DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and Fras1

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_038947596.1 Gene:Fras1 / 289486 RGDID:1306516 Length:4014 Species:Rattus norvegicus


Alignment Length:2260 Identity:414/2260 - (18%)
Similarity:640/2260 - (28%) Gaps:938/2260 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly  1115 GVKTGW---RMSVKECAVKCPLGQVFDECGDGCALSCDDLPSKGSCKRECVEGCRCPHGEYV--- 1173
            ||...|   .:::.|.|       |...|...|......|......|.:..:.||| ||:.|   
  Rat     2 GVFKAWLGVALALAEFA-------VLPHCEGACLYRGSLLADATIWKPDSCQNCRC-HGDIVICK 58

  Fly  1174 ----------NEDGE------------CVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCTDG 1216
                      .|.||            |.|:....|:.:| ..|....|...|.  ..||:||.|
  Rat    59 PVVCKNPRCAFEKGEVLWIAPNQCCPQCAPRTPGSCHHEG-KIREHGTEWASGP--CTLCSCTYG 120

  Fly  1217 VWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTKCAPKE----------------PKTCKNMDK 1265
                               |:|  |:.|.....: |.|:|                .|.|.:...
  Rat   121 -------------------EVR--CSHQQCTPLS-CGPQELEFLAEGHCCPICVGTGKPCSDDGH 163

  Fly  1266 YVADSSD-----CLPGCVCMEG----YVYDTSRLAC-------VLPANC-------SCHHAGKSY 1307
            ...|..|     |.. |||..|    :......|.|       .:|..|       ||..||:.|
  Rat   164 VFQDGEDWPLSHCAK-CVCRNGLTQCFTAQCQPLFCNQDEIVVRVPGKCCSQCSSRSCSTAGQVY 227

  Fly  1308 DDGEKIKED-CNLCECRAGNWKCSKNGCE-------------------------STCSVWGDSHF 1346
            :.||:.||| |.||.|..|..:|.|..|.                         .:||..|...:
  Rat   228 EHGEQWKEDACTLCMCDQGQVRCHKQACPPLRCAKGQSKARHHGQCCEECVSPVRSCSSGGVLRY 292

  Fly  1347 TTFDGHDFDFQG-ACDYVLAKGVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEESLLLS 1410
                 .|..::| ||::.    |.|.|   .:|.|...|..  |.|:...|:.   |.|......
  Rat   293 -----QDEMWKGSACEFC----VCDQG---QVTCQTGECAK--VACAPGEELV---HLEGKCCPE 340

  Fly  1411 ADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRV-YVKLGNE 1474
            ..|                      .|.:.:|:.           |.::.....:.: :|..|.:
  Rat   341 CIS----------------------RNDYCVYEE-----------KAEIMSSNSSEIKHVPEGKK 372

  Fly  1475 WRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHC---SAPVAPIDACKKHPERET 1536
            |.:....||                          ...:.|..|   |.|..|:         .|
  Rat   373 WEEGPCKLC--------------------------ECREAQVTCYEPSCPPCPV---------AT 402

  Fly  1537 WAQLKCGALKSDLFK-ECHAEVPLERFWKRCIFDTCA-----CD---------QGGDCECLCTAV 1586
            .|....|....|... .||.:         |:  ||:     ||         |.|.|...|   
  Rat   403 LAMAVKGQCCPDCTPVHCHPD---------CL--TCSHSPEHCDLCQDPTKLLQNGRCVPSC--- 453

  Fly  1587 AAYADACAQKGINIRWRSQHFCPMQCDPHCS------DYKACTPAC------AVETC-DNFLDQG 1638
                      |:.. :::...| :.|.|.||      :..:|.|..      .|.|| |.|....
  Rat   454 ----------GLGF-YQAGSLC-LACQPQCSTCTSSLECSSCLPPLLMQQGQCVSTCGDGFYQDH 506

  Fly  1639 IAERMCNRENCLEGC------HIKPCEDGFIYLND-----------------------TYRDCVP 1674
            .:..:|: |:| .||      |...|.|..:.|.|                       :.:.|.|
  Rat   507 HSCAVCH-ESC-AGCWGPTEKHCVACRDPLLVLRDGSCENTCGNGFYNRQGTCVACDQSCKSCGP 569

  Fly  1675 KAECKPVCMVRDGKT-FYEGDITFTDSC-------ATCRCSKRKEIC--SGVKCDVPATTGL--- 1726
            .:   |.|:....|| .|:|  |....|       ||.||    ::|  |...|..||....   
  Rat   570 SS---PRCLTCAEKTVLYDG--TCISECPRGYYADATGRC----KVCHVSCASCSGPAAAHCTAC 625

  Fly  1727 --PAPLVEGTTLPT--------------------PLATQNQTKCVKGWTRWCDKDRDTSDKSVRL 1769
              |..|.:|..||:                    .......|.|.:     |.|..  :...|..
  Rat   626 VHPQVLRQGHCLPSCGGGFYPDHGICGACHGSCHTCVGPEPTHCTQ-----CKKPE--AGLQVEQ 683

  Fly  1770 NDEEKVPRYDRMENVYGTCLKQ-----YMTKVE-CRVKDTHEAPEQMDENVVCSLEEGL------ 1822
            :..|.||        ||.|:.|     |:.... |..  .|.:         |.|.||.      
  Rat   684 HSGENVP--------YGKCVSQCGAHFYLESTGLCEA--CHPS---------CLLCEGKSPRNCT 729

  Fly  1823 -----------RCIGKCHD---------YELRAFC-QCDEELEPELPKPTEKPQLGLACDAAVVE 1866
                       ||:.:|.:         .|....| ||...||.:.  .:..|.|.|:.......
  Rat   730 GCGPAHVLLAGRCLSQCPETHFNQEGTCTECHPSCRQCHGPLESDC--VSCHPHLTLSSGRCKAS 792

  Fly  1867 YKE--------FPGDCHKFL-HCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNC 1922
            .|:        :..|||... ||.....:.|.:.::.....:      :|:.||          |
  Rat   793 CKDEQFLNLVGYCADCHPLCQHCVANLQDTGSVCLKCQHARH------LLLGDH----------C 841

  Fly  1923 GLKPEPEPEFEPIKQCPPGKIKS------------ECAN-------------------QCENTC- 1955
                        :..||||..|.            .|.|                   .|.:|| 
  Rat   842 ------------VPDCPPGHYKERGTCKRCHPSCRSCQNGGPFSCSSCNTGLVLTHIGACSSTCF 894

  Fly  1956 --HY-------------------YGSILKKR--------GLCQVGEHCKP--------------- 1976
              ||                   .||....|        |.||. |.|.|               
  Rat   895 PGHYLDDNQACQPCNRHCRSCDSQGSCTSCRDPSKVLLFGECQY-ESCAPQYYLDISTKTCKECD 958

  Fly  1977 ----GCVDELRPDCPKL----------------GKFWRDEDTCVHAD----------EC------ 2005
                .|...||.||.:.                .:.:||..:|...|          ||      
  Rat   959 WSCNACTGPLRTDCLQCMDGYVLQDGVCVEQCSPQHYRDSGSCKRCDSHCLQCQGPHECTRCEGP 1023

  Fly  2006 ------PCM---------DKAEHYVQ---------PHKPVLGEFEVCQCIDNAF---------TC 2037
                  .|:         |.|||...         .||      :.|...|:.|         ||
  Rat  1024 FLLFRAQCVQECAKGYFADHAEHKCTACPQGCLQCSHK------DRCHLCDHGFFLKSGFCMPTC 1082

  Fly  2038 VPNKPEPVPKDEDDDLDLVSVVPIYPVTL------------TPPLQCSPERLIPKIENPAHSLPD 2090
            ||........:...|       .:|..:|            ..||..|    :..|::....:.|
  Rat  1083 VPGFSGHSSNETCTD-------KVYTPSLHVNGSLTLGIGSMKPLDFS----LLNIQHQDGRVED 1136

  Fly  2091 SIFN-----ASSQLAPEHGPKMARL--------------------TKEQPR-GSWSPSINDQMQY 2129
            .:|:     .:.||......|..:|                    :||:.| |.:|..|:||..:
  Rat  1137 LLFHIVSTPTNGQLLLSRNGKEVQLEKAGHFSWKDVNGKKVRFVHSKEKLRKGYFSLKISDQQFF 1201

  Fly  2130 LELNFAKPEPFYGVVMAGSPEFDNYVTLFKILHSHDG----IAYHYL-VDETEKPQ-MFNGPLDS 2188
            .|......:.|    ...:|    ||...::||...|    |....| :.:.:.|| :....||.
  Rat  1202 SEPQLINIQAF----STQAP----YVLRNEVLHISKGERAAITTQLLDIRDDDNPQDVVLNVLDP 1258

  Fly  2189 RAPVQTLFKIPIEASSLRIYPLKWHGSIAMRVELLICGDKEEPKPVPTVSTIL------------ 2241
            ....|.|...|..|:|  :|  ::|.....|..||...|..:     :.|.|:            
  Rat  1259 PRHGQLLRTPPAPAAS--VY--QFHVDELSRGLLLYAHDGSD-----STSDIIVFQANDGHSFQN 1314

  Fly  2242 --------PITERPARLVDLECIDLMGVDEGKMYQ---------------DQVQSSSLWQQPNLG 2283
                    |..:|..|||   ...::.|.||.|.:               |.:........|..|
  Rat  1315 ILFRVKNVPKNDRALRLV---TNSMVWVPEGGMLKITNRILRAQAPGVRADDIIYKITHDHPQFG 1376

  Fly  2284 KKLQLLELLKLSTPLAWRPLANSQNEFIEFDFLEPRNISGFVTKGG--PDGWVTGYKVMFSKK-- 2344
            :.:.|:. |...:|                        :|...:|.  |||.:|.....||::  
  Rat  1377 EVVLLMN-LPADSP------------------------AGPAEEGHHLPDGRMTTPVSTFSQQDI 1416

  Fly  2345 -------KPTWNTVLSTDGQARIFEANHDAETERRHHFKNPILTQYIKIVPAYWEKNINMRIEPL 2402
                   :.:..|..|.....::..|.:..|..:.|.|...||.|.::........:::|.....
  Rat  1417 DDGIVWYRHSGATAQSDSFHFQVSTATNAQEHPQSHMFNIAILPQALEAPKLSLGTSLHMTARED 1481

  Fly  2403 GCFLPYPE---------------IQRQVPVEESK-----------PTKCNICDGVSTSSSTTGCQ 2441
            |..:.:|:               ....||:..::           |.:....:.::         
  Rat  1482 GLSVIHPQSLSFGKAESPSGKIIYNITVPLHPNQGVIEHRGRPNSPIRYFTQEEIN--------- 1537

  Fly  2442 CQDQLFWDGNTCVQHNLCPCIENYVSY-----PIGSKF-------ENSACEDCVCVLGGHKNCKP 2494
             |.|:.:.......|     ::.::::     |...:|       ::::.|..:.:...|.:.:|
  Rat  1538 -QGQIMYRPPAAPPH-----LQEFMAFSFAGLPESVRFYFTVSDGQHTSPEMALTIHLLHSDRQP 1596

  Fly  2495 K----KCP-----PCLGGKL----------RPVITSDCFCKCEPCPKHQRLCPSSGDCIPEILWC 2540
            .    |.|     |  ||:.          ..|:..:.|.:.:..|:|..|...:          
  Rat  1597 PAFQIKAPLLEVSP--GGRTPLGLQLVVRDAEVVPEELFFQLQKPPQHGMLMKYT---------- 1649

  Fly  2541 NGVQDCADDEDASCSDSFTVEPDVSREKNETEVITCPVPVCPPQMKIRITEKKSRKMSKMFTFSK 2605
                 .......|..|:||.:   ..|:|..:.:....|.....|:|.:|               
  Rat  1650 -----AKSSVTMSAGDTFTYD---EVERNVLQYVHDGSPAWEDNMEISVT--------------- 1691

  Fly  2606 QVSIVDDGTTITKTKFISSKEQILAMPNRELDFQLEEQCDEFTCVPIP--------SKQVDKNET 2662
                  ||.|:|.::.   |.::....|||                 |        |..|....|
  Rat  1692 ------DGLTVTTSEV---KVEVSPSENRE-----------------PRLAPGSSLSMTVASQHT 1730

  Fly  2663 VTCT-------EPKCPEKYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISGKSFTTFDGTVFKY 2720
            ...|       :...|:. ::.:.:|:..:     |..:|:.:..|:.|:||.|..|.:      
  Rat  1731 AIITRSHLAYVDDSSPDS-EIWIQLSSLPL-----YGVLLKTSGPDMEELSGDSNFTME------ 1783

  Fly  2721 GPCSHILARDIHSSSWSISV-------------HQQCSD-ETRKVCHKVITIQDTEAGNELILLP 2771
                     ||:|.:...|.             |...|| :..:|.::|.||..|.|.|.    |
  Rat  1784 ---------DINSKNIRYSAVFETEGQSVTDGFHFSVSDMDNNRVDNQVFTITVTPAENP----P 1835

  Fly  2772 HLKLKFNGYEFTVQQLINSPICKASFVVSQPGKTL-------LAVSTKYG 2814
            |: :.|... .||.:...:|:....|..::....|       |:...|||
  Rat  1836 HI-IAFADL-ITVDEGGRAPLSLHHFFATEDQDNLQGDAVIKLSALPKYG 1883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843 3/8 (38%)
TIL 1131..1185 CDD:280072 16/78 (21%)
TIL 1245..1298 CDD:280072 15/84 (18%)
VWD 1327..1498 CDD:214566 30/197 (15%)
C8 1535..1609 CDD:214843 16/88 (18%)
Mucin2_WxxW 1751..1837 CDD:290069 21/117 (18%)
TIL 1938..2005 CDD:280072 30/172 (17%)
FA58C 2089..2223 CDD:238014 36/165 (22%)
FA58C 2104..2225 CDD:214572 34/147 (23%)
FA58C <2299..2404 CDD:214572 18/115 (16%)
FA58C <2299..2403 CDD:238014 18/114 (16%)
VWD 2703..2858 CDD:295339 31/133 (23%)
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
Fras1XP_038947596.1 VWC 27..86 CDD:214564 12/59 (20%)
VWC 94..151 CDD:278520 17/81 (21%)
VWC 158..>198 CDD:327433 9/40 (23%)
VWC 224..277 CDD:278520 15/52 (29%)
VWC 284..341 CDD:214564 18/73 (25%)
VWC 368..415 CDD:327433 12/81 (15%)
VSP 405..780 CDD:146106 88/439 (20%)
VSP 728..1059 CDD:146106 60/361 (17%)
FU 1045..1086 CDD:214589 11/46 (24%)
Cadherin_3 1101..1197 CDD:406568 17/99 (17%)
Cadherin_3 1202..1309 CDD:406568 27/123 (22%)
Cadherin_3 1313..1440 CDD:406568 25/154 (16%)
Cadherin_3 1448..1576 CDD:406568 16/142 (11%)
Cadherin_3 1579..1693 CDD:406568 23/154 (15%)
Cadherin_3 1703..1813 CDD:406568 23/147 (16%)
Cadherin_3 1822..1940 CDD:406568 18/68 (26%)
Cadherin_3 1943..2061 CDD:406568
Cadherin_3 2081..2181 CDD:406568
Cadherin_3 2188..2295 CDD:406568
Cadherin_3 2297..2408 CDD:406568
Cadherin_3 2427..2539 CDD:406568
Calx-beta 2555..2652 CDD:413355
Calx-beta 2677..2763 CDD:413355
caca <2782..>3049 CDD:273296
Calx-beta 3041..3135 CDD:413355
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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