DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and Kcp

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_011239372.1 Gene:Kcp / 333088 MGIID:2141640 Length:2120 Species:Mus musculus


Alignment Length:2491 Identity:484/2491 - (19%)
Similarity:724/2491 - (29%) Gaps:997/2491 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 NFYGGGGHF------LAAFGKCSALQLPSN--VQSECHNGRCKVFCPTGYSFAQDVSVLEMFCSN 183
            ||:|.||..      ||  ...|..|.||:  |..|.|.   :.:||    ..:.:..||     
Mouse    49 NFWGQGGEVSREQPRLA--DAISQQQAPSHSLVPGETHQ---QQWCP----LEERLERLE----- 99

  Fly   184 DGWIIGNSVFAEVPPCQAQCTPPCQNNGI---CISAGVCQCPENYYGP----------------- 228
                      |||...:.      ||..:   .:....|:|    :||                 
Mouse   100 ----------AEVTDLRK------QNRELQARVVQLESCEC----WGPGHTCPEGARWEPDACTA 144

  Fly   229 -LCQQKKSICASFPKAPKNSKVSCKNN---MCHAE-----------CMRGFQFPDGSGITNIECR 278
             :|:...:.|...|..|...  .|.:|   ..|.|           |:.|.....|...:.:.|.
Mouse   145 CVCRDGTAHCGPQPNLPHCR--GCSHNGQSYGHGETFSPDACTTCRCLAGTVQCQGPSCSELNCL 207

  Fly   279 NGQWVHTKTGLSKTP--DCAPTCAPACQNGGQ--------CISFNVC-QCSKMFRGDHCQYNIDR 332
            .          |..|  :|.|.|.|.|:..||        ..|.|.| |||       |..::.|
Mouse   208 E----------SFIPPGECCPICRPGCEYEGQLHQEGSSFLSSSNPCLQCS-------CLRSLVR 255

  Fly   333 CNVTNTNFNGNYKCAYEMDDARCTFSCPQVPGLKIQGRIDIEYKCNYLQGQYLPAPLPKCIFPP- 396
            |                                       :..||.       |:|   |:.|. 
Mouse   256 C---------------------------------------VPVKCQ-------PSP---CLNPVP 271

  Fly   397 --GY---TVRSTSSMQGVTHQNGVYHRGMSGE-------MAYELQTERQKLLALLAKYRD----- 444
              |:   ..:::...:|.:|::........|:       :...:|. ||:..|.|..|..     
Mouse   272 RLGHCCPVCQASGCTEGNSHRDHGQEWTTPGDPCRICQCLEGHIQC-RQRECASLCPYPARPLPG 335

  Fly   445 ----------LERRSEWWSSEETVVTMSSYSLYQSNNLDIVIDKTPRPALCTTWGGINMKTFDGL 499
                      |..|..  ||.|.|.:....|..:..|..:..:..|.|                 
Mouse   336 TCCPVCDGCFLNGREH--SSGEPVGSQDPCSSCRCTNGSVQCEPLPCP----------------- 381

  Fly   500 VFKAPLSCSHTLITDKVSGTFDIILKACPY-GSGYGCAHTLKILWQSVLYTFENLNGTMQLTTPI 563
                |..|.:   ..::.|....:...|.| |..|....|..:                      
Mouse   382 ----PAPCRY---PGRIPGQCCPVCDGCKYQGHEYRSQETFTL---------------------- 417

  Fly   564 KKLPMPVQVMGMKVMPVAQHVQIDLESVGLKLDWDHRQYVSVQAGPQMWGKVGGLCG--TLDGDP 626
                   |..|..:..|.|..::..|    :.|......|...:|||       ||.  .|:|: 
Mouse   418 -------QENGRCLRCVCQAGEVSCE----EQDCPVTPCVRSASGPQ-------LCSACVLNGE- 463

  Fly   627 NTDLTSRTGKKLATVKAFADA--WRVEDRSELCQVENSAEMEFGMDSCEQSKLQKAVSVCERLLA 689
                            .||:.  |..:|:                 .|.....|..|.||..:| 
Mouse   464 ----------------EFAEGIQWEPDDQ-----------------PCTSCSCQDGVPVCRAVL- 494

  Fly   690 NEKLGDCIKPFNYDALIRTCMADYCNCANREHPE----SC--NCDAIAMLAKECAFKGIKLEHGW 748
                                    |:....:||.    :|  :||:       |.:..:...:|.
Mouse   495 ------------------------CSPVPCQHPTQPPGACCPSCDS-------CTYHSLVYANGQ 528

  Fly   749 RNLEI--------------------CPI-SC-----GFGRVYQACGPNVEPTC--------DSDL 779
            ...::                    ||. :|     |.|:....|     |.|        |.: 
Mouse   529 NFTDVDSPCQTCYCEDGTVRCSLINCPFTTCAKPQNGPGQCCPKC-----PDCILEAQVFVDGE- 587

  Fly   780 ALPASKGACNEGCFCPEGTVQYK--------------EACITRELCPCSLRGKEFK-----PEST 825
            ..|..:..|.| |:|.||....:              ..|...:...|:..|||:.     |..|
Mouse   588 RFPHPRDPCQE-CWCQEGQAHCQLRACPSAPCVHPLPGTCCKNDCTGCAFGGKEYPNGADFPHPT 651

  Fly   826 VKKNCNTCTCKNGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQNTSVEAENV 890
              ..|..|.|.:|..:|    ...||..:..|......|   |...:|       .:...:....
Mouse   652 --DPCRLCRCLSGNVQC----LARRCPPLSCPQPVLTPG---DCCPQC-------PDAPADCPQS 700

  Fly   891 ACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEV 955
            .....|....:|..|.|| |::.:.:     ||:.|..:|........:.:..|..|...|    
Mouse   701 GNMVPVRHQEHFFQPGDP-CSRCLCL-----DGSVSCQRLTCPPAPCAHPRRDACCPSCDG---- 755

  Fly   956 LIRRASSTFLTVEFADGIR-----------VWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDD 1009
                  ..:...|||.|.|           :.|:|          |::.:.: .|    :..|..
Mouse   756 ------CLYQGKEFASGERFPSPNVACHVCLCWEG----------SVKCEPR-TC----APAQCP 799

  Fly  1010 FLTPEGDVETAVEPFADKWRTKDTCQFKA----ETHQGPHP---------------CTLNP-EKK 1054
            |.|.|           |.....|:|.:..    .:.:.|.|               ||..| |..
Mouse   800 FPTRE-----------DCCPACDSCDYLGVSYLSSQEFPDPREACNLCTCLGGFVTCTRRPCEPP 853

  Fly  1055 AQAEKFCDWILQDIFQDCHFLVEPEQ---FYEDCLY-------------------DTCACKDEMS 1097
            |     |.          |.|:.||.   ..:.|||                   ..|.|::...
Mouse   854 A-----CS----------HPLIVPEHCCPTCQGCLYHGITAALGETLPDPLDPTCSLCTCEEGSM 903

  Fly  1098 K------------------CFCPILSAYGTECMRQGVK-------TGWRMSVKECAVKCPLGQVF 1137
            :                  ||||:..:    |:.||.:       .|...|.:.|  :|..||| 
Mouse   904 RCQKKPCPPAPCAHPSPGPCFCPVCRS----CLSQGREHQDGEEFEGPEGSCERC--RCLAGQV- 961

  Fly  1138 DECGDGCA-LSCDDLP------SKGSCKRECVEGCRC-----PHG-EYVNEDGECVPKKMCH--- 1186
                 .|. |.|..||      ..|:|...|. ||..     |.| .:|..|..| ...|||   
Mouse   962 -----SCTRLQCPSLPCLHQVTEPGTCCPRCT-GCLARGEEHPEGSSWVPADSPC-SSCMCHKGI 1019

  Fly  1187 ----------------------------CNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDA 1223
                                        |...|..:.|| :..:||....::|.|.:.. |...|
Mouse  1020 ITCAQVQCVSACIWPQEGPSDCCPQCSGCEHGGRKYEPG-ESFQPGADPCEVCICKEQA-DMPTA 1082

  Fly  1224 --EPGDKDKYPPS-----------SELRSKCAKQ--------------------PYAEFTKCAPK 1255
              :.|..|:||.:           |.:.|.|::.                    ..|.|...||.
Mouse  1083 PKDMGVADRYPGAREQLAFHSLGLSSVHSCCSRSVRGLPAFTVVGGSAPAWWAAHQASFFLLAPS 1147

  Fly  1256 ---EPKTCKNMDKYVAD--SSDCLP-----GCVCMEGYVYDTSR----LACVL------PANC-- 1298
               .|...|.:.....|  .|:.:|     .|.|.:.....|.|    |:|.|      |.:|  
Mouse  1148 TAVPPVPVKALSNCTEDLVGSELVPPDPCYTCQCQDLTWLCTHRACPELSCPLWERHTTPGSCCP 1212

  Fly  1299 -------SCHHAGKSYDDGEKIKED-CNLCECRAGNWKCSKNGCE-------------------- 1335
                   ||.|.|:....||:...| |..|.|.||...|....|.                    
Mouse  1213 VCKDPTQSCMHQGRWVASGEQWAVDACTSCSCVAGTVHCQTQRCRKLACSRDEVPALSPGSCCLR 1277

  Fly  1336 -----STCSVWGDSHFTTFDGHDFDFQGACDYVLAKGVFDNGDGFSITIQNVLCGTMGVTCSKSL 1395
                 ::|..:||.|:.||||....|||:|.|||||..  :|:.||:.:.|...|..||..::.:
Mouse  1278 CLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDC--HGEDFSVHVTNDDRGRRGVAWTQEV 1340

  Fly  1396 EIALTGHAEESLLLSADSAYSTDPNKTPIKKLRDS---VNSKGHNAFHIYKAGVFVVVEVIPLKL 1457
            .:.|   ...::.|........|.:...:..||:.   :..:||.          |::...| .|
Mouse  1341 AVLL---GTVAVRLLQGRTVMVDQHTVTLPFLREPLLYIELRGHT----------VILHAQP-GL 1391

  Fly  1458 QVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKL-------Q 1515
            ||.||..::|.|::.:.:|.:..|||||:||.:.||:|.|...|..:...||::||:       :
Mouse  1392 QVLWDGQSQVEVRVPSSYRGQTCGLCGNFNGFAQDDLQGPDGRLLPTEASFGNSWKVPKGLGPGR 1456

  Fly  1516 PHCSA--PVAPIDACKKHPERETWAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGD 1578
            | |||  .|.|..|......||  |..:||.||:..|..|||.||.|.|:..|::|.|||..|..
Mouse  1457 P-CSAGREVDPCRAAGYRARRE--ANARCGILKTSPFSHCHAVVPPEPFFAACVYDLCACGPGSS 1518

  Fly  1579 CE-CLCTAVAAYADACAQKGINIRWRSQHFC---------PMQCDPHCSDYKACTPA-CAVETCD 1632
            .: |||.|:.|||..|.|.|:...||....|         |:|............|| |......
Mouse  1519 SDTCLCDALEAYASHCRQAGVTPVWRGPTLCGNHSWVSKTPLQPQASLDPVPTSLPALCRSRPAS 1583

  Fly  1633 NFLDQGIAERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCVPKAECKPVCMVRDGKTFYEGDITF 1697
            ..|..|:...|...|  :||..                    :|:.|   ::.|           
Mouse  1584 KCLTAGLELPMTLLE--MEGSQ--------------------RAQEK---LLWD----------- 1612

  Fly  1698 TDSCATCRCSKRKEICSGVKCDVPATTGLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRD- 1761
                        .|:.:||      ..||..|...|...........|::|.:.|.|..|:|.: 
Mouse  1613 ------------LELLTGV------GLGLFWPPWAGYCSQRSQTQYAQSQCSQSWGRSVDEDFEQ 1659

  Fly  1762 ---------------------------TSDKSVRLNDEEKVPRYDRMEN---------------- 1783
                                       |...|....:|.:.....|:|.                
Mouse  1660 LSSKLCPPPQAGEAHSESHQLLKGKLATDSSSASDLEEARSDGDPRLEGPIMPAKAVPGSSTGEG 1724

  Fly  1784 -------------VYGTCLKQYMTKVECRVKDTHEAPE--QMDENVVCSLEEGLRCI--GKCHDY 1831
                         ::.|....:.......:||..:..|  |.:.|:..|..:.||..  ||    
Mouse  1725 QEAGGAGVPGAGCLHSTNSSSFKEPGNSELKDPGKMEERSQAEPNIQSSFGQTLRSTQEGK---- 1785

  Fly  1832 ELRAFCQCDEELEPELPKPTEKPQLGLACDAAVVEYKEFPGDCHKFLHCQPKGVEGGWIYVEKTC 1896
                       |..|.|:|::....||:.                 |....||: |..:..|:..
Mouse  1786 -----------LGQEGPEPSDLASQGLSA-----------------LQDLSKGL-GSGLSQERAA 1821

  Fly  1897 GEYMMFNPTMLICDHIATVTEIKPNCGLKPEPEPEFEP---IKQCPPGKIKSECANQCENTCHYY 1958
                                   |...|.|:..||..|   ..|.|.|               |.
Mouse  1822 -----------------------PQTLLTPQGHPEETPQGQRGQSPQG---------------YK 1848

  Fly  1959 GSILK-----------KRGLCQVGEHCK-----PGCVDELRPDCPKLGKFWRDEDTCVHADECPC 2007
            |..::           :|...|.|:..|     .|...|:..:..:....||.|      ::.|.
Mouse  1849 GESIQGQDKGVPQSQSERKQAQQGQEFKIPPLQEGSKSEVWEEVQRGATVWRQE------EDKPQ 1907

  Fly  2008 MDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPK----DEDDDLDLVSVVPIYPVTLTP 2068
            ...::....|.||:                    |:.|.|    .:.....:.........|..|
Mouse  1908 GHPSDFCKSPEKPI--------------------PQHVEKGIAGPQGGSTQVTQAAATQEGTWAP 1952

  Fly  2069 PLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEHGPKMARLTKEQ--PR------GSWSPSIND 2125
            |   :|    |:::.|...:..|       .|.|..|::....:||  ||      .:|....|.
Mouse  1953 P---TP----PQLQGPEGGILVS-------EAQERQPRLPSALREQRVPRDPKPSKDAWPEPRNR 2003

  Fly  2126 Q-----------MQYLELNFA 2135
            :           .:.||||.|
Mouse  2004 EDALASAGQEVLQRLLELNGA 2024

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 22/153 (14%)
C8 680..754 CDD:285899 12/99 (12%)
TIL 758..811 CDD:280072 15/79 (19%)
VWD 840..1015 CDD:214566 32/185 (17%)
C8 1054..1121 CDD:214843 19/113 (17%)
TIL 1131..1185 CDD:280072 19/66 (29%)
TIL 1245..1298 CDD:280072 17/72 (24%)
VWD 1327..1498 CDD:214566 53/198 (27%)
C8 1535..1609 CDD:214843 33/83 (40%)
Mucin2_WxxW 1751..1837 CDD:290069 20/146 (14%)
TIL 1938..2005 CDD:280072 13/82 (16%)
FA58C 2089..2223 CDD:238014 15/66 (23%)
FA58C 2104..2225 CDD:214572 12/51 (24%)
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
KcpXP_011239372.1 VWC 166..220 CDD:278520 12/63 (19%)
VWC 224..280 CDD:327433 19/111 (17%)
VWC 285..341 CDD:327433 9/56 (16%)
VWC 344..399 CDD:327433 13/80 (16%)
VWC 458..514 CDD:278520 16/114 (14%)
VWC 517..573 CDD:327433 7/55 (13%)
VWC 634..690 CDD:327433 16/64 (25%)
VWC <717..753 CDD:327433 9/41 (22%)
VWC 931..987 CDD:327433 17/63 (27%)
VWC <1173..1214 CDD:214564 9/40 (23%)
VWC 1221..1278 CDD:214564 13/56 (23%)
VWD 1285..1432 CDD:365869 51/162 (31%)
C8 1482..1549 CDD:370094 30/66 (45%)
Glutenin_hmw <1757..>1975 CDD:367362 55/328 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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