DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and LOC100495470

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_031756442.1 Gene:LOC100495470 / 100495470 -ID:- Length:5681 Species:Xenopus tropicalis


Alignment Length:2430 Identity:573/2430 - (23%)
Similarity:909/2430 - (37%) Gaps:542/2430 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   451 WWSSEETV---VTMSSYSLYQSNNLDIVIDKTPRPALCTTWGGINMKTFDGLVFKAPLSC----- 507
            |..|..||   ..||...|..::|          ..:|:|||..:.|||||.:|:.|.:|     
 Frog     9 WILSTLTVTCLANMSPQGLNPAHN----------DQVCSTWGNFHFKTFDGDIFQFPGTCNYVFA 63

  Fly   508 SHTLITDKVSGTFDIILKACPYGSGYGCAH-TLKILWQSVLYTFEN---LNGTMQLTTPIKKLPM 568
            ||...|.:   .|:|.::..|........: |:||  :.::...|.   |.|..::|.|..:..:
 Frog    64 SHCKTTYE---DFNIQIRRTPSEERATITYVTMKI--EGLVIELEKGQVLVGGERVTLPYTQFGV 123

  Fly   569 PVQVMGMKVMPVAQHVQIDLESVGLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSR 633
            .:::..:.|...|:        :||.|.|:....:|:...|:.:....||||.:: ....||...
 Frog   124 HIEINSIYVKVSAK--------LGLVLLWNEDDALSLDLQPKYFNSTCGLCGNMN-RVKQDLFKV 179

  Fly   634 TGKKLATVKAFADAWRVEDRSELCQ------VENSAEMEFGMDSCEQSKLQKAVSVCERLLANEK 692
            .|.:|:.:: |.:..:::..:|.|.      .:|.:::               |..|.|:|:|..
 Frog   180 NGIELSPLQ-FGNLQKLDGPTEQCNDVTPSPPKNCSDL---------------VEACSRMLSNPA 228

  Fly   693 LGDCIKPFNYDALIRTCMADYCNCANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPIS 757
            ..||......:..:::|:.|.|||.| ....:|.||.:|..:::||..|.|.:: ||:.:||..|
 Frog   229 FADCELRMPLEPYVQSCVLDLCNCQN-SSDVTCLCDTLAEYSRQCAHAGGKPKN-WRSHQICQRS 291

  Fly   758 CGFGRVYQACGPNVEPTCDSDLALPASKGACNEGCFCPEGTV---QYKEACITRELCPCSLRGKE 819
            |.....|:.||.....||.:..........|.:|||||.|||   .....|:....|.|:...|.
 Frog   292 CPMNMTYEECGSPCADTCSNSDRKTTCADHCIDGCFCPPGTVFDDMNNRGCVPLSECSCTYNNKN 356

  Fly   820 FKPESTVKKNCNTCTCKNGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLK--TQN 882
            :....:...||..|||..|||.|....|...|...|..|..|:||..|:|.|.|||...|  ..|
 Frog   357 YAVGESYSTNCRNCTCVGGQWSCQALPCPGYCSLQGGSHIFTYDGSHYNFHGDCSYVFTKDCVGN 421

  Fly   883 T-SVEAENVACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKL 946
            | :|.||...|          ...|..:|.|::|:..   |...:|:.:....|.::|. ..|::
 Frog   422 TFTVLAELHTC----------GVTDTETCLKSITLSM---DKGQTVVTVKSSGTVLING-IYAQI 472

  Fly   947 PKMLGLGEVLIRRASSTFLTVEFADG--IRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDD 1009
            |  :....:.:.:||:.:|.::...|  |:|....|.::|:......:|.|.||||.||:...||
 Frog   473 P--MTTENITVFQASTFYLIIQSFSGLQIQVQLTPVMQLYVTLESEYQGNTCGLCGDFNNVRTDD 535

  Fly  1010 FLTPEGDVETAVEPFADKWRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWILQDI---FQD 1071
            |.:..|.:|.....||:.|:::..|....:::.  :||:|:.|.:..|:.:|. :|.|.   |..
 Frog   536 FRSLSGAMEGTAAAFANTWKSQADCDNIKDSYN--NPCSLSVENEKYAQHWCS-MLTDANGPFAP 597

  Fly  1072 CHFLVEPEQFYEDCLYDTCAC-KDEMSKCFCPILSAYGTECMRQGVK-TGWRMSVKEC---AVKC 1131
            ||.:|.|..:.::|:||:|.. |.|.|  .|..:|.|...|..:|:. .|||.:|  |   ...|
 Frog   598 CHAVVNPTLYEKNCMYDSCNYEKSEDS--VCAAMSFYVHACAVEGISLNGWRTTV--CGNYTKNC 658

  Fly  1132 PLGQVFDECGDGCALSCDDLPSKG---SCKRECVEGCRCPHGEYVNEDGECVPKKMCHCNFDGMS 1193
            |....:......|..:|..|....   |.....|:||.||:|.|::|.|.|||...|.|.:.|  
 Frog   659 PKNTTYQYSISSCQPTCRSLSEPDPTCSVSFPPVDGCGCPNGTYLDESGSCVPDHNCPCYYKG-- 721

  Fly  1194 FRPGYKEVRPGEKFLD---LCTCTDGVWDC--QDAEPGDKDKYPPSSELRSKCAKQPY-AEFTKC 1252
                 ..:..||...|   :|||..|...|  :...|.:    .|.:.:...||.... |...:|
 Frog   722 -----TPMPAGEVIYDNGAMCTCQSGRLQCVGKTLSPAE----CPENMVYFDCANASMGARGAEC 777

  Fly  1253 APKEPKTCKNMDKYVADSSDCLPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDC 1317
                .|||..:|.... |..|..||:|.:|.|.:.:. :||....|.|.|.|:.|..||.|::||
 Frog   778 ----QKTCHTLDMDCI-SIQCASGCICPDGLVLNNNG-SCVPEEQCPCMHNGEMYHSGETIQQDC 836

  Fly  1318 NLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFDFQGACDYVLAKG--VFDNGDG-FSITI 1379
            |.|.|:...|.|:...|..:|.|:|:.|:.||||..|.|.|.|:|.|.:.  ..:.|:| |.:..
 Frog   837 NTCVCKDRKWNCTNKACHRSCVVYGEGHYKTFDGKQFHFSGDCEYTLTQDYCASNTGNGSFRVIT 901

  Fly  1380 QNVLCGTMGVTCSKSLEIALTGHAEESLLLSADSAYSTD-PNKTPIKKLRDSVNSKGHNAFHIYK 1443
            :|:.||:.|.|||||:::.| |:.|..|..........| .::.|               :.|.:
 Frog   902 ENIPCGSTGATCSKSIKVFL-GNFELQLSEGGFDVIERDIGSEVP---------------YQIRQ 950

  Fly  1444 AGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLF 1508
            .|:::|:|. ...|.:.||:.|.:.:||..|::..|.||||||:|:..:::.|.|..:..:...|
 Frog   951 MGIYLVIEA-KNGLILIWDKKTSIMIKLSPEFQGNVCGLCGNYDGSVYNELTTRSQSVVVNVQEF 1014

  Fly  1509 GHAWKLQPHCSAPVAPIDACKKHPERETWAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCAC 1573
            |::||..|.|.........|..:|.|::|||..|..:.|.:|.:|.::|....|::.|:.|:|||
 Frog  1015 GNSWKESPTCPDAQPLRHPCVANPYRQSWAQKHCSVIISSVFAKCQSKVDPTTFYEACVHDSCAC 1079

  Fly  1574 DQGGDCECLCTAVAAYADACAQKGINIRWRSQHFCPMQCDPHCSD------YKACTPACAVETCD 1632
            |.||||||.||||||||.||...||.|.||:...||:.||.:..|      ||.|...| ::||.
 Frog  1080 DSGGDCECFCTAVAAYAAACNDAGICIAWRTPEICPLFCDYYNPDGECEWHYKPCGAPC-MKTCR 1143

  Fly  1633 NFLDQGIAERMCNRENC------LEGCHIKPCEDGFIYLNDTYRDCVPKAECKPVCMVRDGKTFY 1691
            |  ..|         ||      ||||:.| |.....:.::....||.:|.|.  |...|||.:.
 Frog  1144 N--PSG---------NCKNQLPGLEGCYPK-CPKDRPFFDEDVMKCVAQANCG--CYDDDGKRYS 1194

  Fly  1692 EGD-ITFTDSCATCRCSKRKEIC--------------------------SGV------KCD---- 1719
            .|: :....:|.:|.|:|:...|                          .|:      .|.    
 Frog  1195 IGNMVPSVKNCESCICTKKGRRCQMDLRACYCYYGNMKYNYGDVIYNTTDGIGGCITATCSTNGT 1259

  Fly  1720 -------------VPATT----GLPAPLVE-GTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKS 1766
                         .|:||    ...:|.|. .||.|..:.:.:..:.|..|:.|.|         
 Frog  1260 INRSVYPCVPSTVAPSTTFFFNATTSPAVNLSTTEPVSVTSVSCLEEVCKWSTWYD--------- 1315

  Fly  1767 VRLNDEEKVPRYDRMENVYGTCLK---------QYMTKVECRVKDTHEAP-EQMDENVVCSLEEG 1821
                  ...|:|...:..:.|..|         :..:.||||.:...:.| ..:.:.:.|:...|
 Frog  1316 ------ATCPKYGENDGDFETFEKIRETGHTVCKVPSDVECRAQKFPKIPVRDLGQIIQCNKSVG 1374

  Fly  1822 LRCIGK------CHDYELRAFCQCDEELEPELPKPTEKPQLGLACDAAVVEYKEFPGDCHKFLHC 1880
            |.|..|      |.:||:|..|                                    | .::.|
 Frog  1375 LVCRNKDQFSQLCFNYEIRILC------------------------------------C-SYVPC 1402

  Fly  1881 QPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLKPEPEPEFEPIKQCPPGKIKS 1945
                   |...:..|.|......|:.:......|::....:.......:.:....|.......||
 Frog  1403 -------GQSSISPTPGASTYSQPSSMTSSFAKTLSTTASHSSKTSTVKSKTTSPKTAGTSTTKS 1460

  Fly  1946 E-------CANQ-CENTCHY---YGSILKKRGLCQVGEHCKPGCVDELRPDCPKLGKFWRDEDTC 1999
            .       |.|| |..|..|   :.||....|..:..|:.|..                 ....|
 Frog  1461 SIKTSTTPCKNQICTWTPWYDVHFPSIASSDGDFETFENIKAA-----------------GNSIC 1508

  Fly  2000 VHADECPCMDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPKDEDDDLDLVSVVPI--- 2061
            ...:...|  :||.:...:...:|:...|. :.|...|         |::|.|.:.    |:   
 Frog  1509 QKPENIEC--RAERFPTKNITEIGQVVTCN-VKNGLIC---------KNQDQDWNF----PLCYN 1557

  Fly  2062 YPVTLTPPLQCSPE----------RLIPKIENPAHSLPDSIFNASSQLAPEHGPKMARLTK---E 2113
            |.|.:   |.||.|          ......|..:.....:||:..:.:..:|...|...|.   :
 Frog  1558 YQVRV---LCCSLEDCDSSTTHVKMTTRSSEETSKFGKTTIFSTRNIITSKHVTDMESKTSTSHK 1619

  Fly  2114 QPRGSWSPSINDQMQYLELNFAK-PEPFYGVVMAGS-----------------PEFDNYVTLFKI 2160
            :.:.:..|..:.....:.:...: |.....|....|                 .:|....|  |.
 Frog  1620 ETKSTTMPIKSTPQTPISVKTTRVPATSVEVTSTRSTTPVRKTTTGEAHSKSTTQFPKSTT--KA 1682

  Fly  2161 LHSHDGIAYHYLVDETEKPQMFNGPLDSRAPVQTLFKIPIEASSLRIYPLKWHGSIAMRVELLIC 2225
            .|..:..:...:..:|.:....:|.:.|......:.|....:.|    ...:|.|   ..|....
 Frog  1683 SHEQETSSQKPISTKTTRVSTASGEVTSHKATTVVKKSTTSSKS----TTGFHKS---TTEFSHK 1740

  Fly  2226 GDKEEPKPVPTVSTILPITE---RPARLVDLECIDLMGVDEGKMYQDQVQSSSLWQQPNLGKKLQ 2287
            ......||:...:|.:|.|.   ..||    ....|.....|::|......||..:.....|...
 Frog  1741 ETSTPQKPISVKTTTIPTTSVEVTSAR----STTPLRKSTTGQVYSKPTTKSSHEEATTFQKSTS 1801

  Fly  2288 L------LELLKLSTPLAWRPLANSQNEFIEFDFLEPRNISGFVTKGGPD-----GWVTGYKVMF 2341
            |      .|..::|:..|..|:..|.:|...      :.::..||....|     .|...:.|.|
 Frog  1802 LKTTRVSTESGEVSSTKATTPIKKSTSESTS------KVLTFGVTSSETDCKPICDWSQWFDVSF 1860

  Fly  2342 SKKKPTWNTVLSTDGQARIFEANHDAETERRHHFKNPILTQYIKIVPAYWEKNINMRIEPLGCFL 2406
            ..:                 |.|.|.||     ::| |......|.    |:..:::..|    .
 Frog  1861 PNE-----------------ETNGDFET-----YEN-IRNSGFSIC----EEPSDIQCRP----A 1894

  Fly  2407 PYPEIQRQVPVEE-SKPTKCNICDGVSTSSSTTGCQCQDQLFWDGNTCVQHNLCPCIENYVSYPI 2470
            .:|||    |:|: .:..:||:..|::                            |..:..:.|.
 Frog  1895 DFPEI----PIEDLQQNLQCNVSSGLT----------------------------CYNDEQNGPF 1927

  Fly  2471 GSKFENSACEDCVCVLGGHKNCKPKKCPPCLGGKLRPVITSDCFCKCEP---------CPKHQRL 2526
            ...|.......|              |..|         .|..|....|         .|....:
 Frog  1928 AFCFNYEIRIFC--------------CSKC---------ASTSFTASSPLYPTETVSVTPFSLTV 1969

  Fly  2527 CPSSGDCIPEILWCNGVQDCADDEDAS--CSDSFTVEPDVSREKNETEVITCPVPVCPPQMKIRI 2589
            ..||    .||.......:.|..:..|  .|..:|.....:.|.::.||.:...||     .|:|
 Frog  1970 STSS----EEIESSEATTNIAVSKSTSTLASPIYTGSQKTTEESSQEEVTSTKKPV-----SIKI 2025

  Fly  2590 TE------KKSRKMSKMFTFSKQVSIVDDGTT------------ITKTKFISSKEQILAMPNREL 2636
            ||      ||....:|:.|.:..:|.:...:|            .|..|.||.|...:|....||
 Frog  2026 TESAAATSKKITTPTKLSTTNPIISKISTASTQGLLLTTESEEEATSVKLISVKTTKVATLPMEL 2090

  Fly  2637 DFQLEEQCDEFTCVPIPSKQVDKNE 2661
            ....|......|.....|......|
 Frog  2091 ISTKETTSSRLTTTQTTSSHTPTTE 2115

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 40/159 (25%)
C8 680..754 CDD:285899 23/73 (32%)
TIL 758..811 CDD:280072 16/55 (29%)
VWD 840..1015 CDD:214566 51/179 (28%)
C8 1054..1121 CDD:214843 22/71 (31%)
TIL 1131..1185 CDD:280072 18/56 (32%)
TIL 1245..1298 CDD:280072 15/53 (28%)
VWD 1327..1498 CDD:214566 55/174 (32%)
C8 1535..1609 CDD:214843 36/73 (49%)
Mucin2_WxxW 1751..1837 CDD:290069 21/101 (21%)
TIL 1938..2005 CDD:280072 14/77 (18%)
FA58C 2089..2223 CDD:238014 21/154 (14%)
FA58C 2104..2225 CDD:214572 18/141 (13%)
FA58C <2299..2404 CDD:214572 20/109 (18%)
FA58C <2299..2403 CDD:238014 20/108 (19%)
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
LOC100495470XP_031756442.1 VWD 29..170 CDD:214566 39/163 (24%)
C8 220..288 CDD:400886 22/69 (32%)
TIL 292..348 CDD:410995 16/55 (29%)
VWC_out 350..>394 CDD:214565 14/43 (33%)
VWD 377..541 CDD:214566 51/179 (28%)
C8 578..651 CDD:214843 25/77 (32%)
TIL 658..715 CDD:410995 18/56 (32%)
TIL 756..817 CDD:410995 18/66 (27%)
VWC 819..>853 CDD:327433 14/33 (42%)
VWD 846..1004 CDD:214566 55/174 (32%)
C8 1043..1115 CDD:214843 36/71 (51%)
Mucin2_WxxW 1310..1396 CDD:404246 21/100 (21%)
Mucin2_WxxW 1476..1564 CDD:404246 21/123 (17%)
Mucin2_WxxW 1852..1939 CDD:404246 24/149 (16%)
Herpes_BLLF1 <1945..2346 CDD:282904 39/180 (22%)
Herpes_BLLF1 <2182..2640 CDD:282904
Treacle 2424..2936 CDD:397558
Herpes_BLLF1 <2865..3335 CDD:282904
Herpes_BLLF1 <3280..3735 CDD:282904
Treacle 3583..4038 CDD:397558
ser_rich_anae_1 <3880..>4235 CDD:411418
ser_rich_anae_1 <4149..>4471 CDD:411418
VWC 4613..4663 CDD:327433
VWD 4662..4829 CDD:214566
C8 4941..5004 CDD:400886
TIL 5011..5071 CDD:410995
VWC 5071..>5117 CDD:327433
VWC 5180..5246 CDD:214564
CT 5336..5412 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 76 1.000 Domainoid score I8782
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm72276
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2291
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.010

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