Protein Alignment Hml and Tecta

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: NP_033373.2
• Gene: Tecta / 21683
• MGIID: 109575
• Length: 2155
• Species: Mus musculus
• Alignment Length: 1761
• Identity: 409/1761 - (23%)
• Similarity: 636/1761 - (36%)
• Gaps: 472/1761 - (26%)

  Fly   485 CTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGT----FDIILKACPYG--------------S 531
            |..:|..:..||||.:|....||::.|....:..:    |.:..|....|              :
Mouse   322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVKELSVEVN 386

  Fly   532 GYGCAHTLKILWQSVLYTFENLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESVGLKLD 596
            ||      |||.....|      |.:::...:..||:.:::..:|:........::.: .||.:.
Mouse   387 GY------KILIPKGSY------GKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETD-FGLLVT 438

  Fly   597 WDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSELCQ--- 658
            :|.:.|.|:...........||||..:.:|..|.....|:...:|....::|||......|.
Mouse   439 FDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCGSGC 503

  Fly   659 VENSAEME-------FGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCNC 716
            |:|..:.:       ||.|.|  ..|.|         .:..|.:|....:..|.:.:|:.|.|:.
Mouse   504 VDNCTQCDAATEALYFGSDYC--GFLNK---------TDGPLWECGTVVDATAFVHSCVYDLCSV 557

  Fly   717 ANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEIC--PISCGFGRVYQACGPNVEPTCDSDL 779
            .:.   .:..|.||...|..|...||.: ..||....|  .:.|.....|..|..:...|| |||
Mouse   558 RDN---GTLLCQAIQAYALVCQALGIPI-GDWRIQTGCVSTVRCPSFSHYSVCTSSCPDTC-SDL 617

  Fly   780 ALPASKGA---CNEGCFCPEGTVQYKEACITRELCPCSLRGK-----EFKPESTVKKNCNT-CTC 835
            .  ||:..   |.|||.|.||.|.....|:....|.|...|.     ||   .....||.. |.|
Mouse   618 T--ASQNCATPCTEGCECNEGFVLSTSQCVPLHKCGCDFDGHYYTMGEF---FWATANCTVQCLC 677

  Fly   836 -KNGQWRCTEDKC--GARCGAVGDPHYQ-------------------TFDGKRYDFMGKCSYHLL 878
             :.|...|....|  |..| ||.| .||                   ||||..|.|..:.||.||
Mouse   678 EEGGDVYCFNKTCRSGEVC-AVED-GYQGCFPKRETVCLLSQNQVLHTFDGAAYAFPSELSYTLL 740

  Fly   879 KTQNTSVEAENVACSGAVSESMNFAAPD-DPSCTKAVTIRFILRDGTPSVIKLD--QGLTTIVND 940
            ||.....|...:        .:|...|| .|:..:.|  |.::.|   ..:|:.  ..|...:|.
Mouse   741 KTCPERPEYLEI--------DINKKKPDAGPAWLRGV--RILVAD---QEVKIGGVGALEVKLNG 792

  Fly   941 KPIAKLPKMLGLGEVLIRRASSTFLTVEFADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSN 1005
            :.: :||.....|.:.|.|..:: .|||....:.|.:..|..:||.........|.||||.||:|
Mouse   793 QDV-ELPFFHPSGRLEIHRNKNS-TTVESKGVVSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNAN 855

  Fly  1006 TQDDFLTPEGDVETAVEPFADKWRT-KDTCQ------FKAETHQGPHPCTLNPE--KKAQAEKFC 1061
            ..|:|..|.|.....:..|.:.|.| ::.|.      .||        |..:.|  |..::...|
Mouse   856 ASDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKA--------CNNDSELLKFYRSRSRC 912

  Fly  1062 DWILQD----IFQDCHFLVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQGVKTG-WR 1121
            . |:.|    .|.:||.:|....:|..||:..|......|: .|..::.|.:.|....|:.| ||
Mouse   913 G-IINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESE-LCDSVARYASACKNADVEVGPWR 975

  Fly  1122 MSVKECAVKCPLGQVFDECGDGCALSCDDLPSKGSCKRECVEGCRCPHGEYVNEDGECVPKKMCH 1186
             :...|.::||....|:||.. |..:|:.|.....|...|.|||:|..| |..:..:|||:..|.
Mouse   976 -TYDFCPLECPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEG-YALQGSQCVPRSECG 1037

  Fly  1187 CNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTK 1251
            |||:|       .::...|.|          |..||                  |....|
Mouse  1038 CNFEG-------HQLATNETF----------WVDQD------------------CQIFCY----- 1062

  Fly  1252 CAPKEPKTCKNMDKYV-ADSSDCLPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKE 1315
                    |...|..| .::..|.....|||                    .:|..|
Mouse  1063 --------CNGTDNSVHCETIPCRDDEYCME--------------------ESGLYY-------- 1091

  Fly  1316 DCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFDFQGACDYVL----AKGVFDNGDGFS 1376
                |:.|.          :::|.|.|..|:.||||:.||||.:|..:|    ::.:.|:...|.
Mouse  1092 ----CQPRT----------DASCIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSRPISDSFPKFI 1142

  Fly  1377 ITIQNVLCGTMGVTCSKSLEIALTGHA-------EESLLLSADSAYSTDPNKTPIKKLRDSVNSK 1434
            :|.:|...........|.:::.:.|::       :.::|::.:..|      .|:|        .
Mouse  1143 VTAKNEDRDPSLALWVKQVDVNVFGYSIVIHRAYKHTVLVNNERLY------LPLK--------L 1193

  Fly  1435 GHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSM 1499
            |....:|:..|..||||. ...|:|.:|..|.:.:.:....:....||||.||||..||::.| |
Mouse  1194 GQGKINIFSFGFHVVVET-DFGLKVVYDWKTFLSITVPRSMQNGTYGLCGRYNGNPDDDLEMP-M 1256

  Fly  1500 GLETSPML----FGHAW-KLQPHCSAPVAPIDACKKHPERETWAQLK--CGALKSDL--FKECHA 1555
            ||   |.|    ||.:| |....|.  |...|.|....:.|.:::::  |..:.:..  |.:||:
Mouse  1257 GL---PALSINEFGQSWVKRDTFCQ--VGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAGFAKCHS 1316

  Fly  1556 EVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIR-WRSQHFCPMQCDPHCSDY 1619
            :|....|:|.|:||:|.  .||..:..|:.:..||..|..:||.:. ||:...|.:.|.|: |.|
Mouse  1317 KVNPTFFYKNCLFDSCI--DGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTSCSVTCPPN-SHY 1378

  Fly  1620 KACT----PACAV----ETCDNFLDQGIAERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCVPKA 1676
            ::|.    |.||.    ..|:::              |:|||.   |:.|:: ||.  :.|:...
Mouse  1379 ESCVSVCQPRCAAIRLKSDCNHY--------------CVEGCQ---CDAGYV-LNG--KSCILPH 1423

  Fly  1677 ECKPVCMVRDGK------TFYEGDITFTDSCATCRCSKRK------------EIC---SGVK-CD 1719
            .|.  | ..|||      .|:.||.|     ..|||.:|.            |.|   |||: |.
Mouse  1424 NCG--C-YSDGKYYEPKQLFWNGDCT-----RRCRCFRRNLIQCDPRQCKSDEECALRSGVRGCF 1480

  Fly  1720 VPATT------GLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRY 1778
            ...|:      |......:|..|..|      ..|....:..|.|..|.|.:.:...|:...|..
Mouse  1481 STKTSYCLAAGGGVFRTFDGAFLRFP------ANCAFVLSTICQKLPDISFQLIINFDKWSSPNL 1539

  Fly  1779 DRMENVYGTCLKQYMTKVECRVKDTHEAP---EQMDENVVCSL------EEGLRCIGKCHDYELR 1834
            ..:..||     .|:.:.:..:.|.:...   .|::...:..|      .||...|....|.::
Mouse  1540 TIISPVY-----FYINEEQILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQI- 1598

  Fly  1835 AFCQCDEELEPELPKPTEKPQLGLACDAAVVEYKEFPGD-CHKFLHCQPKGVEGGWIYVEK---- 1894
             :......::..:.:..:....|| |.       .|.|| ...::..:.|.|....:..:.
Mouse  1599 -YYNGFNVIKISISERLQNKVCGL-CG-------NFNGDMTDDYVTLRGKPVVSSVVLAQSWKTN 1654

  Fly  1895 ---------TCGEYMMFNPTMLICDHI-----------ATVTEIK----PNCGLKPEPEPEFEPI 1935
                     :|.| :.|:.....||::           ..:|::|    |..||. :|.|.:|
Mouse  1655 GMQKRPLAPSCNE-LQFSQYAATCDNVHIQAMQGDGYCLKLTDMKGFFQPCYGLL-DPLPFYE-- 1715

  Fly  1936 KQCPPGKIKSECANQCENTCHYYGSILKKR-----GLCQVGEHCKPGCVDELRPDCPKLGKFWRD 1995
                              :|:..|....|:     .|...||.|:...:         |...|.:
Mouse  1716 ------------------SCYLDGCYNHKKFQLCGSLAAYGEACRSFGI---------LSTEWIE 1753

  Fly  1996 --------EDTCVHADECP---C-MDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPKD 2048
                    ||.||.|| ||   | :|...             |:|.||:         |.|...:
Mouse  1754 KENCSGVVEDPCVGAD-CPNRTCELDNGG-------------ELCGCIE---------PPPYGNN 1795

  Fly  2049 EDDDLD 2054
            ..|.:|
Mouse  1796 SHDIID 1801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671	34/168 (20%)
		C8	684..754	CDD:462584	15/69 (22%)
		TIL	758..811	CDD:410995	19/55 (35%)
		VWD	840..1015	CDD:214566	55/198 (28%)
		C8	1054..1121	CDD:214843	17/71 (24%)
		TIL	1131..1185	CDD:410995	19/53 (36%)
		TIL	1245..1298	CDD:460351	8/53 (15%)
		VWD	1327..1498	CDD:214566	45/181 (25%)
		C8	1535..1609	CDD:214843	22/78 (28%)
		TIL	1938..2005	CDD:473303	15/79 (19%)
		FA58C	2089..2223	CDD:238014
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:459671
		TIL	2974..3030	CDD:460351
		VWD	3035..3198	CDD:459671
		C8	3248..3313	CDD:462584
		VWC	3397..3451	CDD:450195
		GHB_like	<3755..3813	CDD:473907
Tecta	NP_033373.2	NIDO	98..254	CDD:214712
		VWD	313..477	CDD:214566	34/167 (20%)
		C8	517..591	CDD:214843	21/88 (24%)
		TIL	597..650	CDD:460351	19/55 (35%)
		VWC	652..706	CDD:450195	18/58 (31%)
		VWD	713..866	CDD:459671	46/167 (28%)
		C8	905..981	CDD:214843	19/78 (24%)
		TIL	984..1036	CDD:410995	19/53 (36%)
		VWD	1100..1258	CDD:459671	47/173 (27%)
		C8	1300..1368	CDD:462584	21/69 (30%)
		TIL	1372..1425	CDD:410995	18/73 (25%)
		VWD	1487..1639	CDD:459671	27/172 (16%)
		C8	1685..1757	CDD:214843	17/101 (17%)
		ZP	1805..2059	CDD:214579
		FXa_inhibition	2089..2121	CDD:464251