRCECLPGLCTFPQCSAGMSPQV-----------MSRGDG---TPGRCCDVFECVNE 325

  Fly  3387 I--ACT--------------------KCDDGL----------------HLPD------------- 3400
            .  |||                    :|..|:                ::||
Zfish   326 TKPACTLNGVEYHDGDMFRMDACRFCRCQGGVSVCFTAQCGVLHCERYYVPDGECCPVCEDPIYP 390

  Fly  3401 -----------------EKWKKDKCTECQCDSKGKTTCVEKKCQVEENICAEGYRPETIVSVDEC 3448
                             :.|::|.||.|||.| |...||...|   .:.|   ..|.|:..  ||
Zfish   391 VLSLAGCYVNGQILAHGDHWREDDCTFCQCVS-GDARCVAAAC---GHSC---LNPVTVPG--EC 446

  Fly  3449 CPRYRCVPETKDPSKLCLAPLVPICG--------------------------------------- 3474
            |      |..::|:.:.:||  |.||
Zfish   447 C------PVCEEPTYITMAP--PACGSLDNCTLLEQSCAFGFRLDPSGCRTCACKSREELCGGLM 503

  Fly  3475 -------PGQFKKEKKDVNGCSQYICECIPK-DQCEIIELRELLPGEIIVNVEEGCCPTQKIECK 3531
                   |..|   :.|::||.  :|:|.|: .:|:.:...:..|...|.| :.||     ..|:
Zfish   504 ASCTLKCPFGF---QTDIHGCD--VCQCRPRHKKCKAVACAKDCPFGYIKN-KHGC-----DTCR 557

  Fly  3532 PETCPKAPVN----------------CQERFYEVKTIK---EPGMCCS----KHSCVPPKDLCIV 3573
            .:.||:.|.:                ||.|.....::.   :.|.|.|    :|
Zfish   558 CKKCPELPCDKACPMGFQHDELGCLICQCRDQSSSSVTPAVKLGSCLSMDGRRH----------- 611

  Fly  3574 QYELDEATKFTKTVGDKWTHA-KEVCKQETCSYGPDGNAQVVSTLEQCLTDCAPGFSYQNLDKTK 3637
                :....:.....|.:.|| :|:|...:|...|..|..:           .||         .
Zfish   612 ----ENGQSWHDGCRDCYCHAGREMCALISCPVPPCDNPTI-----------RPG---------H 652

  Fly  3638 CCGKCVQTSCIFEQKLYEVNA-------------LWKSADNCTTYSCLKKDGQFLVTTSREVCPD 3689
            ||..|.:.|...:.:|.|.:.             .| :.|:||..:|  ..|:.|..|  ||||.
Zfish   653 CCPTCPEESSSHKPELSEASVCLAPGGEYFVEGETW-NIDSCTQCTC--HSGRVLCET--EVCPP 712

  Fly  3690 VGSCLSHLLYQDGCCKRCKSEPLV---------------ED------------------------ 3715
            : .|.|.:..||.||..|..:|:.               ||
Zfish   713 L-LCHSPIRTQDSCCPHCPDDPVTPQTPSNDSMPSYCRNEDGDIFLAAESWKPNVCSSCVCLDGA 776

  Fly  3716 ----KSSCLPVSLAESRTKEILKFPVQGHGT----CVNADPIQGFTDCEGACSSGSKYNTLTDMH 3772
                ..||.||:.|.         ||...|.    |::|.|       ...|    .:|..|.|.
Zfish   777 ISCFSESCPPVNCAR---------PVLRKGQCCPYCLDATP-------RAVC----HFNGKTYMD 821

  Fly  3773 EK----------FC----TCCSIKS------YHPISVKMICDDGHTFTQKHEVPSNCGCSPCSE 3816
            |:          :|    |.||..|      :.|::|:..|                 |..|.|
Zfish   822 EERWDIDSCTHCYCLQGQTLCSTVSCPALPCHQPLTVEGSC-----------------CPMCPE 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339	6/27 (22%)
		C8	3257..3313	CDD:285899	15/67 (22%)
		VWC	3397..3451	CDD:302663	20/83 (24%)
		GHB_like	<3755..3813	CDD:304424	14/77 (18%)
crim1	NP_997986.1	IGFBP	33..84	CDD:278641
		Cell attachment site. /evidence=ECO:0000255	308..310		1/1 (100%)
		VWC	330..384	CDD:214564	6/53 (11%)
		VWC	397..450	CDD:302663	19/67 (28%)
		Antistasin	561..586	CDD:280912	4/24 (17%)
		VWC	607..657	CDD:302663	13/84 (15%)
		VWC	678..729	CDD:302663	18/56 (32%)
		VWC	751..803	CDD:302663	10/60 (17%)
		VWC	812..866	CDD:302663	14/74 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	877..897
		Cell attachment site. /evidence=ECO:0000255	883..885

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900