Protein Alignment Hml and Bmper

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: NP_001129271.1
• Gene: Bmper / 300455
• RGDID: 1563373
• Length: 685
• Species: Rattus norvegicus
• Alignment Length: 697
• Identity: 167/697 - (23%)
• Similarity: 251/697 - (36%)
• Gaps: 183/697 - (26%)

  Fly   630 LTSRTGKKLATVKAF--ADAWRVEDRSELCQVE------------NSAEMEFGMDSCEQSKLQKA 680
            |.:.:|..::...:|  ....:.|:..|:.|:.            ::.|:....:.|.......|
  Rat    28 LLNCSGVPMSLASSFLTGSVAKCENEGEVLQIPFITDNPCIMCVCSNKEVTCKREKCPVLSRDCA 92

  Fly   681 VSVCERLLANEKLGDCI-------KPFNYDALIRTCMADYC--------------NCAN-REHPE 723
            :::.:|....|:...|.       ..|.:.:....|....|              :|.| .|||.
  Rat    93 LAIKQRGACCERCKGCTHEGRTYNSSFKWQSPAEPCALRQCQEGVVTESEVRCVVHCKNPAEHPG 157

  Fly   724 SC--NCDAIAMLAKECAFKGIKLEHGWR--------------------NLEICPI---------- 756
            :|  .|..       |.|:|::...|..                    ..|:|||
  Rat   158 ACCPTCPG-------CVFEGVQYREGEEFQPEANKCIKCSCVGGRTQCVREVCPILSCPQHLSHT 215

  Fly   757 ---------------------SC---------GFGRVYQACGPNVEPTCDSDLALPASK----GA 787
                                 ||         |...||..|   ...||.....:...|    |.
  Rat   216 PSGQCCPKCLGQRKVFDLPFGSCLFRSDVYDNGASFVYDNC---TVCTCKDSTMVCKKKCSHPGV 277

  Fly   788 CN--EGCFCPEGTVQYKEACITR----ELCPCSLRGKEFKP-ESTVKKNCNTCTCKNGQWRCTED 845
            ||  |...|        |.|:.|    ::..|....|.|:. |.....||:.|.|..|:..|.:.
  Rat   278 CNTDEDACC--------EECLLRVPPEDVKVCKFGSKIFRDGEMWSSVNCSICACVKGKTECRKK 334

  Fly   846 KC-------------------------GARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQNTSV 885
            :|                         |. |...|||||.||||:.::|.|.|.|.|.|..::..
  Rat   335 QCVPVSSCPQGKILNRKGCCPICTEKPGV-CTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPA 398

  Fly   886 EAENVACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLP--- 947
            ....|........:.:|      |.||:|.:  :|.:.|   :.|.|.||...|...|| ||
  Rat   399 SPFQVLVKNDARRTRSF------SWTKSVEL--VLGEST---VSLQQHLTVRWNGSRIA-LPCHT 451

  Fly   948 --KMLGLGEVLIRRASSTFLTVEFADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDF 1010
              ..:.|...|::        |....|:.:.|||.|.|.:.|.|.|:|:..||||.:|.:.:||.
  Rat   452 PHFHIDLDGYLLK--------VTTRAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDL 508

  Fly  1011 LTPEGDVETAVEPFADKWRTKDTCQFKAETHQGPHP--CTLNPEKKAQAEKFCDWILQDIFQDCH 1073
            :..:|:.:..|:.||:.||.:.. :|.....:.|.|  |....:.|.:|.:.|..:....||.||
  Rat   509 IGGDGNFKFDVDDFAESWRVESN-EFCNRPQRKPVPELCQGTVKVKLRAHRECQKLKSWEFQTCH 572

  Fly  1074 FLVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQGVKTGWRMSVKECAVKCPLGQVFD 1138
            ..|:...||..|:.|.|.|... ..|:|....||...|.|:|:|..|.......|.:|..|.|:|
  Rat   573 STVDYTTFYRSCVTDMCECPVH-KNCYCESFLAYTRACQREGIKVHWEPQQSCAATQCKHGAVYD 636

  Fly  1139 ECGDGCALSCDDLPSKGSCKRECVEGCRCPHGEYVNEDGECVPKKMC 1185
            .||.||..:||:....|.|.:.|:.||.|| ...|...|.|:...:|
  Rat   637 TCGPGCVKTCDNWNEIGPCNKPCIAGCHCP-ANLVLHKGRCIKPVLC 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671	1/5 (20%)
		C8	684..754	CDD:462584	18/113 (16%)
		TIL	758..811	CDD:410995	16/71 (23%)
		VWD	840..1015	CDD:214566	56/204 (27%)
		C8	1054..1121	CDD:214843	22/66 (33%)
		TIL	1131..1185	CDD:410995	20/53 (38%)
		TIL	1245..1298	CDD:460351
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		TIL	1938..2005	CDD:473303
		FA58C	2089..2223	CDD:238014
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:459671
		TIL	2974..3030	CDD:460351
		VWD	3035..3198	CDD:459671
		C8	3248..3313	CDD:462584
		VWC	3397..3451	CDD:450195
		GHB_like	<3755..3813	CDD:473907
Bmper	NP_001129271.1	VWC	166..224	CDD:278520	8/57 (14%)
		VWC	301..357	CDD:450195	11/55 (20%)
		VWD	364..508	CDD:459671	52/163 (32%)
		C8	560..624	CDD:462584	21/64 (33%)
		TIL	629..682	CDD:410995	20/53 (38%)