DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and muc5f

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_005169116.2 Gene:muc5f / 101885395 ZFINID:ZDB-GENE-110411-240 Length:2380 Species:Danio rerio


Alignment Length:2532 Identity:503/2532 - (19%)
Similarity:760/2532 - (30%) Gaps:1020/2532 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  1181 PKKMCHCNF-DGMSFRPGYKEVRPGE---------KFLDLCTCTDGVWDCQDAEPGDKDKYPP-- 1233
            ||.:|.|.: |.:.|:.....:..||         ...:.||....| :|:      ...||.  
Zfish   532 PKPVCSCRWSDWLDFKQPTTGLEGGEIISIQNILYSLPNFCTALKDV-ECR------AKNYPTLR 589

  Fly  1234 SSELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYVADSSDCLPGCV---CMEGYVYDTSRLACVLP 1295
            .|:|.         :..||..|:...|.|  ||..::..|....:   |..|....|:.|...||
Zfish   590 LSQLN---------QVVKCNVKDGLVCLN--KYQGNTYQCFDYEIRVSCCSGNCGSTTTLTPNLP 643

  Fly  1296 A-----NCSCHHAG-------KSYDDGEKIKE----------DCN---LCECRAGNW---KCSKN 1332
            :     .|.||.:|       .:..:|.||..          .|:   :.||||..:   ..|:.
Zfish   644 SVTPALGCICHWSGWMDFGSVTTDPEGGKIISISKISDAYPLVCSAPKVLECRAKLYPELSLSQL 708

  Fly  1333 GCESTCSVWGDSHFTTFDGHDFDFQGACDYVLAKGVFDNGDGFSITIQ------NVLC--GTMGV 1389
            |...||:                   |.|.::......|     ||.|      .:||  |    
Zfish   709 GQIVTCN-------------------AKDGLICLNKQQN-----ITQQCFDYDIRILCCHG---- 745

  Fly  1390 TCSKSLEIALTGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIP 1454
            .||.|.:.|.|            ||..:....||:     |::                    |.
Zfish   746 KCSSSEQAATT------------SAMQSPSATTPV-----SLD--------------------IT 773

  Fly  1455 LKLQVKWDEGTRVYVKLGN---EWRQKVSGLCGNYNGNSLDDMQTPSMG------------LETS 1504
            ||.|.|....::.......   .|.:.:             |...|::|            .:|.
Zfish   774 LKQQSKPFSTSKSVTSTSACVCHWSEPL-------------DFDGPTVGPNGGQIVPIKKITDTY 825

  Fly  1505 PMLFGHAWKLQPHCSAPVAPIDACKKHPERETWAQL--------KCGAL----KSDLFKECHAEV 1557
            |.:          ||||.....:.|.:|:... .||        |.|.|    ..|:.::|    
Zfish   826 PTV----------CSAPKEVKCSSKLYPQLSV-LQLGQVVICNEKDGLLCLNKNQDITQQC---- 875

  Fly  1558 PLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRWRSQHFCPMQCDPHCSDYKAC 1622
                      ||.       |...||                        |..:|| :.:..|..
Zfish   876 ----------FDY-------DIRVLC------------------------CHGKCD-NSTQAKTT 898

  Fly  1623 TPACAVET-------------------CDNFLDQGIAERMCNRENCL---------EGCHIKPCE 1659
            ||:.:|.|                   |           :|.....|         ||..|.|.:
Zfish   899 TPSSSVSTKAKDSPAFKPTETTNLNTSC-----------ICQWSEALDFGGPTVGPEGGQIVPIK 952

  Fly  1660 DGFIYLNDTY-------RDCVPKAECKP-----------VCMVRDGKTFYEGDITFTDSCATCRC 1706
            .    :.|||       |..|..|:..|           :|..:||.......   .|:...|..
Zfish   953 K----ITDTYPTVCAAPRKVVCSAKHYPQLSVLQLGQTIICNEKDGLLCLNKK---QDTTQQCFD 1010

  Fly  1707 SKRKEICSGVKCD--VPATTGLPAPLVEGTTLP--TPLATQNQTK------------CVKGWTRW 1755
            ...:.:|...|||  ..|.|..|.......||.  .|||....:|            |:..|::|
Zfish  1011 YDIRVLCCYGKCDNSTQAPTASPMLSASANTLSANAPLAASISSKPFNAIPITAIPLCICHWSKW 1075

  Fly  1756 CDKDRDTS-DKSVRLNDEEKVPRYDRMENVYG-TCLKQYMTKVECRVK-DTHEAPEQMDENVVCS 1817
            .|....|: .|..:|     :| ...:.:.|. .|.|.  .|||||.| ....|..|:.:.|.|:
Zfish  1076 LDFGTSTTGPKGGKL-----IP-IKAITDAYPIICSKP--QKVECRSKLYPALALSQLGQTVTCN 1132

  Fly  1818 LEEGLRCIGK-------CHDYELRAFCQCDEE-LEPELP---------------KPTEKPQLGLA 1859
            ||:||.|:.|       |.|||:|..| |.|| :...||               ..|..|:..||
Zfish  1133 LEDGLVCLNKNQSITQQCFDYEMRLLC-CHEECVSATLPAAVSLVLNSSSTSVRSTTSPPKRDLA 1196

  Fly  1860 CDAAVVEYKEFPGDCHKFLHCQ----------PKGVEGGWIYVEKTCGEYMMFNPTMLICDHIAT 1914
              |.:.|  .||..|    .||          ..|.:||.:.                   .|..
Zfish  1197 --ATISE--TFPSHC----ICQWSNWVNNGSPTTGPKGGKLI-------------------SIKV 1234

  Fly  1915 VTEIKPNCGLKPEPEPEFEPIKQCPPGKIKSECANQCENTCHYYGSILKKRGLCQVGEHCKPGCV 1979
            :|:..|....||:                |.||..:.     |.|     ..|.|:|:..     
Zfish  1235 ITDTYPTTCSKPQ----------------KVECRAKL-----YPG-----LALSQLGQTV----- 1268

  Fly  1980 DELRPDCPKLGKFWRDEDTCVHADECPCMDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEP 2044
                              ||...|...|::|.:...|            ||.|            
Zfish  1269 ------------------TCNLEDGLLCLNKNQSITQ------------QCFD------------ 1291

  Fly  2045 VPKDEDDDLDLVSVVPIYPVTLTPPLQCSPERLIPKIENPA---HSLPDSIFNASSQLAP---EH 2103
                             |.:.|   |.|..|.:...:  ||   .:|..|..|.|:...|   ::
Zfish  1292 -----------------YEMRL---LCCHEECVSATL--PAAITQALRSSSSNVSTTTVPLSIDN 1334

  Fly  2104 GPKMARLTKEQPRGSWSPSINDQMQYLELNFAKPEPFYGVVMAGSPEFDNYVTLFKILHSHDGIA 2168
            ...:::....:....||..:|                :|...|| ||....:.:..|..::.   
Zfish  1335 NITISKTLNSKCICQWSDWVN----------------FGSPTAG-PEGGKLIPVKVITDTYP--- 1379

  Fly  2169 YHYLVDETEKPQMFNGPLDSRAPVQTLFKIPIEASSLRIYP---LKWHG-SIAMRV-ELLICGDK 2228
                 ....|||    .::.||               ::||   |...| ::...| :..||.:|
Zfish  1380 -----TTCSKPQ----EIECRA---------------KLYPGLALSQLGQTVTCNVKDGFICLNK 1420

  Fly  2229 EEPKPVPTVSTILPITERPARLVDLECIDLMGVDEGKMYQDQVQSSSLWQQPNLGKKLQLL---- 2289
            .:           .||:        :|.|.                          :::||    
Zfish  1421 NQ-----------SITQ--------QCFDY--------------------------EMRLLCCHE 1440

  Fly  2290 ELLKLSTPLAWRPLANSQNEFIEFDFLEPRNISGFVTKGGPDGWVTGYKVMFSKKKPTWNTVLST 2354
            |.:..:.|.|......:.:..:....|.||.          |...|..|.:.||....|:..:  
Zfish  1441 ECVSATLPAAITQALRNSSTSVSSTTLAPRR----------DVNTTISKTLNSKCICQWSDWV-- 1493

  Fly  2355 DGQARIFEANHDAETERRHHFKNP--------ILTQYIKIVPAYWEKNINMRIEPLGCFLP---- 2407
                               :|.:|        ::|  :|::         ..|.|..|..|    
Zfish  1494 -------------------NFGSPTTGPQGGELIT--VKLI---------TDIYPTICSKPQKIE 1528

  Fly  2408 -----YPEIQRQVPVEESKPTKCNICDGVSTSSSTTGC--QCQD---QLFWDGNTCVQHNLCPCI 2462
                 ||.:...   :..:..|||:.||:...:.....  ||.|   :|......||...|...|
Zfish  1529 CRAKFYPGLALS---QLGQTVKCNLEDGLVCLNKNQNITQQCFDYEIRLLCCHEECVSATLPAAI 1590

  Fly  2463 ------------------ENYVSYPIGSKFENSACEDCVCVLGGHKNC-KPKKCPPCLGGKLRPV 2508
                              :..|:..| ||..||   .|:|......|. .|...|.  ||||.||
Zfish  1591 ALASRSSSTSVSTTAVPQKRDVNTTI-SKTMNS---KCICQWSNWVNFGSPTTGPE--GGKLIPV 1649

  Fly  2509 -ITSDCFCKCEP--CPKHQRLCPSSGDC------------IPEILWCNGVQD---CADDEDASCS 2555
             :.:|.:    |  |.|.|.:     :|            :.:.:.|| |:|   |.:...:...
Zfish  1650 KVITDTY----PTTCSKPQEI-----ECRAKLYPGLPLSQLGQTVTCN-VKDGFVCLNRNQSITQ 1704

  Fly  2556 DSFTVEPDVSREKNETEVITCPVPV---------------CPPQMKIRITEKKS------RKMSK 2599
            ..|..|..:.....|....|.|..:               .||:..|..|..|:      .|.|.
Zfish  1705 QCFDYEMRLLCCHEECVSATLPAAITLALRSYSRSISSTTVPPRRDIAATISKTFPSSCICKWSD 1769

  Fly  2600 MFTFSKQVSIVDDGTTITKTKFISSKEQILAMPNRELDFQLEEQCDEFTCVPIPSKQVDK-NETV 2663
            ...|....:..:.|..:..|...::...|...|.       |.:|   .....|..|:.: .:.|
Zfish  1770 WMDFGSPTTGPEGGEIVPMTNITNTYSNICPAPT-------EAEC---RAKHYPGVQLSQLGQVV 1824

  Fly  2664 TCTEPKCPEKYDVELDMSASKVG-DCLRYSCVLRPNKDDVCEISGKSFTTFDGTVFKYGPCSHIL 2727
            ||.                |:.| .||        ||:.:                         
Zfish  1825 TCN----------------SQEGLVCL--------NKNQL------------------------- 1840

  Fly  2728 ARDIHSSSWSISVHQQCSD-ETRKVCHKVITIQDTEAGNELILLPHLKLKFNGYEFTVQQLINSP 2791
                        |.|||.| |.:.:|.:.:..:.::....:..|.|                   
Zfish  1841 ------------VTQQCFDYEIKVLCCQGLCGKSSKISPRIQRLSH------------------- 1874

  Fly  2792 ICKASFVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPD 2856
                |.||:.|....:.||:                  ........|.:|..| ||    ..:|:
Zfish  1875 ----SAVVTPPSLPAVTVSS------------------GGHITARHDCVCEVY-GN----TFNPE 1912

  Fly  2857 GQIIPNTEKFGDSWYDKRIPKDQCGDLKCPREMQAKALQLCNIIHHPTFARCHKAVNYKQFLNNY 2921
            .:|...|:  ||.|         |...||     .|..:.|::                :.::..
Zfish  1913 SEIYNITD--GDGW---------CYVAKC-----VKTEERCDV----------------KKISGP 1945

  Fly  2922 CLEAACNCMMANNGDPAACKCNILESFVKKCLSVNPLVQLTTWRAVAQCEINCPSPLVHTDCYK- 2985
            ||....         |||.                  :.||     ..||.:.| ||.:.:..| 
Zfish  1946 CLTTVF---------PAAS------------------MSLT-----GNCEKHTP-PLTNGESVKV 1977

  Fly  2986 RRCE-PSCDNVH----GDDC-PVLPDACFPGC---YCPEGTVRKGPNCVPISECKDCVCNSLGAS 3041
            ..|: .:|:|.:    ..|| ||.    :|.|   :.|. .:.....|....||: |:||.....
Zfish  1978 GNCQIGTCNNGYIQYKAVDCDPVQ----YPVCENKFSPL-NISDESGCCFKHECQ-CICNGFRNL 2036

  Fly  3042 KYMTYDRKSFSFNGNCTYLLSRDVVLPGVHTFQVYVS-----MDDCKKLGQPTPVEGGSCAKSLH 3101
            .|:|:|...:.|.||.:.:|.:::  ...:.|.|.|.     .||.            ||.||| 
Zfish  2037 HYITFDGIYYPFQGNSSRVLVQEI--KPKYNFSVVVDNICDIEDDL------------SCPKSL- 2086

  Fly  3102 ILNGDHVIH--------VQRVPQKPKSLQVLVDGFEVKKIPYKDSWISLRQVVGKELVLSLPESH 3158
                  |:|        .|||........:.|:..:| ::|::...:...: .|.|.::.|  |.
Zfish  2087 ------VVHYKSFKIFMTQRVSAGAVMNLISVNNKKV-RLPFQYEDVHATE-TGIESIVVL--SE 2141

  Fly  3159 VELTASFEDLIFSLGVPSIKYGSKMEGLCGDCNGNAGNDLQ-PNPAKKKAGVDVIQSWQADE--- 3219
            ::...||...:||:.:|..|:....|||||.|:.:..||.: ||.....:..|:...|...:   
Zfish  2142 IDAQISFTGTMFSIHLPWQKFHGNTEGLCGVCDNDQTNDCRLPNGTIISSCQDMASYWHVHDSNN 2206

  Fly  3220 --------PKLGLVEECLSEDVPK--EHCIPLPPEKDPCLQFYNAELFGKCPLAVDPIAYVSACQ 3274
                    |:...|..|.|..:.|  ||                 ::|.||...|....|||||.
Zfish  2207 SKNFLPSRPESTTVSSCPSSAMCKIIEH-----------------KIFEKCHRFVPVEPYVSACT 2254

  Fly  3275 QDICKPGNTQQGVCVALAAYAKECNQHGICTNWRRPQ--LCPYECPSDMVYEPCG--CAKNCDTI 3335
            .|:|...|...| |.:|.|||.||...|:|.:||...  :|.::|.|...|..||  ....||  
Zfish  2255 FDVCNKSNATIG-CASLQAYAHECAMAGVCVDWRDATNGVCDFKCKSPQTYLACGPQVEPTCD-- 2316

  Fly  3336 KALSEFDAVSLK-NEAVVHTVKTDEMCLSSERFEGCFCPPGKVM---DGGQCVPEIACTKCD 3393
               ..|:...|. |.|..::        .|..:|||:||.|...   :...|||     .||
Zfish  2317 ---ERFNQKHLHGNNAFSNS--------ESMLWEGCYCPRGTTRLRHNSNICVP-----SCD 2362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072
VWD 840..1015 CDD:214566
C8 1054..1121 CDD:214843
TIL 1131..1185 CDD:280072 2/3 (67%)
TIL 1245..1298 CDD:280072 14/60 (23%)
VWD 1327..1498 CDD:214566 30/184 (16%)
C8 1535..1609 CDD:214843 12/85 (14%)
Mucin2_WxxW 1751..1837 CDD:290069 31/95 (33%)
TIL 1938..2005 CDD:280072 11/66 (17%)
FA58C 2089..2223 CDD:238014 23/141 (16%)
FA58C 2104..2225 CDD:214572 19/125 (15%)
FA58C <2299..2404 CDD:214572 16/112 (14%)
FA58C <2299..2403 CDD:238014 16/111 (14%)
VWD 2703..2858 CDD:295339 21/155 (14%)
C8 2893..2970 CDD:285899 8/76 (11%)
TIL 2974..3030 CDD:280072 15/65 (23%)
VWD 3035..3198 CDD:295339 44/175 (25%)
C8 3257..3313 CDD:285899 24/57 (42%)
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
muc5fXP_005169116.2 Endomucin 102..>228 CDD:330316
Mucin2_WxxW 540..627 CDD:315900 20/104 (19%)
Mucin2_WxxW 654..742 CDD:315900 20/111 (18%)
Mucin2_WxxW 796..884 CDD:315900 22/132 (17%)
Mucin2_WxxW 929..1017 CDD:315900 17/94 (18%)
Mucin2_WxxW 1071..1159 CDD:315900 31/95 (33%)
Mucin2_WxxW 1210..1298 CDD:315900 28/199 (14%)
Mucin2_WxxW 1349..1437 CDD:315900 27/176 (15%)
Mucin2_WxxW 1488..1576 CDD:315900 20/122 (16%)
Mucin2_WxxW 1627..1715 CDD:315900 22/99 (22%)
Mucin2_WxxW 1767..1854 CDD:315900 25/157 (16%)
VWD 2020..2186 CDD:214566 50/191 (26%)
C8 2228..2291 CDD:312319 27/80 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 64 1.000 Domainoid score I10109
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

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