Protein Alignment Hml and VWCE

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: NP_689931.2
• Gene: VWCE / 220001
• HGNCID: 26487
• Length: 955
• Species: Homo sapiens
• Alignment Length: 972
• Identity: 190/972 - (19%)
• Similarity: 282/972 - (29%)
• Gaps: 377/972 - (38%)

  Fly  2952 CLSVNPLVQLTTWRAVAQCE-----INCPSPLVHTDCYKRRCEPSCDNVHGD------DCPV--- 3002
            |::.|          |..|:     ..||.  .|..|.:..|:.:|:  ||.      .|||
Human    80 CIAPN----------VCSCQDGEQGATCPE--THGPCGEYGCDLTCN--HGGCQEVARVCPVGFS 130

  Fly  3003 ----------------LPDACFPGCYCPEG--TVRKGP---------NCVPISECKDCVC----- 3035
                            :..:|...|...||  ....||         :|....||....|
Human   131 MTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCK 195

  Fly  3036 NSLGASKYMTYDRKSFSFNGN---CTYLLSRDVVLPGVHTFQVYVSMDDCKKLGQPTPVEGGSCA 3097
            ||:|:  |....|..|..:||   |                   |.:::|::     |:|...|.
Human   196 NSIGS--YKCSCRTGFHLHGNRHSC-------------------VDVNECRR-----PLERRVCH 234

  Fly  3098 KSLHILNGDHVIHVQRVPQKPKSLQVLVDGFEVKKIPYKDSWISLRQVVGKELVLSLPESHVELT 3162
            .|.|...|..:. ..|...:.::.:|..:.|. |.:....:.:..||...|.|:| |||:
Human   235 HSCHNTVGSFLC-TCRPGFRLRADRVSCEAFP-KAVLAPSAILQPRQHPSKMLLL-LPEA----- 291

  Fly  3163 ASFEDLIFSLGVPSIKYG-SKMEGLCGDCNGNAGNDLQPNPAKKKAGVDVIQSWQADEPKLGLVE 3226
                      |.|::..| |...|..|...|.....| |:|..:      :.:.....| :.|:.
Human   292 ----------GRPALSPGHSPPSGAPGPPAGVRTTRL-PSPTPR------LPTSSPSAP-VWLLS 338

  Fly  3227 ECLSEDVPKEHCIPLPPEKDPCLQFYNAELFGKCPLAVDPIAYVSACQQDIC-KPGNTQQGVCVA 3290
            ..|:..||                  .|.|.|.       :...|..|.::. .|.:.:......
Human   339 TLLATPVP------------------TASLLGN-------LRPPSLLQGEVMGTPSSPRGPESPR 378

  Fly  3291 LAAYAKEC----NQHGICTNWRRPQLCPYECPSDMVYEPCGCAKNCDTIKALSEFDAVSLKNEAV 3351
            |||....|    ..|...:.|..|                ||::
Human   379 LAAGPSPCWHLGAMHESRSRWTEP----------------GCSQ--------------------- 406

  Fly  3352 VHTVKTDEMCLSSERFEGCFCPPGKV-----------------MDGGQCVPEIACTKC------- 3392
                              |:|..|||                 .||| |.|  :||.|
Human   407 ------------------CWCEDGKVTCEKVRCEAACSHPIPSRDGG-CCP--SCTGCFHSGVVR 450

  Fly  3393 --DDGLHLPDEKWKKDKCTECQCDSKGKTTCVEKKCQVEENICAEGYRPETIVSVDECCPRYRCV 3455
              .|....|:|     .||.|.| ..|..:|:..:|
Human   451 AEGDVFSPPNE-----NCTVCVC-LAGNVSCISPEC----------------------------- 480

  Fly  3456 PETKDPSKLCLAPLVPICGPGQFKKEKKDVNGCSQYICECIPKDQCEIIELRELLPGEIIVNVEE 3520
                 ||..|..|....|                   |.|:|. :| ....|....|.:.....:
Human   481 -----PSGPCQTPPQTDC-------------------CTCVPV-RC-YFHGRWYADGAVFSGGGD 519

  Fly  3521 GC----CPTQKIECKPETCPKAPVNCQERFYEVKTIKEPGMCCSKHSCVPPKDLCIVQYELDEAT 3581
            .|    |...::||....||:  :.|....:.:    .||.||.......|...|.:.   |...
Human   520 ECTTCVCQNGEVECSFMPCPE--LACPREEWRL----GPGQCCFTCQEPTPSTGCSLD---DNGV 575

  Fly  3582 KFTKTVGDKWTHAKEVCKQETCSYGPDGNAQVVSTLEQCLTDC-----APGFSYQNLDKTKCCGK 3641
            :|  .:|..|:.. :.|  |.|....||:.....|  .|:..|     .||         :||..
Human   576 EF--PIGQIWSPG-DPC--ELCICQADGSVSCKRT--DCVDSCPHPIRIPG---------QCCPD 624

  Fly  3642 CVQTSCIFEQKLYEVNALWKSA-DNCTTYSCLKKDGQFLVTTSREVCPDVGSCLSHLLYQDG-CC 3704
            | ...|.:..:::..|..:.|. |.|.:..||...    |..|...||.  :| ::..:.|| ||
Human   625 C-SAGCTYTGRIFYNNETFPSVLDPCLSCICLLGS----VACSPVDCPI--TC-TYPFHPDGECC 681

  Fly  3705 KRCK------------------SEPLVEDKSSCLPVSLAESRTKEILKFPVQGHGTCVNADPIQG 3751
            ..|:                  .||..  :.:|   .|.|...:   |.|.|  ..|  |||...
Human   682 PVCRDCNYEGRKVANGQVFTLDDEPCT--RCTC---QLGEVSCE---KVPCQ--RAC--ADPALL 734

  Fly  3752 FTDCEGACSSGSKYNTLTDMHEKFCTCCSIKSYHPISVKMICDDGHTFTQKHEVPSNCGCSP 3813
            ..||..:|.     ::|:.:.||       :...|.........|.:.....|.|.||...|
Human   735 PGDCCSSCP-----DSLSPLEEK-------QGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCP 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671
		C8	684..754	CDD:462584
		TIL	758..811	CDD:410995
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:410995
		TIL	1245..1298	CDD:460351
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		TIL	1938..2005	CDD:473303
		FA58C	2089..2223	CDD:238014
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:459671
		TIL	2974..3030	CDD:460351	18/91 (20%)
		VWD	3035..3198	CDD:459671	37/171 (22%)
		C8	3248..3313	CDD:462584	13/69 (19%)
		VWC	3397..3451	CDD:450195	9/53 (17%)
		GHB_like	<3755..3813	CDD:473907	11/57 (19%)
VWCE	NP_689931.2	EGF_CA	142..180	CDD:214542	6/37 (16%)
		FXa_inhibition	190..218	CDD:464251	9/29 (31%)
		EGF_CA	220..262	CDD:214542	9/47 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	292..329		10/43 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..380		2/19 (11%)
		VWC	386..440	CDD:450195	16/111 (14%)
		VWC	443..>488	CDD:450195	14/84 (17%)
		VWC	501..559	CDD:450195	14/64 (22%)
		VWC	572..625	CDD:214564	16/68 (24%)
		VWC	629..684	CDD:450195	16/61 (26%)
		VWC	687..742	CDD:450195	14/66 (21%)
		PHA03247	<726..944	CDD:223021	17/73 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	812..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	903..955