DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and R11G1.1

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:NP_001361923.1 Gene:R11G1.1 / 187815 WormBaseID:WBGene00020010 Length:1745 Species:Caenorhabditis elegans


Alignment Length:1489 Identity:281/1489 - (18%)
Similarity:455/1489 - (30%) Gaps:593/1489 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1671 DCVPKAECKPVCMVRDGKT---------FYEGDITFTDSCATCRCSKRKEICSGVKCDVPATTGL 1726
            || ...:|.|:...||||.         .:.|.:    ||....|:..|:   .:.|.|      
 Worm    39 DC-GLGQCVPISQFRDGKPDCMDGSDEWCFIGQV----SCGPVYCADYKD---ALPCIV------ 89

  Fly  1727 PAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTC-LK 1790
             .|..:|::...|               ||     ::.|.....||...|.     ..||.| |.
 Worm    90 -YPKCDGSSKQLP---------------WC-----STSKEKLCADETSFPC-----KGYGECVLW 128

  Fly  1791 QYMTKVECRVKDTHEAPEQMDENVVCSLEEGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQ 1855
            :::...:   ||.::..:: |||.|..||...||........|.         :|..|.|.:.|.
 Worm   129 EWLLDGK---KDCNDGSDE-DENYVMPLEHAYRCARNQSGLYLP---------KPVPPPPEDHPS 180

  Fly  1856 LGL-ACDAA------------VVEYKE-----------------------FPGDCHKF--LHCQP 1882
            |.: .|...            |::|..                       ||.:..|.  ...:|
 Worm   181 LYVEGCSMCSKPSTVTLPSNPVIDYTTPKYPFITSPLLGNTKPPLSNFPVFPSEESKLGDFFPEP 245

  Fly  1883 KGVE----GGWIYVEKTCGEYMMFN------PTMLICD----HIATVTEIK----PNCGLKPEPE 1929
            .|||    .|:....:..|::...:      ||..:..    .:.|:..|.    |...|.....
 Worm   246 SGVEISRVTGFHKPNEPIGDFFPTHSSTPVPPTEAVTQSHTFRLITIPSISQTQFPQAPLIFPGR 310

  Fly  1930 PEFEPIKQCPPGKIKSECANQCENT--CHYYGSI------LKKRGLCQVGEHCKPGC-----VDE 1981
            |:..||  ..|..:.:........|  .|:.|.:      ..:.|..:: ...|||.     |..
 Worm   311 PDLPPI--TAPSPLNNWPIPIVTTTPDPHHQGPLPPITYPTIEEGSEKI-PPIKPGIIISRPVTS 372

  Fly  1982 LRPDCPKLGKFWRDEDTCVHADECPCMDKAEHYVQPHKPVL--GEFEVCQCIDNAFTCVP----- 2039
            .:||.|  .:|.....|.....:.|.|:..:...:|..|:.  |.|::       |..||     
 Worm   373 RKPDLP--SEFEYGGGTGDGISQPPGMNPFDMLTRPSVPMTTPGPFDM-------FPNVPPVDLR 428

  Fly  2040 ----------NKPEP---VPKDEDDDLD-LVSVVP--IYPVTLTP-PLQC--------SPERLIP 2079
                      .||.|   :|.::....| |:.::|  |.|...|| ||..        ||.|  |
 Worm   429 PVTRPWESEKTKPYPGVTIPDEQKSGTDTLIPLIPGRILPTFATPRPLSIPSFFTTPQSPHR--P 491

  Fly  2080 KI-ENPAH-SLPDSIFNA------SSQLAPEHGPKMARLTKEQPRGSWS--------PSINDQMQ 2128
            .: :||.| :||..|..|      .:::.|..|       .|.|.|.::        ||      
 Worm   492 FVTQNPPHGALPTLIPQAEIEKYVQTEVPPHSG-------FEIPGGGFTTPGSHITHPS------ 543

  Fly  2129 YLELNFAKPEPFYGVVMAGSPEFDNYVTL------------------FKILH-SHDGIAYHYLVD 2174
                  ..||.|.......:|..:|..|.                  .||:| ..:|:...  :|
 Worm   544 ------KVPEGFIEEKTLLTPSTNNAQTTQIDRNLTPKTTTLKATSRTKIIHVGPNGVVEE--ID 600

  Fly  2175 ETEKPQMFN----GPLDSRAPVQTLFKIPIEASSLRIYPLKWHGSIAMRVELLICGDKEEPKPVP 2235
            ..|..::.|    |..:.:.       :|.....:.|.|..                |..|.|..
 Worm   601 NNESTKIENETNLGEHEGQI-------VPGSDKVIHIGPTV----------------KTTPTPSS 642

  Fly  2236 TVSTILPITERPARL-------------------VDLECIDLMGVDEGKMYQDQVQSSSLWQQPN 2281
            ..|||  :||..:..                   || :|:..|. |.|        .|.:...||
 Worm   643 GTSTI--VTENSSTFESVSTSSVPTTTVKTGDPQVD-DCLRRMS-DSG--------GSVICDCPN 695

  Fly  2282 LGKKLQLLELLKLSTPLAWRPLANSQNEFIEFDFLEPRNISGFVTKGGPDGWVTGYKVMFSKKKP 2346
             |:               ::...|.|.|         ..:|..|.|         .||       
 Worm   696 -GQ---------------FKNTGNGQCE---------ETLSLVVVK---------VKV------- 719

  Fly  2347 TWNTVLSTD---------------GQAR---IFEANHDA--------------ETERRHHFKNPI 2379
              |||.:||               ||:.   |..|.||:              |.:|       :
 Worm   720 --NTVCNTDKASLEQKQRILHQKIGQSYKSCIRSAEHDSALVAIVQCSDCTLQEIDR-------L 775

  Fly  2380 LTQYIKIVPAYWEK-NINMRIEPLG-----------------CFLPYPEIQRQVPVEESKPTKCN 2426
            ||     ..::.|. |:|:..|.||                 |.|.          :|:....|.
 Worm   776 LT-----TRSFGEPGNLNLTAEALGTDLCSNSEFNHCHVYSDCILD----------DENLRYACK 825

  Fly  2427 ICDGVSTSSSTTGCQCQDQLFWDGNTCVQ-HNLCPCIENYVSYPIGSKFENSACEDCVCVLGGHK 2490
            ...|.:.||...|..|:.  |.:.:.||. ..:|..:  ::.:.:||.|.:...  |:.      
 Worm   826 CKKGTTDSSDGYGRSCEG--FPEESDCVMVFGICLIV--WLIFLLGSFFLSLLA--CIA------ 878

  Fly  2491 NCKPKKCPPCLGGKLRPVITSDCFCKC-EPCPKHQRLCPSSGDCIPEILWCNGVQDCADDEDASC 2554
                                  |:..| :.|.::..:.|::.|         |:|.....:.|:.
 Worm   879 ----------------------CYALCRKRCCRYIAIHPANAD---------GLQTVVVGQKAAK 912

  Fly  2555 SDSFTVEPDVSREKNETEVITCPVPVCPPQMKIRITE--KKSRKMSKMFTFSKQVSIVDDGTTIT 2617
            |    :|.|.:|||             .|.||....|  |.|.|                |:|..
 Worm   913 S----LEMDGNREK-------------LPHMKAIFAESLKHSAK----------------GSTSV 944

  Fly  2618 KTKFISS---KEQILAMPNRELDFQLEEQCDEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVELD 2679
            .:.|..:   ::::...|:..   |:.|:.:|     .|:..:..:|::    ||......:...
 Worm   945 ASAFALADFKRKKVSRPPDMS---QVIEEVNE-----NPTASIHNSESL----PKVSSLAKISTH 997

  Fly  2680 MSASK----VGDCLRYSCVLRPNKDDVCEISGK---------------------SFTTFDGTVFK 2719
            .:.|:    ||  :..:.:|..|...|..:|..                     |.|..:.|..|
 Worm   998 TANSEPPTPVG--VIETPILEKNSSSVSLVSANDNAPQLPSLPLPLPVPITTSASTTNLEETTGK 1060

  Fly  2720 Y-----GPCSHILARDIH-------SSSWSISVHQQCSDETRKVCHKVITIQDTEAGNELILLPH 2772
            .     |..||..|::..       :||.|:.| |....||.:|..:..:..|         |..
 Worm  1061 ENGREGGGGSHASAQEQQVPETERPASSHSVGV-QPTIWETYRVLGQQYSKSD---------LTE 1115

  Fly  2773 LKLKFNGYEFTVQQLINSPICKASFVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSKFIRTV 2837
            .|...:    :::|:..:.:.:    .|:..||:..|.|.     :.|:..|:   .::|     
 Worm  1116 RKASVD----SLEQMFEARLAE----TSRTTKTIPTVRTD-----KSDNSAII---FTAK----- 1159

  Fly  2838 DGLCGYYNGNQK------DDKRSPDGQIIPNTEKFGDSWYDKRIPKDQCGDLKCPREMQ 2890
                .|....:|      :.|::||...: |.||          |.|...|:|...|.|
 Worm  1160 ----PYKKDTEKPTLVSEETKKTPDNAEV-NLEK----------PSDTTQDIKQNLEEQ 1203

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843
TIL 1131..1185 CDD:280072
TIL 1245..1298 CDD:280072
VWD 1327..1498 CDD:214566
C8 1535..1609 CDD:214843
Mucin2_WxxW 1751..1837 CDD:290069 21/86 (24%)
TIL 1938..2005 CDD:280072 14/79 (18%)
FA58C 2089..2223 CDD:238014 27/170 (16%)
FA58C 2104..2225 CDD:214572 23/151 (15%)
FA58C <2299..2404 CDD:214572 29/154 (19%)
FA58C <2299..2403 CDD:238014 27/136 (20%)
VWD 2703..2858 CDD:295339 34/193 (18%)
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
R11G1.1NP_001361923.1 LDLa 32..64 CDD:197566 8/25 (32%)
LDLa 113..145 CDD:238060 9/40 (23%)
PHA03247 <268..594 CDD:223021 72/358 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.