DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hml and Kcp

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	XP_038964921.1	Gene:	Kcp / 296952	RGDID:	1561119	Length:	1671	Species:	Rattus norvegicus

Alignment Length:	1816	Identity:	378/1816 - (20%)
Similarity:	566/1816 - (31%)	Gaps:	646/1816 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 EVPPCQAQCT-PPCQNNGICISAGVCQCPENYYGPLCQQKKSICASFPKAPKNSKVSCKNN---M 255
            ::..|:...| |.|...|.....|....|:.....:|:...:.|...|..|...  .|.:|   .
  Rat   172 QLESCKCCSTSPQCWGPGHPCPEGARWEPDACTACVCRDGTTHCGPQPNLPHCR--GCSHNGQSY 234

  Fly   256 CHAE-----------CMRGFQFPDGSGITNIECRNGQWVHTKTGLSKTP--DCAPTCAPACQNGG 307
            .|.|           |:.|.....|...:.:.|..          |.||  :|.|.|.|.|:..|
  Rat   235 GHGETFSPDACTTCRCLAGAVQCQGPSCSELNCLE----------SFTPPGECCPICRPGCEYEG 289

  Fly   308 QC----ISF----NVC-QCSKMFRGDHCQYNIDRCNVTNTNFNGNYKCAYEMDDARCTFSCPQVP 363
            |.    .||    |.| |||       |..::.||
  Rat   290 QLHQEGTSFLSTSNPCLQCS-------CLRSLVRC------------------------------ 317

  Fly   364 GLKIQGRIDIEYKCNYLQGQYLPAPLPKCIFPPGY---TVRSTSSMQGVTHQNGVYHRGMSGE-- 423
                     :..||.       |:|.|..:..||:   ..:::...:|.:|::........|:
  Rat   318 ---------VPVKCQ-------PSPCPNPVLRPGHCCPVCQASGCTEGHSHRDHGQEWTTPGDPC 366

  Fly   424 -----MAYELQTERQKLLALLAKYRD---------------LERRSEWWSSEETVVTMSSYSLYQ 468
                 :...:|. ||:..|.|..|..               |..|..  ||.|.|.:....|...
  Rat   367 RICQCLEGHIQC-RQQECASLCPYPARPLPGTCCPVCDGCFLNGREH--SSGEPVGSQDPCSSCH 428

  Fly   469 SNNLDIVIDKTP-RPALCTTWG------------------GINMKTFD------------GLVFK 502
            ..|..:..:..| .||.|...|                  .:|.:..:            ...|.
  Rat   429 CANGSVQCEPLPCPPAPCRYPGRIPGQCCPVCDVPCPPVQAVNTRDMNIGARRPLPSKRMAAAFG 493

  Fly   503 APLSCSHTLITDKVSGTFDI-ILKACPYGSGYGCAHTLKILWQSVLYTFENLNGTMQLTTPIKKL 566
            ||.......:.::.:.:..: .|...|..:...|:....:|..|        :|: |:|:|:  |
  Rat   494 APARLVKYPVRNRTARSPPVSTLPPAPSSAQPVCSMVRSLLRGS--------SGS-QMTSPV--L 547

  Fly   567 PMPVQVMGMKVMPVAQHVQIDLESVGLKLDWDHRQY---------VSVQAGPQMWG--------- 613
            |:|.:.   :.:....|..:              ||         ||.|..|...|
  Rat   548 PVPAKT---ECLCAGLHFAL--------------QYPANILPSRPVSAQPDPVFSGFDQPTLTSL 595

  Fly   614 -KVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSELCQVEN---------------- 661
             .:|..|.:.:......|....|:....|.:.......||.:..|.|.|
  Rat   596 PHLGACCPSCESCTYHGLVYSNGQNFTDVDSPCQTCYCEDGTVRCSVINCPSLTCAKPQNGPGQC 660

  Fly   662 ---------SAEM-------EFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCM 710
                     .|:|       ....|.|::...|:..:.|:....:.  ..|..|.........|.
  Rat   661 CPKCPDCILEAQMFVDGERFPHPRDPCQECLCQEGQTHCQLRACHS--APCGHPLPSTCCRNDCK 723

  Fly   711 A------DYCNCANREHP----ESCNC--DAIAMLAKEC---------------------AFKGI 742
            .      :|.|.|:..||    ..|.|  ..:..||:.|                     |..|.
  Rat   724 GCAFGGKEYLNGADFPHPTDPCRMCRCLSGNVQCLARRCPPLACPQPVLTPGDCCPQCPDAPAGC 788

  Fly   743 ----------KLEHGWRNLEIC------------------PISCGFGRVYQACGPNVEPTCDSDL 779
                      ..||.::..:.|                  |..|...|....|     |:||..|
  Rat   789 PQSGNTVLVRHQEHFFQPGDPCSRCLCLDGSVSCQRLPCPPAPCAHPRQGACC-----PSCDGCL 848

  Fly   780 ----------ALPASKGACNEGCFCPEGTVQYK-EACI-------TRE-LCP----CS------L 815
                      ..|:....|:. |.|.||:|..: .||.       ||| .||    |.      |
  Rat   849 YHGKEFANGERFPSPSVTCHV-CLCWEGSVNCEPRACAPAQCPFPTREDCCPACDSCEYLGVSYL 912

  Fly   816 RGKEFKPESTVKKNCNTCTCKNGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKT 880
            ..:|| |:.  ::.||.|||..|...||...|        :|             ..||:.|:..
  Rat   913 NSQEF-PDP--REACNLCTCLGGFVTCTRRPC--------EP-------------PACSHPLILP 953

  Fly   881 QNTSVEAENVACSGAVSESMNFAAPD--DPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPI 943
            ::.....:.....| ::.::....||  ||:|               |:...::| :...:.||
  Rat   954 KHCCPTCQGCLYHG-ITAALGETLPDPLDPTC---------------SLCTCEEG-SMRCHKKP- 1000

  Fly   944 AKLPKMLGLGEVLIRRASSTFLTVEFADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQD 1008
                                                       .||:|
  Rat  1001 -------------------------------------------CPPAL----------------- 1005

  Fly  1009 DFLTPEGDVETAVEPFADKWRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWILQDIFQDCH 1073
                                     |     ||..|.||            ||     .:.:.|.
  Rat  1006 -------------------------C-----THPSPGPC------------FC-----PVCRSCL 1023

  Fly  1074 FLVEPEQFYED-------CLYDTCACKDEMSKCF---CPILSAYGTECMRQGVKTGWRMSVKECA 1128
            |..:..|..|:       |  :.|.|......|.   ||.|     .|:.|..:.|      .|.
  Rat  1024 FQGQEHQDGEEFEGPEGSC--ERCRCLAGQVSCMRLQCPPL-----PCLLQATEPG------TCC 1075

  Fly  1129 VKC----------PLGQVFDECGDGCALSCDDLPSKG--SCKR-ECVEGCRCPHGEYVNEDGECV 1180
            .:|          |.|..:......|: ||  :..||  :|.: :||..|..|.    ....:|.
  Rat  1076 PRCTGCRVRGEEHPEGSSWVPADSPCS-SC--MCHKGIVTCAQVQCVSACIWPQ----QGPSDCC 1133

  Fly  1181 PKKMCH-CNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQ 1244
            |.  |. |..:|..:.|| :..:||:...::|.|.            .|.|.|||..    |.::
  Rat  1134 PS--CSGCEHEGRKYEPG-ESFQPGDDPCEVCICE------------LKGKGPPSLH----CRRR 1179

  Fly  1245 PYAEFTKCAPKE-----PKTC-----KNMDKYVAD--SSDCLP-----GCVCMEGYVYDTSR--- 1289
            .......|.|.:     |:.|     :.:.....|  .|:.:|     .|.|.:.....|.|
  Rat  1180 QCPSLVGCPPSQLLPPGPQHCCPACAQALSNCTEDLLGSELVPPDPCYTCQCQDLTWLCTHRACP 1244

  Fly  1290 -LACVL------PANC---------SCHHAGKSYDDGEK-IKEDCNLCECRAGNWKCSKNGCE-- 1335
             |:|.|      |.:|         ||.|.|:....||. |.:.|..|.|.||...|....|.
  Rat  1245 ALSCPLWEHHTTPGSCCPVCKDPTGSCSHQGRWVASGEHWIVDACTSCACVAGTVHCQSQRCRNL 1309

  Fly  1336 -----------------------STCSVWGDSHFTTFDGHDFDFQGACDYVLAKGVFDNGDGFSI 1377
                                   ::|..:||.|:.||||....|||:|.|||||..  :.:.||:
  Rat  1310 SCGRDEVPALSPGSCCPRCLPGLASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDC--HSEDFSV 1372

  Fly  1378 TIQNVLCGTMGVTCSKSLEIALTGHAEESLLLSADSAYSTDPNKTPIKKLRDS---VNSKGHNAF 1439
            .:.|...|..||..::.:.:.|   ...::.|........|.:...:..||:.   :..:||.
  Rat  1373 HVTNDDRGRRGVAWTQEVAVLL---GTVAVRLLQGRTVMVDQHTVTLPFLREPLLYIELRGHT-- 1432

  Fly  1440 HIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETS 1504
                    |::...| .|||.||..::|.|::.:.:|.:..|||||:||.:.||:|.|...|..:
  Rat  1433 --------VILHAQP-GLQVLWDGQSQVEVRVPSSYRGQTCGLCGNFNGFAQDDLQGPDGRLLPT 1488

  Fly  1505 PMLFGHAWKL-------QPHCSA--PVAPIDACKKHPERETWAQLKCGALKSDLFKECHAEVPLE 1560
            ...||::||:       :| |||  .|.|..|......||  |..:||.|||..|..|||.||.|
  Rat  1489 EAAFGNSWKVPKGLGPGRP-CSAGREVDPCRAAGYRARRE--ANARCGILKSSPFSRCHAVVPPE 1550

  Fly  1561 RFWKRCIFDTCACDQGGDCE-CLCTAVAAYADACAQKGINIRWRSQHFCPMQCDPHCS-DYKACT 1623
            .|:..|::|.|||..|...: |||.|:.|||..|.|.|:...||....|.:.|..... .:..|.
  Rat  1551 PFFAACVYDLCACGPGSSADTCLCDALEAYASHCRQAGVTPVWRGPTLCVVGCPVERGFVFDECG 1615

  Fly  1624 PACAVETCDN-FLDQGIAERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCVPKAECKPVCM 1683
            |.|. .||.| .:..|.....|.|. |:.||.   |..|.:   :....|:....|..|.:
  Rat  1616 PPCP-RTCFNQHIPLGELAAHCVRP-CVPGCQ---CPAGLV---EHEGHCISPEACPSVLL 1668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339	29/200 (15%)
		C8	680..754	CDD:285899	18/116 (16%)
		TIL	758..811	CDD:280072	19/71 (27%)
		VWD	840..1015	CDD:214566	20/176 (11%)
		C8	1054..1121	CDD:214843	16/76 (21%)
		TIL	1131..1185	CDD:280072	15/66 (23%)
		TIL	1245..1298	CDD:280072	15/79 (19%)
		VWD	1327..1498	CDD:214566	52/198 (26%)
		C8	1535..1609	CDD:214843	33/74 (45%)
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
Kcp	XP_038964921.1	VWC	227..281	CDD:278520	13/63 (21%)
		VWC	285..341	CDD:327433	20/108 (19%)
		VWC	405..460	CDD:327433	13/56 (23%)
		VWC	608..664	CDD:327433	8/55 (15%)
		VWC	725..781	CDD:327433	10/55 (18%)
		VWC	1022..1078	CDD:327433	15/68 (22%)
		VWC	1139..1204	CDD:327433	18/81 (22%)
		VWC	<1223..1264	CDD:327433	9/40 (23%)
		VWC	1271..1328	CDD:327433	13/56 (23%)
		VWD	1335..1484	CDD:395046	51/164 (31%)
		C8	1527..1599	CDD:214843	33/73 (45%)
		TIL	1610..1663	CDD:410995	15/60 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900