DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and kcp

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_002931908.3 Gene:kcp / 100491140 XenbaseID:XB-GENE-486713 Length:2327 Species:Xenopus tropicalis


Alignment Length:2912 Identity:581/2912 - (19%)
Similarity:849/2912 - (29%) Gaps:1223/2912 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   796 EGTVQYKEACITRELCPCSLRGKEFKPESTVKKN-CNTCTCKNGQWRCTEDKCGARCGAVGDPHY 859
            :..|:|.|:|..|. ..|...|||::...|.||: ||.|.|..|...|:..|...:|  :|..| 
 Frog   325 QARVKYLESCECRR-STCVWEGKEYQDNETWKKDACNICVCVGGSVTCSVRKDWPQC--LGCFH- 385

  Fly   860 QTFDGKRYDFMGKCSYHLLKTQNTSVEAENVAC---SGAVSESMNFAAPDDPSCTKAVTIRFILR 921
               :||.|:           .|:|.......||   ||.|            .||          
 Frog   386 ---EGKNYN-----------NQDTFSAGSCTACICQSGEV------------ICT---------- 414

  Fly   922 DGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFLTVEFADGIRVWWDGVSRVYID 986
                                     ||:                              ...|...
 Frog   415 -------------------------PKL------------------------------CPPVTCS 424

  Fly   987 APPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRTKD-----TCQ---FKAETHQG 1043
            .|.:|..:...||.|..||..     .|||.          || ||     |||   ...|..|.
 Frog   425 DPVTLPNECCPLCVTGCSNGH-----KEGDT----------WR-KDICTICTCQNGIISCEREQC 473

  Fly  1044 PH-PCTLNPEKKAQAEKFCDWILQDIFQDCHFLVEPEQFYEDCLYD-------------TCACKD 1094
            |. .|........|....|.       |.|.        ||...|.             .|:|.:
 Frog   474 PDLTCLKRYIPPGQCCATCQ-------QGCE--------YEGLTYKNGDYFLSQSNPCVNCSCMN 523

  Fly  1095 EMSKCF---CPILSAYGTECMRQGVKTGWRMSVKECAVKCPLGQVFDE---------CGDGCAL- 1146
            .:.:|.   ||:     ..|.......|      :|...||:.::...         ..|||.| 
 Frog   524 NLVRCLPVQCPL-----PACTNPVPIPG------QCCPSCPVCELDGHPLIPGQNVTTKDGCRLC 577

  Fly  1147 SCDDLPSKGSCKRECVEGCRCPH--GEYVNEDGECVPKKMCHCNFD----GMSFRPGYKEVRPGE 1205
            :|.|      .|.:|.|..||||  ...|..:..|.....|..|.|    |::|:   ..:.|.|
 Frog   578 ACQD------GKVQCRESVRCPHICTHGVKRNSCCPDCSACEMNGDIIPNGITFQ---GNMDPCE 633

  Fly  1206 KFLDLCTCTDGVWDCQDAEPGD-----KDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDK 1265
            .    |||.||...|..|...:     .:|.|  .|..|:|        ..|.....|. |:.::
 Frog   634 S----CTCQDGNVHCVRASCPELSCVLHEKIP--GECCSQC--------QSCVDGTVKH-KHGEE 683

  Fly  1266 YVADSSDCLPGCVCMEGYVYDTSRLACVL--------PANC-----SCHHAGKSYDDGEKIK--E 1315
            :......| ..|.|:||.:....|....|        |..|     .|.:.|.||.:|.:::  :
 Frog   684 WKPQGEPC-QSCRCLEGRIQCRRRHCAALCRNPLPPRPGTCCPVCDGCLYNGHSYLNGHRVRSTD 747

  Fly  1316 DCNLCECRAGNWKCS--------------KNG-----CESTCSVWGDSHFTTFDGHDFDFQGACD 1361
            .|..|.|..||.:|.              |.|     |||                       |:
 Frog   748 QCKQCFCENGNVQCEPITCPQAPCRNPVRKTGECCPRCES-----------------------CE 789

  Fly  1362 YVLAKGVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEESLLLSADSAYSTDPNKTPIKK 1426
            |  ...:|..|:.|: |:.:. |  :..||                 ||.:.:......|.|..:
 Frog   790 Y--DSRLFTEGEVFT-TVHDP-C--LQCTC-----------------LSGEVSCEHLDRKCPPSQ 831

  Fly  1427 LRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSL 1491
            ......:||               :..|                        ...:| ::.|...
 Frog   832 CSHPGRAKG---------------QCCP------------------------SCEVC-DFEGILY 856

  Fly  1492 DDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERETWAQLKCGALKSDLFKECHAE 1556
            .|.|:                 .||....|      |           |||...|.::       
 Frog   857 TDRQS-----------------FQPLGHGP------C-----------LKCFCAKGNV------- 880

  Fly  1557 VPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRWRSQHFCPMQCDPHCSDYKA 1621
                    ||:.:||.                                    |..|.....|.:.
 Frog   881 --------RCVEETCP------------------------------------PALCPNPVRDPEQ 901

  Fly  1622 CTPACAVETCD--NFLDQGIAERM----CNRENCLEG---CHIKPCEDGFIYLNDTYRDCVPKAE 1677
            |.|.|.|...|  .|| :||...:    |:...|..|   |.:..| .....|:.|.::    .|
 Frog   902 CCPVCKVCVQDGVEFL-EGIEWELNGNPCSSCTCRNGDTICGVSEC-PSVTCLHPTKKE----GE 960

  Fly  1678 CKPVCMVRDGKTF----YEGDITFTD---SCATCRCSKRKEICSGVKCDVPATTGLPAPLVEGTT 1735
            |.|:|   |..|:    |..:..|||   .|..|:|......||.:.|         .|::  .|
 Frog   961 CCPLC---DSCTYNQRVYSNEQIFTDPDNPCQDCQCKDGTVQCSSIVC---------PPVL--CT 1011

  Fly  1736 LPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTKVECRV 1800
            :|.....|...||..  .|:.|:        |.|..|:       ..|....|       .||..
 Frog  1012 IPERTPGQCCAKCPD--CRYQDQ--------VFLEGEQ-------FSNPLNQC-------QECWC 1052

  Fly  1801 KDTHEAPEQMDENVVCSLEEGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQLGLACDAAVV 1865
            :|.|         |.|: :.|  |.|....|.|...| |.....              .|:.|..
 Frog  1053 RDGH---------VTCT-DRG--CPGALCSYPLPGTC-CQNNCN--------------GCNYAGK 1090

  Fly  1866 EY---KEFP---GDCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGL 1924
            ||   .:||   ..|.: .||    :.|....:.:.|       |.:|..:......|..|.|.:
 Frog  1091 EYPNGADFPHLTDKCRQ-CHC----INGNVQCLAQRC-------PPLLCAEPFPVPGECCPQCPV 1143

  Fly  1925 KPEPEPE-----------FEPIKQCPPGKIKSECANQCENTCHYYGSILKKRGLCQVGEHCKP-G 1977
            .|...|.           ::|..:|      .:|.  |.|     |::..:|      :.|.| .
 Frog  1144 PPADCPYSGVTYRHMQRFYDPSDKC------RDCI--CNN-----GTVTCQR------KPCAPTP 1189

  Fly  1978 CVDELRPDCPKLGKFWRDEDTCVHADECPCMDK----AEHYVQPHKPVLGEFEVCQCIDNAFTCV 2038
            |...|:.||            |...|.|....|    .|.:.||..|.    .||.|.:.:..|.
 Frog  1190 CSHPLQGDC------------CRSCDGCLMSGKELANGEQFPQPSDPC----SVCVCWEGSVKCQ 1238

  Fly  2039 PNKPEPVPKDEDDDLDLVSVVPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEH 2103
            |                 ...|:.......|.||..|                            
 Frog  1239 P-----------------KTCPVLSCPFPAPGQCCKE---------------------------- 1258

  Fly  2104 GPKMARLTKEQPRGSWSPSINDQMQYLELNFAKPEPFYGVVMAGSPEF-------------DNYV 2155
                                ....|||           |.|.....||             |.:|
 Frog  1259 --------------------CQDCQYL-----------GEVYLNGQEFSSPQDSCSRCVCADGFV 1292

  Fly  2156 T-----LFKILHSH------------DGIAYH--YLVDETEKPQMFNGPLDSRAPVQTLFKIPIE 2201
            |     .:|...:|            ||.:|:  .|::....|...| ||.|....:|       
 Frog  1293 TCSKKPCYKAGCTHPSTPPGKCCPVCDGCSYNGDALINGQSVPDPSN-PLCSECTCRT------- 1349

  Fly  2202 ASSLRIYPLKWHGSIAMRVELLICGDKEEPKPVPTVSTILPI-----------------TERPAR 2249
                        ||:....:|  ||....|.|| |.....||                 |..|:.
 Frog  1350 ------------GSVQCVRKL--CGPTSCPHPV-TGPCDCPICQGCHFQGRNYIDGDVFTSSPSP 1399

  Fly  2250 LVDLECIDLMG-VDEGKMYQDQVQSSSLWQQPNLGKKLQLLELLKLSTPL------AWRPLANSQ 2307
            .....|  :.| |..|....|||......:.|.:             .|:      :.|...|.:
 Frog  1400 CEQCRC--MRGHVTCGPRPCDQVTCPHPAEDPCM-------------CPVCDGCNYSGRDCTNGE 1449

  Fly  2308 NEFIEFDFLEPRNISGFVTKGGPDGWVTGYKVMFSKKK------------PTWNTVLSTDGQARI 2360
            :      ||:|.:.....|  ..:|.||...|...:..            |....:...:|  |:
 Frog  1450 S------FLDPEDECNHCT--CRNGEVTCISVPCPRISCLYPITPPGECCPRCTGICKHNG--RV 1504

  Fly  2361 FEANHDAETERRHHFKNPILTQYIKIVPAYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKC 2425
            :: |.|.     .|....|.|:.:.       :|..:..:.:.|   ..|....||...|  :.|
 Frog  1505 YQ-NGDT-----FHPSGDICTKCLC-------QNEMVTCQRVRC---SQECSHPVPSPAS--SCC 1551

  Fly  2426 NICDG--------------VSTSSSTTGCQCQDQLFWDGNTCVQHNLCPCIENYVS--YPI---- 2470
            .:||.              .|||.....|.|     .||.....|.:||    |||  .||    
 Frog  1552 PVCDRCFYENQEYANHETFTSTSDPCQRCVC-----LDGTVTCTHVVCP----YVSCANPITKPE 1607

  Fly  2471 ------------GSKFENSA--------CEDCVCVLGGHKNCKPKKCP--PCLGGKLRPVITSDC 2513
                        |.::...|        |..|.|. .|:..|:|.:||  ||......|   ..|
 Frog  1608 QCCRECPVCRYQGKEYSEDAHWVPVTDLCLKCTCT-NGNVVCEPPQCPPLPCTQQVTDP---GAC 1668

  Fly  2514 FCKCEPCPKHQRLCP------SSGD------CIPEILWCNGVQDCADDEDASCSDSFTVEPDVSR 2566
            ..:|..|..:.|...      ||.|      |:..:..|:.:| |.:    ||::..||..:   
 Frog  1669 CPRCRGCIYNGREYKDNSNWLSSSDPCMSCMCVDGVTTCSKLQ-CIN----SCTNQITVPGE--- 1725

  Fly  2567 EKNETEVITCPVPVCPPQMKIRITEKKSRKMSKMFTFSKQVSIVDDGTTITKTKFISSKEQILAM 2631
                     | .|||                                     ...|||.:  :.:
 Frog  1726 ---------C-CPVC-------------------------------------ADCISSNK--VYL 1741

  Fly  2632 PNRELDFQLEEQCDEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCLRYSCVLR 2696
            |. |.....::.|:..||..:|:.|..::    ||:.:||            .:.||.| :.:|.
 Frog  1742 PG-ESYHPSKDPCEICTCERLPNGQQYRH----CTKKQCP------------SLLDCPR-NYILP 1788

  Fly  2697 PNKDDVCEISGKSFTTFDGTVF------KYGPCSHILARDIHSSSWSISVHQQCSDETRKVCHKV 2755
            |.:...|....::.:....|:.      ...||.....:|:   :| :.|||.|           
 Frog  1789 PAEGQCCSTCAQALSNCTDTLVGNEIQATDDPCYTCHCKDL---TW-VCVHQPC----------- 1838

  Fly  2756 ITIQDTEAGNELILLPHLKLKFNGYEFTVQQLINS----PICKASFVVSQPGKTLLAVSTKYGFW 2816
                      .::..|.           .:|..:|    |:||...|                  
 Frog  1839 ----------PVLSCPR-----------AEQFTHSGSCCPVCKECVV------------------ 1864

  Fly  2817 VQLDDIGIVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPDGQIIPNTEKFGDSWYDKRIP----- 2876
                               .::|            :|.||          |::|.|::.|     
 Frog  1865 -------------------EIEG------------RRVPD----------GETWTDRQDPCVTCT 1888

  Fly  2877 ---------KDQCGDLKCPR-EMQAKALQLCNIIHHPTFARCHKAVNYKQFLNNYCLEAACNCMM 2931
                     .::|..::|.. ||:.:....|          ||:           |...|.:|..
 Frog  1889 CTLGHVECQIEECQPVQCQEGEMRVRRPGAC----------CHE-----------CQAPAVSCWY 1932

  Fly  2932 ANNGDPAACKCNILESFVKKCLSVNPLVQLTTWRAVAQC-EINCPSPLVHTDCYKRRC-EPSCDN 2994
            ..            :.|:..          ..|: |.:| ...|.|..||  |:..|| :.||. 
 Frog  1933 QG------------QRFLSN----------EHWQ-VDECTACTCVSGEVH--CHSERCPQVSCT- 1971

  Fly  2995 VHGDDCPVLPDACFPGCYCPEGTVRKGPNCVPISECKDCVCNSLGASKYMTYDRKSFSFNGNCTY 3059
              .::.|.|    .||..|        |:|:|    :...|.:.|...|.|:|.|.:.|.|:|||
 Frog  1972 --AEETPAL----IPGMCC--------PHCIP----RPATCIAFGDPHYRTFDGKMYHFQGSCTY 2018

  Fly  3060 LLSRDVVLPGVHTFQVYVSMDDCKKLGQPTPVEGGSCAKSLHILNGDHVIHVQRVPQKPKSLQ-- 3122
            :||.|  ..| ..|.::|:.||       ..:.|.|..|.:.:|.||.|:.:         ||  
 Frog  2019 VLSED--CEG-GDFSIHVTNDD-------RGLRGVSWTKEVTVLIGDAVVQL---------LQDW 2064

  Fly  3123 -VLVDGFEVKKIPY----------KDSWISLRQVVGKELVLSLPESHVELTASFEDLIFSLGVPS 3176
             |:|| ::..::|:          |.:.|.|...:|.::..: ..||:|::           ||.
 Frog  2065 VVMVD-YQTVELPFLKEPYIYIERKTNTILLNSNIGVKVQWN-GRSHLEVS-----------VPG 2116

  Fly  3177 IKYGSKMEGLCGDCNGNAGNDLQPNPAKKKAGVDVI------QSWQADEPKLGLVEECLSEDVPK 3235
             .|...:.||||:.|....:||     :.:.|..::      .||:..............:||  
 Frog  2117 -TYRDHLCGLCGNFNNYPQDDL-----RDRRGQILLSEAAFGNSWRVQSSNDSSSSCWDGQDV-- 2173

  Fly  3236 EHCIPLPPEKDPCLQF-YNA--ELFGKCPL-----------AVDPIAYVSACQQDICKPGNTQQG 3286
                      |||.|. |.|  |..|:|.|           .|.|..:.::|..|:|..|...:.
 Frog  2174 ----------DPCKQAGYRARKEANGRCKLLKSTVFEPCHRVVPPEMFFASCVYDLCACGAGDEC 2228

  Fly  3287 VCVALAAYAKECNQHGICTNWRRPQLCPYECPSD--MVYEPCG--CAKNCDTIKALSEFDAVSLK 3347
            :|..|.|||.||.:.|:...||.|.||...||.|  .|::.||  |.|.|              .
 Frog  2229 LCDVLEAYASECREAGVILQWRSPALCAVGCPHDRGYVFDECGPPCPKTC--------------F 2279

  Fly  3348 NEAVVHTVKTDEMCLSSERFE----GCFCPPGKVMDGGQCVPEIACTKCDDG 3395
            |:.|...|      |.|..|:    ||.||.|.|.....|:|..:|.|...|
 Frog  2280 NKDVPLGV------LESHCFKPCVPGCQCPAGLVEHESHCIPPESCPKVIHG 2325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339
C8 680..754 CDD:285899
TIL 758..811 CDD:280072 5/14 (36%)
VWD 840..1015 CDD:214566 27/177 (15%)
C8 1054..1121 CDD:214843 14/82 (17%)
TIL 1131..1185 CDD:280072 17/65 (26%)
TIL 1245..1298 CDD:280072 11/60 (18%)
VWD 1327..1498 CDD:214566 26/189 (14%)
C8 1535..1609 CDD:214843 8/73 (11%)
Mucin2_WxxW 1751..1837 CDD:290069 18/85 (21%)
TIL 1938..2005 CDD:280072 14/67 (21%)
FA58C 2089..2223 CDD:238014 24/165 (15%)
FA58C 2104..2225 CDD:214572 25/152 (16%)
FA58C <2299..2404 CDD:214572 19/116 (16%)
FA58C <2299..2403 CDD:238014 19/115 (17%)
VWD 2703..2858 CDD:295339 21/164 (13%)
C8 2893..2970 CDD:285899 9/76 (12%)
TIL 2974..3030 CDD:280072 17/56 (30%)
VWD 3035..3198 CDD:295339 47/175 (27%)
C8 3257..3313 CDD:285899 20/66 (30%)
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
kcpXP_002931908.3 LamG 39..>186 CDD:419873
VWC 383..437 CDD:327433 18/145 (12%)
VWC 445..492 CDD:327433 15/62 (24%)
VWC 496..552 CDD:327433 12/74 (16%)
VWC 612..668 CDD:327433 18/64 (28%)
VWC 671..727 CDD:327433 12/57 (21%)
VWC 730..785 CDD:327433 13/54 (24%)
VWC 788..846 CDD:327433 16/119 (13%)
VWC 849..906 CDD:327433 21/142 (15%)
VWC 968..1024 CDD:327433 15/66 (23%)
VWC <1103..1141 CDD:327433 9/49 (18%)
VWC 1262..1318 CDD:327433 12/66 (18%)
Amnionless <1461..>1497 CDD:405512 6/37 (16%)
VWC 1498..1554 CDD:327433 14/75 (19%)
VWC 1557..1613 CDD:327433 15/64 (23%)
VWC 1616..1672 CDD:327433 14/59 (24%)
VWC 1733..1798 CDD:327433 20/84 (24%)
VWC 1930..1987 CDD:327433 20/96 (21%)
VWD 1985..2142 CDD:214566 52/198 (26%)
C8 2190..2255 CDD:400886 19/64 (30%)
TIL 2266..2319 CDD:410995 20/72 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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