Protein Alignment Hml and LOC100497756

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: XP_031756630.1
• Gene: LOC100497756 / 100497756
• XenbaseID: XB-GENE-29083839
• Length: 1713
• Species: Xenopus tropicalis
• Alignment Length: 2682
• Identity: 543/2682 - (20%)
• Similarity: 861/2682 - (32%)
• Gaps: 1066/2682 - (39%)

  Fly   420 MSGEMAYELQTERQKLLALLAKYRDLERRSEW-WSSEETVVTMSSYSLYQSNNLDIV----IDKT 479
            |:.:...||||.|                 .| |    ..:|:|..|.|     ||:    :|.|
 Frog     1 MAKKQTMELQTPR-----------------IWVW----LALTLSFSSAY-----DIIPGRPVDHT 39

  Fly   480 PRPALCTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGTFDIILKACPYGSGYGCAHTLKILWQ 544
              .::|::||..:.|||||::::.|.:|::.|              |...|..|   |...:..|
 Frog    40 --KSICSSWGNFHYKTFDGVIYQFPGTCNYNL--------------ASHCGDSY---HEFSVHIQ 85

  Fly   545 SVL----------------YTFE------NLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQID 587
            ..:                .|.|      .:||.:.:|        |....|:.:.....:.::.
 Frog    86 RAIEDGDPVIHQIFMQIKDVTIELKRDAAKVNGQIFVT--------PYFNYGVFINKKDGYTKVH 142

  Fly   588 LESVGLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVED 652
            .: :||.|.|:....|.::...:...|:.||||..:|.|.::........|..:: |.:...:.|
 Frog   143 TK-IGLTLTWNQEDSVMLEVDSKYQNKMCGLCGDYNGAPVSNEFYLNDMPLNPIQ-FGNMQNIND 205

  Fly   653 RSELC-QVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCNC 716
            .:..| .|:.|.:|  .:.||.|     ..|||:..|.......|....:....:..||.|.|:|
 Frog   206 PTITCTNVDESQQM--NVSSCGQ-----YYSVCKSYLTQNAFSSCQDLLDVSDYVMACMLDVCSC 263

  Fly   717 ANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVEPTCDSDLAL 781
            ::.:  .||.|..:...:::|...| .:...||..::||..|....||:..|    ..|.|..:.
 Frog   264 SSAD--VSCLCSTLTEYSRQCTHAG-GIPQNWRTDDLCPKQCPGNMVYKESG----SPCISSCSH 321

  Fly   782 PASKGACNE----GCFCPEGTV---QYKEACITRELCPCSLRGKEFKPESTVKKNCNTCTCKNGQ 839
            ....|.|.|    |||||:|||   .....||:...|.|..:.|.:.|.|.:..:|..|:|..|:
 Frog   322 HEVSGLCEEHNIDGCFCPDGTVWDDHNNAGCISISECHCKYQEKFYAPGSKILNDCEECSCNAGK 386

  Fly   840 WRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQN----TSVEAENVACSGAVSESM 900
            |.||...|...|...|..|::|||||.|.|.|.| |:||...|    .::.||...|:....|
 Frog   387 WTCTHGVCPKVCSIEGGAHFKTFDGKPYKFHGNC-YYLLSKANHGGTHNIVAEMTPCNAYSRE-- 448

  Fly   901 NFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFL 965
                    :|.|  .|:| ..|...:|:.:....:.::||..|: ||.:.|...|:....|:.|:
 Frog   449 --------TCLK--NIQF-YTDDNENVLSIRADGSVLLNDLKIS-LPHVTGSFSVIQPTESNIFV 501

  Fly   966 TVEFADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRT 1030
            ..:|...::::...:.::||....:.....:||||.||....|||:|..|..|:....||:.|:.
 Frog   502 KTKFGLQMQIYLLPLMQLYITMDNTDNNTFEGLCGNFNYKEGDDFITSAGIEESTASAFANTWKI 566

  Fly  1031 KDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWILQDI---FQDCHFLVEPEQFYEDCLYDTCAC 1092
            :.|||...|..  ..||:.:.|.|..|||:|. :|:|.   |..|||.|:|.::::.|.||||:|
 Frog   567 QPTCQDSVEVL--IDPCSFSMETKIYAEKWCS-MLRDSESPFWKCHFAVDPSEYFKRCEYDTCSC 628

  Fly  1093 KDEMSKCFCPILSAYGTECMRQG-VKTGWRMSVKECAV-KCPLGQVFDECGDGCALSCDDLPSKG 1155
             .....|.|..||:|...|..:| :...|:..:.:..: .||..|::......|..:|..|..:
 Frog   629 -SHSEACMCATLSSYARACAAKGIILWDWKKGICDKEIPSCPDSQIYLYNITTCQPTCRSLALE- 691

  Fly  1156 SCKREC------VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCT 1214
              ::||      |:||.||.|.|:||...||||..|.|...||..||.....|..|:    |:|.
 Frog   692 --EKECDSEFTPVDGCGCPDGMYLNEKDSCVPKSQCSCYHQGMYLRPNEVFYRMDER----CSCH 750

  Fly  1215 DGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYVADSSDCLPGCVC 1279
            :|..:| |:...|...   :.::...|.|:..:..::     .::|:.:: .....:.|:.||||
 Frog   751 EGKLNC-DSFINDTCS---NGKVFLDCKKEKRSHMSR-----HRSCRTLN-IGPMGTGCISGCVC 805

  Fly  1280 MEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCSKNGCESTCSVWGDS 1344
            .:| :.|.....||:.::|.|.:..|.:..|.::.|:|..|.|.:|.|.|.:..|..||:::|..
 Frog   806 PDG-LLDDGHGGCVVESSCPCSYNNKVFAHGSRLIEECKSCTCESGLWSCIQTPCYGTCTIYGSG 869

  Fly  1345 HFTTFDGHDFDFQGACDYVLAK---GVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEES 1406
            |:.|||...:||.|:|::|:|:   |...:...|.|..:|:.|||.|||||||::|.| |:.|..
 Frog   870 HYITFDKKFYDFDGSCEFVVAQDYCGDSASNGTFRIITENIPCGTTGVTCSKSIKIYL-GNTELK 933

  Fly  1407 LLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKL 1471
            |           .|....||..:.....|   :.:.:.|:::.:.. ...:.:.||:.|.:.::|
 Frog   934 L-----------TNSHMEKKFGEFETEVG---YKVREVGLYLAIRT-SSDISLIWDKKTSLLIRL 983

  Fly  1472 GNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERET 1536
            .:.::.||.||||||:.|:.:|..|......::.|.||::||....|....:....|...|.|.:
 Frog   984 PSSYQGKVCGLCGNYDDNANNDFLTSQSIQASNAMPFGNSWKRSNDCPDANSIPQPCLAAPHRRS 1048

  Fly  1537 WAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIR 1601
            ||:.||..:.:::|..||::|..:.|:..|:.|.|:||.||||||.||||||||..||:..:.|.
 Frog  1049 WAEKKCDIITNNVFARCHSKVDPKPFYDACVNDVCSCDTGGDCECFCTAVAAYAQLCAKADVCIH 1113

  Fly  1602 WRSQHFCPMQCDPHCSDYKACTPACAVETCDNFLDQGIAERMCNRENCLEGCHIKPCEDGFIYLN 1666
            ||:...||:.||                                                  |.|
 Frog  1114 WRTPEICPIFCD--------------------------------------------------YYN 1128

  Fly  1667 DTYRDCV-PKAECKPVCMVRDGKTFYEGDITFTDSCATCRCSKRKEICSGVKCDVPATTGLPAPL 1730
            ....:|: ....|.|
 Frog  1129 TNENECMWHYFACGP-------------------------------------------------- 1143

  Fly  1731 VEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTK 1795
                          :.:.:...|::|..                 |....:|..|.||
 Frog  1144 --------------EDRSIHHITKYCHS-----------------PSVTHLEGCYPTC------- 1170

  Fly  1796 VECRVKDTHEAPEQMDENVVCSLEEGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQLGLAC 1860
                                                                  |||:|.
 Frog  1171 ------------------------------------------------------PTERPY----- 1176

  Fly  1861 DAAVVEYKEFPGDCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLK 1925
                  |.|....|  ..||              :|   ::.|.|..|...|
 Frog  1177 ------YDEINKSC--VSHC--------------SC---IINNITYSIGQQI------------- 1203

  Fly  1926 PEPEPEFEPIKQCPPGKIKSECANQCENTCHYYGSILKKRGLCQV--GEHCKPGCVDELRPDCPK 1988
            |.|||                                     ||:  .:|.|     :|:....:
 Frog  1204 PNPEP-------------------------------------CQIWHTKHTK-----QLQMQYRR 1226

  Fly  1989 LGKFWRDEDTCVHADECPCMDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPKDEDDDL 2053
            |...||                 ::|
 Frog  1227 LEHHWR-----------------KNY--------------------------------------- 1235

  Fly  2054 DLVSVVPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEHGPKMARLTKEQPRGS 2118
                                        .|..|:..|::.|.|:
 Frog  1236 ----------------------------SNNFHNYKDALDNFSN--------------------- 1251

  Fly  2119 WSPSINDQMQYLELNFAKPEPFYGVVMAGSPEFDNYVTLFKILHSHDGIAYHYLVDETEKPQMFN 2183
                        :|:||.                            :|
 Frog  1252 ------------DLSFAA----------------------------EG----------------- 1259

  Fly  2184 GPLDSRAPVQTLFKIPIEASSLRIYPLKWHGSIAMRVELLICGDKEEPKPVPTVSTILPITERPA 2248
                    .|.|.:.||:..|                         .|:.||.::.
 Frog  1260 --------TQHLQQQPIQQQS-------------------------TPQNVPVITM--------- 1282

  Fly  2249 RLVDLECIDLMGVDEGKMYQDQVQSSSLWQQPNLGKKLQLLELLKLSTPLAWRPLANSQNEFIEF 2313
                          |..:.|.|                                   :.||...|
 Frog  1283 --------------EKHICQGQ-----------------------------------ATNERASF 1298

  Fly  2314 DFLEPRNISGFVTKGGPDGWVTGYKVMFSKKKPTWNTVLSTDGQARIFEANHDAETERRHHFKNP 2378
                                 ||.::.                                   :|.
 Frog  1299 ---------------------TGEEIT-----------------------------------RNK 1307

  Fly  2379 ILTQYIKIV--------PAYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKCNI------CD 2429
            ||.:..|:|        ||                ..:|......|...:.|||...      ..
 Frog  1308 ILGKCYKVVCDGNCGEIPA----------------TEFPCESTTTPTTPTTPTKTTTKTTTPSST 1356

  Fly  2430 GVSTSSSTTGCQCQDQLFWDGNTCVQHNLCPCIENYVSYPIGSKFENSACEDCVCVLGGHKNCKP 2494
            .:||.|:||                     ||:. :.|:.|.|      |...||...|......
 Frog  1357 TISTISTTT---------------------PCVP-HTSWQIFS------CTKAVCNGNGELQIVQ 1393

  Fly  2495 KKCPPCLGGKLRPVITSDCFCKCEPCPKHQRLCPSSGDCIPEILWCNGVQDCADDEDASCSDSFT 2559
            |.|.|                            |      |||       :||
 Frog  1394 KSCTP----------------------------P------PEI-------NCA------------ 1405

  Fly  2560 VEPDVSREKNETEVITCPVPVCPPQMKIRITEKKSRKMSKMFTFSKQVSIVDDGTTITKTKFISS 2624
                                                  :||    |.:::.||
 Frog  1406 --------------------------------------NKM----KPIAVPDD------------ 1416

  Fly  2625 KEQILAMPNRELDFQLEEQCDEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCL 2689
                             :.|                    |...:||
 Frog  1417 -----------------DSC--------------------CWHWECP------------------ 1426

  Fly  2690 RYSCVLRPNKDDVCEISGKS-FTTFDGTVFKY-GPCSHILARDIHSSSWSISVH---QQCSDETR 2749
               |        ||...|.| :.|||||.:.| |.|:::|..:|..:..:..::   ..|..:|.
 Frog  1427 ---C--------VCSGWGDSHYLTFDGTYYSYQGRCTYVLVEEIVKTIDNFGIYLDNSDCGHKTG 1480

  Fly  2750 KVCHKVITIQ------------------DTEAGNELILLPHLKLKFNGYEFTVQQLINSPICKAS 2796
            ..|.:.:|::                  :|.....|:|||:.|.....|:..|..:|..|..:.:
 Frog  1481 ITCPRKLTVRHNTREILISPKTSTPSSLETHVNGNLVLLPYTKYGVTIYQSGVYLVIEIPELQTN 1545

  Fly  2797 FVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPDGQIIP 2861
              |:..|.| .::...||                 ||.:...|.||....||.||....:|::..
 Frog  1546 --VTYNGLT-FSIMMPYG-----------------KFYKNTHGQCGTCTNNQADDLMMANGKVTT 1590

  Fly  2862 NTEKFGDSWYDKRIPKDQCGDLKCPREMQAKALQLCNIIHHPTFARCHKAVNYKQFLNNYCLEAA 2926
            :.....||:......|.:|..:........|: .:|::|..|.|..|| |.:..:.....||..:
 Frog  1591 SAVAMADSFMVHNPDKPRCNSIPPVHHNTCKS-AVCDLIMGPVFQNCH-AFHSPEPFYQACLLDS 1653

  Fly  2927 CNCMMANNGDPAACKCNILESFVKKCLSVNPLVQLTTWRAVA-QCEINCPSPLVHTDCYKRRCEP 2990
            ||...:||      :|:.|:.:...|......:|   ||:.| .|...|||..|:..|
 Frog  1654 CNKASSNN------ECSSLQHYASVCGDRGVCIQ---WRSHAPSCPFTCPSNKVYDAC------- 1702

  Fly  2991 SCDNVHGDDCPVLPDAC 3007
                     .|.||..|
 Frog  1703 ---------GPALPITC 1710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671	35/172 (20%)
		C8	684..754	CDD:462584	15/69 (22%)
		TIL	758..811	CDD:410995	19/59 (32%)
		VWD	840..1015	CDD:214566	52/178 (29%)
		C8	1054..1121	CDD:214843	26/70 (37%)
		TIL	1131..1185	CDD:410995	21/59 (36%)
		TIL	1245..1298	CDD:460351	10/52 (19%)
		VWD	1327..1498	CDD:214566	55/173 (32%)
		C8	1535..1609	CDD:214843	33/73 (45%)
		TIL	1938..2005	CDD:473303	8/68 (12%)
		FA58C	2089..2223	CDD:238014	12/133 (9%)
		FA58C	<2299..2403	CDD:238014	12/111 (11%)
		VWD	2703..2858	CDD:459671	41/177 (23%)
		TIL	2974..3030	CDD:460351	9/34 (26%)
		VWD	3035..3198	CDD:459671
		C8	3248..3313	CDD:462584
		VWC	3397..3451	CDD:450195
		GHB_like	<3755..3813	CDD:473907
LOC100497756	XP_031756630.1	VWD	38..189	CDD:214566	36/178 (20%)
		C8	231..298	CDD:462584	15/69 (22%)
		TIL	302..358	CDD:410995	19/59 (32%)
		VWD	398..551	CDD:459671	48/167 (29%)
		C8	590..656	CDD:214843	25/67 (37%)
		TIL	668..725	CDD:410995	21/59 (36%)
		VWC	825..>871	CDD:450195	14/45 (31%)
		VWD	852..1010	CDD:214566	55/173 (32%)
		C8	1049..1121	CDD:214843	33/71 (46%)
		VWD	1419..1586	CDD:214566	47/235 (20%)
		C8	1625..1690	CDD:214843	20/74 (27%)