DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hml and LOC110439905

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	XP_021333306.1	Gene:	LOC110439905 / 110439905	-ID:	-	Length:	699	Species:	Danio rerio

Alignment Length:	754	Identity:	150/754 - (19%)
Similarity:	235/754 - (31%)	Gaps:	236/754 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1494 MQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERETWAQLKCGALKSDLFKECHAE-- 1556
            :.|.|.|:.|.|:....::....:.|....|   .|..|   |:...|.|...|.....||..
Zfish     9 LTTVSGGMSTPPITKSTSFISSTNTSTSTTP---SKTSP---TFTTSKTGTFTSSPECNCHWSDW 67

  Fly  1557 ---------------VPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRWR--- 1603
                           ||:|...|  .|..|:..:    |..|.|........:|.|..|:..
Zfish    68 NDFGGLTTGPDGGEIVPIETITK--TFHVCSTPK----ELQCRAKRYPGVPVSQLGQVIKCNTID 126

  Fly  1604 -----SQHFCPMQCDPHCSDYKACTPACAVETCDNFLDQ----GIAERMCNRENCLEGCHIKPCE 1659
                 ::|   ......|.||:. ...|..|.|.|...|    ..|....:.:..::.....|.
Zfish   127 GLVCLNRH---QGLTQQCYDYEV-RLFCCDENCGNITTQTSSTDPATMSTSTKETVQSSASGPS- 186

  Fly  1660 DGFIYLNDTYRDCVPKAECKPVCMVRDGKTFYEGDITFT---------DSCATCRCSKRKEICSG 1715
                  |.|....:.:|...|..     .|.....:|.|         .|.:|...::|
Zfish   187 ------NPTTTQAISRATPLPAF-----STVMSTPLTETTSVQNYSSFTSISTTTTTER------ 234

  Fly  1716 VKCDVPATTGLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDR 1780
              ...|:|...|:..::.:||   ::|..   |...|:.|.|....|:..    :..|.:.....
Zfish   235 --ISTPSTIDSPSSTMKTSTL---ISTSG---CNCHWSDWSDHGGSTTGP----DGGEVISIETI 287

  Fly  1781 MENVYGTCLKQYMTKVECRVKDTHEAP-EQMDENVVCSLEEGLRCIGK-------CHDYELRAFC 1837
            :|:...||  ..:.:::||.|.....| .|:.::|.|:..:||.|:.|       |:||::|..|
Zfish   288 IESSSSTC--SAIKEIQCRAKRYPGVPLSQLGQDVKCNTIDGLVCLNKHQGLTQQCYDYDIRVLC 350

  Fly  1838 QCDEELEP------------------ELP-KPTEKPQLG-----LACDAAVVEYKEFP-----GD 1873
             |||..:.                  .|| .||...|:.     ::.|.::......|     ||
Zfish   351 -CDENCDNITTQTFSTAPTTLSSTSFNLPSSPTSTVQISSSVSVISTDTSIKTPTSMPLTTVSGD 414

  Fly  1874 CHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIA---TVTEIKPNCGLKPEPEPEFEPI 1935
                 ...|                     ||.....||:   |.|...|:     :..|.|..:
Zfish   415 -----KSSP---------------------PTTTFTSHISSTNTSTSTTPS-----KTSPTFTTL 448

  Fly  1936 KQCPPGKIKS--ECANQCENTCHY-----YGSILKKRGLCQVGEHCKPGCVDELRPDCPKLGKFW 1993
            |   .|...|  ||      .||:     :|.:                   ...||..::....
Zfish   449 K---TGTFTSSPEC------NCHWSDWNDFGGL-------------------TTGPDGGEIVPIE 485

  Fly  1994 RDEDT---CVHADECPCMDKAEHYVQPHKPV--LGEFEVCQCIDNAFTCVPNKPEPVPKDEDDDL 2053
            |..:|   |....|..|  :|:.|  |..|:  ||:...|..|| ...|: |:.:.:.:...|
Zfish   486 RITETFYLCSTPKEVQC--RAKRY--PGVPLAQLGQVIKCNTID-GLVCL-NRHQGLTQQCYD-- 542

  Fly  2054 DLVSVVPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEHGPKMARLTKEQPRGS 2118
                    |.:.|.    |..|..            |:|...:|...|   ..|:..||:..:.|
Zfish   543 --------YEIRLF----CCDENC------------DNITTQTSSTDP---ATMSTSTKQTVQSS 580

  Fly  2119 WS-PSINDQMQYLELNFAKPEPFYGV--VMAGSPEFDNY 2154
            .| ||.....|.:....|.|....||  .:..:....||
Zfish   581 ASGPSNPTTTQAMPTATALPALSTGVTTTLTETTSVQNY 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566	1/3 (33%)
		C8	1535..1609	CDD:214843	19/98 (19%)
		Mucin2_WxxW	1751..1837	CDD:290069	23/93 (25%)
		TIL	1938..2005	CDD:280072	12/76 (16%)
		FA58C	2089..2223	CDD:238014	18/69 (26%)
		FA58C	2104..2225	CDD:214572	14/54 (26%)
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
LOC110439905	XP_021333306.1	Mucin2_WxxW	63..150	CDD:315900	17/96 (18%)
		Mucin2_WxxW	262..350	CDD:315900	23/93 (25%)
		Mucin2_WxxW	462..549	CDD:315900	23/125 (18%)
		SSL_OB	<552..>671	CDD:332684	19/83 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12226at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010