DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and BMPER

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:NP_001352237.1 Gene:BMPER / 168667 HGNCID:24154 Length:685 Species:Homo sapiens


Alignment Length:682 Identity:172/682 - (25%)
Similarity:261/682 - (38%) Gaps:158/682 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1085 CLYDTCACKDEMSKCFCPILSAYGTECMRQGVKTGWRMSVKECAVKCPLGQVFDECGDGCALSCD 1149
            ||.....||.|.    ||:||   .:|         .:::|:....|      ::| .||....:
Human    72 CLNKEVTCKREK----CPVLS---RDC---------ALAIKQRGACC------EQC-KGCTYEGN 113

  Fly  1150 --------DLPSKGSCKRECVEG------------CRCPHGEYVNEDGECVPKKMC-HCNFDGMS 1193
                    ..|::....|:|.||            |:.|    :...|.|.|  .| .|.|:|:.
Human   114 TYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCVVHCKNP----LEHLGMCCP--TCPGCVFEGVQ 172

  Fly  1194 FRPGYKEVRPGEKFLDLCTCTDGVWDCQD------AEPGDKDKYPPSSELRSKCAKQPYA---EF 1249
            ::.| :|.:|.......|:||.|...|..      :.|......|| .:...||..|...   .|
Human   173 YQEG-EEFQPEGSKCTKCSCTGGRTQCVREVCPILSCPQHLSHIPP-GQCCPKCLGQRKVFDLPF 235

  Fly  1250 TKCAPKEPKTCKNMDKYVADSS---DCLPGCVCMEGYVYDTSRLACVLPANCS------------ 1299
            ..|..:.       |.|...||   |....|.|.:..|  ..:..|..|..|.            
Human   236 GSCLFRS-------DVYDNGSSFLYDNCTACTCRDSTV--VCKRKCSHPGGCDQGQEGCCEECLL 291

  Fly  1300 ---------CHHAGKSYDDGEKIKE-DCNLCECRAGNWKC-----------------SKNGC--- 1334
                     |....|.:.|||.... :|.:|.|..|..:|                 ::.||   
Human   292 RVPPEDIKVCKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKILNRKGCCPI 356

  Fly  1335 ----ESTCSVWGDSHFTTFDGHDFDFQGACDYVLAKGVFDNGDGFSITIQNVLCGTMGVTCSKSL 1395
                ...|:|:||.|:.||||..|:|||.|.|||.|........|.:.::|....|...:.:||:
Human   357 CTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASPFQVLVKNDARRTRSFSWTKSV 421

  Fly  1396 EIALTGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVK 1460
            |:.| |.:..||.......::......|.:.....::..|:......|||           |::.
Human   422 ELVL-GESRVSLQQHLTVRWNGSRIALPCRAPHFHIDLDGYLLKVTTKAG-----------LEIS 474

  Fly  1461 WDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPH--CSAPV- 1522
            ||..:.|.|......:.|:.||||||||:..||:.......:.....|..:|:::.:  |:.|. 
Human   475 WDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDLIGGDGNFKFDVDDFAESWRVESNEFCNRPQR 539

  Fly  1523 API-DACKKHPERETWAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAV 1586
            .|: :.|:...:.:..|..:|..|||..|:.||:.|....|::.|:.|.|.|....:  |.|.:.
Human   540 KPVPELCQGTVKVKLRAHRECQKLKSWEFQTCHSTVDYATFYRSCVTDMCECPVHKN--CYCESF 602

  Fly  1587 AAYADACAQKGINIRWRSQHFC-PMQCDPHCSDYKACTPACAVETCDNFLDQGIAERMCNRENCL 1650
            .||..||.::||.:.|..|..| ..|| .|.:.|..|.|.| ::||||:.:.|    .||:. |:
Human   603 LAYTRACQREGIKVHWEPQQNCAATQC-KHGAVYDTCGPGC-IKTCDNWNEIG----PCNKP-CV 660

  Fly  1651 EGCHIKPCEDGFIYLNDTYRDCVPKAEC-KPV 1681
            .|||   |....:         :.|..| |||
Human   661 AGCH---CPANLV---------LHKGRCIKPV 680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843 10/35 (29%)
TIL 1131..1185 CDD:280072 14/73 (19%)
TIL 1245..1298 CDD:280072 12/58 (21%)
VWD 1327..1498 CDD:214566 52/194 (27%)
C8 1535..1609 CDD:214843 25/74 (34%)
Mucin2_WxxW 1751..1837 CDD:290069
TIL 1938..2005 CDD:280072
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
BMPERNP_001352237.1 VWC 166..224 CDD:278520 14/59 (24%)
VWC 301..357 CDD:327433 12/55 (22%)
VWD 364..508 CDD:306577 48/155 (31%)
C8 560..624 CDD:312319 23/65 (35%)
TIL 629..682 CDD:307783 23/71 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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