DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and LOC100497756

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_031756630.1 Gene:LOC100497756 / 100497756 -ID:- Length:1713 Species:Xenopus tropicalis


Alignment Length:2682 Identity:543/2682 - (20%)
Similarity:861/2682 - (32%) Gaps:1066/2682 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   420 MSGEMAYELQTERQKLLALLAKYRDLERRSEW-WSSEETVVTMSSYSLYQSNNLDIV----IDKT 479
            |:.:...||||.|                 .| |    ..:|:|..|.|     ||:    :|.|
 Frog     1 MAKKQTMELQTPR-----------------IWVW----LALTLSFSSAY-----DIIPGRPVDHT 39

  Fly   480 PRPALCTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGTFDIILKACPYGSGYGCAHTLKILWQ 544
              .::|::||..:.|||||::::.|.:|::.|              |...|..|   |...:..|
 Frog    40 --KSICSSWGNFHYKTFDGVIYQFPGTCNYNL--------------ASHCGDSY---HEFSVHIQ 85

  Fly   545 SVL----------------YTFE------NLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQID 587
            ..:                .|.|      .:||.:.:|        |....|:.:.....:.::.
 Frog    86 RAIEDGDPVIHQIFMQIKDVTIELKRDAAKVNGQIFVT--------PYFNYGVFINKKDGYTKVH 142

  Fly   588 LESVGLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVED 652
            .: :||.|.|:....|.::...:...|:.||||..:|.|.::........|..:: |.:...:.|
 Frog   143 TK-IGLTLTWNQEDSVMLEVDSKYQNKMCGLCGDYNGAPVSNEFYLNDMPLNPIQ-FGNMQNIND 205

  Fly   653 RSELC-QVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCNC 716
            .:..| .|:.|.:|  .:.||.|     ..|||:..|.......|....:....:..||.|.|:|
 Frog   206 PTITCTNVDESQQM--NVSSCGQ-----YYSVCKSYLTQNAFSSCQDLLDVSDYVMACMLDVCSC 263

  Fly   717 ANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVEPTCDSDLAL 781
            ::.:  .||.|..:...:::|...| .:...||..::||..|....||:..|    ..|.|..:.
 Frog   264 SSAD--VSCLCSTLTEYSRQCTHAG-GIPQNWRTDDLCPKQCPGNMVYKESG----SPCISSCSH 321

  Fly   782 PASKGACNE----GCFCPEGTV---QYKEACITRELCPCSLRGKEFKPESTVKKNCNTCTCKNGQ 839
            ....|.|.|    |||||:|||   .....||:...|.|..:.|.:.|.|.:..:|..|:|..|:
 Frog   322 HEVSGLCEEHNIDGCFCPDGTVWDDHNNAGCISISECHCKYQEKFYAPGSKILNDCEECSCNAGK 386

  Fly   840 WRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQN----TSVEAENVACSGAVSESM 900
            |.||...|...|...|..|::|||||.|.|.|.| |:||...|    .::.||...|:....|  
 Frog   387 WTCTHGVCPKVCSIEGGAHFKTFDGKPYKFHGNC-YYLLSKANHGGTHNIVAEMTPCNAYSRE-- 448

  Fly   901 NFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFL 965
                    :|.|  .|:| ..|...:|:.:....:.::||..|: ||.:.|...|:....|:.|:
 Frog   449 --------TCLK--NIQF-YTDDNENVLSIRADGSVLLNDLKIS-LPHVTGSFSVIQPTESNIFV 501

  Fly   966 TVEFADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRT 1030
            ..:|...::::...:.::||....:.....:||||.||....|||:|..|..|:....||:.|:.
 Frog   502 KTKFGLQMQIYLLPLMQLYITMDNTDNNTFEGLCGNFNYKEGDDFITSAGIEESTASAFANTWKI 566

  Fly  1031 KDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWILQDI---FQDCHFLVEPEQFYEDCLYDTCAC 1092
            :.|||...|..  ..||:.:.|.|..|||:|. :|:|.   |..|||.|:|.::::.|.||||:|
 Frog   567 QPTCQDSVEVL--IDPCSFSMETKIYAEKWCS-MLRDSESPFWKCHFAVDPSEYFKRCEYDTCSC 628

  Fly  1093 KDEMSKCFCPILSAYGTECMRQG-VKTGWRMSVKECAV-KCPLGQVFDECGDGCALSCDDLPSKG 1155
             .....|.|..||:|...|..:| :...|:..:.:..: .||..|::......|..:|..|..: 
 Frog   629 -SHSEACMCATLSSYARACAAKGIILWDWKKGICDKEIPSCPDSQIYLYNITTCQPTCRSLALE- 691

  Fly  1156 SCKREC------VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCT 1214
              ::||      |:||.||.|.|:||...||||..|.|...||..||.....|..|:    |:|.
 Frog   692 --EKECDSEFTPVDGCGCPDGMYLNEKDSCVPKSQCSCYHQGMYLRPNEVFYRMDER----CSCH 750

  Fly  1215 DGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYVADSSDCLPGCVC 1279
            :|..:| |:...|...   :.::...|.|:..:..::     .::|:.:: .....:.|:.||||
 Frog   751 EGKLNC-DSFINDTCS---NGKVFLDCKKEKRSHMSR-----HRSCRTLN-IGPMGTGCISGCVC 805

  Fly  1280 MEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCSKNGCESTCSVWGDS 1344
            .:| :.|.....||:.::|.|.:..|.:..|.::.|:|..|.|.:|.|.|.:..|..||:::|..
 Frog   806 PDG-LLDDGHGGCVVESSCPCSYNNKVFAHGSRLIEECKSCTCESGLWSCIQTPCYGTCTIYGSG 869

  Fly  1345 HFTTFDGHDFDFQGACDYVLAK---GVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEES 1406
            |:.|||...:||.|:|::|:|:   |...:...|.|..:|:.|||.|||||||::|.| |:.|..
 Frog   870 HYITFDKKFYDFDGSCEFVVAQDYCGDSASNGTFRIITENIPCGTTGVTCSKSIKIYL-GNTELK 933

  Fly  1407 LLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKL 1471
            |           .|....||..:.....|   :.:.:.|:::.:.. ...:.:.||:.|.:.::|
 Frog   934 L-----------TNSHMEKKFGEFETEVG---YKVREVGLYLAIRT-SSDISLIWDKKTSLLIRL 983

  Fly  1472 GNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERET 1536
            .:.::.||.||||||:.|:.:|..|......::.|.||::||....|....:....|...|.|.:
 Frog   984 PSSYQGKVCGLCGNYDDNANNDFLTSQSIQASNAMPFGNSWKRSNDCPDANSIPQPCLAAPHRRS 1048

  Fly  1537 WAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIR 1601
            ||:.||..:.:::|..||::|..:.|:..|:.|.|:||.||||||.||||||||..||:..:.|.
 Frog  1049 WAEKKCDIITNNVFARCHSKVDPKPFYDACVNDVCSCDTGGDCECFCTAVAAYAQLCAKADVCIH 1113

  Fly  1602 WRSQHFCPMQCDPHCSDYKACTPACAVETCDNFLDQGIAERMCNRENCLEGCHIKPCEDGFIYLN 1666
            ||:...||:.||                                                  |.|
 Frog  1114 WRTPEICPIFCD--------------------------------------------------YYN 1128

  Fly  1667 DTYRDCV-PKAECKPVCMVRDGKTFYEGDITFTDSCATCRCSKRKEICSGVKCDVPATTGLPAPL 1730
            ....:|: ....|.|                                                  
 Frog  1129 TNENECMWHYFACGP-------------------------------------------------- 1143

  Fly  1731 VEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTK 1795
                          :.:.:...|::|..                 |....:|..|.||       
 Frog  1144 --------------EDRSIHHITKYCHS-----------------PSVTHLEGCYPTC------- 1170

  Fly  1796 VECRVKDTHEAPEQMDENVVCSLEEGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQLGLAC 1860
                                                                  |||:|.     
 Frog  1171 ------------------------------------------------------PTERPY----- 1176

  Fly  1861 DAAVVEYKEFPGDCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLK 1925
                  |.|....|  ..||              :|   ::.|.|..|...|             
 Frog  1177 ------YDEINKSC--VSHC--------------SC---IINNITYSIGQQI------------- 1203

  Fly  1926 PEPEPEFEPIKQCPPGKIKSECANQCENTCHYYGSILKKRGLCQV--GEHCKPGCVDELRPDCPK 1988
            |.|||                                     ||:  .:|.|     :|:....:
 Frog  1204 PNPEP-------------------------------------CQIWHTKHTK-----QLQMQYRR 1226

  Fly  1989 LGKFWRDEDTCVHADECPCMDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPKDEDDDL 2053
            |...||                 ::|                                       
 Frog  1227 LEHHWR-----------------KNY--------------------------------------- 1235

  Fly  2054 DLVSVVPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEHGPKMARLTKEQPRGS 2118
                                        .|..|:..|::.|.|:                     
 Frog  1236 ----------------------------SNNFHNYKDALDNFSN--------------------- 1251

  Fly  2119 WSPSINDQMQYLELNFAKPEPFYGVVMAGSPEFDNYVTLFKILHSHDGIAYHYLVDETEKPQMFN 2183
                        :|:||.                            :|                 
 Frog  1252 ------------DLSFAA----------------------------EG----------------- 1259

  Fly  2184 GPLDSRAPVQTLFKIPIEASSLRIYPLKWHGSIAMRVELLICGDKEEPKPVPTVSTILPITERPA 2248
                    .|.|.:.||:..|                         .|:.||.::.         
 Frog  1260 --------TQHLQQQPIQQQS-------------------------TPQNVPVITM--------- 1282

  Fly  2249 RLVDLECIDLMGVDEGKMYQDQVQSSSLWQQPNLGKKLQLLELLKLSTPLAWRPLANSQNEFIEF 2313
                          |..:.|.|                                   :.||...|
 Frog  1283 --------------EKHICQGQ-----------------------------------ATNERASF 1298

  Fly  2314 DFLEPRNISGFVTKGGPDGWVTGYKVMFSKKKPTWNTVLSTDGQARIFEANHDAETERRHHFKNP 2378
                                 ||.::.                                   :|.
 Frog  1299 ---------------------TGEEIT-----------------------------------RNK 1307

  Fly  2379 ILTQYIKIV--------PAYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKCNI------CD 2429
            ||.:..|:|        ||                ..:|......|...:.|||...      ..
 Frog  1308 ILGKCYKVVCDGNCGEIPA----------------TEFPCESTTTPTTPTTPTKTTTKTTTPSST 1356

  Fly  2430 GVSTSSSTTGCQCQDQLFWDGNTCVQHNLCPCIENYVSYPIGSKFENSACEDCVCVLGGHKNCKP 2494
            .:||.|:||                     ||:. :.|:.|.|      |...||...|......
 Frog  1357 TISTISTTT---------------------PCVP-HTSWQIFS------CTKAVCNGNGELQIVQ 1393

  Fly  2495 KKCPPCLGGKLRPVITSDCFCKCEPCPKHQRLCPSSGDCIPEILWCNGVQDCADDEDASCSDSFT 2559
            |.|.|                            |      |||       :||            
 Frog  1394 KSCTP----------------------------P------PEI-------NCA------------ 1405

  Fly  2560 VEPDVSREKNETEVITCPVPVCPPQMKIRITEKKSRKMSKMFTFSKQVSIVDDGTTITKTKFISS 2624
                                                  :||    |.:::.||            
 Frog  1406 --------------------------------------NKM----KPIAVPDD------------ 1416

  Fly  2625 KEQILAMPNRELDFQLEEQCDEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCL 2689
                             :.|                    |...:||                  
 Frog  1417 -----------------DSC--------------------CWHWECP------------------ 1426

  Fly  2690 RYSCVLRPNKDDVCEISGKS-FTTFDGTVFKY-GPCSHILARDIHSSSWSISVH---QQCSDETR 2749
               |        ||...|.| :.|||||.:.| |.|:::|..:|..:..:..::   ..|..:|.
 Frog  1427 ---C--------VCSGWGDSHYLTFDGTYYSYQGRCTYVLVEEIVKTIDNFGIYLDNSDCGHKTG 1480

  Fly  2750 KVCHKVITIQ------------------DTEAGNELILLPHLKLKFNGYEFTVQQLINSPICKAS 2796
            ..|.:.:|::                  :|.....|:|||:.|.....|:..|..:|..|..:.:
 Frog  1481 ITCPRKLTVRHNTREILISPKTSTPSSLETHVNGNLVLLPYTKYGVTIYQSGVYLVIEIPELQTN 1545

  Fly  2797 FVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPDGQIIP 2861
              |:..|.| .::...||                 ||.:...|.||....||.||....:|::..
 Frog  1546 --VTYNGLT-FSIMMPYG-----------------KFYKNTHGQCGTCTNNQADDLMMANGKVTT 1590

  Fly  2862 NTEKFGDSWYDKRIPKDQCGDLKCPREMQAKALQLCNIIHHPTFARCHKAVNYKQFLNNYCLEAA 2926
            :.....||:......|.:|..:........|: .:|::|..|.|..|| |.:..:.....||..:
 Frog  1591 SAVAMADSFMVHNPDKPRCNSIPPVHHNTCKS-AVCDLIMGPVFQNCH-AFHSPEPFYQACLLDS 1653

  Fly  2927 CNCMMANNGDPAACKCNILESFVKKCLSVNPLVQLTTWRAVA-QCEINCPSPLVHTDCYKRRCEP 2990
            ||...:||      :|:.|:.:...|......:|   ||:.| .|...|||..|:..|       
 Frog  1654 CNKASSNN------ECSSLQHYASVCGDRGVCIQ---WRSHAPSCPFTCPSNKVYDAC------- 1702

  Fly  2991 SCDNVHGDDCPVLPDAC 3007
                     .|.||..|
 Frog  1703 ---------GPALPITC 1710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 35/172 (20%)
C8 680..754 CDD:285899 17/73 (23%)
TIL 758..811 CDD:280072 19/59 (32%)
VWD 840..1015 CDD:214566 52/178 (29%)
C8 1054..1121 CDD:214843 26/70 (37%)
TIL 1131..1185 CDD:280072 21/59 (36%)
TIL 1245..1298 CDD:280072 10/52 (19%)
VWD 1327..1498 CDD:214566 55/173 (32%)
C8 1535..1609 CDD:214843 33/73 (45%)
Mucin2_WxxW 1751..1837 CDD:290069 7/85 (8%)
TIL 1938..2005 CDD:280072 8/68 (12%)
FA58C 2089..2223 CDD:238014 12/133 (9%)
FA58C 2104..2225 CDD:214572 9/120 (8%)
FA58C <2299..2404 CDD:214572 12/112 (11%)
FA58C <2299..2403 CDD:238014 12/111 (11%)
VWD 2703..2858 CDD:295339 41/177 (23%)
C8 2893..2970 CDD:285899 20/77 (26%)
TIL 2974..3030 CDD:280072 9/34 (26%)
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
LOC100497756XP_031756630.1 VWD 38..189 CDD:214566 36/178 (20%)
C8 239..298 CDD:400886 13/61 (21%)
TIL 302..358 CDD:410995 19/59 (32%)
VWD 387..551 CDD:214566 52/178 (29%)
C8 590..656 CDD:214843 25/67 (37%)
TIL 668..725 CDD:410995 21/59 (36%)
VWC 825..>871 CDD:327433 14/45 (31%)
VWD 852..1010 CDD:214566 55/173 (32%)
C8 1049..1121 CDD:214843 33/71 (46%)
VWD 1419..1586 CDD:214566 47/235 (20%)
C8 1624..1686 CDD:400886 19/71 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I11152
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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