DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and LOC100494113

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_031757178.1 Gene:LOC100494113 / 100494113 -ID:- Length:1252 Species:Xenopus tropicalis


Alignment Length:1268 Identity:364/1268 - (28%)
Similarity:573/1268 - (45%) Gaps:176/1268 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   478 KTPRPALCTTWGGINMKTFDGLVFKAPLSCSHTLIT---DKVSGTFDIILKACPYGSGYGCAHTL 539
            |..|..:|:|||..:.||||..:::....|::.|::   |... .|.:.:|. ....|:.....:
 Frog    66 KNNRKNVCSTWGNFHFKTFDNELYQFKGGCTYNLLSHCQDSYQ-EFSVFIKR-DIVEGHPLIDKI 128

  Fly   540 KILWQSVLYTFENLNG-----TMQLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESVGLKLDWDH 599
            .|..:.|:.   ||.|     ..||.|.      |....|:.:.....::.:..: |||.:.::.
 Frog   129 TISIKDVII---NLRGKTVFVNNQLITE------PYYNYGILIYNNTAYLNVQTK-VGLNIFYNQ 183

  Fly   600 RQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGK---------------KLATVKAFADAWR 649
            ...|.::..|:...|..||||..:|      .||...               .|..|:...:.|.
 Frog   184 EDAVMLELDPKFMNKTCGLCGDYNG------VSRYTNYTILEDVLLYPIEFGNLPVVQNTDECWP 242

  Fly   650 V-EDRSELCQVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKP-FNYDALIRTCMAD 712
            | ||:.:.            :..|.|.     :.||::.|.......|.|. ...|..|..|:.|
 Frog   243 VTEDQQQT------------LSDCSQH-----IPVCKQYLEQSAFDTCTKSLMQEDFYIYACVLD 290

  Fly   713 YCNCANREHPES-CNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVEPTCD 776
            .|:|.  ::.:| |.|..|...:|:|...|.|.:. |||...|...|....:|:..|.....:| 
 Frog   291 MCSCG--QYQDSFCLCSTITEYSKQCCHSGGKPDE-WRNNTFCSKKCPGNMIYKESGSTCMNSC- 351

  Fly   777 SDLALPASKGACNE----GCFCPEGTVQ--YK-EACITRELCPCSLRGKEFKPESTVKKNCNTCT 834
            |.|..|.   .|.|    |||||||||:  |. ..|:....|.|...|:.:.|..::..:|.||.
 Frog   352 SHLESPT---PCEEHFMNGCFCPEGTVRDDYNWRGCVNESECYCKYAGELYAPGKSIIHSCETCK 413

  Fly   835 CKNGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQ-----NTSVEAENVACSG 894
            |.:|:|.|||:.|.|.|...|...:.|||.|:|.|.|.|.|.|.:.:     :..:..|...|  
 Frog   414 CISGRWNCTEEPCPALCSIEGGADFTTFDEKKYTFHGNCYYVLSQARYFFGTDFVILGELTPC-- 476

  Fly   895 AVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRR 959
            .:||.        .:|.|.::   :|.|...:|:.:......::||..|. ||.:  ...:.:..
 Frog   477 GISER--------DTCLKTIS---LLMDNNQNVLSIKADGNVLLNDLKIT-LPHV--TANISVTE 527

  Fly   960 ASSTFLTVEFA---DGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAV 1021
            .|:.::.::.:   :.|.:..:...::||.|.....|:.:||||.||....|||....|.||...
 Frog   528 YSNAYILLDTSFDENVIFIKLNPKMQLYITAGVDAMGKLKGLCGNFNFKESDDFEGSGGLVEATA 592

  Fly  1022 EPFADKWRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWILQDI---FQDCHFLVEPEQFYE 1083
            ..||:.|:...:||.:.:...  .||.:|.||...||.:|. :|::.   |..|:.:|.|..:.:
 Frog   593 SAFANTWKAHPSCQDRVDWLD--DPCHINIEKCKYAEYWCS-LLENTNTPFSPCYGVVNPSDYAK 654

  Fly  1084 DCLYDTCACKDEMSKCFCPILSAYGTECMRQG-VKTGWRMSV-KECAVKCPLGQVFDECGDGCAL 1146
            .|.|.||.|::. ..|.|..||:|.|.|..:| :...||..: .:....|...|::......|.|
 Frog   655 RCRYHTCNCENS-EICMCAALSSYATACAIKGIILKDWRKGICDKYITACEPSQIYLYSLTTCPL 718

  Fly  1147 SCDDLPSKGSC--KRECVEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLD 1209
            .|..|..:..|  |...|:||.|..|||:||:.|||....|.|.:.||..:|.....:..|:   
 Frog   719 KCQSLAEEEVCIPKLLPVDGCGCKAGEYMNENEECVQISQCSCYYGGMYLKPQEIIYKQNER--- 780

  Fly  1210 LCTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNMD-KYVADSSDC 1273
             |.|.||...|    ....::..|..::...|:..|.:...|     ..||:.:: :|.  ..:|
 Frog   781 -CICHDGKLFC----TAHFEESCPEGKIYLNCSITPNSVTAK-----HSTCQTLNSEYF--RKEC 833

  Fly  1274 LPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCSKNGCESTC 1338
            :.||||.||.| |..:.:||....|||.|..:...||..||.|||.|.|:.|.|.||...|..||
 Frog   834 ISGCVCPEGLV-DDGKGSCVPEEQCSCVHDKQFLPDGSHIKVDCNTCICKGGQWICSDYACYGTC 897

  Fly  1339 SVWGDSHFTTFDGHDFDFQGACDYVLAKGVFD----NGDGFSITIQNVLCGTMGVTCSKSLEIAL 1399
            :.:.|.|:.||||..:||||.|:||:|:....    ||. ||||.:::.||:.|:.|||:::|.:
 Frog   898 TAYSDGHYITFDGKIYDFQGTCEYVVAQDYCGHKPANGT-FSITTESIPCGSTGIACSKAIKIFI 961

  Fly  1400 TGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEG 1464
             |:.|..|            .:..:|.::.:.:...|...|::  |.::|: :|...:.:.||:.
 Frog   962 -GNTELKL------------EEKQMKVIQGTADDHLHYQAHVH--GNYLVI-LIRKGVYLIWDKK 1010

  Fly  1465 TRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACK 1529
            |.::::...|::.|:.|||||::..|.:|....::...|:.:.||:.||:.|.|...:..||.|.
 Frog  1011 TSIFIRASPEYKGKLCGLCGNFDDKSSNDFTINNILHVTNIIEFGNTWKVNPACPDVIEKIDPCT 1075

  Fly  1530 KHPERETWAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACA 1594
            ..|.|.:||:.||..:|||:||.||.:|....|::.|:.|.|.||..|||||.|:|||.||..|.
 Frog  1076 LTPHRRSWAEKKCSLIKSDVFKSCHNKVDPTPFFENCVSDACFCDVDGDCECFCSAVAVYAHECI 1140

  Fly  1595 QKGINIRWRSQHFCPMQCD---PH---------CSDYKACTPACAVETCDNF--LDQGIAERMCN 1645
            :..:.|.||:...||:.||   ||         |.::       .::||.:.  :::.|.     
 Frog  1141 KAEVCIYWRTPDICPIFCDYYNPHEECEWHYYPCGNH-------TIQTCSSMDVVNENIT----- 1193

  Fly  1646 RENCLEGCHIKPCEDGFIYLNDTYRDCVPKAEC 1678
             ...||||: ..|.....|.:|....||....|
 Frog  1194 -FTYLEGCY-PSCPPTKPYFDDILGICVEVCGC 1224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 37/158 (23%)
C8 680..754 CDD:285899 22/75 (29%)
TIL 758..811 CDD:280072 20/59 (34%)
VWD 840..1015 CDD:214566 47/182 (26%)
C8 1054..1121 CDD:214843 21/70 (30%)
TIL 1131..1185 CDD:280072 20/55 (36%)
TIL 1245..1298 CDD:280072 16/53 (30%)
VWD 1327..1498 CDD:214566 54/174 (31%)
C8 1535..1609 CDD:214843 33/73 (45%)
Mucin2_WxxW 1751..1837 CDD:290069
TIL 1938..2005 CDD:280072
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
LOC100494113XP_031757178.1 VWD 72..208 CDD:214566 34/147 (23%)
C8 266..330 CDD:400886 19/66 (29%)
TIL 334..390 CDD:410995 20/59 (34%)
VWC 392..>427 CDD:327433 12/34 (35%)
VWD 419..581 CDD:214566 45/177 (25%)
C8 624..693 CDD:214843 22/70 (31%)
TIL 703..759 CDD:410995 20/55 (36%)
TIL 798..857 CDD:410995 18/66 (27%)
VWD 886..1041 CDD:214566 54/171 (32%)
C8 1083..1155 CDD:214843 33/71 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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