Protein Alignment Hml and LOC108181583

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: XP_073798921.1
• Gene: LOC108181583 / 108181583
• -ID: -
• Length: 803
• Species: Danio rerio
• Alignment Length: 884
• Identity: 242/884 - (27%)
• Similarity: 369/884 - (41%)
• Gaps: 132/884 - (14%)

  Fly   484 LCTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGTFDIILKACPYGSGYGCAHTLKILWQSVLY 548
            :|:||...:.|||||.:::.|..|.:.|::|..|..|.:.:|.....||           ..:..
Zfish     1 MCSTWESFHFKTFDGDIYQYPGLCEYNLVSDCTSKQFSVDVKRTQTSSG-----------PKISR 54

  Fly   549 TFENLNGTM--------QLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESVGLKLDWDHRQYVSV 605
            ...::||.|        .:...|.||  ||...|:.:.....:..| ....||.:.|.....|:|
Zfish    55 IVVSINGKMFSISENNVMIDDQITKL--PVYESGILIEENTIYTNI-RSKTGLTVMWSKDGAVTV 116

  Fly   606 QAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSELCQVENSAEMEFGMD 670
            :...:...|..||||..:...:..:|.....:......|.:..:|.:..|.|  ||.:|
Zfish   117 ELDNKYQNKTCGLCGNFNRIRDEFITEPGNTEKIGYIEFGNKHKVFNPMEFC--ENPSE------ 173

  Fly   671 SCEQSKLQKAV-----SVCERLLANEKLGDCIKPFNYDALIRTCMADYCNCANREHPESCNCDAI 730
             .::....||:     :.||.|...:....|  ..:|...:..|:.|.|...:     |..|..:
Zfish   174 -TDEKNNWKAICGSYQADCEELFRAKAWSSC--AMSYHPYVDACVYDRCFSKS-----SSLCATL 230

  Fly   731 AMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVEPTCDSDLALPASKGACNE----G 791
            :..:::|:..| .....||..:.|.::|.:..|:...|.....||.|:    .:...|.|    |
Zfish   231 SEYSRQCSRNG-GTPSTWRTKDFCAVTCPYNTVHFESGSPCIDTCSSE----NTNTQCEEHNIDG 290

  Fly   792 CFCPEGTV---QYKEACITRELCPCSLRGKEFKPESTVKKNCNTCTCKNGQWRCTEDKCGARCGA 853
            ||||.|||   .....||.||.|.|. ..:.:||:..:.:....|.|:||:|.|.......||..
Zfish   291 CFCPPGTVFDDILNMGCIPREQCHCK-HDRIYKPQEELHEVGQDCVCQNGKWNCKIKPVLGRCSV 354

  Fly   854 VGDPHYQTFDGKRYDFMGKCSYHLLKTQNTS---VEAENVACSGAVSESMNFAAPDDPSCTKAVT 915
            ....|:.||||:.:.|.|.|:|.|.|....|   :..:...|:..:.:          :|.|::.
Zfish   355 EEGSHFTTFDGQEFTFHGDCTYVLSKDSVGSKFIILGQISPCASLIYD----------TCLKSID 409

  Fly   916 IRF---------ILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFLTVEFAD 971
            :.|         |..|||             |.......||......:.::...||.::.::...
Zfish   410 VIFNSDTVNRLVISEDGT-------------VKHNAAVLLPYTPASRQFVVFSPSSFYILIDTNF 461

  Fly   972 GIRVWWDGV--SRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRTKDTC 1034
            |:||....|  .:|||......:|:|.||||.||....||..||:|.||.....||:.|..:..|
Zfish   462 GLRVLVQLVPLMQVYITMDKRFQGKTHGLCGNFNKVLADDMKTPQGLVEGTAVSFANAWEVETNC 526

  Fly  1035 QFKAETHQGPHPCTLNPEKKAQAEKFCDWIL--QDIFQDCHFLVEPEQFYEDCLYDTCACKDEMS 1097
            :    :.:...||:.|...:..||.:|..|:  .|:|..||..|.||.:|:.|.|.:|.| :...
Zfish   527 R----SDKSVIPCSHNSVSENYAEHWCYKIMDKSDVFAQCHSKVNPESYYKRCKYASCTC-ERSE 586

  Fly  1098 KCFCPILSAYGTECMRQGVK-TGWRMSVKECA---VKCPLGQVFDECGDGCALSCDDLPSK-GSC 1157
            .|.|.:.|:|...||.:.|. .|||.:|  |.   ..||..|.:......|..:|..|.|: .||
Zfish   587 DCLCAVFSSYVHACMIKNVTLEGWRENV--CGKYIQNCPAPQRYFYYLKSCQPTCLSLSSEHTSC 649

  Fly  1158 KREC--VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDL----CTCTDG 1216
            |.:.  |:||.||.|.|.::||:|||.:.|.|.  ||.     |..:||.. :|:    |.|.:|
Zfish   650 KEDFVPVDGCACPDGLYKDQDGQCVPIEKCPCY--GMG-----KIAQPGTS-IDINGQYCVCVNG 706

  Fly  1217 VWDCQDAEPGDKDKYPPSSELRSKCA-KQPYAEFTKCAPKEPKTCKNMDKYV-ADSSDCLPGCVC 1279
            |..|:..:|...:  .||.::...|: .:|.....||.|    ||  |.|.. ..|..|..||:|
Zfish   707 VLHCESEKPHILE--CPSPKVLFNCSTARPDQHGLKCKP----TC--MQKIENCFSQTCESGCLC 763

  Fly  1280 MEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDCN 1318
            ..| :.|..|..||...:|.|.|.|:.|....:|..|||
Zfish   764 PSG-LLDDDRGNCVERKDCPCPHGGQLYQPETEITVDCN 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671	38/158 (24%)
		C8	684..754	CDD:462584	14/69 (20%)
		TIL	758..811	CDD:410995	20/59 (34%)
		VWD	840..1015	CDD:214566	48/188 (26%)
		C8	1054..1121	CDD:214843	24/69 (35%)
		TIL	1131..1185	CDD:410995	22/56 (39%)
		TIL	1245..1298	CDD:460351	18/53 (34%)
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		TIL	1938..2005	CDD:473303
		FA58C	2089..2223	CDD:238014
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:459671
		TIL	2974..3030	CDD:460351
		VWD	3035..3198	CDD:459671
		C8	3248..3313	CDD:462584
		VWC	3397..3451	CDD:450195
		GHB_like	<3755..3813	CDD:473907
LOC108181583	XP_073798921.1	None