DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and LOC108190762

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_021333305.1 Gene:LOC108190762 / 108190762 -ID:- Length:2115 Species:Danio rerio


Alignment Length:2530 Identity:465/2530 - (18%)
Similarity:716/2530 - (28%) Gaps:926/2530 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   791 GCFC--------------PEGTVQYKEACITRELCPCSLRGKEFKPESTVKKNCNTCTC-KNGQW 840
            ||.|              |:|                   |:....||.:|.:.:||:. |..|.
Zfish    89 GCNCHWSDWSDHGGSTTGPDG-------------------GEVISIESIIKSSSSTCSAIKEIQC 134

  Fly   841 RC------------TEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQN-TSVEAENVAC 892
            |.            .:.||....|.|....:|....:.||:..:.   |...:| .::..:..:.
Zfish   135 RAKRYPGVPLSQLGQDVKCNIIDGLVCLNKHQGLTQQCYDYDIRV---LCCDENCDNITTQTFST 196

  Fly   893 SGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQG--------LTTIVNDKPIAKLPKM 949
            :.....|.:|..|..|:.|..::       .:.|||..|..        |||:..||        
Zfish   197 APTTLSSTSFNLPSSPTSTVQIS-------SSVSVISTDTSIKTPTSMPLTTVSGDK-------- 246

  Fly   950 LGLGEVLIRRASSTFLTVEFADGIRVWWDGVSRVYIDAPPSLR-----GQTQGLCGTFNSNTQDD 1009
                                                .:||:..     ..|.....|..|.|...
Zfish   247 ------------------------------------SSPPTTTLTSHISSTNTSTSTTPSKTSPT 275

  Fly  1010 FLTPEGDVETAVEPFADKWRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWILQDIFQDCHF 1074
            |.|.:....|:......:|  .|...|...| .||....:.|.::.                   
Zfish   276 FTTSKTGTLTSSPECNCQW--SDWNDFGGLT-TGPDGGEIVPIERI------------------- 318

  Fly  1075 LVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQGVKTGWRMSVKECAVK-------CP 1132
               .|.||      :|:...|:                             :|..|       ..
Zfish   319 ---TETFY------SCSTPKEV-----------------------------QCRAKRYPGVPVSQ 345

  Fly  1133 LGQVFDECG-----------DGCALSCDDLPSKGSCKRECVEGCRCPHGEYVNEDGECV---PKK 1183
            ||||. :|.           .|....|.|...:..|   |.|.|.....:..:.|...:   .|:
Zfish   346 LGQVI-KCNTIDGLVCLNRHQGLTQQCYDYEVRLFC---CDENCSNITTQTSSTDPATISTSTKQ 406

  Fly  1184 MCHCNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAE 1248
            ....:..|.| .|...:..|....|.  ..:.||                ::.|....:.|.|:.
Zfish   407 TVQSSASGPS-NPTTTQAMPTATALP--ALSTGV----------------TTTLSETTSVQNYSN 452

  Fly  1249 FTKCAPKEPKTCKNMDKYVADSSDCLPGCVCMEGYVYDTSRLACVLPANCSCH------HAGKSY 1307
            ||..: ..|.|          ::...|..:........||.|  :..:.|:||      |.|.:.
Zfish   453 FTSIS-TTPTT----------NTFSSPSTIHSTPTTMKTSTL--ISTSGCNCHWSDWSDHGGSTT 504

  Fly  1308 --DDGEK------IKEDCNLC------ECRAGNW---KCSKNGCESTCSVWGDSHFTTFDG---- 1351
              |.||.      ||...:.|      :|||..:   ..|:.|.:..|::        .||    
Zfish   505 GPDGGEVISIESIIKSSLSTCSAIKEIQCRAKRYPGVPLSQLGQDVKCNI--------IDGLVCL 561

  Fly  1352 ----------HDFDFQG-ACDYVLAKGVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEE 1405
                      :|:|.:. .||        :|.|  :||.|..  .|...|.| |..:.|......
Zfish   562 NKHQGLTQQCYDYDIRVLCCD--------ENCD--NITTQTF--STASTTVS-STSLHLPSSTTS 613

  Fly  1406 SLLLSAD-SAYSTDPN-KTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVY 1468
            ::.:|:. |..|||.: |||..                           :|| ..|..|:.:...
Zfish   614 TVQISSSVSVISTDTSIKTPTS---------------------------MPL-TTVSGDKSSPPT 650

  Fly  1469 VKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPE 1533
            ..:       .|.:...|...|    .|||   :|||                            
Zfish   651 TTI-------TSHISSTYTSTS----TTPS---KTSP---------------------------- 673

  Fly  1534 RETWAQLKCGALKSDLFKECHAE-------------------VPLERFWKRCIFDTCACDQGGDC 1579
              |:...|.|...|  ..||:..                   ||:||..:  .|.:|:..:    
Zfish   674 --TFTTSKTGTFTS--IPECNCHWSDWNDFGGLTTGPDGGEIVPIERITE--TFYSCSTPK---- 728

  Fly  1580 ECLCTAVAAYADACAQKGINIRWR--------SQHFCPMQCDPHCSDYKACTPACAVETCDNFLD 1636
            |..|.|........:|.|..|:..        ::|   ......|.||:. ...|..|.|.|...
Zfish   729 EVQCRAKRYPGVPVSQLGQVIKCNTIDGLVCLNRH---QGLTQQCYDYEV-RLFCCNENCGNITT 789

  Fly  1637 Q----GIAERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCVPKAECKPVCMVRDGKTFYEGDITF 1697
            |    ..|....:.:..::.....|.       |.|....:|.|...|.  :..|.|     .|.
Zfish   790 QTSSTDPATMSTSTKQTVQSSASGPS-------NPTTTQAMPTATALPA--LSTGLT-----TTL 840

  Fly  1698 TDSCATCRCSKRKEICSGVKCDVPATTGLPAPLVEGTTLPTPLATQ---NQTKCVKGWTRWCDKD 1759
            |::.:....|....|.:     .|.|....:|....:| ||.:.|.   :.:.|...|:.|.|..
Zfish   841 TETTSVQNYSNFTSIST-----TPTTNTFSSPSTIHST-PTTMKTSTLISTSGCNCHWSDWSDHG 899

  Fly  1760 RDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTKVECRVKDTHEAP-EQMDENVVCSLEEGLR 1823
            ..|:..    :..|.:.....:|:....|  ..:.:::||.|.....| .|:.::|.|:..:||.
Zfish   900 GSTTGP----DGGEVISIESIIESSSSRC--SAIKEIQCRAKRYPGVPLSQLGQDVKCNTIDGLV 958

  Fly  1824 CIGK-------CHDYELRAFCQCDEELEP------------------ELPKPTEKP-QLG----- 1857
            |..:       |:|||:|.|| |||..:.                  .||..|... |:.     
Zfish   959 CFNRNQGLTQQCYDYEVRLFC-CDENCDSITTQTFSTAPTTLSSTSFNLPSSTTSTVQISSSVSV 1022

  Fly  1858 LACDAAVVEYKEFP-----GDCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIA---T 1914
            ::.|.::......|     ||....|                          |..:..||:   |
Zfish  1023 ISTDTSMKTPTSMPLTTVSGDKSSPL--------------------------TTTLTSHISSTNT 1061

  Fly  1915 VTEIKPNCGLKPEPEPEFEPIKQCPPGKIKS--ECANQCENTCHY-----YGSILKKRGLCQVGE 1972
            .|...|:     :..|.|...|   .|...|  ||      .||:     :|.:           
Zfish  1062 STSTTPS-----KTSPTFTTSK---TGTFTSIPEC------NCHWSDWNDFGGL----------- 1101

  Fly  1973 HCKPGCVDELRPDCPKLGKFWRDEDT---CVHADECPCMDKAEHYVQPHKPV--LGEFEVCQCID 2032
                    ...||..::....|..:|   |....|..|  :|:.|  |..||  ||:...|..||
Zfish  1102 --------TTGPDGGEIVPIERITETFYSCSTPKEVQC--RAKRY--PGVPVSQLGQVIKCNTID 1154

  Fly  2033 NAFTCVPNKPEPVPKDEDDDLDLVSVVPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIFNASS 2097
             ...|: |:.:.:.:...|          |.|.|.    |..|..            |:|...:|
Zfish  1155 -GLVCL-NRHQGLTQQCYD----------YEVRLF----CCDENC------------DNITTQTS 1191

  Fly  2098 QLAPEHGPKMARLTKEQPRGSWS-PSINDQMQYLELNFAKPEPFYGV--VMAGSPEFDNYVTLFK 2159
            ...|   ..|:..||:..:.|.| ||.....|.:......|....||  .:..:....||.....
Zfish  1192 STDP---ATMSTSTKQTVQSSASGPSNPTTTQAMPTATVLPALSTGVTTTLTETTSVQNYSNFTS 1253

  Fly  2160 ILHSHDGIAYHYLVDETEKPQMFNGPLDSRAPVQTL-FKIPIEASSLRIYPLKW--HGSI----- 2216
            |             ..|.....|:.|....:|..|: ....|..|....:...|  ||..     
Zfish  1254 I-------------STTPTTNTFSSPSTIDSPSSTMKTSTLISTSGCNCHWSDWSDHGGSTTGPD 1305

  Fly  2217 ---AMRVELLICGDKEEPKPVPTVSTILPITERPARL---------VDLECIDLMGV-----DEG 2264
               .:.:|.:|.....      |.|.|..|..|..|.         .|::|..:.|:     .:|
Zfish  1306 GGEVISIESIIKSSSS------TCSAIKEIQCRAKRYPGVPLSQLGQDVKCNIIDGLVCLNKHQG 1364

  Fly  2265 KMYQ---------------DQVQSSSLWQQPNLGKKLQLLELLKLSTPLAWRPLANSQNEFIEFD 2314
            ...|               |.:.:.|....|.        .|...|..|:..|.:..:       
Zfish  1365 LTQQCYDYDIRVLCCDENCDNITTQSFSTAPT--------TLSSTSFNLSSSPTSTVR------- 1414

  Fly  2315 FLEPRNISGFVTKGGPDGWVTGYKVMFSKKKPTWNTVLSTDGQARIFEANHDAETERRHHFKNPI 2379
                  ||..|:....|         .|.|.||...:.:..|..                 .:|.
Zfish  1415 ------ISSSVSVISTD---------TSIKTPTSMLLTTVPGDK-----------------SSPP 1447

  Fly  2380 LTQYIKIVPAYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKCNICDGVSTSSSTTGCQCQD 2444
            .|.:...:.:   .|.:....|                .::.||...:..|..|||....|...|
Zfish  1448 TTTFTSHISS---TNTSTSTTP----------------SKTSPTFTTLKTGTLTSSPECNCHWSD 1493

  Fly  2445 QLFW----------DGNTCVQHNLCPCIENYVSYPIGSKFENSACEDCVCVLGGHKNCKPKKCPP 2499
               |          ||...|.      ||.     |...|.:       |.......|:.|:.|.
Zfish  1494 ---WNDFGGLTTGPDGGEIVP------IER-----ITEAFYS-------CTTPKEVQCRAKRYPE 1537

  Fly  2500 CLGGKLRPVITSDCFCKCEPCP------KHQRLCPSSGDCIPEILWCNGVQDC---------ADD 2549
            ....:|..||      ||....      :||||.....|....:..|:  ::|         .|.
Zfish  1538 VPVSQLGQVI------KCNTIDGLVCLNRHQRLTQQCYDYEVRLFCCD--ENCDNITTQTSSTDP 1594

  Fly  2550 EDASCSDSFTVEPDVSREKNETEVITCPVPVCPPQMKIRITEKKSRKMS--------------KM 2600
            ...|.|...||:...|...|.|.....|.....|.:...:|...:...|              |.
Zfish  1595 ATMSTSTKQTVQSSASGPSNPTTTQAMPTATALPALSTGVTTTLTETTSVQIYSNFTSISTTPKT 1659

  Fly  2601 FTFSKQVSIVDDGTTITKTKFIS---------------------------SKEQILAMPNRELDF 2638
            .|||...:|....||:..:..||                           |.|.|:...:.....
Zfish  1660 NTFSSPSTINSTPTTMKTSTLISTSGCNCHWSDWSDHGGSTTGPDGGEVISIESIIKSSSSTCSA 1724

  Fly  2639 QLEEQCDEFTCVPIPSKQVDKNETVTCT--------------EPKCPEKYDVELDMSASKVGDCL 2689
            ..|.||.......:|..|:  .:.|.|.              ..:|   ||.:           :
Zfish  1725 IKEIQCRAKRYPGVPLSQL--GQDVKCNIIDGLVCLNKHQGLTQQC---YDYD-----------I 1773

  Fly  2690 RYSCVLRPNKDDVCE-ISGKSF----TTFDGTVFKY--GPCSHILARDIHSSSWSISVHQQCSDE 2747
            |..|.     |:.|: |:.::|    ||...|.|..  .|.|.:      ..|.|:||....:..
Zfish  1774 RVLCC-----DENCDNITTQTFSTAPTTLSSTSFNLSSSPTSTV------QMSSSVSVISPDTSI 1827

  Fly  2748 TRKVCHKVITIQ-DTEAGNELILLPHLKLKFNGYEFTVQQLINSPICKASFVVSQPGKTLLAVST 2811
            .......:.|:. |..:.....|..|:.........|..:  .||    :|..|:.| |..:...
Zfish  1828 KTPTSMPLTTVSGDKSSPPTTTLTSHISSSNTSTSTTPSK--TSP----TFTTSKTG-TFTSSPE 1885

  Fly  2812 KYGFWVQLDDIGIVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPD-GQIIPNTEKFGDSWYDKRI 2875
            ....|...:|.|.:..|                          || |:|:| .|:..:::|....
Zfish  1886 CNCHWSDWNDFGGLTTG--------------------------PDGGEIVP-IERITETFYSCST 1923

  Fly  2876 PKD-QCGDLKCPREMQAKALQLCNIIHHPTFARCHK-----AVNYKQFLNNYCLE-----AAC-- 2927
            ||: ||   :..|.......||..:|      :|:.     .:|..|.|...|.:     ..|  
Zfish  1924 PKELQC---RAKRYPGVPVSQLGQVI------KCNTIDGLVCLNRDQGLTQQCYDYEIRLFCCDE 1979

  Fly  2928 NC----MMANNGDPAACKCNILESFVKKCLS--VNPLVQLTTWRAVAQCEINCPSPLVHT 2981
            ||    ...::.|||....:..:: |:...|  .||    ||.:|:::.   .|.|.:.|
Zfish  1980 NCSNITTQTSSTDPATMSTSTKQT-VQSSASGPSNP----TTTQAISRA---TPLPALST 2031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072 5/33 (15%)
VWD 840..1015 CDD:214566 32/200 (16%)
C8 1054..1121 CDD:214843 5/66 (8%)
TIL 1131..1185 CDD:280072 14/67 (21%)
TIL 1245..1298 CDD:280072 9/52 (17%)
VWD 1327..1498 CDD:214566 35/190 (18%)
C8 1535..1609 CDD:214843 19/100 (19%)
Mucin2_WxxW 1751..1837 CDD:290069 22/93 (24%)
TIL 1938..2005 CDD:280072 12/76 (16%)
FA58C 2089..2223 CDD:238014 29/147 (20%)
FA58C 2104..2225 CDD:214572 25/134 (19%)
FA58C <2299..2404 CDD:214572 14/104 (13%)
FA58C <2299..2403 CDD:238014 14/103 (14%)
VWD 2703..2858 CDD:295339 30/163 (18%)
C8 2893..2970 CDD:285899 21/94 (22%)
TIL 2974..3030 CDD:280072 3/8 (38%)
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
LOC108190762XP_021333305.1 Mucin2_WxxW 93..181 CDD:315900 18/109 (17%)
Mucin2_WxxW 293..380 CDD:315900 22/147 (15%)
Spr <394..>501 CDD:333284 24/138 (17%)
Mucin2_WxxW 492..580 CDD:315900 19/95 (20%)
Mucin2_WxxW 692..779 CDD:315900 16/96 (17%)
Mucin2_WxxW 891..979 CDD:315900 22/93 (24%)
Mucin2_WxxW 1091..1178 CDD:315900 25/125 (20%)
Mucin2_WxxW 1290..1378 CDD:315900 16/93 (17%)
Mucin2_WxxW 1490..1577 CDD:315900 23/113 (20%)
Mucin2_WxxW 1689..1777 CDD:315900 14/103 (14%)
Mucin2_WxxW 1889..1976 CDD:315900 24/122 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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