DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hml and Muc14A

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster

Alignment Length:	870	Identity:	161/870 - (18%)
Similarity:	281/870 - (32%)	Gaps:	295/870 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2216 IAMRVELLICGDKEEPKPVPTVSTILPITERPARLVDLECIDLMGVDEGKMYQDQVQSSSLWQQP 2280
            |....|.:...|..||.     |.|...|       ..|||....:......:..::.:.|.:.|
  Fly   443 IIFEFETITFSDAPEPN-----SDITGYT-------STECIKCSELTTTVPIETTIERTKLSETP 495

  Fly  2281 NLGKKLQLLELLKLSTPLAWRPLANSQNEF---IEFDFLEPRNISGFVTKGGPDGWVTGYKVMFS 2342
                    |:.|:.|||      ..|.|.|   ::.:.:...:|....||  .|.:.|..:...|
  Fly   496 --------LQKLQFSTP------KKSTNRFASVLQLNAVTDSSIKVLNTK--TDQFDTEEETSLS 544

  Fly  2343 KKKPTWNTVLSTDGQARIFEANHDAETERRHHFKNPILTQYIKIVPAYWEKNINM---------- 2397
            :..|.|.|||.:..|....|........:..|.:...|::.|..:..:   .||:
  Fly   545 EFLPEWPTVLGSSLQFSTIETQPSTNNGQLTHTEKTTLSKSINHIKHH---KINLGQNAEAASHF 606

  Fly  2398 RIEP--------LGCFLPYPEIQRQ----VPVEESKPTKCNICDGVSTSSSTTGCQCQDQLFWDG 2450
            .|:|        .|.:  :|.::::    :|:..:|....|:||          |.|:.::..|
  Fly   607 NIQPGALHTISTTGGY--HPTVKKKQSETLPLLSTKSISLNMCD----------CTCKLEIAKD- 658

  Fly  2451 NTCVQHNLCPC--------------------------------IENYVSYPIGSKFENSACEDCV 2483
             :|:    |.|                                :::|.  |.|:....:|..:..
  Fly   659 -SCI----CECNLKKSTSDISKGVTASASNQSLPTETNRKLHSMKDYA--PNGTSLLTNASPEPF 716

  Fly  2484 CV--------LGGHKNCKPKKCPPCLGGKLRPVITSD-CFCKCEPCPKHQRLCPSSGD-CIPEIL 2538
            .:        |.|.|...|.:....  .|:.||.|.| |.|.|        |.....| |.
  Fly   717 TIDDVTYKGNLAGKKTTMPSELSSL--KKIEPVKTHDVCECTC--------LLEQGNDSCT---- 767

  Fly  2539 WCNGVQDCADDEDASCSDSFTVEPD-VSREK--NETEVITCPVPVCPPQ----MKIRITEKKSRK 2596
             ||    |..|..::.....:..|| :|:.|  |:::    .||:...:    |||..|.|..:.
  Fly   768 -CN----CMTDFISTSIQISSTGPDQISQNKMGNQSQ----SVPLLNTEFSDLMKISTTYKMHQT 823

  Fly  2597 MSKMFTFSKQ---VSIVDDG-----TTITKTKFISSKEQILAMPNREL--DFQLEEQ----CD-- 2645
            .:.:...||.   :|....|     ||.|..|   .|:|..::|:...  :|..|:.    ||
  Fly   824 QNDIEKLSKSPPVLSTTSSGLPKWPTTRTLEK---KKQQSKSLPSLSTISNFHFEKSNFHGCDCT 885

  Fly  2646 ------EFTCV-------------------PIPSK--QVDKNETVTCTEPKCPEKYDVELDMSAS 2683
                  ..:|:                   |:|:|  .|..|...:.|..........:|....:
  Fly   886 CQLELGRDSCICECNFKESTSDVSTSRSNQPLPTKLHSVKDNAPHSLTNANPESLTSKDLTTKGN 950

  Fly  2684 KVGDCLRYSCVLRPNKDDVCEISGKSFTTFDGTVFKYGPCSHILARDIHSSSWSISVHQQCSDET 2748
            .|.| .:.:.:.:.:.|:|||                  |:.:|.:...|.:.:      |..:|
  Fly   951 GVTD-NKITTLSKLSSDNVCE------------------CTCLLEQGNDSCTCN------CMTDT 990

  Fly  2749 RKVCHKVITIQDTEAGNELILLPHLKLKFNGYEFTVQQLINSPICKASFV-VSQPGK-----TLL 2807
            ..:...::|.....:..:|                 |...|.|..|::.. .:..||     |||
  Fly   991 NSIDESILTASQIVSSEDL-----------------QYSSNPPSYKSTQENTNTKGKNKNLSTLL 1038

  Fly  2808 AVSTKYGFWVQLDDIG---------------IVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPDG 2857
            .:|:...:.:...:||               |.|:..:.|...|:|        .:::..:||
  Fly  1039 QISSTGPYQIYQSEIGNQSQYVPPSSTLFSDITKISNTDKDHPTLD--------EEENISKSP-- 1093

  Fly  2858 QIIPNTEKFGDSWYDKRIPKDQCGDLKCPREMQAKALQLCNIIHHPTFARCHKAVNYKQFLNNYC 2922
                    ...|.....:||                :|:..:.|.| |......:.::|...:.|
  Fly  1094 --------LHLSTTSSSLPK----------------IQITGVSHLP-FLSTISNIKFEQSSFHGC 1133

  Fly  2923 LEAACNCMMANNGDPAACKCNILES 2947
               .|.|.:....|...|:||:.||
  Fly  1134 ---DCTCQLEIGKDSCICECNLKES 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014	2/6 (33%)
		FA58C	2104..2225	CDD:214572	2/8 (25%)
		FA58C	<2299..2404	CDD:214572	23/125 (18%)
		FA58C	<2299..2403	CDD:238014	23/124 (19%)
		VWD	2703..2858	CDD:295339	28/175 (16%)
		C8	2893..2970	CDD:285899	14/55 (25%)
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900