Protein Alignment Hml and Crim1

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: NP_001162574.1
• Gene: Crim1 / 298744
• RGDID: 1308710
• Length: 1037
• Species: Rattus norvegicus
• Alignment Length: 1075
• Identity: 225/1075 - (20%)
• Similarity: 329/1075 - (30%)
• Gaps: 430/1075 - (40%)

  Fly  2880 CGDLKC--PREMQAKALQ-LCNIIHHPTFARCHKAVNYKQFLNNYC-----LEAACN----CMMA 2932
            |.:.||  ||......:| :|..        |:.....:   |..|     |..||:    |::.
  Rat    40 CDESKCEEPRSCPGSIVQGVCGC--------CYMCARQR---NESCGGAYGLHGACDRGLRCVIR 93

  Fly  2933 N--NGDP------AACK--------------CNILESFVKKCLSVNPLVQLTTWRAVAQCEINCP 2975
            .  |||.      ..|:              ||  |:.:..|..:|...:.:|.|       .|.
  Rat    94 PPLNGDSITEYEVGVCEDEDWDDDQLLGFEPCN--ENLISGCNIINGRCECSTIR-------TCN 149

  Fly  2976 SPL-----------------VHTDCYKRRCE----PSC--DNV-------HGDDCPVLPDACF-- 3008
            :|.                 ...||.|.|||    |.|  |::       .|:.|| ||..|.
  Rat   150 NPFEFPRKDMCLSALKRIEEEKPDCTKARCEVQFSPRCPEDSILIEGYAPPGECCP-LPSRCVCD 213

  Fly  3009 -PGC---YCPEGTVR--------KGPNCVPISECK-----DC-----------VCNSLGASKYMT 3045
             .||   .|..|.:.        |...|..:.|||     ||           ||   ....|.|
  Rat   214 PAGCLRKVCQPGYLNILVSKASGKPGECCDLYECKPVFSVDCSTVECPPVQQAVC---PLDSYET 275

  Fly  3046 YDRKSFSFNGNCTYLLSRDVVLPGVHTFQVYVSMDDCK--------KLGQPTPVEGGSCAKSLHI 3102
            ..|  .:.:|.|| |.:|...|.|:..|.|      |:        ..|..||   |.|......
  Rat   276 QVR--LTADGCCT-LPARCECLSGLCAFPV------CEVGSTPRIVSRGDGTP---GKCCDVFEC 328

  Fly  3103 LNGDHVIHVQRVPQKPKSLQVLVDGFEVKKIPYKDSWISLRQVVGKELVLSLPESHVELTASFED 3167
            :|          ..||..:        ...:.|.|.                            |
  Rat   329 VN----------ETKPACV--------FNSVEYYDG----------------------------D 347

  Fly  3168 LIFSLGVPSIKYGSKMEGLCGDCNGNAGNDLQPNPAKKKAGVDVIQSWQADEPKLGLVEECLSED 3232
            :.            :|:. |..|             :.:.||.:..:.|..|      ..|....
  Rat   348 MF------------RMDN-CRFC-------------RCQGGVSICFTAQCGE------LNCERYY 380

  Fly  3233 VPKEHCIPLPPEKDPCLQFYNAELFGKCPLAVDPIAYVSACQQDICKPGNTQQGV--CVALAAYA 3295
            ||:..|.|:.  :||...|.|.   ..|.......|:....::|.|.......|.  |||.|
  Rat   381 VPEGECCPVC--EDPIYPFNNP---AGCYANGQIRAHGDRWREDDCTFCQCINGEPHCVATA--- 437

  Fly  3296 KECNQHGICTNWRRPQLCPYEC------PSDMVYEP--CGCAKNCDTIKALSEFDAV-------- 3344
              |.|.  |.:   |...|.||      |:.:..:|  ||...||    .|.|.|.|
  Rat   438 --CGQS--CMH---PVKVPGECCPVCEEPTYITIDPPACGELSNC----TLKEKDCVYGFKLDHN 491

  Fly  3345 ---------------SLKNEAVVH-------TVKTDEMCLSSERFEGC-------FCPPGKVMDG 3380
                           :||....:.       .|...|:|....|.:.|       |||.|.:.:.
  Rat   492 GCRTCQCKNREERCLALKRACTLDCPFGFLTDVHNCELCQCRPRPKKCRPTICDKFCPLGFLRNK 556

  Fly  3381 GQC-------VPEIACTK---------------CD--------------------DGLHLPDEKW 3403
            ..|       .||:.|:|               |.                    ||.|..:|:.
  Rat   557 HGCDICRCKKCPELPCSKVCPLGFQEDSHGCLICKCREVPTSAGPPVLSGTCLSMDGHHHKNEES 621

  Fly  3404 KKDKCTECQCDSKGKTTCVEKKCQVEENICAE-GYRPETIVSVDECCPRYRCV-------PETKD 3460
            ..|.|.||.|.: ||..|....|.|.  .|.. ..||      .:|||  .|.       ||...
  Rat   622 WHDGCRECYCHN-GKEMCALITCPVP--ACGNPTIRP------GQCCP--SCADDFVVQKPELST 675

  Fly  3461 PSKLCLAPLVPICGPGQF--KKEKKDVNGCSQYICECIPKDQCEIIELRELLPGEIIVNVEEGCC 3523
            || :|.||      .|::  :.|..:::.|:|..|.
  Rat   676 PS-ICHAP------GGEYFVEGETWNIDSCTQCTCH----------------------------- 704

  Fly  3524 PTQKIECKPETCPKAPVNCQERFYEVKTIKEPGMCCSKHSCVPPKDLCIVQYELDEATKFTKTV- 3587
             :.::.|:.|.||  |:.||          .|..  ::.||.|.   | .:..|..:|...::|
  Rat   705 -SGRVLCETEVCP--PLLCQ----------NPSR--TQDSCCPQ---C-TEDPLQPSTSHNESVP 750

  Fly  3588 -------GDKWTHAKEVCKQETCSYGPDGNAQVVSTLEQCLTDCAPGFSYQN--LDKTKCCGKCV 3643
                   ||.:. |.|..|.:.|:     :...:.:...|.::..|..:.:.  |.|.:||..|:
  Rat   751 SYCRNDEGDIFL-AAESWKPDVCT-----SCVCMDSSISCYSESCPSVACERPVLRKGQCCPYCL 809

  Fly  3644 QTS------CIFEQKLYEVNALWKSADNCTTYSCLKKDGQFLVTTSREVCPDVGSCLSHLLYQDG 3702
            :.:      |.|..|.|.....| ..|:||...||:  ||.|.:|..  ||.: .|...:..:..
  Rat   810 EDTIPKKVVCHFSGKTYADEERW-DIDSCTHCYCLQ--GQTLCSTVS--CPPL-PCAEPIKVEGS 868

  Fly  3703 CCKRCKSEPLVEDKSSCLPVSLAESRTKEILKFPV 3737
            ||..| .|..|.:.:: :|:.....|.:..|:.|:
  Rat   869 CCPMC-PEMYVPEPTN-VPIEKKNHRGEIDLEVPM 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671
		C8	684..754	CDD:462584
		TIL	758..811	CDD:410995
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:410995
		TIL	1245..1298	CDD:460351
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		TIL	1938..2005	CDD:473303
		FA58C	2089..2223	CDD:238014
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:459671
		TIL	2974..3030	CDD:460351	23/99 (23%)
		VWD	3035..3198	CDD:459671	28/170 (16%)
		C8	3248..3313	CDD:462584	15/66 (23%)
		VWC	3397..3451	CDD:450195	17/54 (31%)
		GHB_like	<3755..3813	CDD:473907
Crim1	NP_001162574.1	IGFBP	39..90	CDD:459717	13/60 (22%)
		VWC	336..390	CDD:214564	15/121 (12%)
		VWC	403..456	CDD:214564	16/62 (26%)
		Antistasin	539..564	CDD:460713	6/24 (25%)
		Antistasin	567..592	CDD:460713	5/24 (21%)
		VWC	612..662	CDD:450195	20/60 (33%)
		VWC	683..734	CDD:450195	16/97 (16%)
		VWC	758..808	CDD:450195	12/55 (22%)
		VWC	819..873	CDD:450195	19/59 (32%)
		CRIM1_C	907..1037	CDD:437274