Protein Alignment Hml and kcp

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: XP_002931908.3
• Gene: kcp / 100491140
• XenbaseID: XB-GENE-486713
• Length: 2327
• Species: Xenopus tropicalis
• Alignment Length: 2906
• Identity: 575/2906 - (19%)
• Similarity: 848/2906 - (29%)
• Gaps: 1211/2906 - (41%)

  Fly   796 EGTVQYKEACITRELCPCSLRGKEFKPESTVKKN-CNTCTCKNGQWRCTEDKCGARCGAVGDPHY 859
            :..|:|.|:|..|. ..|...|||::...|.||: ||.|.|..|...|:..|...:|  :|..|
 Frog   325 QARVKYLESCECRR-STCVWEGKEYQDNETWKKDACNICVCVGGSVTCSVRKDWPQC--LGCFH- 385

  Fly   860 QTFDGKRYDFMGKCSYHLLKTQNTSVEAENVAC---SGAVSESMNFAAPDDPSCTKAVTIRFILR 921
               :||.|:           .|:|.......||   ||.|            .||
 Frog   386 ---EGKNYN-----------NQDTFSAGSCTACICQSGEV------------ICT---------- 414

  Fly   922 DGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFLTVEFADGIRVWWDGVSRVYID 986
                                     ||:                              ...|...
 Frog   415 -------------------------PKL------------------------------CPPVTCS 424

  Fly   987 APPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRTKD-----TCQ---FKAETHQG 1043
            .|.:|..:...||.|..||..     .|||.          || ||     |||   ...|..|.
 Frog   425 DPVTLPNECCPLCVTGCSNGH-----KEGDT----------WR-KDICTICTCQNGIISCEREQC 473

  Fly  1044 PH-PCTLNPEKKAQAEKFCDWILQDIFQDCHFLVEPEQFYEDCLYD-------------TCACKD 1094
            |. .|........|....|.       |.|.        ||...|.             .|:|.:
 Frog   474 PDLTCLKRYIPPGQCCATCQ-------QGCE--------YEGLTYKNGDYFLSQSNPCVNCSCMN 523

  Fly  1095 EMSKCF---CPILSAYGTECMRQGVKTGWRMSVKECAVKCPLGQVFDE---------CGDGCAL- 1146
            .:.:|.   ||:     ..|.......|      :|...||:.::...         ..|||.|
 Frog   524 NLVRCLPVQCPL-----PACTNPVPIPG------QCCPSCPVCELDGHPLIPGQNVTTKDGCRLC 577

  Fly  1147 SCDDLPSKGSCKRECVEGCRCPH--GEYVNEDGECVPKKMCHCNFD----GMSFRPGYKEVRPGE 1205
            :|.|      .|.:|.|..||||  ...|..:..|.....|..|.|    |::|:   ..:.|.|
 Frog   578 ACQD------GKVQCRESVRCPHICTHGVKRNSCCPDCSACEMNGDIIPNGITFQ---GNMDPCE 633

  Fly  1206 KFLDLCTCTDGVWDCQDAEPGD-----KDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDK 1265
            .    |||.||...|..|...:     .:|.|  .|..|:|        ..|.....|. |:.::
 Frog   634 S----CTCQDGNVHCVRASCPELSCVLHEKIP--GECCSQC--------QSCVDGTVKH-KHGEE 683

  Fly  1266 YVADSSDCLPGCVCMEGYVYDTSRLACVL--------PANC-----SCHHAGKSYDDGEKIK--E 1315
            :......| ..|.|:||.:....|....|        |..|     .|.:.|.||.:|.:::  :
 Frog   684 WKPQGEPC-QSCRCLEGRIQCRRRHCAALCRNPLPPRPGTCCPVCDGCLYNGHSYLNGHRVRSTD 747

  Fly  1316 DCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFDFQGACDYVLAKGVFDNGDGFSITIQ 1380
            .|..|.|..||.:|..
 Frog   748 QCKQCFCENGNVQCEP------------------------------------------------- 763

  Fly  1381 NVLCGTMGVTCSKSLEIALTGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAG 1445
                    :||.::                        |.:.|::|
 Frog   764 --------ITCPQA------------------------PCRNPVRK------------------- 777

  Fly  1446 VFVVVEVIPLKLQVKWD-----EGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSP 1505
               ..|..|.....::|     || .|:..:.:...| .:.|.|..:...||....||.
 Frog   778 ---TGECCPRCESCEYDSRLFTEG-EVFTTVHDPCLQ-CTCLSGEVSCEHLDRKCPPSQ------ 831

  Fly  1506 MLFGHAWKLQPHC--SAPVAPIDACKKHPERETWAQ------LKCGALKSDLFKECHAEVPLERF 1562
              ..|..:.:..|  |..|...:.. .:.:|:::..      |||...|.::
 Frog   832 --CSHPGRAKGQCCPSCEVCDFEGI-LYTDRQSFQPLGHGPCLKCFCAKGNV------------- 880

  Fly  1563 WKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRWRSQHFCPMQCDPHCSDYKACTPACA 1627
              ||:.:||.                                    |..|.....|.:.|.|.|.
 Frog   881 --RCVEETCP------------------------------------PALCPNPVRDPEQCCPVCK 907

  Fly  1628 VETCD--NFLDQGIAERM----CNRENCLEG---CHIKPCEDGFIYLNDTYRDCVPKAECKPVCM 1683
            |...|  .|| :||...:    |:...|..|   |.:..| .....|:.|.::    .||.|:|
 Frog   908 VCVQDGVEFL-EGIEWELNGNPCSSCTCRNGDTICGVSEC-PSVTCLHPTKKE----GECCPLC- 965

  Fly  1684 VRDGKTF----YEGDITFTD---SCATCRCSKRKEICSGVKCDVPATTGLPAPLVEGTTLPTPLA 1741
              |..|:    |..:..|||   .|..|:|......||.:.|         .|::  .|:|....
 Frog   966 --DSCTYNQRVYSNEQIFTDPDNPCQDCQCKDGTVQCSSIVC---------PPVL--CTIPERTP 1017

  Fly  1742 TQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTKVECRVKDTHEA 1806
            .|...||..  .|:.|:        |.|..|:       ..|....|       .||..:|.|
 Frog  1018 GQCCAKCPD--CRYQDQ--------VFLEGEQ-------FSNPLNQC-------QECWCRDGH-- 1056

  Fly  1807 PEQMDENVVCSLEEGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQLGLACDAAVVEY---K 1868
                   |.|: :.|  |.|....|.|...| |.....              .|:.|..||   .
 Frog  1057 -------VTCT-DRG--CPGALCSYPLPGTC-CQNNCN--------------GCNYAGKEYPNGA 1096

  Fly  1869 EFP---GDCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLKPEPEP 1930
            :||   ..|.: .||    :.|....:.:.|       |.:|..:......|..|.|.:.|...|
 Frog  1097 DFPHLTDKCRQ-CHC----INGNVQCLAQRC-------PPLLCAEPFPVPGECCPQCPVPPADCP 1149

  Fly  1931 E-----------FEPIKQCPPGKIKSECANQCENTCHYYGSILKKRGLCQVGEHCKP-GCVDELR 1983
            .           ::|..:|      .:|.  |.|     |::..:|      :.|.| .|...|:
 Frog  1150 YSGVTYRHMQRFYDPSDKC------RDCI--CNN-----GTVTCQR------KPCAPTPCSHPLQ 1195

  Fly  1984 PDCPKLGKFWRDEDTCVHADECPCMDK----AEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEP 2044
            .||            |...|.|....|    .|.:.||..|.    .||.|.:.:..|.|
 Frog  1196 GDC------------CRSCDGCLMSGKELANGEQFPQPSDPC----SVCVCWEGSVKCQP----- 1239

  Fly  2045 VPKDEDDDLDLVSVVPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEHGPKMAR 2109
                        ...|:.......|.||..|
 Frog  1240 ------------KTCPVLSCPFPAPGQCCKE---------------------------------- 1258

  Fly  2110 LTKEQPRGSWSPSINDQMQYLELNFAKPEPFYGVVMAGSPEF-------------DNYVT----- 2156
                          ....|||           |.|.....||             |.:||
 Frog  1259 --------------CQDCQYL-----------GEVYLNGQEFSSPQDSCSRCVCADGFVTCSKKP 1298

  Fly  2157 LFKILHSH------------DGIAYH--YLVDETEKPQMFNGPLDSRAPVQTLFKIPIEASSLRI 2207
            .:|...:|            ||.:|:  .|::....|...| ||.|....:|
 Frog  1299 CYKAGCTHPSTPPGKCCPVCDGCSYNGDALINGQSVPDPSN-PLCSECTCRT------------- 1349

  Fly  2208 YPLKWHGSIAMRVELLICGDKEEPKPVPTVSTILPI-----------------TERPARLVDLEC 2255
                  ||:....:|  ||....|.|| |.....||                 |..|:......|
 Frog  1350 ------GSVQCVRKL--CGPTSCPHPV-TGPCDCPICQGCHFQGRNYIDGDVFTSSPSPCEQCRC 1405

  Fly  2256 IDLMG-VDEGKMYQDQVQSSSLWQQPNLGKKLQLLELLKLSTPL------AWRPLANSQNEFIEF 2313
              :.| |..|....|||......:.|.:             .|:      :.|...|.::
 Frog  1406 --MRGHVTCGPRPCDQVTCPHPAEDPCM-------------CPVCDGCNYSGRDCTNGES----- 1450

  Fly  2314 DFLEPRNISGFVTKGGPDGWVTGYKVMFSKKK------------PTWNTVLSTDGQARIFEANHD 2366
             ||:|.:.....|  ..:|.||...|...:..            |....:...:|  |::: |.|
 Frog  1451 -FLDPEDECNHCT--CRNGEVTCISVPCPRISCLYPITPPGECCPRCTGICKHNG--RVYQ-NGD 1509

  Fly  2367 AETERRHHFKNPILTQYIKIVPAYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKCNICDG- 2430
            .     .|....|.|:.:.       :|..:..:.:.|   ..|....||...|  :.|.:||.
 Frog  1510 T-----FHPSGDICTKCLC-------QNEMVTCQRVRC---SQECSHPVPSPAS--SCCPVCDRC 1557

  Fly  2431 -------------VSTSSSTTGCQCQDQLFWDGNTCVQHNLCPCIENYVS--YPI---------- 2470
                         .|||.....|.|     .||.....|.:||    |||  .||
 Frog  1558 FYENQEYANHETFTSTSDPCQRCVC-----LDGTVTCTHVVCP----YVSCANPITKPEQCCREC 1613

  Fly  2471 ------GSKFENSA--------CEDCVCVLGGHKNCKPKKCP--PCLGGKLRPVITSDCFCKCEP 2519
                  |.::...|        |..|.|. .|:..|:|.:||  ||......|   ..|..:|..
 Frog  1614 PVCRYQGKEYSEDAHWVPVTDLCLKCTCT-NGNVVCEPPQCPPLPCTQQVTDP---GACCPRCRG 1674

  Fly  2520 CPKHQRLCP------SSGD------CIPEILWCNGVQDCADDEDASCSDSFTVEPDVSREKNETE 2572
            |..:.|...      ||.|      |:..:..|:.:| |.:    ||::..||..:
 Frog  1675 CIYNGREYKDNSNWLSSSDPCMSCMCVDGVTTCSKLQ-CIN----SCTNQITVPGE--------- 1725

  Fly  2573 VITCPVPVCPPQMKIRITEKKSRKMSKMFTFSKQVSIVDDGTTITKTKFISSKEQILAMPNRELD 2637
               | .|||                                     ...|||.:  :.:|. |..
 Frog  1726 ---C-CPVC-------------------------------------ADCISSNK--VYLPG-ESY 1746

  Fly  2638 FQLEEQCDEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCLRYSCVLRPNKDDV 2702
            ...::.|:..||..:|:.|..::    ||:.:||            .:.||.| :.:|.|.:...
 Frog  1747 HPSKDPCEICTCERLPNGQQYRH----CTKKQCP------------SLLDCPR-NYILPPAEGQC 1794

  Fly  2703 CEISGKSFTTFDGTVF------KYGPCSHILARDIHSSSWSISVHQQCSDETRKVCHKVITIQDT 2761
            |....::.:....|:.      ...||.....:|:   :| :.|||.|
 Frog  1795 CSTCAQALSNCTDTLVGNEIQATDDPCYTCHCKDL---TW-VCVHQPC----------------- 1838

  Fly  2762 EAGNELILLPHLKLKFNGYEFTVQQLINS----PICKASFVVSQPGKTLLAVSTKYGFWVQLDDI 2822
                .::..|.           .:|..:|    |:||...|
 Frog  1839 ----PVLSCPR-----------AEQFTHSGSCCPVCKECVV------------------------ 1864

  Fly  2823 GIVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPDGQIIPNTEKFGDSWYDKRIP----------- 2876
                         .::|            :|.||          |::|.|::.|
 Frog  1865 -------------EIEG------------RRVPD----------GETWTDRQDPCVTCTCTLGHV 1894

  Fly  2877 ---KDQCGDLKCPR-EMQAKALQLCNIIHHPTFARCHKAVNYKQFLNNYCLEAACNCMMANNGDP 2937
               .::|..::|.. ||:.:....|          ||:           |...|.:|....
 Frog  1895 ECQIEECQPVQCQEGEMRVRRPGAC----------CHE-----------CQAPAVSCWYQG---- 1934

  Fly  2938 AACKCNILESFVKKCLSVNPLVQLTTWRAVAQC-EINCPSPLVHTDCYKRRC-EPSCDNVHGDDC 3000
                    :.|:..          ..|: |.:| ...|.|..||  |:..|| :.||.   .::.
 Frog  1935 --------QRFLSN----------EHWQ-VDECTACTCVSGEVH--CHSERCPQVSCT---AEET 1975

  Fly  3001 PVLPDACFPGCYCPEGTVRKGPNCVPISECKDCVCNSLGASKYMTYDRKSFSFNGNCTYLLSRDV 3065
            |.|    .||..|        |:|:|    :...|.:.|...|.|:|.|.:.|.|:|||:||.|
 Frog  1976 PAL----IPGMCC--------PHCIP----RPATCIAFGDPHYRTFDGKMYHFQGSCTYVLSED- 2023

  Fly  3066 VLPGVHTFQVYVSMDDCKKLGQPTPVEGGSCAKSLHILNGDHVIHVQRVPQKPKSLQ---VLVDG 3127
             ..| ..|.::|:.||       ..:.|.|..|.:.:|.||.|:.:         ||   |:||
 Frog  2024 -CEG-GDFSIHVTNDD-------RGLRGVSWTKEVTVLIGDAVVQL---------LQDWVVMVD- 2069

  Fly  3128 FEVKKIPY----------KDSWISLRQVVGKELVLSLPESHVELTASFEDLIFSLGVPSIKYGSK 3182
            ::..::|:          |.:.|.|...:|.::..: ..||:|::           ||. .|...
 Frog  2070 YQTVELPFLKEPYIYIERKTNTILLNSNIGVKVQWN-GRSHLEVS-----------VPG-TYRDH 2121

  Fly  3183 MEGLCGDCNGNAGNDLQPNPAKKKAGVDVI------QSWQADEPKLGLVEECLSEDVPKEHCIPL 3241
            :.||||:.|....:||     :.:.|..::      .||:..............:||
 Frog  2122 LCGLCGNFNNYPQDDL-----RDRRGQILLSEAAFGNSWRVQSSNDSSSSCWDGQDV-------- 2173

  Fly  3242 PPEKDPCLQF-YNA--ELFGKCPL-----------AVDPIAYVSACQQDICKPGNTQQGVCVALA 3292
                |||.|. |.|  |..|:|.|           .|.|..:.::|..|:|..|...:.:|..|.
 Frog  2174 ----DPCKQAGYRARKEANGRCKLLKSTVFEPCHRVVPPEMFFASCVYDLCACGAGDECLCDVLE 2234

  Fly  3293 AYAKECNQHGICTNWRRPQLCPYECPSD--MVYEPCG--CAKNCDTIKALSEFDAVSLKNEAVVH 3353
            |||.||.:.|:...||.|.||...||.|  .|::.||  |.|.|              .|:.|..
 Frog  2235 AYASECREAGVILQWRSPALCAVGCPHDRGYVFDECGPPCPKTC--------------FNKDVPL 2285

  Fly  3354 TVKTDEMCLSSERFE----GCFCPPGKVMDGGQCVPEIACTKCDDG 3395
            .|      |.|..|:    ||.||.|.|.....|:|..:|.|...|
 Frog  2286 GV------LESHCFKPCVPGCQCPAGLVEHESHCIPPESCPKVIHG 2325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671
		C8	684..754	CDD:462584
		TIL	758..811	CDD:410995	5/14 (36%)
		VWD	840..1015	CDD:214566	27/177 (15%)
		C8	1054..1121	CDD:214843	14/82 (17%)
		TIL	1131..1185	CDD:410995	17/65 (26%)
		TIL	1245..1298	CDD:460351	11/60 (18%)
		VWD	1327..1498	CDD:214566	17/175 (10%)
		C8	1535..1609	CDD:214843	8/79 (10%)
		TIL	1938..2005	CDD:473303	14/67 (21%)
		FA58C	2089..2223	CDD:238014	24/165 (15%)
		FA58C	<2299..2403	CDD:238014	19/115 (17%)
		VWD	2703..2858	CDD:459671	21/164 (13%)
		TIL	2974..3030	CDD:460351	17/56 (30%)
		VWD	3035..3198	CDD:459671	47/175 (27%)
		C8	3248..3313	CDD:462584	25/78 (32%)
		VWC	3397..3451	CDD:450195
		GHB_like	<3755..3813	CDD:473907
kcp	XP_002931908.3	LamG	39..>186	CDD:473984
		VWC	383..437	CDD:450195	18/145 (12%)
		VWC	445..492	CDD:450195	15/62 (24%)
		VWC	496..552	CDD:450195	12/74 (16%)
		VWC	612..668	CDD:450195	18/64 (28%)
		VWC	671..727	CDD:450195	12/57 (21%)
		VWC	730..785	CDD:450195	18/157 (11%)
		VWC	788..846	CDD:450195	13/67 (19%)
		VWC	849..906	CDD:450195	14/108 (13%)
		VWC	968..1024	CDD:450195	15/66 (23%)
		VWC	<1103..1141	CDD:450195	9/49 (18%)
		VWC	1262..1318	CDD:450195	12/66 (18%)
		Amnionless	<1461..>1497	CDD:464340	6/37 (16%)
		VWC	1498..1554	CDD:450195	14/75 (19%)
		VWC	1557..1613	CDD:450195	15/64 (23%)
		VWC	1616..1672	CDD:450195	14/59 (24%)
		VWC	1733..1798	CDD:450195	20/84 (24%)
		VWC	1930..1987	CDD:450195	20/96 (21%)
		VWD	1985..2142	CDD:214566	52/198 (26%)
		C8	2185..2256	CDD:214843	22/70 (31%)
		TIL	2266..2319	CDD:410995	20/72 (28%)