DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and Muc6

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:NP_001355882.2 Gene:Muc6 / 353328 MGIID:2663233 Length:4931 Species:Mus musculus


Alignment Length:1395 Identity:409/1395 - (29%)
Similarity:609/1395 - (43%) Gaps:213/1395 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   432 RQKLLALLAKYRDLERRSEWWSSEETVVTMSSYSLYQSNNLDIVIDKTPRPALCTTWGGINMKTF 496
            ||.||.||.:...::..:  |:.:.|           .::.:..:..:|....|:|||..:..||
Mouse     5 RQLLLLLLFRGPLIDAGA--WTGDVT-----------DSDTEDNLQSSPEKGWCSTWGAGHFSTF 56

  Fly   497 DGLVFKAPLSCSHTLIT---DKVSGTFDIILKACPYGSGYGCAHTLKILWQSVLYTFENLNGTMQ 558
            ||..:.....|::....   |.|..||.|.|:....|:   .:..:..|..||:    .:|....
Mouse    57 DGHEYNFQGMCNYIFTATCGDDVPATFSIQLRRDMEGN---ISRIIMELGASVV----TVNKETI 114

  Fly   559 LTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESVGLKL--DWDHRQYVSVQAGPQMWGKVGGLCGT 621
            ....|..:.:|....|:::.|..|.||:..:.:.|:|  .|....:::||...:..||:.||||.
Mouse   115 SVRDIGVVSLPYTSNGLQITPYGQSVQLVAKQLELELVITWGPDAHLTVQVETKYMGKLCGLCGN 179

  Fly   622 LDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSELCQVENSAEMEFGMDSCEQSKLQKAVSVCER 686
            .||..:.:..|..||.|...| :|...:::|.:|:|..|       .:.|....|.:.| .:|.:
Mouse   180 FDGKIDNEFLSEDGKLLEAHK-YATLQKLDDPNEICAHE-------AIPSTIILKTRYA-QICNQ 235

  Fly   687 LLANEKLGDCIKPFNYDALIRTCMADYCNCANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNL 751
            ||.....| |..|  .:.|:.:|.||...||....| :|:|..::..::.|:..|..:.: ||..
Mouse   236 LLTLVSPG-CDVP--KETLMLSCQADMAACARPGQP-NCSCATLSEYSRRCSMTGQPVRN-WRTP 295

  Fly   752 EICPIS-CGFGRVYQACGPNVEPTCDSDLALP--ASKGACNEGCFCPEGT----VQYKEACITRE 809
            .:||:| |...:|||.||.....||.:    |  :....|..|||||.||    :...::|:...
Mouse   296 ALCPMSQCPANQVYQECGEVCIKTCSN----PQHSCSSPCTFGCFCPHGTLLDDISGNQSCVPVN 356

  Fly   810 LCPCSLRGKEFKPESTVKKNCNTCTCKNGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCS 874
            .|||.|.|..:.|....|..|.||.|..|:|.||:..|...|...|.....|||.:.|.|.|.|:
Mouse   357 QCPCMLNGMVYGPGEITKTACQTCQCTMGRWTCTKQPCPGHCSLEGGSFVTTFDARPYRFHGTCT 421

  Fly   875 YHLLKTQNTSVEAENVACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVN 939
            |.||:    |.:..|.....||.:...::..:    |..|.|.::.:. ...||..|:   .|.|
Mouse   422 YTLLQ----SPQLPNEGTLMAVYDKSGYSHSE----TSLVAIMYLSKK-DKIVISEDE---VITN 474

  Fly   940 DKPIAKLPKMLGLGEVLIRRASSTFLTVEFADGIRVWW--DGVSRVYIDAPPSLRGQTQGLCGTF 1002
            :.....||  .....:.|.|.:||.|.:....|:.:.:  ..|.:|||...|..:|||:||||.|
Mouse   475 NGDTKLLP--YKTHNITIFRQTSTHLQMATTFGLELVFQMQPVFQVYITVGPQFKGQTRGLCGNF 537

  Fly  1003 NSNTQDDFLTPEGDVETAVEPFADKWRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWILQ- 1066
            |.:|.|||.|..|..|.....|.|.||. ..|....|...  .||:::...|..||..|..:|: 
Mouse   538 NGDTTDDFTTSMGIDEGTASLFVDSWRA-GNCPAALEREM--DPCSMSQLNKVCAETHCSMLLKK 599

  Fly  1067 -DIFQDCHFLVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQGVKT-GWRMSVKECAV 1129
             .:|:.||.:|.|:.||:.|:|..|. .:|.....|..|.||...|..:|:.. |||.||..|.|
Mouse   600 GSVFEKCHSVVNPQPFYKRCVYQACN-YEETFPHICSALGAYAHACSARGILLWGWRNSVDNCTV 663

  Fly  1130 KCPLGQVFDECGDGCALSCDDLPSKGSCKREC------VEGCRCPHGEYVNEDGECVPKKMCHCN 1188
            .|...:.|......|..:|..|..:   :.||      |:||.||.|.|:|...|||.|..|.|.
Mouse   664 PCTGNRTFSYDSQACDRTCLSLSDR---ETECHVSPVPVDGCNCPEGTYLNHKAECVHKAQCPCL 725

  Fly  1189 FDGMSFRPGYKEVRPGEKFL---DLCTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFT 1250
            .|      .||.|:..:..:   .:|.|.:|                     |..|.:|....|.
Mouse   726 LD------DYKFVQADQSTMINGVICHCING---------------------RLSCPRQAEMFFA 763

  Fly  1251 KCAPKEPKTCKNM-----DKY----------VADSSDCLP-----GCVCMEGYVYDTSRLACVLP 1295
            .|  .||||.::.     ||:          :|...||:|     ||||.:| :|:.|...||..
Mouse   764 SC--PEPKTFQSCSQSSEDKFGAACAPTCQMLATGIDCVPTKCESGCVCPKG-LYENSDGQCVPA 825

  Fly  1296 ANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCS-KNGCESTCSVWGDSHFTTFDGHDFDFQGA 1359
            ..|.|.:||.||..|.::..||..|.|..|.|.|. ...|.|||.::|:.|..||||..|.|.|.
Mouse   826 EECPCDYAGVSYPGGFELHTDCKTCTCSQGRWTCQLSTQCPSTCVLYGEGHIITFDGQRFVFDGD 890

  Fly  1360 CDYVLAK---GVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEESLLLSADSAYSTDPNK 1421
            |:|:||.   |...:...|.:..:||:||..|||||::::|:|.|    ..:..|||.| |...:
Mouse   891 CEYMLATDDCGANSSQPTFKVLTENVICGKSGVTCSRAIKISLGG----LFITMADSNY-TVSGE 950

  Fly  1422 TPIKKLRDSVNSKGHNAFHIYKAGVFVVVEV-IP--LKLQVKWDEGTRVYVKLGNEWRQKVSGLC 1483
            .|:..|:            :..:.:.:|::: ||  |.|.:.|::...|.:|:....:..:.|||
Mouse   951 EPLVHLK------------VKPSPLNLVLDIDIPGRLNLTLVWNKHMSVSIKIRRATQDALCGLC 1003

  Fly  1484 GNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERETWAQLKCGALKSD 1548
            ||.|||..||.:|.|..:.::.:.|.::||..|.|......:|.|..:..|.:||:.||..:.|.
Mouse  1004 GNANGNMKDDFETRSKYVASNELEFVNSWKESPLCGDASYAVDPCSLNTFRRSWAERKCNIINSQ 1068

  Fly  1549 LFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRWRSQHFCPMQCD 1613
            .|..||::|....:::.|:.|.|.||.||||||||.||||||.||..||:.:.||:..|||:.||
Mouse  1069 TFAACHSKVYHLPYYEACVRDACGCDTGGDCECLCDAVAAYAKACLDKGVCVDWRTPDFCPIYCD 1133

  Fly  1614 ---PHC----SDYK-----ACT----PACAVETCDNFLDQGIAERMCNRENCLEGCHIKPCEDGF 1662
               .|.    ::|:     .||    |.....:..:|.|..           .|||:.....:.|
Mouse  1134 FYNTHTLVGENEYQYAQESNCTWHYQPCLCPGSLGSFPDTN-----------TEGCYNCSQNEYF 1187

  Fly  1663 IYLNDTYRDCVPKAECKPVCMVRDGKTFYEGDITFTDSCATCRCSKRKEICSGVKCDVPAT---- 1723
            .:...|...|.|.....|.              |.|.|..|...:...|..|....:.|..    
Mouse  1188 DHSEGTCVPCAPPTTTLPP--------------TTTGSQPTTETTISTEFHSSTSANTPVAPSYL 1238

  Fly  1724 TGLPAPLVEGTTLPTPLATQNQTKCVKGWT 1753
            .|||.|         |.:..:.|:.:..||
Mouse  1239 PGLPTP---------PPSAPSSTEELTVWT 1259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 41/155 (26%)
C8 680..754 CDD:285899 20/73 (27%)
TIL 758..811 CDD:280072 18/58 (31%)
VWD 840..1015 CDD:214566 55/176 (31%)
C8 1054..1121 CDD:214843 23/69 (33%)
TIL 1131..1185 CDD:280072 19/59 (32%)
TIL 1245..1298 CDD:280072 21/72 (29%)
VWD 1327..1498 CDD:214566 59/177 (33%)
C8 1535..1609 CDD:214843 35/73 (48%)
Mucin2_WxxW 1751..1837 CDD:290069 2/3 (67%)
TIL 1938..2005 CDD:280072
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
Muc6NP_001355882.2 VWD 45..194 CDD:395046 41/155 (26%)
C8 232..298 CDD:400886 19/70 (27%)
TIL 303..358 CDD:396409 18/58 (31%)
VWC_out 360..>404 CDD:214565 16/43 (37%)
VWD 387..550 CDD:214566 55/176 (31%)
C8 589..661 CDD:214843 26/72 (36%)
TIL 665..722 CDD:410995 19/59 (32%)
TIL 765..828 CDD:410995 20/65 (31%)
VWC_out 830..887 CDD:214565 24/56 (43%)
VWD 869..1020 CDD:395046 55/167 (33%)
C8 1057..1129 CDD:214843 35/71 (49%)
ROM1 1406..>1624 CDD:227709
Herpes_BLLF1 <1553..1968 CDD:282904
Herpes_BLLF1 <1858..2241 CDD:282904
PHA03247 <2099..2563 CDD:223021
Herpes_BLLF1 <2510..2925 CDD:282904
Herpes_BLLF1 <2791..3187 CDD:282904
PHA03247 <3329..3784 CDD:223021
COG3889 <3886..4052 CDD:226406
Herpes_BLLF1 <4013..4471 CDD:282904
PHA03247 <4320..4742 CDD:223021
CT 4847..4926 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 100 1.000 Domainoid score I6994
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11339
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.020

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