Protein Alignment Hml and Fcgbpl1

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: NP_001158128.1
• Gene: Fcgbpl1 / 292746
• RGDID: 1311906
• Length: 2581
• Species: Rattus norvegicus
• Alignment Length: 3259
• Identity: 678/3259 - (20%)
• Similarity: 1034/3259 - (31%)
• Gaps: 1190/3259 - (36%)

  Fly   480 PRP-ALCTTWGGINMKTFDGLVFKAPLSCSHTLI----------------------TDKVSGTFD 521
            |.| |:|...|..:..||||..:....:|::.|.                      ::|||....
  Rat    50 PEPRAVCRAQGDPHYTTFDGRRYDMMGTCTYVLTELRSTKDSLLAFKVEAKNKHRSSNKVSYVRL 114

  Fly   522 IILKACPYGSGYGCAHTLKILWQSVLYTFENLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQI 586
            :.:.|..|        |:.:::..:        |..::......||:.:....::|........|
  Rat   115 VTVHAYDY--------TVSLMYGEI--------GFAKINYQYSVLPVSLSKGRLRVYQSGTRGII 163

  Fly   587 DLESVGLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVE 651
            :|: .||.:.:|....:|:....:...:|.||||..:|||..|..:..||:.:.|..|..:|:|:
  Rat   164 ELD-FGLVVTYDWDCLLSLSLPKRFQDQVSGLCGNYNGDPADDFLTPDGKQASDVLNFTKSWKVQ 227

  Fly   652 DRSELCQVENSAEMEFGMDSC---------EQSKLQKAVSVCERL-LANEKLGDCIKPFNYDALI 706
            |:..||.           |.|         .|:::.|....|..| |.:....||.|..:....:
  Rat   228 DKDLLCD-----------DGCYGNCPSCIPSQAEIFKKDPFCGMLILPSGPFADCHKFLDPKPFL 281

  Fly   707 RTCMADYCNCANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNV 771
            ..|:.|.|.....   ....|..:...|..|...||.:.. ||:...||::|.....|:.|.|..
  Rat   282 EECVYDMCVTGGE---RLTLCHGLNAYALACVDMGISVRE-WRSRTNCPLTCPANSRYELCSPAC 342

  Fly   772 EPTCDSDLALP--ASKGACNEGCFCPEGTVQYKEACITRELCPCSLRGKEFKP--ESTVKKNCN- 831
            ..:|:|: |||  .|...|.|||.|..|.|..:..|:....|.|:.:.:...|  |....:.|:
  Rat   343 PASCNSE-ALPTNCSSRPCVEGCVCFPGFVASRGLCMPVSSCGCTFQDRLLAPGQEVYADEKCHL 406

  Fly   832 --TC-------TCKNGQWRCTEDKCGAR-------------CGAVGDPHYQTFDGKRYDFMGKCS 874
              ||       .|:|.......:.||.|             |.|.|||||.:.|.:.::|||.|:
  Rat   407 RCTCDADFQEVICRNTSGCLLHEHCGVRNGSFGCSPEYFRICRASGDPHYMSLDERIFNFMGTCT 471

  Fly   875 YHLLKT--QNTS-------VEAENVACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKL 930
            |....:  |:.|       :|.|...     |:|::|...                      :||
  Rat   472 YLFTASCGQHPSLPDFKVFIENERRG-----SQSVSFVRS----------------------VKL 509

  Fly   931 DQ-GLTTIVNDKPIAK---------LP-KMLGLGEVLIRRASSTFLTVEFADGIRVWWDGVSRVY 984
            :. |::..|..:...|         || :.||...|:.|:.....|...|:..|...||  :.|.
  Rat   510 EAFGISLEVRREYQGKVLMNGILHYLPFQALGGKLVVFRQGKYAILRTNFSLTISYNWD--THVT 572

  Fly   985 IDAPPSLRGQTQGLCGTFNSNTQDDF-LTPEGDVETAVEP--FADKWRTKDTCQFKAETHQGPHP 1046
            ...|.:......||||.||.:.:||. :...|:   |::|  |..||        ...:|.|
  Rat   573 AKVPSNYFKGVCGLCGNFNGDPRDDLGVQIRGE---ALDPRDFGKKW--------LVSSHPG--- 623

  Fly  1047 CTLNPEKKAQAEKFCDWILQDIFQDCHFLVEPEQFYE-------------DCLYDTCACKDEMSK 1098
            |  ..:::.....|...|::.|.:.||.|......:.             :|:||.|....: :|
  Rat   624 C--RTDEQLLCPSFKKEIVKSITKKCHILGNISGEFRHCWRVPAFNSALIECMYDCCRMPGQ-TK 685

  Fly  1099 CFCPILSAYGTECMRQGVKT-GWRMSVKECAVKCPLGQVFDECGDGCALSCDDLPSKGSCKRECV 1162
            ..|..|:.|.:.|...||.. .|| :...|.:.||....::.|..||.|:|.|.|..|.|..:|.
  Rat   686 PLCDSLATYTSICQSSGVAVLPWR-TEDLCPMNCPPHSHYELCQRGCPLTCGDQPVPGGCGSDCY 749

  Fly  1163 EGCRCPHGEYVNEDGE-CVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCT-DGVWDCQDAEP 1225
            |.|.|..|..::  || |:|...|.|.:.|:...|| .:..||.:...||.|. .|:..||
  Rat   750 ESCVCDEGFVLS--GEICIPLSSCGCVYQGIYHAPG-DDFYPGPECNSLCHCNKGGLVSCQ---- 807

  Fly  1226 GDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYVADSSDCLPGCVCMEGYVYDTSRL 1290
                   ||                .|.|.|  .||.:|                       ..|
  Rat   808 -------PS----------------YCGPHE--VCKVID-----------------------GIL 824

  Fly  1291 ACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFD 1355
            .||...:.:||                                      |.|.||:|||||..||
  Rat   825 RCVGVGSATCH--------------------------------------VSGASHYTTFDGRRFD 851

  Fly  1356 FQGACDYVLAKGVFDNG--DGFSITIQNVLCGTMGVTCSKSLEIALTGHAEESLLLSADSAYSTD 1418
            |.|.|.||||:..:...  ..|:|..:||:.|...::.:|.:.|.:           |:.....:
  Rat   852 FMGTCVYVLAQTCWTQPGLQPFTILQENVVRGDKQISVTKMITIEV-----------ANYTLQLE 905

  Fly  1419 PNKTPIK------KLRDSVNSKGHNAF-HIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWR 1476
            .|:..:|      |:..|::.:...|| |    |..||::. ...|.|.:|....|.|.:...:.
  Rat   906 QNQWKVKVNAVYMKMPVSLDGERVQAFLH----GTDVVIKT-KFGLLVSYDLKYSVRVTVPRNYY 965

  Fly  1477 QKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAW-KLQPHCSAPVAPIDACKK--------HP 1532
            :.:.||||:||.|..:|.|........||...|.:| |..|..|.  .|..|||.        :|
  Rat   966 KHMCGLCGDYNNNPKNDFQKSDGSQAVSPGELGKSWEKTVPGSSC--TPRPACKPGQDCTPKCYP 1028

  Fly  1533 --ERETWAQLKCGALKSDL--FKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADAC 1593
              ||:......||.|.:..  ...||..:..:...:.|:||.|.  .||:...||.::.||..||
  Rat  1029 TLERKYSGNEFCGLLTNPTGPLAACHKLLDPQGPLQNCVFDLCL--GGGNLSILCNSIHAYVSAC 1091

  Fly  1594 AQKGINIR-WRSQHFCPMQCDPHCSDYKACTPACAVETCDNFLDQGIAERMCNRENCLEGCHIKP 1657
            .:.|..:: ||:|.||||:|.|| |.|:.|...|::
  Rat  1092 QEAGGTVKPWRNQTFCPMECSPH-SHYEVCADTCSL----------------------------- 1126

  Fly  1658 CEDGFIYLNDTYRDCVPKAECKPVCMVRDGKTFYEGDITFTDSCATCRCSKRKEICSGVKCDVPA 1722
                         ||
  Rat  1127 -------------DC-------------------------------------------------- 1128

  Fly  1723 TTGLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGT 1787
                       :|:.||:      ||:|                                    |
  Rat  1129 -----------STITTPI------KCLK------------------------------------T 1140

  Fly  1788 CLKQYMTKVECRVKDTHEAPEQMDENVVCSLEEGLRCIGKCHDYELRAFCQCDEELEPELPKPTE 1852
            |                              .||               |:||          |:
  Rat  1141 C------------------------------SEG---------------CECD----------TD 1150

  Fly  1853 KPQLGLACDAAVVEYKEFPGDCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTE 1917
            ..|...||                             :.:|| ||           |.|
  Rat  1151 FLQSITAC-----------------------------VPMEK-CG-----------CHH------ 1168

  Fly  1918 IKPNCGLKPEPEPEFEPIKQCPPGKIKSECANQCENTCHYYGSILKKRGLCQVGEHCKPG----- 1977
                .|:..|||...          :...|...|  .||....::.:...|:.||.|||.
  Rat  1169 ----NGVYYEPEESV----------LIENCQQHC--VCHPGTGMVCQDHSCKPGEVCKPSRGVLT 1217

  Fly  1978 CVDELRPDCPKLGKFWRDEDTCVHAD---ECPCMDKAEHYV--QPHKPVLGEFEVCQCIDNAF-- 2035
            |:::    .|..|...|.::||...|   .|....:::.:|  .||      :.....::..|
  Rat  1218 CINK----DPCKGVTCRSQETCTERDGKGVCTANYESKCWVWGDPH------YHSFDGLNTNFHG 1272

  Fly  2036 TCVPNKPEPVPKDEDDDLDLVSVVPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLA 2100
            ||                       .|.:..|.....|.|.|.|             ||..::..
  Rat  1273 TC-----------------------SYQLAGTGCPGISAEGLTP-------------FNVVTKHE 1301

  Fly  2101 PEHGPKMARLTKEQPRGSWSPSI---NDQMQYLELNFAKPEPFYGVVMAGSPEFDNYVTLFKILH 2162
            .:..|.::.: |:....:::.||   ..::..:::|        ||:||    ...|:...:|..
  Rat  1302 SQSNPTVSNV-KKVTVTTYNTSITIHKKKIGRVQVN--------GVLMA----LPVYLAEGRISV 1353

  Fly  2163 SHDGIAYHYLVDETEKPQMFNGPLDSRAPVQTLFKIPIEAS-SLRI---YPLKWHGSIAMRVELL 2223
            .|.|                     ::|.::|.|.:.:... :.|:   .|..::|::..
  Rat  1354 VHGG---------------------TKAVLETDFGLQVTYDWTWRVQVTLPSSYYGAVCG----- 1392

  Fly  2224 ICGDKEE-PK-----PVPTVSTILPITERPARLVDLECIDLMGVDEGKMYQDQVQSSSLWQQPNL 2282
            :||:.:: ||     |..||:..:|..                             ...||.|..
  Rat  1393 LCGNMDKNPKNDQVFPNGTVALSIPAW-----------------------------GGSWQVPGW 1428

  Fly  2283 GKKLQLLELLKLSTPLAWRPLANSQNEFIEFDFLEPRNISGFVTKGGPDGWVTGYKVMFSKKKPT 2347
                         .||.|.....|.....| |.:|.....||.....||
  Rat  1429 -------------DPLCWNECQGSCPTCPE-DRVEEYEGPGFCGPLSPD---------------- 1463

  Fly  2348 WNTVLSTDGQARIFEANHDAETERRHHFKNPI----------------LTQYIKIVPAYWEKNIN 2396
                  |.|.   |.:.| :.......||..:                |..|.:...|:..|..:
  Rat  1464 ------TVGP---FASCH-SHVPPESFFKGCVLDLCLGGQVKDILCQALAAYAEACQAHGIKIQD 1518

  Fly  2397 MRIEPLGCFLPYPEIQR------QVPVEESKPTKCN---ICDGVSTSSSTTGCQCQDQLFWDGNT 2452
            .|.: .||.:..|:...      :.||....||:.|   .|||
  Rat  1519 WRTQ-AGCEISCPDNSHYELCGPRCPVSCPPPTRHNPPTACDG---------------------- 1560

  Fly  2453 CVQHNLCPCIENYVSYPIGSKFENSACEDCVCVLGGHKNCKPKKCPPCLGGKLRPVITSDCFCKC 2517
                   ||:|.                 |.|.||...:.  .:|.|..||           |.|
  Rat  1561 -------PCVEG-----------------CQCDLGFVLSA--DQCVPLDGG-----------CGC 1588

  Fly  2518 EPCPKHQRLCPSSGDCIPEILWCNGVQDCADDE---DASCSDSFTVEPDVSREKNETEVITCPVP 2579
                                 |.||....|..|   |.:||
  Rat  1589 ---------------------WVNGTYHEAGTEFWTDTTCS------------------------ 1608

  Fly  2580 VCPPQMKIRITEKKSRKMSKMFTFSKQVSIVDDGTTITKTKFISSKEQILAMPNRELDFQLEEQC 2644
                                                                          ::|
  Rat  1609 --------------------------------------------------------------KRC 1611

  Fly  2645 DEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISG-K 2708
            .   |.|       ..:::.|....|....:..| :.:.::|      |  :|.....|:|.| .
  Rat  1612 H---CGP-------GGDSLICKSASCGLGEECAL-LPSGEIG------C--QPTSIAECQILGDP 1657

  Fly  2709 SFTTFDGTVFKY-GPCSHILARDIHS-----SSWSISV---HQ--QCSDETRKVCHKVITIQDT- 2761
            .:.|.||..|.: |.|.::|:...|:     ..::::|   |:  |....||.|...:..:..|
  Rat  1658 RYITLDGHRFDFQGTCEYLLSAPCHAPPPGIEYFNVTVANEHRGSQAVSYTRSVTLHIYGLSLTL 1722

  Fly  2762 --------EAGNELILLPHLKLKFNGYEFTVQQLINSPICKASFVVSQPGKTLLAVSTKYGFWVQ 2818
                    :...|::.||          |.:|.|:         :|...| |.|.|.|.:|..:.
  Rat  1723 STQWPRQLQVDGEMVTLP----------FQLQSLL---------LVHLSG-TGLIVHTTWGLSLV 1767

  Fly  2819 LDDIGIVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPDGQIIPNTEKFGDSWYDKRIPK-DQCGD 2882
            .|....|::.:.:.:..|:.||||.||.|..||..:.||:  |...|.|.:      |. |||..
  Rat  1768 FDGDNFVRLRVPAAYAGTLCGLCGNYNKNSSDDLTAVDGK--PEGWKVGGA------PDCDQCQL 1824

  Fly  2883 LKCPR----EMQA--KALQLCNIIHHP--TFARCHKAVNYKQFLNNYCLEAACNCMMANNGDPAA 2939
            ..||:    |.|.  .....|.||..|  ..|.||..|....|. ..||..||..    .|.|..
  Rat  1825 RPCPKPCTPEQQKHFDGPNACGIITAPKGPLAPCHSLVPPTLFF-EACLLDACQV----QGHPGG 1884

  Fly  2940 CKCNILESFVKKCLSVNPLVQLTTWRAVAQCEINCPSPLVHTDCYKRRCEPSCDNVHGDDCPV-- 3002
            . |..:.::|..|....  .||..||....|.:.||:...:..|             ||.|||
  Rat  1885 L-CPAIATYVIACQDAK--AQLGEWRKPDFCPLQCPAHSHYQLC-------------GDSCPVSC 1933

  Fly  3003 --------LPDACFPGCYCPEGTVRKGPNCVPISEC----------------------KDCVCNS 3037
                    ....|..||.|..|.|..|..|||:|:|                      :.|.|..
  Rat  1934 PSLSAPKGCETICREGCVCDSGFVLSGDTCVPVSQCGCLHNGRYYVLGDTFYPGPECERLCECGP 1998

  Fly  3038 LG---------------------------ASK---------YMTYDRKSFSFNGNCTYLLSRDVV 3066
            .|                           :||         |.|.|...:...|:|:|:|::...
  Rat  1999 GGQVTCRIEICGIHEECRIEDGIRSCHPKSSKLMLVLHGIHYTTPDGLVYDLYGSCSYILAQLCF 2063

  Fly  3067 L-PGVHTFQVYVSMDDCKKLGQPTPVEGGSCAKSLHILNGDHVIHVQRVPQKPKSLQVLVDGFEV 3130
            | ||...|.:.:..|   ..|:|..|.         :...|.|:.:.:.|      ||.||. ||
  Rat  2064 LKPGEEEFSIVLEKD---LAGEPQRVV---------VTVADQVVVLAKGP------QVTVDS-EV 2109

  Fly  3131 KKIPY--KDSWISLRQVVGKELVLSLPESHVELTASFEDLIFSLGVPSIKYGSKMEGLCGDCNGN 3193
            ..:|.  ..::|:..   |:.:.|..... ::|....:|.|. :.:|| .:..::.||||:.|||
  Rat  2110 VALPIVAGSTYITAE---GRNIFLQTKRG-LKLLFDGDDHIL-MSIPS-AFRGRICGLCGNFNGN 2168

  Fly  3194 AGND-LQPNPAKKKAGVDVI-QSWQADEPKLGLVEECLSEDVPKEHCIPLPPE----KDPCLQFY 3252
            ..:| :.||.| ....||.. .:|:.....||..|.|..:..|.  |:....|    .|.|.:..
  Rat  2169 QSDDFVLPNGA-VAPNVDAFGAAWRVPGSSLGCGEGCGPQGCPM--CLAEKREAFEKNDACGKIR 2230

  Fly  3253 NAE-LFGKCPLAVDPIAYVSACQQDICKPGNTQQGVCVALAAYAKECNQHGICTN-WRRPQLCPY 3315
            :.: .|..|...:....|...|..|:|........:|.:||||...|...|.... ||....||.
  Rat  2231 DPQGPFATCHKVLSHSEYFHQCVFDLCTHNGDNAYLCRSLAAYTAACQAAGAAVKPWRTDSFCPL 2295

  Fly  3316 ECPSDMVYEPC--GCAKNCDTIKALSEFDAVSLKNEAVVHTVKTDEMCLSSERFEGCFCPPGKVM 3378
            :||:...|..|  .|..:|..:..|:.                    | :|:.||||.|....::
  Rat  2296 QCPAHSHYSVCTYSCQGSCAALSGLTG--------------------C-TSQCFEGCECDDHFLL 2339

  Fly  3379 DGGQCVPEIACTKCDDGLHLP-DEKWKKDKCTE-CQCDSKGKTTCVEKKCQVEENICAEGYRPET 3441
            ..|.|:|...|....:|.::| :.......|.| |.|......||.|..|. ...:|      |.
  Rat  2340 SQGVCIPAQDCGCVHNGQYVPVNSSLVSSDCIERCFCSPNNGLTCHEAGCP-SGRVC------EI 2397

  Fly  3442 IVSVDECCP 3450
            ...|..|.|
  Rat  2398 QAGVRGCWP 2406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671	33/172 (19%)
		C8	684..754	CDD:462584	16/70 (23%)
		TIL	758..811	CDD:410995	18/54 (33%)
		VWD	840..1015	CDD:214566	49/208 (24%)
		C8	1054..1121	CDD:214843	17/80 (21%)
		TIL	1131..1185	CDD:410995	20/54 (37%)
		TIL	1245..1298	CDD:460351	9/52 (17%)
		VWD	1327..1498	CDD:214566	50/179 (28%)
		C8	1535..1609	CDD:214843	22/76 (29%)
		TIL	1938..2005	CDD:473303	17/74 (23%)
		FA58C	2089..2223	CDD:238014	21/140 (15%)
		FA58C	<2299..2403	CDD:238014	20/119 (17%)
		VWD	2703..2858	CDD:459671	44/175 (25%)
		TIL	2974..3030	CDD:460351	19/65 (29%)
		VWD	3035..3198	CDD:459671	45/202 (22%)
		C8	3248..3313	CDD:462584	16/66 (24%)
		VWC	3397..3451	CDD:450195	14/56 (25%)
		GHB_like	<3755..3813	CDD:473907
Fcgbpl1	NP_001158128.1	VWD	56..212	CDD:459671	33/172 (19%)
		C8	252..326	CDD:214843	17/77 (22%)
		TIL	329..383	CDD:460351	18/54 (33%)
		VWD	447..598	CDD:214566	45/179 (25%)
		C8	646..714	CDD:462584	16/69 (23%)
		TIL	718..771	CDD:410995	20/54 (37%)
		VWC	773..827	CDD:450195	21/106 (20%)
		VWD	831..988	CDD:214566	52/210 (25%)
		C8	1033..1108	CDD:214843	22/76 (29%)
		TIL	1111..1164	CDD:460351	28/283 (10%)
		VWC	1166..1218	CDD:450195	16/73 (22%)
		VWD	1244..1410	CDD:214566	39/246 (16%)
		C8	1450..1525	CDD:214843	15/101 (15%)
		TIL	1529..1583	CDD:410995	18/101 (18%)
		VWD	1651..1807	CDD:459671	44/175 (25%)
		C8	1838..1913	CDD:214843	22/82 (27%)
		TIL	1916..1969	CDD:460351	19/65 (29%)
		VWC	1974..2025	CDD:450195	3/50 (6%)
		VWD	2037..2178	CDD:214566	42/165 (25%)
		C8	2220..2294	CDD:214843	17/73 (23%)
		TIL	2297..2350	CDD:460351	17/73 (23%)
		VWC	2355..2404	CDD:450195	13/55 (24%)
		VWD	2404..2558	CDD:214566	2/3 (67%)