DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hml and Muc2

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	XP_038957198.1	Gene:	Muc2 / 24572	RGDID:	3123	Length:	4745	Species:	Rattus norvegicus

Alignment Length:	1493	Identity:	439/1493 - (29%)
Similarity:	665/1493 - (44%)	Gaps:	220/1493 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 SNNLDIVIDKTPRPALCTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSG--TFDIILKACPYGS 531
            :..|::..:...|..:|:|||..:.|||||.||:.|..|.:...:|....  .|.:.||.   |.
  Rat    18 AKGLELQKEARSRNHVCSTWGDFHYKTFDGDVFRFPGLCDYNFASDCRDSYKEFAVHLKR---GL 79

  Fly   532 GYGCAHTLKILWQSVLYTFEN-----------LNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQ 585
            .....|:   ..:|||.|.::           :||.|..|        |....|:.:.....:.:
  Rat    80 DKAGGHS---SIESVLITIKDDTIYLTHKLAVVNGAMVST--------PHYSSGLLIEKNDAYTK 133

  Fly   586 IDLESVGLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDG-DPNTDLTSRTGKKLATVKAFADAWR 649
            : ....||.|.|:....:.|:...:......||||..:| ..|.:..| .|.:.:.:: |.:..:
  Rat   134 V-YSRAGLSLMWNREDALMVELDGRFQNHTCGLCGDFNGMQANNEFLS-DGIRFSAIE-FGNMQK 195

  Fly   650 VEDRSELCQVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYC 714
            :.....:|  |:..|:: ..:||.:.:.:     |||||.:....||......:..:..||.|.|
  Rat   196 INKPEVVC--EDPEEVQ-EPESCSEHRAE-----CERLLTSTAFEDCQARVPVELYVLACMHDRC 252

  Fly   715 NCANREHPE--SCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVEPTCDS 777
            .|     |:  :|.|..:|..:::|:..|.:.|: ||...:||..|....||...|.....|| |
  Rat   253 QC-----PQGGACECSTLAEFSRQCSHAGGRPEN-WRTASLCPKKCPGNMVYLESGSPCVDTC-S 310

  Fly   778 DLALPASKGACNE----GCFCPEGTVQYKE----ACITRELCPCSLRGKEFKPESTVKKNCNTCT 834
            .|.:   ...|.|    ||||||||| |.:    .||....|.|.|.|..:.|...:..:|..|.
  Rat   311 HLEV---SSLCEEHYMDGCFCPEGTV-YDDITGSGCIPVSQCHCKLHGHLYMPGQEITNDCEQCV 371

  Fly   835 CKNGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQNTSVEAENVACSGAVSES 899
            |..|:|.|.:..|...|...|..|..|||||::.|.|.|.|.|.||:.....|       .:.|.
  Rat   372 CNAGRWMCKDLPCPETCALEGGSHITTFDGKKFTFHGDCYYVLTKTKYNDSYA-------LLGEL 429

  Fly   900 MNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTF 964
            .:..:.|..:|.|.|.   :|.|...:|:....|.:.::|:..:: ||.:  .....|.:.||..
  Rat   430 ASCGSTDKQTCLKTVV---LLTDNKKNVVAFKSGGSVLLNEMEVS-LPHV--AASFSIFKPSSYH 488

  Fly   965 LTVEFADGIR--VWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADK 1027
            :.|....|:|  :....|.::::....|.:||.|||||.||....|||:|..|.||.....||:.
  Rat   489 IVVNTMFGLRLQIQLVPVMQLFVTLDQSAQGQVQGLCGNFNGLESDDFMTSGGMVEATGAGFANT 553

  Fly  1028 WRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWI--LQDIFQDCHFLVEPEQFYEDCLYDTC 1090
            |:.:.:|..|.:...  .||:||.|....||.:|..:  .:..|..||..|:|.::|:.|.||||
  Rat   554 WKAQSSCHDKLDWLD--DPCSLNIESANYAEHWCSLLKRSETPFARCHLAVDPTEYYKRCKYDTC 616

  Fly  1091 ACKDEMSKCFCPILSAYGTECMRQGVKT-GWRMSVKECAV-KCPLGQVFDECGDGCALSCDDLPS 1153
            .|::. ..|.|..||:|...|..:||.. |||.||....| .||..|:|......|..:|..: |
  Rat   617 NCQNN-EDCMCAALSSYARACAAKGVMLWGWRESVCNKDVHACPSSQIFMYNLTTCQQTCRSI-S 679

  Fly  1154 KGSCKREC------VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCT 1212
            :|.  ..|      ||||.||...:::|.|.|||...|.|...|:....|...:|..|:    |.
  Rat   680 EGD--THCLKGFAPVEGCGCPDHTFMDEKGRCVPLSKCSCYHHGLYLEAGDVILRQEER----CI 738

  Fly  1213 CTDGVWDCQDAE-PGDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPK--TCKNMDKYVAD--SSD 1272
            |.:|...|...: .|..   .||.::...|     ...|..|.:||:  :|:.:   ||.  .::
  Rat   739 CRNGRLQCTQVKLIGHT---CPSPQILVDC-----NNLTALAIREPRPTSCQTL---VAGYYHTE 792

  Fly  1273 CLPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDC-NLCECRAGNWKCSKNGCES 1336
            |:.||||.:| :.|..|..||:...|.|.|..:.||.|:.||.|| |.|.|:.|.|:|::..|.|
  Rat   793 CISGCVCPDG-LLDNGRGGCVVEDECPCIHNKQFYDSGKTIKLDCNNTCTCQKGRWECTRYACHS 856

  Fly  1337 TCSVWGDSHFTTFDGHDFDFQGACDYVLAKGVF-DNGDG-FSITIQNVLCGTMGVTCSKSLEIAL 1399
            |||::|..|:.||||..:||.|.|.||..:... .|..| |||..:||.|||.||||||:::|.:
  Rat   857 TCSIYGSGHYITFDGKHYDFDGHCSYVAVQDYCGQNSTGSFSIITENVPCGTTGVTCSKAIKIFI 921

  Fly  1400 TGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNSKGHNA-FHIYKAGVFVVVEVIPLKLQVKWDE 1463
             |..|..|:         |.::. :|:|.:     ||:. |...:.|:::|||| ...:.|.||:
  Rat   922 -GGTELKLV---------DKHRV-VKQLEE-----GHHVPFITREVGLYLVVEV-SSGIIVIWDK 969

  Fly  1464 GTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDAC 1528
            .|.:::||...::..|.|||||::..:.:|..|....:..|.:.||::||....|.......|.|
  Rat   970 KTTIFIKLDPSYKGNVCGLCGNFDDQTKNDFTTRDHMVVASELDFGNSWKEASTCPDVSHNPDPC 1034

  Fly  1529 KKHPERETWAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADAC 1593
            ..:|.|.:||:.:|..:|||:|..||.:|....|:..|:.|:|:||.||||||.|:|||:||..|
  Rat  1035 SLNPHRRSWAEKQCSIIKSDVFLACHGKVDPTVFYDACVHDSCSCDTGGDCECFCSAVASYAQEC 1099

  Fly  1594 AQKGINIRWRSQHFCPMQCD-----PHCS-DYKACTPACAVETCDNFLDQGIAERMCNRENCLEG 1652
            .:....:.||:...||:.||     ..|. .|:.|... :.|||...  .||...:  ..:.|||
  Rat  1100 TKAEACVFWRTPDLCPVFCDYYNPPDECEWHYEPCGNR-SFETCRTL--NGIHSNI--SVSYLEG 1159

  Fly  1653 CHIKPCEDGFIYLNDTYRDCVPKAECKPVCMVRDGKTFYEGDITFTDSCATCRCSKRKE-IC--- 1713
            |:.:..||..|| ::..:.||...:|.  |.:.|.:....|.:...:.|.:|.|:...| ||
  Rat  1160 CYPRCPEDRPIY-DEDLKKCVSGDKCG--CYIEDTRYPPGGSVPTDEICMSCTCTNTSEIICRPD 1221

  Fly  1714 ---------SGVKC--DVPATTGL--------------PAPLVEGTTLPTPLAT----------- 1742
                     .|:.|  ::..:.|.              |..|...||..||::|
  Rat  1222 EGKIINQTQDGIFCYWEICGSNGTAEKYFNICGSSTPSPTSLTSFTTTSTPISTTPISTTITTTS 1286

  Fly  1743 -QNQTKCVKG-------WTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTKVECR 1799
             ...|....|       |:.|.:.:..|:...   .|.|      ..|:|...     ...:|||
  Rat  1287 ATATTTVTTGEAPPCCFWSDWINNNHPTNGNG---GDRE------TFEHVCSA-----PEDIECR 1337

  Fly  1800 -VKDTHEAPEQMDENVVCSLEEGLRCIGK----------CHDYELRAFCQCDEELEPELPKPT 1851
             ..|......::.:.|.|::.|||.|..:          |:|||:|..|....|..|....||
  Rat  1338 AATDPKLDWTELGQKVQCNVSEGLICNNEDQYGSGQFELCYDYEIRVNCCIPMEYCPSTISPT 1400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339	41/164 (25%)
		C8	680..754	CDD:285899	21/75 (28%)
		TIL	758..811	CDD:280072	22/60 (37%)
		VWD	840..1015	CDD:214566	52/176 (30%)
		C8	1054..1121	CDD:214843	24/69 (35%)
		TIL	1131..1185	CDD:280072	20/59 (34%)
		TIL	1245..1298	CDD:280072	17/56 (30%)
		VWD	1327..1498	CDD:214566	64/173 (37%)
		C8	1535..1609	CDD:214843	31/73 (42%)
		Mucin2_WxxW	1751..1837	CDD:290069	23/103 (22%)
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
Muc2	XP_038957198.1	VWD	34..182	CDD:395046	41/163 (25%)
		C8	222..288	CDD:400886	21/71 (30%)
		TIL	292..348	CDD:410995	22/60 (37%)
		VWD	388..542	CDD:395046	49/166 (30%)
		C8	579..649	CDD:214843	26/70 (37%)
		TIL	658..715	CDD:410995	20/59 (34%)
		VWD	847..1005	CDD:214566	64/174 (37%)
		C8	1043..1115	CDD:214843	31/71 (44%)
		Mucin2_WxxW	1304..1386	CDD:404246	22/95 (23%)
		Mucin2_WxxW	1971..2059	CDD:404246
		VWD	4041..4208	CDD:214566
		C8	4258..4320	CDD:400886
		VWC	4491..4555	CDD:214564
		CT	4643..4722	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4757
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12226at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46300
orthoMCL	1	0.900	-	-		OOG6_100854
Panther	1	1.100	-	-	O	PTHR11339
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920