DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and Muc2

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:NP_076055.4 Gene:Muc2 / 17831 MGIID:1339364 Length:4576 Species:Mus musculus


Alignment Length:1482 Identity:434/1482 - (29%)
Similarity:666/1482 - (44%) Gaps:225/1482 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   481 RPALCTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSG--TFDIILKACPYGSGYGCAHTLKILW 543
            |..:|:|||..:.|||||.|::.|..|.:...:|....  .|.:.||.   |.|....|: :|  
Mouse    30 RNHVCSTWGDFHYKTFDGDVYRFPGLCDYNFASDCRDSYKEFAVHLKR---GLGEAGGHS-QI-- 88

  Fly   544 QSVLYTFEN-----------LNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESVGLKLDW 597
            :|:|.|.::           :||.|..|        |....|:.:.....:.:: ....||.|.|
Mouse    89 ESILITIKDDTIYLTHKLAVVNGAMVST--------PHYSSGLLIEKNDAYTKV-YSRAGLSLMW 144

  Fly   598 DHRQYVSVQAGPQMWGKVGGLCGTLDG-DPNTDLTSRTGKKLATVKAFADAWRVEDRSELCQVEN 661
            :....:.|:...:......||||..:| ..|.:..|..|.:.:.:: |.:..::......|:...
Mouse   145 NREDALMVELDSRFQNHTCGLCGDFNGMQTNYEFLSEEGIQFSAIE-FGNMQKINKPEVQCEDPE 208

  Fly   662 SAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCNCANREHPE--S 724
            :.:..   :||.:.:.:     |||||.:....||......::.:|.||.|.|.|     |:  :
Mouse   209 AVQEP---ESCSEHRAE-----CERLLTSAAFEDCQTRVPVESYVRACMHDRCQC-----PKGGA 260

  Fly   725 CNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVY-QACGPNVEPTCDSDLALPASKGAC 788
            |.|..:|..:::|:..|.:.|: ||...:||..|....|| ::..|.|: || |.|.:   ...|
Mouse   261 CECSTLAEFSRQCSHAGGRPEN-WRTASLCPKKCPNNMVYLESSSPCVD-TC-SHLEV---SSLC 319

  Fly   789 NE----GCFCPEGTVQYKE----ACITRELCPCSLRGKEFKPESTVKKNCNTCTCKNGQWRCTED 845
            .|    ||||||||| |.:    .||....|.|.|.|..:.|......:|..|.|..|:|.|.:.
Mouse   320 EEHYMDGCFCPEGTV-YDDITGSGCIPVSQCHCKLHGHLYMPGQEFTNDCEQCVCNAGRWVCKDL 383

  Fly   846 KCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQNTSVEAENVACSGAVSESMNFAAPDDPSC 910
            .|...|...|..|..|||||::.|.|.|.|.|.|:::....|       .:.|..:..:.|..:|
Mouse   384 PCPETCALEGGSHITTFDGKKFTFHGDCYYVLTKSEHNDSYA-------LLGELASCGSTDKQTC 441

  Fly   911 TKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFLTVEFADGIRV 975
            .|.|.   :|.|...:|:....|.:.::|:..:. ||.:  .....|.:.||..:.|....|:|:
Mouse   442 LKTVV---LLTDDKKNVVAFKSGGSVLLNEMEVT-LPHV--AASFSIFQPSSYHIVVNTKFGLRL 500

  Fly   976 WWD--GVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRTKDTCQFKA 1038
            ...  .|.::::....:.:||.|||||.||....|||:|..|.||.....||:.|:.:.:|..|.
Mouse   501 QIQLLPVMQLFVTLDQAAQGQVQGLCGNFNGLESDDFMTSGGMVEATGAGFANTWKAQSSCHDKL 565

  Fly  1039 ETHQGPHPCTLNPEKKAQAEKFCDWI--LQDIFQDCHFLVEPEQFYEDCLYDTCACKDEMSKCFC 1101
            :...  .||:||.|....||.:|..:  .:..|..||..|:|.::|:.|.||||.|::. ..|.|
Mouse   566 DWLD--DPCSLNIESANYAEHWCSLLKRSETPFARCHLAVDPTEYYKRCKYDTCNCQNN-EDCMC 627

  Fly  1102 PILSAYGTECMRQGVKT-GWRMSVKECAV-KCPLGQVFDECGDGCALSCDDLPSKGSCKREC--- 1161
            ..||:|...|..:||.. |||..|....| .||..|:|......|..:|..| |:|.  ..|   
Mouse   628 AALSSYARACAAKGVMLWGWRERVCNKDVHACPSSQIFMYNLTTCQQTCRSL-SEGD--SHCLKG 689

  Fly  1162 ---VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDA 1223
               ||||.||...:::|.|.|||...|.|...|:....|...:|..|:    |.|.:|...|...
Mouse   690 FAPVEGCGCPDHTFMDEKGRCVPLAKCSCYHHGLYLEAGDVILRQEER----CICRNGRLQCTQV 750

  Fly  1224 E-PGDKDKYP----PSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYVAD--SSDCLPGCVCME 1281
            : .|...:||    ..:.|.:...::|          .|.:|:.:   ||.  .::|:.||||.:
Mouse   751 KLIGHTCQYPKILVDCNNLTALAVRKP----------RPTSCQTL---VAGYYHTECISGCVCPD 802

  Fly  1282 GYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDC-NLCECRAGNWKCSKNGCESTCSVWGDSH 1345
            | :.|..|..||....|.|.|....|..||.||.|| |.|.|:.|.|:|::..|.||||::|..|
Mouse   803 G-LLDDGRGGCVEEDKCPCIHNKDLYSSGESIKLDCNNTCTCQKGRWECTRYACHSTCSIYGSGH 866

  Fly  1346 FTTFDGHDFDFQGACDYVLAKGVF-DNGDG-FSITIQNVLCGTMGVTCSKSLEIALTGHAEESLL 1408
            :.||||..:||.|.|.||..:... .|..| |||..:||.|||.||||||:::|.: |..|..|:
Mouse   867 YITFDGKHYDFDGHCSYVAVQDYCGQNSTGSFSIITENVPCGTTGVTCSKAIKIFI-GGTELKLV 930

  Fly  1409 LSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYK-AGVFVVVEVIPLKLQVKWDEGTRVYVKLG 1472
                     |.::. :|:|.:     ||:..:|.: .|.::|||. ...:.|.||:.|.:::||.
Mouse   931 ---------DKHRV-VKQLEE-----GHHVPYITREVGQYLVVEA-SSGIIVIWDKKTTIFIKLD 979

  Fly  1473 NEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERETW 1537
            ..::..|.|||||::..:.:|..|....:.||.:.||::||....|.......|.|..:|.|.:|
Mouse   980 PSYKGTVCGLCGNFDDQTKNDFTTRDHMVVTSELDFGNSWKEASTCPDVSHNPDPCSLNPHRRSW 1044

  Fly  1538 AQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRW 1602
            |:.:|..:||.:||.||::|....|::.|:.|:|:||.||||:|.|:|||:||..|.:....:.|
Mouse  1045 AEKQCSIIKSRVFKVCHSKVDPTVFYEACVHDSCSCDTGGDCDCFCSAVASYAQECTKAEACVFW 1109

  Fly  1603 RSQHFCPMQCD-----PHCS-DYKACTPACAVETCDNFLDQGIAERMCNRENCLEGCHIKPCEDG 1661
            |:...||:.||     ..|. .|:.|... :.|||...  .||...:  ..:.||||:.:..||.
Mouse  1110 RTPDLCPIFCDYYNPPDECEWHYEPCGNR-SFETCRTL--NGIHSNI--SVSYLEGCYPRCPEDR 1169

  Fly  1662 FIYLNDTYRDCVPKAECKPVCMVRDGKTFYEGDITFTDSCATCRCSKRKEI-C------------ 1713
            .|| ::..:.||...:|.  |.:.|.:....|.:...:.|.:|.|:...:| |            
Mouse  1170 PIY-DEDLKKCVTGDKCG--CYIEDTRYPPGGSVPTDEICKSCTCTNTSKIECHPDEGKILNMTQ 1231

  Fly  1714 SGVKC----------------DVPATTGLPAPLVEGTTLPTPLA---------------TQNQTK 1747
            .|:.|                ...::|.:|:.....||:.||::               |..|..
Mouse  1232 DGIFCYWEFCGPNGTVGQHFNICGSSTAIPSTTTSFTTISTPISTTPISTTITTTTVTMTTEQVP 1296

  Fly  1748 CVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTKVECR-VKDTHEAPEQMD 1811
            |. .|:.|.:|...|.:..   .|.|..           |.:......:||| ..|...:.|::.
Mouse  1297 CC-FWSDWINKYHPTKENG---GDRETF-----------THVCSAPEDIECRAATDPKLSWEELG 1346

  Fly  1812 ENVVCSLEEGLRC-------IGK---CHDYELRAFCQC--DEELEPELPKPT 1851
            :.|.|::..||.|       ||:   |:|||:|..| |  .|...|....||
Mouse  1347 QKVQCNVSTGLICNNEDQYGIGEFELCYDYEIRVNC-CYPMEYCTPSTISPT 1397

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 41/164 (25%)
C8 680..754 CDD:285899 22/75 (29%)
TIL 758..811 CDD:280072 23/61 (38%)
VWD 840..1015 CDD:214566 50/176 (28%)
C8 1054..1121 CDD:214843 24/69 (35%)
TIL 1131..1185 CDD:280072 21/59 (36%)
TIL 1245..1298 CDD:280072 15/54 (28%)
VWD 1327..1498 CDD:214566 63/173 (36%)
C8 1535..1609 CDD:214843 30/73 (41%)
Mucin2_WxxW 1751..1837 CDD:290069 24/96 (25%)
TIL 1938..2005 CDD:280072
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
Muc2NP_076055.4 VWD 34..183 CDD:395046 41/163 (25%)
C8 223..289 CDD:400886 22/71 (31%)
TIL 293..349 CDD:410995 23/61 (38%)
VWD 389..543 CDD:395046 47/166 (28%)
C8 580..649 CDD:214843 25/69 (36%)
VWD 848..1006 CDD:214566 63/174 (36%)
C8 1044..1116 CDD:214843 30/71 (42%)
Mucin2_WxxW 1300..1382 CDD:404246 24/95 (25%)
Mucin2_WxxW 2877..2965 CDD:404246
PARM <3553..>3644 CDD:407229
VWD 3872..4039 CDD:214566
C8 4089..4151 CDD:400886
VWC 4322..4386 CDD:214564
CT 4474..4553 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 144 1.000 Domainoid score I4579
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm44206
orthoMCL 1 0.900 - - OOG6_100854
Panther 1 1.100 - - O PTHR11339
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.920

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