DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and Nefm

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:NP_032717.2 Gene:Nefm / 18040 MGIID:97314 Length:848 Species:Mus musculus


Alignment Length:284 Identity:56/284 - (19%)
Similarity:88/284 - (30%) Gaps:105/284 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1767 VRLNDEEK--------------VPRYDRMENVYGTCLKQYMTKVE---------------CRVKD 1802
            :|.|.||:              |.|.|.::....|.||:..:::|               ||...
Mouse   232 LRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLECHSDQNMHQAEEWFKCRYAK 296

  Fly  1803 THEAPEQMDENVVC---------------------------SLEEGLRCIGKCHDYELRAFCQCD 1840
            ..||.||..|.:..                           |||..|..|.:.|:::|.::....
Mouse   297 LTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTI 361

  Fly  1841 EELEPE-----------LPKPTEKPQLGLACDAAVVEYKE-----------FPGDC--HKFLHCQ 1881
            ::||.|           |.:..:...:.:|.|..:..|::           |.|..  ..:.|.|
Mouse   362 QQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQ 426

  Fly  1882 PKGVEGGWI---------------YVEKTCGE--------YMMFNPTMLICDHIATVTEIKPNCG 1923
            |.......|               :||:...|        .|....|.:..:..|:..|.|....
Mouse   427 PSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEETLTAIAEELAASAKEEKEEAE 491

  Fly  1924 LK-PEPEPEFEPIKQCPPGKIKSE 1946
            .| .|||.|..|:|. |..|.:.|
Mouse   492 EKEEEPEAEKSPVKS-PEAKEEEE 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843
TIL 1131..1185 CDD:280072
TIL 1245..1298 CDD:280072
VWD 1327..1498 CDD:214566
C8 1535..1609 CDD:214843
Mucin2_WxxW 1751..1837 CDD:290069 25/125 (20%)
TIL 1938..2005 CDD:280072 3/9 (33%)
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
NefmNP_032717.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51
Head 2..102
Filament_head 10..97 CDD:282575
Filament 98..409 CDD:278467 32/176 (18%)
Coil 1A 103..134
Linker 1 135..147
Coil 1B 148..246 4/13 (31%)
Linker 12 247..263 3/15 (20%)
Coil 2A 264..285 4/20 (20%)
Linker 2 286..289 0/2 (0%)
Coil 2B 290..410 21/119 (18%)
Tail 411..848 24/105 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..785 12/34 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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