DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hml and Tecta

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	NP_001100284.1	Gene:	Tecta / 300653	RGDID:	1309824	Length:	2155	Species:	Rattus norvegicus

Alignment Length:	1776	Identity:	402/1776 - (22%)
Similarity:	628/1776 - (35%)	Gaps:	502/1776 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 CTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGT----FDIILKACPYG--------------S 531
            |..:|..:..||||.:|....||::.|....:..:    |.:..|....|              :
  Rat   322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVKELSVEVN 386

  Fly   532 GYGCAHTLKILWQSVLYTFENLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESVGLKLD 596
            ||      |||.....|      |.:::...:..||:.:::..:|:........::.: .||.:.
  Rat   387 GY------KILIPKGSY------GKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETD-FGLLVT 438

  Fly   597 WDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVE---------- 651
            :|.:.|.|:...........||||..:.:|..|.....|:...:|....::|||.
  Rat   439 FDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHTDWKCGSGC 503

  Fly   652 -DRSELCQVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCN 715
             |....|.....| :.||.|.|  ..|.|         .:..|.:|....:..|.:.:|:.|.|:
  Rat   504 IDNCTQCDAATEA-LYFGSDYC--GFLNK---------TDGPLWECGTVVDATAFVHSCVYDLCS 556

  Fly   716 CANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEIC--PISCGFGRVYQACGPNVEPTCDSD 778
            ..:.   .:..|.||...|..|...||.: ..||....|  .:.|.....|..|..:...|| ||
  Rat   557 VRDN---GTLLCQAIQAYALVCQALGIPI-GDWRIQTGCVSTVRCPSFSHYSVCTSSCPDTC-SD 616

  Fly   779 LALPASKGA---CNEGCFCPEGTVQYKEACITRELCPCSLRGK-----EFKPESTVKKNCNT-CT 834
            |.  ||:..   |.|||.|.||.|.....|:....|.|...|.     ||   .....||.. |.
  Rat   617 LT--ASQNCATPCTEGCECNEGFVLSTSQCVPLHKCGCDFEGHYYTMGEF---FWATANCTVQCL 676

  Fly   835 C-KNGQWRCTEDKC--GARCGAVGDPHYQ-------------------TFDGKRYDFMGKCSYHL 877
            | :.|...|....|  |..| ||.| .||                   ||||..|.|..:.||.|
  Rat   677 CEEGGDVYCFNKTCRSGEVC-AVED-GYQGCFPKRETVCLLSQNQVLHTFDGAAYAFPSELSYTL 739

  Fly   878 LKTQNTSVEAENVACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKP 942
            |||                       .|:.|...: :.|.....|..|:.::   |:..:|.|:.
  Rat   740 LKT-----------------------CPERPEYLE-IDINKRKPDAGPAWLR---GVRILVADQE 777

  Fly   943 IAKLPKMLGLGEVLI---------------------RRASSTFLTVEFADGIRVWWDGVSRVYID 986
            :    |:.|:|.:.:                     |..:||  |||....:.|.:..|..:||.
  Rat   778 V----KIGGVGALEVKLNGHDVELPFFHPSGRLEIHRNKNST--TVESKGVVSVQYSDVGLLYIR 836

  Fly   987 APPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRT-KDTCQ------FKAETHQGP 1044
            ........|.||||.||:|..|:|..|.|.....:..|.:.|.| ::.|.      .||
  Rat   837 LSTMYFNCTGGLCGFFNANASDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKA------ 895

  Fly  1045 HPCTLNPE--KKAQAEKFCDWILQD----IFQDCHFLVEPEQFYEDCLYDTCACKDEMSKCFCPI 1103
              |..:.|  |..::...|. |:.|    .|.:||.:|....:|..||:..|......|: .|..
  Rat   896 --CNNDSELLKFYRSRSRCG-IINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESE-LCDS 956

  Fly  1104 LSAYGTECMRQGVKTG-WRMSVKECAVKCPLGQVFDECGDGCALSCDDLPSKGSCKRECVEGCRC 1167
            ::.|.:.|....|:.| || :...|.::||....|:||.. |..:|:.|.....|...|.|||:|
  Rat   957 VARYASACKNADVEVGPWR-TYDFCPLECPENSHFEECMT-CTETCETLALGPICVDSCSEGCQC 1019

  Fly  1168 PHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYP 1232
            ..| |..:..:||.:..|.|||:|       .::...|.|          |..||
  Rat  1020 DEG-YALQGSQCVTRSECGCNFEG-------HQLATNETF----------WVDQD---------- 1056

  Fly  1233 PSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYV-ADSSDCLPGCVCMEGYVYDTSRLACVLPA 1296
                    |....|             |...|..| .::..|.....|||
  Rat  1057 --------CQIFCY-------------CNGTDNSVHCETIPCRDDDYCME--------------- 1085

  Fly  1297 NCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFDFQGACD 1361
                 .:|..|            |:.|.          :::|.|.|..|:.||||:.||||.:|.
  Rat  1086 -----ESGLYY------------CQPRT----------DASCIVSGYGHYLTFDGYPFDFQTSCP 1123

  Fly  1362 YVL----AKGVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHA-------EESLLLSADSAY 1415
            .:|    ::.:.|:...|.:|.:|...........|.:::.:.|::       :.::|::.:..|
  Rat  1124 LILCTTGSRSISDSFPKFIVTAKNEDRDPSLALWVKQVDVTVFGYSIVIHRAYKHTVLVNNERLY 1188

  Fly  1416 STDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVS 1480
                  .|:|        .|....:|:..|..||||. ...|:|.:|..|.:.:.:....:....
  Rat  1189 ------LPLK--------LGQGKINIFSFGFHVVVET-DFGLKVVYDWKTFLSITVPRSMQNSTY 1238

  Fly  1481 GLCGNYNGNSLDDMQTPSMGLETSPMLFGHAW-KLQPHCSAPVAPIDACKKHPERETWAQLK--C 1542
            ||||.||||..||::.|...|..|...||.:| |....|.  |...|.|....:.|.:::::  |
  Rat  1239 GLCGRYNGNPGDDLEMPMGLLALSINEFGQSWVKRDTFCQ--VGCGDRCPSCAKVEGFSKVQQLC 1301

  Fly  1543 GALKSDL--FKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIR-WRS 1604
            ..:.:..  |.:||::|....|:|.|:||:|.  .||..:..|:.:..||..|..:|:.:. ||:
  Rat  1302 SLIPNQNAGFAKCHSKVNPTFFYKNCLFDSCI--DGGAVQTACSWLQNYASTCQTQGVAVTGWRN 1364

  Fly  1605 QHFCPMQCDPHCSDYKACT----PACAV----ETCDNFLDQGIAERMCNRENCLEGCHIKPCEDG 1661
            ...|.:.|.|: |.|::|.    |.||.    ..|:::              |:|||.   |:.|
  Rat  1365 YTSCSVTCPPN-SHYESCVSVCQPRCAAIRLKSDCNHY--------------CVEGCQ---CDAG 1411

  Fly  1662 FIYLNDTYRDCVPKAECKPVCMVRDGK------TFYEGDITFTDSCATCRCSKRK---------- 1710
            :: ||.  :.|:....|.  | ..|||      .|:.||.|     ..|||.:|.
  Rat  1412 YV-LNG--KSCILPHNCG--C-YSDGKYYEPKQLFWNGDCT-----RRCRCFRRNLIQCDPRQCK 1465

  Fly  1711 --EIC---SGVK-CDVPATT------GLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTS 1763
              |.|   |||: |....|:      |......:|..|..|      ..|....:..|.|..|.|
  Rat  1466 SDEECALRSGVRGCFSTKTSYCLAAGGGVFRTFDGAFLRFP------ANCAFVLSTICQKLPDIS 1524

  Fly  1764 DKSVRLNDEEKVPRYDRMENVYGTCLKQYMTKVECRVKDTHEAP---EQMDENVVCSL------E 1819
            .:.:...|:...|....:..||     .|:.:.:..:.|.:...   .|::...:..|      .
  Rat  1525 FQLIINFDKWSSPNLTIISPVY-----FYINEEQILINDRNTVKVNGTQVNVPFITGLATKIYSS 1584

  Fly  1820 EGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQLGLACDAAVVEYKEFPGD-CHKFLHCQPK 1883
            ||...|....|.::  :......::..:.:..:....|| |.       .|.|| ...::..:.|
  Rat  1585 EGFLVIDTSPDIQI--YYNGFNVIKISISERLQNKVCGL-CG-------NFNGDMTDDYVTLRGK 1639

  Fly  1884 GVEGGWIYVEK-------------TCGEYMMFNPTMLICDHI-----------ATVTEIK----P 1920
            .|....:..:.             :|.| :.|:.....||::           ..:|::|    |
  Rat  1640 PVVSSVVLAQSWKTNGMQKRPLTPSCNE-LQFSQYAATCDNVHIQAMQGDGYCLKLTDMKGFFQP 1703

  Fly  1921 NCGLKPEPEPEFEPIKQCPPGKIKSECANQCENTCHYYGSILKKR-----GLCQVGEHCKPGCVD 1980
            ..||. :|.|.:|                    :|:..|....|:     .|...||.|:...:
  Rat  1704 CYGLL-DPLPFYE--------------------SCYLDGCYNHKKFQLCGSLAAYGEACRSFGI- 1746

  Fly  1981 ELRPDCPKLGKFWRD--------EDTCVHADECP---C-MDKAEHYVQPHKPVLGEFEVCQCIDN 2033
                    |...|.:        ||.||.|| ||   | :|...             |:|.||:
  Rat  1747 --------LSTEWIEKENCSGVVEDPCVGAD-CPNRTCELDNGG-------------ELCGCIE- 1788

  Fly  2034 AFTCVPNKPEPVPKDEDDDLD 2054
                    |.|...:..|.:|
  Rat  1789 --------PPPYGNNSHDIID 1801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339	34/168 (20%)
		C8	680..754	CDD:285899	15/73 (21%)
		TIL	758..811	CDD:280072	19/55 (35%)
		VWD	840..1015	CDD:214566	53/216 (25%)
		C8	1054..1121	CDD:214843	17/71 (24%)
		TIL	1131..1185	CDD:280072	18/53 (34%)
		TIL	1245..1298	CDD:280072	8/53 (15%)
		VWD	1327..1498	CDD:214566	45/181 (25%)
		C8	1535..1609	CDD:214843	21/78 (27%)
		Mucin2_WxxW	1751..1837	CDD:290069	16/94 (17%)
		TIL	1938..2005	CDD:280072	15/79 (19%)
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
Tecta	NP_001100284.1	NIDO	98..254	CDD:214712
		VWD	322..478	CDD:278521	34/168 (20%)
		C8	517..591	CDD:214843	21/88 (24%)
		TIL	597..650	CDD:280072	19/55 (35%)
		VWC	652..706	CDD:302663	18/58 (31%)
		VWD	703..865	CDD:214566	45/194 (23%)
		C8	905..981	CDD:214843	19/78 (24%)
		TIL	984..1036	CDD:280072	18/53 (34%)
		VWD	1100..1258	CDD:278521	46/172 (27%)
		C8	1298..1368	CDD:285899	20/71 (28%)
		TIL	1372..1425	CDD:280072	18/73 (25%)
		VWD	1487..1639	CDD:278521	27/172 (16%)
		C8	1685..1757	CDD:214843	17/101 (17%)
		ZP	1805..2059	CDD:214579
		Zona_pellucida	1937..2057	CDD:278526
		FXa_inhibition	2089..2121	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.860