DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hml and F19C6.3

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	NP_509679.1	Gene:	F19C6.3 / 184675	WormBaseID:	WBGene00008952	Length:	429	Species:	Caenorhabditis elegans

Alignment Length:	391	Identity:	78/391 - (19%)
Similarity:	110/391 - (28%)	Gaps:	167/391 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly  3303 ICTNWRRPQLCPY----------ECPSDMV---------------YEPCGCAKNCDTIKALSEFD 3342
            |..||:.|:...:          :|..|.|               |||             |..|
Worm   145 IVDNWKGPEPTQFLIGSGWPIGQKCKHDGVKKKYADAYTEKIERNYEP-------------SAID 196

  Fly  3343 AVSLKNEAVVHTVKTDEMCLSSERFEGCFCPPGKVMDGGQCVPEIACTKCDDGLHLPDEKWKKDK 3407
            |:   ||....||..              .|||  .||        | |.::.| |...:.|...
Worm   197 AI---NEIFFETVVQ--------------VPPG--FDG--------C-KINNAL-LNINETKTVN 232

  Fly  3408 CTECQCDSKGKTTCVEKKCQVEENICAEGYRPETIVSVDECCPRYRCVPETKDPSKLCLAPLVPI 3472
            |..|.|..:....|....|...  .|.     ..::..|:|||.
Worm   233 CNTCTCVDRDNVVCQAVDCPAV--TCT-----HPMIRKDDCCPS--------------------- 269

  Fly  3473 CGPGQFKKEKKDVNGCSQ-------YICECIPKDQCEIIELRELLPGEIIVNVEEGCCPTQKIEC 3530
            ||...|.:..|..|...:       |.|:|..|                     :..|.::...|
Worm   270 CGEQCFYESHKIANPHGEVFWPGDCYRCQCWDK---------------------KVHCSSEYATC 313

  Fly  3531 KPETCPKAPVNCQERFYEVKTIKEPGMCCSKHSCVPPKDLCIVQYELDEATKFTKTVGDK----- 3590
            :|.:||:......|:|          .||.|  |......|.|:.....||......|.|
Worm   314 EPPSCPEEDWVYNEKF----------NCCPK--CRDFARFCAVKPCHKYATCTDSKRGPKCSCDT 366

  Fly  3591 -----WTHAKEVCKQETCSYGPDGNAQVVSTLEQCLT-------------DCAPGFSYQNLDKTK 3637
                 .|:.:::   :.||:..|...|    |..||:             ||.||  ||.:.:..
Worm   367 GFQGNGTYCEDI---DECSFSQDAKEQ----LGGCLSGSTCRNVPGSYKCDCLPG--YQMIGENT 422

  Fly  3638 C 3638
            |
Worm   423 C 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899	4/9 (44%)
		VWC	3397..3451	CDD:302663	11/53 (21%)
		GHB_like	<3755..3813	CDD:304424
F19C6.3	NP_509679.1	VWC	216..270	CDD:214564	15/83 (18%)
		EGF_3	346..375	CDD:289699	5/28 (18%)
		EGF_CA	377..416	CDD:214542	11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900