DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and Tecta

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:NP_001365531.1 Gene:Tecta / 21683 MGIID:109575 Length:2155 Species:Mus musculus


Alignment Length:1761 Identity:409/1761 - (23%)
Similarity:636/1761 - (36%) Gaps:472/1761 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   485 CTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGT----FDIILKACPYG--------------S 531
            |..:|..:..||||.:|....||::.|....:..:    |.:..|....|              :
Mouse   322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVKELSVEVN 386

  Fly   532 GYGCAHTLKILWQSVLYTFENLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESVGLKLD 596
            ||      |||.....|      |.:::...:..||:.:::..:|:........::.: .||.:.
Mouse   387 GY------KILIPKGSY------GKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETD-FGLLVT 438

  Fly   597 WDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSELCQ--- 658
            :|.:.|.|:...........||||..:.:|..|.....|:...:|....::|||......|.   
Mouse   439 FDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCGSGC 503

  Fly   659 VENSAEME-------FGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCNC 716
            |:|..:.:       ||.|.|  ..|.|         .:..|.:|....:..|.:.:|:.|.|:.
Mouse   504 VDNCTQCDAATEALYFGSDYC--GFLNK---------TDGPLWECGTVVDATAFVHSCVYDLCSV 557

  Fly   717 ANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEIC--PISCGFGRVYQACGPNVEPTCDSDL 779
            .:.   .:..|.||...|..|...||.: ..||....|  .:.|.....|..|..:...|| |||
Mouse   558 RDN---GTLLCQAIQAYALVCQALGIPI-GDWRIQTGCVSTVRCPSFSHYSVCTSSCPDTC-SDL 617

  Fly   780 ALPASKGA---CNEGCFCPEGTVQYKEACITRELCPCSLRGK-----EFKPESTVKKNCNT-CTC 835
            .  ||:..   |.|||.|.||.|.....|:....|.|...|.     ||   .....||.. |.|
Mouse   618 T--ASQNCATPCTEGCECNEGFVLSTSQCVPLHKCGCDFDGHYYTMGEF---FWATANCTVQCLC 677

  Fly   836 -KNGQWRCTEDKC--GARCGAVGDPHYQ-------------------TFDGKRYDFMGKCSYHLL 878
             :.|...|....|  |..| ||.| .||                   ||||..|.|..:.||.||
Mouse   678 EEGGDVYCFNKTCRSGEVC-AVED-GYQGCFPKRETVCLLSQNQVLHTFDGAAYAFPSELSYTLL 740

  Fly   879 KTQNTSVEAENVACSGAVSESMNFAAPD-DPSCTKAVTIRFILRDGTPSVIKLD--QGLTTIVND 940
            ||.....|...:        .:|...|| .|:..:.|  |.::.|   ..:|:.  ..|...:|.
Mouse   741 KTCPERPEYLEI--------DINKKKPDAGPAWLRGV--RILVAD---QEVKIGGVGALEVKLNG 792

  Fly   941 KPIAKLPKMLGLGEVLIRRASSTFLTVEFADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSN 1005
            :.: :||.....|.:.|.|..:: .|||....:.|.:..|..:||.........|.||||.||:|
Mouse   793 QDV-ELPFFHPSGRLEIHRNKNS-TTVESKGVVSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNAN 855

  Fly  1006 TQDDFLTPEGDVETAVEPFADKWRT-KDTCQ------FKAETHQGPHPCTLNPE--KKAQAEKFC 1061
            ..|:|..|.|.....:..|.:.|.| ::.|.      .||        |..:.|  |..::...|
Mouse   856 ASDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKA--------CNNDSELLKFYRSRSRC 912

  Fly  1062 DWILQD----IFQDCHFLVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQGVKTG-WR 1121
            . |:.|    .|.:||.:|....:|..||:..|......|: .|..::.|.:.|....|:.| ||
Mouse   913 G-IINDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESE-LCDSVARYASACKNADVEVGPWR 975

  Fly  1122 MSVKECAVKCPLGQVFDECGDGCALSCDDLPSKGSCKRECVEGCRCPHGEYVNEDGECVPKKMCH 1186
             :...|.::||....|:||.. |..:|:.|.....|...|.|||:|..| |..:..:|||:..|.
Mouse   976 -TYDFCPLECPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEG-YALQGSQCVPRSECG 1037

  Fly  1187 CNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTK 1251
            |||:|       .::...|.|          |..||                  |....|     
Mouse  1038 CNFEG-------HQLATNETF----------WVDQD------------------CQIFCY----- 1062

  Fly  1252 CAPKEPKTCKNMDKYV-ADSSDCLPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKE 1315
                    |...|..| .::..|.....|||                    .:|..|        
Mouse  1063 --------CNGTDNSVHCETIPCRDDEYCME--------------------ESGLYY-------- 1091

  Fly  1316 DCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFDFQGACDYVL----AKGVFDNGDGFS 1376
                |:.|.          :::|.|.|..|:.||||:.||||.:|..:|    ::.:.|:...|.
Mouse  1092 ----CQPRT----------DASCIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSRPISDSFPKFI 1142

  Fly  1377 ITIQNVLCGTMGVTCSKSLEIALTGHA-------EESLLLSADSAYSTDPNKTPIKKLRDSVNSK 1434
            :|.:|...........|.:::.:.|::       :.::|::.:..|      .|:|        .
Mouse  1143 VTAKNEDRDPSLALWVKQVDVNVFGYSIVIHRAYKHTVLVNNERLY------LPLK--------L 1193

  Fly  1435 GHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSM 1499
            |....:|:..|..||||. ...|:|.:|..|.:.:.:....:....||||.||||..||::.| |
Mouse  1194 GQGKINIFSFGFHVVVET-DFGLKVVYDWKTFLSITVPRSMQNGTYGLCGRYNGNPDDDLEMP-M 1256

  Fly  1500 GLETSPML----FGHAW-KLQPHCSAPVAPIDACKKHPERETWAQLK--CGALKSDL--FKECHA 1555
            ||   |.|    ||.:| |....|.  |...|.|....:.|.:::::  |..:.:..  |.:||:
Mouse  1257 GL---PALSINEFGQSWVKRDTFCQ--VGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAGFAKCHS 1316

  Fly  1556 EVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIR-WRSQHFCPMQCDPHCSDY 1619
            :|....|:|.|:||:|.  .||..:..|:.:..||..|..:||.:. ||:...|.:.|.|: |.|
Mouse  1317 KVNPTFFYKNCLFDSCI--DGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTSCSVTCPPN-SHY 1378

  Fly  1620 KACT----PACAV----ETCDNFLDQGIAERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCVPKA 1676
            ::|.    |.||.    ..|:::              |:|||.   |:.|:: ||.  :.|:...
Mouse  1379 ESCVSVCQPRCAAIRLKSDCNHY--------------CVEGCQ---CDAGYV-LNG--KSCILPH 1423

  Fly  1677 ECKPVCMVRDGK------TFYEGDITFTDSCATCRCSKRK------------EIC---SGVK-CD 1719
            .|.  | ..|||      .|:.||.|     ..|||.:|.            |.|   |||: |.
Mouse  1424 NCG--C-YSDGKYYEPKQLFWNGDCT-----RRCRCFRRNLIQCDPRQCKSDEECALRSGVRGCF 1480

  Fly  1720 VPATT------GLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRY 1778
            ...|:      |......:|..|..|      ..|....:..|.|..|.|.:.:...|:...|..
Mouse  1481 STKTSYCLAAGGGVFRTFDGAFLRFP------ANCAFVLSTICQKLPDISFQLIINFDKWSSPNL 1539

  Fly  1779 DRMENVYGTCLKQYMTKVECRVKDTHEAP---EQMDENVVCSL------EEGLRCIGKCHDYELR 1834
            ..:..||     .|:.:.:..:.|.:...   .|::...:..|      .||...|....|.:: 
Mouse  1540 TIISPVY-----FYINEEQILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQI- 1598

  Fly  1835 AFCQCDEELEPELPKPTEKPQLGLACDAAVVEYKEFPGD-CHKFLHCQPKGVEGGWIYVEK---- 1894
             :......::..:.:..:....|| |.       .|.|| ...::..:.|.|....:..:.    
Mouse  1599 -YYNGFNVIKISISERLQNKVCGL-CG-------NFNGDMTDDYVTLRGKPVVSSVVLAQSWKTN 1654

  Fly  1895 ---------TCGEYMMFNPTMLICDHI-----------ATVTEIK----PNCGLKPEPEPEFEPI 1935
                     :|.| :.|:.....||::           ..:|::|    |..||. :|.|.:|  
Mouse  1655 GMQKRPLAPSCNE-LQFSQYAATCDNVHIQAMQGDGYCLKLTDMKGFFQPCYGLL-DPLPFYE-- 1715

  Fly  1936 KQCPPGKIKSECANQCENTCHYYGSILKKR-----GLCQVGEHCKPGCVDELRPDCPKLGKFWRD 1995
                              :|:..|....|:     .|...||.|:...:         |...|.:
Mouse  1716 ------------------SCYLDGCYNHKKFQLCGSLAAYGEACRSFGI---------LSTEWIE 1753

  Fly  1996 --------EDTCVHADECP---C-MDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPKD 2048
                    ||.||.|| ||   | :|...             |:|.||:         |.|...:
Mouse  1754 KENCSGVVEDPCVGAD-CPNRTCELDNGG-------------ELCGCIE---------PPPYGNN 1795

  Fly  2049 EDDDLD 2054
            ..|.:|
Mouse  1796 SHDIID 1801

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 34/168 (20%)
C8 680..754 CDD:285899 15/73 (21%)
TIL 758..811 CDD:280072 19/55 (35%)
VWD 840..1015 CDD:214566 55/198 (28%)
C8 1054..1121 CDD:214843 17/71 (24%)
TIL 1131..1185 CDD:280072 19/53 (36%)
TIL 1245..1298 CDD:280072 8/53 (15%)
VWD 1327..1498 CDD:214566 45/181 (25%)
C8 1535..1609 CDD:214843 22/78 (28%)
Mucin2_WxxW 1751..1837 CDD:290069 16/94 (17%)
TIL 1938..2005 CDD:280072 15/79 (19%)
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
TectaNP_001365531.1 NIDO 98..254 CDD:214712
VWD 322..478 CDD:395046 34/168 (20%)
C8 517..591 CDD:214843 21/88 (24%)
TIL 597..650 CDD:410995 19/55 (35%)
VWC 652..706 CDD:327433 18/58 (31%)
VWD 703..865 CDD:214566 47/176 (27%)
C8 905..981 CDD:214843 19/78 (24%)
TIL 984..1036 CDD:410995 19/53 (36%)
VWD 1100..1258 CDD:395046 47/173 (27%)
C8 1300..1368 CDD:400886 21/69 (30%)
TIL 1372..1425 CDD:410995 18/73 (25%)
VWD 1487..1639 CDD:395046 27/172 (16%)
C8 1685..1757 CDD:214843 17/101 (17%)
ZP 1805..2059 CDD:214579
FXa_inhibition 2089..2121 CDD:405372
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
21.860

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