DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hml and COCH

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	NP_001334649.1	Gene:	COCH / 1690	HGNCID:	2180	Length:	615	Species:	Homo sapiens

Alignment Length:	406	Identity:	82/406 - (20%)
Similarity:	130/406 - (32%)	Gaps:	154/406 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2976 SPLVHTDCYKRRCEPSCDNVHGDDCPVLPDACFPGCYCPEGTVRKGPNCVPISECKDC------- 3033
            :|:..| |:.|..:     :..:...||   |..||...|.:|.  .|.|..|....|
Human    93 APIAIT-CFTRGLD-----IRKEKADVL---CPGGCPLEEFSVY--GNIVYASVSSICGAAVHRG 146

  Fly  3034 -VCNSLGASK-YMTYDRKSFS---FNGNCTYLLSRDVVLPGVHTFQVYVSMDDCKKLGQPTPVEG 3093
             :.||.|..: |....|:::|   .||..:.:|||            :.:.....|....|....
Human   147 VISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSR------------WSASFTVTKGKSSTQEAT 199

  Fly  3094 GSCAKSLHILNGDHVIHVQRVPQK-------PKSLQVLVDG--------FEVKKIPYKDSWISLR 3143
            |....:.|...|.   .:::.|:|       ...:..|:||        |.::|
Human   200 GQAVSTAHPPTGK---RLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQK----------- 250

  Fly  3144 QVVGK-ELVLSLPES--HVELT---------------ASFEDLIFSLGVPSIKYGSKMEGLCGDC 3190
            ..||| .|:|.:...  ||.|.               .|.:|::|::         |..|..|.
Human   251 NFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAI---------KEVGFRGG- 305

  Fly  3191 NGNAGNDLQPNPAKKKAGVDV-------------IQSWQADEPKLGLVEECLSEDVPKEHCI--- 3239
            |.|.|..|: :.|:|...||.             |..|.:|:     :||  :..|.:|..:
Human   306 NSNTGKALK-HTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDD-----IEE--AGIVAREFGVNVF 362

  Fly  3240 ------PLPPE-----------KDPC-----LQFYNAELFGKCPLAVDPIAYVSACQQDICKPGN 3282
                  |:|.|           |..|     ..::....||       ...||....|.:|   .
Human   363 IVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFG-------TTKYVKPLVQKLC---T 417

  Fly  3283 TQQGVCVALAAYAKEC 3298
            .:|.:|      :|.|
Human   418 HEQMMC------SKTC 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072	14/53 (26%)
		VWD	3035..3198	CDD:295339	40/199 (20%)
		C8	3257..3313	CDD:285899	10/42 (24%)
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
COCH	NP_001334649.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900