DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hml and MUC19

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	NP_775871.2	Gene:	MUC19 / 283463	HGNCID:	14362	Length:	8384	Species:	Homo sapiens

Alignment Length:	1930	Identity:	488/1930 - (25%)
Similarity:	752/1930 - (38%)	Gaps:	454/1930 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IFVALWLLFISSVLTENGDIIITDDDDEDINPLLQAAPEVVDKENERNERHISFNILKAPAVSAR 70
            :.||||..|                  :|:..||.         .::::..|      |.:.|..
Human     8 LVVALWCFF------------------KDVEALLY---------RQKSDGKI------AASRSGG 39

  Fly    71 YTYGGSEGG-----RSGFGGGYGVGG----------GGGG------GYGGIKTSHAAGGLLTKTL 114
            ::||.|..|     :..|...:|..|          ..|.      ..||...|.::.|...:|.
Human    40 FSYGSSSSGDLDRKKPLFSLEFGSPGETEDKSRQRQDAGSPKSEDTPAGGFFNSSSSSGDSDRTK 104

  Fly   115 GF--LGMGGQG--------SQ-------------GNFYGGGGH---------FLAAFGKCSALQL 147
            .|  ||:|..|        ||             |.|||....         |...||.....:.
Human   105 PFFSLGLGAPGKAEDKSGDSQDAGGSKSEDTPPGGFFYGSSSSGDSDKKKPLFSFEFGATGEDED 169

  Fly   148 PSNVQSECHNGRCKVFCPT-------GYSFAQDVSVLEMFCSNDGWIIGNSVFAEVPPCQAQCTP 205
            .|..:.:..|.|.: ..|.       |..|:...:.|::   ..||.|.:....||.....:.|
Human   170 KSRERWDAGNSRSE-DSPADSTNTRYGAGFSSSGASLDV---GFGWGISDEKGLEVSKADGRET- 229

  Fly   206 PCQNNGICISAGVCQCPEN-YYGPLCQQKKSICASFPKAPKNSKVSCKNNMCHAECMRGFQFPDG 269
              :.:|   |||    .|. .:||.........:|          ..|......:...||:..|.
Human   230 --RGSG---SAG----GETIVFGPDAGSSVGTGSS----------GLKLGAGKGDAAFGFEVSDS 275

  Fly   270 SGITNIECRNGQWVHTKTGL-SKTPDCAPTCAPACQNGGQCISFNVCQCSKMFRGDHCQYNIDRC 333
            :...:            ||: |||.:...|     .:.|..:|.::...|  ||.:: |:
Human   276 NSFGD------------TGISSKTVEGNQT-----SSSGGSVSIDLGDTS--FRSEN-QF----- 315

  Fly   334 NVTNTNFNGNYKCAYEMDDARCTFSCPQVPGLKIQGRIDIE--YKCNYLQGQYLPAPLPKCIFPP 396
             |...:.|   ..:...|..:..|...::.|..:.|.:..|  :|
Human   316 -VGGGSLN---SISNLWDSGQEGFGINEIGGNGMSGSVSAEAGFK-------------------- 356

  Fly   397 GYTVRSTSS-----------MQGVTHQNGVYHRGMSGEMAYELQT---ERQKL-----LALLAKY 442
            |:...|:||           ..|::..:||. .|.|.:...||..   .|::.     ...|:..
Human   357 GFGSDSSSSGDSSARNGFENSSGISEDSGVI-LGSSDQHEVELSRTGGNRKRSSDPDEAGNLSPG 420

  Fly   443 RDL-ERRSEWWSSEE-----TVVTMSSYSLYQSNNLDI------VIDKTPRPA-------LCTTW 488
            .|: :.....|||:.     .|.:.|.||  .|..|:.      :.:.||:.:       ..:||
Human   421 SDVSDSGGNTWSSDSGSGGGGVTSSSEYS--TSGPLNTPEKGSHIPEATPKYSETNAIIGEISTW 483

  Fly   489 GGINMKTFDGLVFKAPLSCSHTLITDKV--SGTFDIILKACPYGSGYGCAHTLKILWQSVLYTFE 551
            .....|:|:|.:|....||.:|.....:  .|.|:|.:|.                        .
Human   484 SKGAYKSFNGRIFFFESSCPYTFCRHCIESGGDFNIEIKR------------------------N 524

  Fly   552 NLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQ-------IDLESVG-----------LKLDWD 598
            |.:...::|..|..  ..|.:.|..::...:.||       |.::..|           |.|.||
Human   525 NDSEIEKITVLIDN--NDVSIFGDTILVNGESVQIPYNNKLIHIKKYGEHNVLNSRRGILTLMWD 587

  Fly   599 ---------HRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRS 654
                     |:||.:.           ||||..:..|..|:    .:.:|..|...|......:|
Human   588 KNNKLSLTLHKQYPTC-----------GLCGNFNSTPGQDI----NEHIANSKIPGDCPNAVGKS 637

  Fly   655 -ELCQVENSAEMEFGMDSCEQSKLQKAVSVCERLLAN--EKLGDCIKPFNYDALIRTCMADYCNC 716
             |:|                    :..:..|.:::..  ||.|......|...:|  |:.:||..
Human   638 YEVC--------------------EDGIQHCNKIIGTYFEKCGKVAALSNDYKMI--CIDEYCQT 680

  Fly   717 ANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGR-----VYQACGPNVEPTCD 776
            .::    :..||..:.|::.||..|......||:  ...:.||..|     :|:.|||:...||
Human   681 RDK----TSTCDTYSELSRLCASDGPGTFESWRS--DSDVVCGTQRCPEQHIYKECGPSNPATC- 738

  Fly   777 SDLALPASKGACNEGCFCPEG----TVQYKEACITRELCPCSLRGKEFKPESTVKKNCNT-CTCK 836
            |::| |.....|..||.||||    .:..|..|:.:..|||...|..::|....:..|.: |||:
Human   739 SNVA-PFQDSECVSGCTCPEGYLLDDIGEKGKCVLKAECPCESSGTVYQPGEVREGPCGSQCTCQ 802

  Fly   837 NGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQNTSVEAENVAC-SGAVSESM 900
            :.:|.|||..|..||...|. ...||||.:|:|.|.|.:..:..::.|:..|...| ||...
Human   803 DAKWSCTEALCPGRCKVEGS-SLTTFDGVKYNFPGNCHFLAVHNEDWSISVELRPCPSGQTG--- 863

  Fly   901 NFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLG-----EVLIRRA 960
                    :|..:||:  :|....|....:.....|:.||       |:...|     ::.|..|
Human   864 --------TCLNSVTL--LLNSSVPVDKYVFNSDGTVTND-------KIRNQGYYYSDKIQIFNA 911

  Fly   961 SSTFLTVE--FADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEP 1023
            ||::|.||  |...:::....|.::|:..||:....|.||||::|:..:|||::.:..:|...:.
Human   912 SSSYLQVETYFHVKLQIQIVPVMQLYVSMPPNQFTDTVGLCGSYNNKAEDDFMSSQNILEKTSQA 976

  Fly  1024 FADKWRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWILQDI--FQDCHFLVEPEQFYEDCL 1086
            ||:.|... :|     ....|..| ::.||:..||:.|..:|...  ...||.:|.|:.::|:|.
Human   977 FANSWEMM-SC-----PKGNPSSC-ISIEKEKFAERHCGILLDSSGPLASCHPIVNPKPYHEECK 1034

  Fly  1087 YDTCACKDEMSKCFCPILSAYGTECM-RQGVKTGWRMSVKECAVKCPLGQVFDECGDGCALSCDD 1150
            ..||.|::... |.|.||..|...|. ::....|||..:  |...||.|.||......|..||..
Human  1035 KYTCTCENSQD-CLCTILGNYVKACAEKETYIVGWRTGL--CEHSCPSGLVFKYNVKACNSSCRS 1096

  Fly  1151 LPSKG-SCKRE--CVEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDL-- 1210
            |..:. ||..|  .|:||.||...|.|.:|.||.|..|.|..:....:||        |.:.:
Human  1097 LSERDRSCDVEDVPVDGCTCPDAMYQNNEGNCVLKSQCDCYINDEVMQPG--------KLIHIDD 1153

  Fly  1211 --CTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTKCA-PKEP----KTCKNMDKYVA 1268
              |.|.||:..||         .|....|:: |:..  ||:..|: ||..    :||...:..|.
Human  1154 NKCVCRDGILLCQ---------IPIDLTLQN-CSGG--AEYVDCSDPKAQRRTNRTCSTRNIPVF 1206

  Fly  1269 DSS-DCLPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCSKN 1332
            |.: .|..||.|.||.|.: |:..||.|.:|.|...|:.||:|......||.|.|..|:|.|::|
Human  1207 DENLPCKRGCFCPEGMVRN-SKGICVFPNDCPCSFGGREYDEGSVTSVGCNECTCIKGSWSCTQN 1270

  Fly  1333 GCESTCSVWGDSHFTTFDGHDFDFQGACDYVLAKGVFDNGDG-FSITIQNVLCGTMGVTCSKSLE 1396
            .|::.|.::|:.|..||||..:.|.|.|.|...:....:.:| |.|..::|.|...|:|||:.:.
Human  1271 ECQTICHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRILTESVPCCEDGLTCSRKII 1335

  Fly  1397 IALTGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQ--- 1458
            :|.   .:::::|.       |...|.:|...........||:.|:..|::::     ||.|
Human  1336 VAF---QDQNIVLQ-------DGKVTAVKSTESKKCELNANAYSIHTVGLYLI-----LKFQNGI 1385

  Fly  1459 -VKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPV 1522
             |.||:.||:.|.|...|..||.|||||.||:..||..|....:.:..:.||::||....||..|
Human  1386 IVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTRYSSVASGALEFGNSWKTSQECSDTV 1450

  Fly  1523 APIDACKKHPERETWAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVA 1587
            |....|..:|..:.||..||..|:...|::||.:|....:...||.:.||||..|.....|||||
Human  1451 AQTFPCDSNPYCKAWAVRKCEILRDSTFRDCHNKVDPSAYHDACIEEACACDMEGKYLGFCTAVA 1515

  Fly  1588 AYADACAQKGINIRWRSQHFCPMQCDPH-----CS-DYKACTPACAVETCDNFLDQGIAERMCNR 1646
            .||:||:..|:.:.||..:.||:.||.:     |. .|:.|....| :||.   ||.:.::.
Human  1516 MYAEACSAVGVCVSWRKPNLCPVYCDYYNAPGECRWHYEPCGTVTA-KTCK---DQLVGQKF--- 1573

  Fly  1647 ENCLEGCHIKPCEDGFIYLNDTYRDCVPKAECKPVCMVRDGKTFYEGDI----TFTDSCA-TCRC 1706
            .:.||||:.| |.|...||::....||..:||.  |       ||...|    ...|:|. ||.|
Human  1574 SSLLEGCYAK-CPDSAPYLDENTMKCVSLSECS--C-------FYNDVIPAGGVIEDNCGRTCYC 1628

  Fly  1707 SKRKEICSGVKCDVPATTGLPAPLVEGTTLPTPLATQNQTKCVKG 1751
                 |...::|...|.|. ....|..||..|.|:|......|.|
Human  1629 -----IAGQLECSETAPTN-STFAVSTTTATTILSTGAAITLVTG 1667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339	35/179 (20%)
		C8	680..754	CDD:285899	17/75 (23%)
		TIL	758..811	CDD:280072	21/61 (34%)
		VWD	840..1015	CDD:214566	52/182 (29%)
		C8	1054..1121	CDD:214843	20/69 (29%)
		TIL	1131..1185	CDD:280072	23/56 (41%)
		TIL	1245..1298	CDD:280072	20/58 (34%)
		VWD	1327..1498	CDD:214566	56/175 (32%)
		C8	1535..1609	CDD:214843	28/73 (38%)
		Mucin2_WxxW	1751..1837	CDD:290069	1/1 (100%)
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
MUC19	NP_775871.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..197		34/164 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..247		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..305		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..467		28/157 (18%)
		VWD	481..616	CDD:214566	34/171 (20%)
		TIL	721..776	CDD:280072	18/56 (32%)
		VWC	778..>814	CDD:214564	11/35 (31%)
		VWD	806..968	CDD:214566	52/182 (29%)
		C8	1003..1073	CDD:285899	22/72 (31%)
		TIL	1077..1134	CDD:280072	23/56 (41%)
		TIL	1176..1236	CDD:280072	21/62 (34%)
		VWC	1238..>1273	CDD:302663	13/34 (38%)
		VWD	1265..1425	CDD:214566	55/174 (32%)
		C8	1466..1536	CDD:285899	27/69 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1680..1699
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1732..2464
		Approximate repeats of G-V-T-G-T-T-G-P-S-A. /evidence=ECO:0000305	2238..6086
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2484..2526
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2540..2827
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2850..2917
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2984..3027
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3075..3368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3386..3428
		FhaB	3428..4424	CDD:225751
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3585..3628
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3667..3736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4105..4147
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4187..4251
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4315..4390
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4414..4455
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4510..4583
		FhaB	4620..5458	CDD:225751
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4790..4843
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4895..4930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5130..5161
		FhaB	5235..6216	CDD:225751
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5429..5452
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5464..5494
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5880..5918
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	6069..6403
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	6440..6918
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	6953..7223
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	7250..7749
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	7783..7975
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	8020..8133
		VWC	8161..8221	CDD:214564
		CT	8295..8376	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7243
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	807	1.000	Inparanoid score	I494
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12226at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100854
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870