DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and LOC100490280

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_031757167.1 Gene:LOC100490280 / 100490280 -ID:- Length:1680 Species:Xenopus tropicalis


Alignment Length:1711 Identity:440/1711 - (25%)
Similarity:722/1711 - (42%) Gaps:334/1711 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   469 SNNLDIV----IDKTPRPALCTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGTFDIILKACPY 529
            |...||:    :|.|  .::|::||..:.|||||::::.|.:|::.|.:.            |. 
 Frog    19 SRAYDIIPGKPVDHT--KSICSSWGNFHYKTFDGVIYQFPGTCNYNLASH------------CE- 68

  Fly   530 GSGYGCAHTLKILWQSVLYTFENLNGTM-QLTTPIKKLPMPVQVMGMKV------MPVAQH-VQI 586
             |.|   |...:   .:..:.||.:..: |:...:|.:|:.::....||      .|...: |.|
 Frog    69 -SSY---HEFSV---HIQRSIENGSPVIHQIFIQVKDVPIELKRDAQKVNGEIFETPYFNYGVFI 126

  Fly   587 DLE--------SVGLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKA 643
            ..:        .:||.|.|:....|.::...:...|:.||||..:|....:........|..:: 
 Frog   127 TKKDGYTKVTTKIGLTLTWNQEDSVMLEVDSKYRNKMCGLCGDYNGIEAHNEFFLNDMPLNPIQ- 190

  Fly   644 FADAWRVEDRSELC-QVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIR 707
            |.:...:.|.:..| .|:.|.:|  .:.||.|     ..|||:..|:......|....:....:.
 Frog   191 FGNMQHINDPAITCTNVDESQQM--NVSSCGQ-----YYSVCKSYLSQSAFSSCQDLLDVSDYVM 248

  Fly   708 TCMADYCNCANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVE 772
            .||.|.|:|::.:  .||.|..:...:::|...| .:...||..::||..|....||:..|    
 Frog   249 ACMLDVCSCSSAD--VSCLCSTLTEYSRQCTHAG-GIPQNWRTDDLCPKHCPGNMVYKESG---- 306

  Fly   773 PTCDSDLALPASKGACNE----GCFCPEGTV--QYKEA-CITRELCPCSLRGKEFKPESTVKKNC 830
            ..|.|..:....|..|.|    |||||:|||  .|..| ||:...|.|..:.:.:.|.|.:..:|
 Frog   307 SPCISSCSHRVVKSLCEEHDVDGCFCPDGTVWDDYNNAGCISTSKCYCKYQDQLYAPGSKILNDC 371

  Fly   831 NTCTCKNGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKT---QNTSVEAENVAC 892
            ..|:|..|:|.|....|...|...|..|::|||||.|.|.|.|:|.|.|.   :..::.||...|
 Frog   372 EACSCNAGKWTCMHGICPKVCSIEGGAHFKTFDGKPYKFHGNCNYLLSKASHGETHTIVAELTPC 436

  Fly   893 SGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLI 957
            :....|          :|.|  ||:| ..|...:|:.:....:.::|:..|: ||.:.|...|:.
 Frog   437 NAFSRE----------TCLK--TIQF-YTDDNQNVLSIRADGSVLMNELKIS-LPHVTGSFSVIQ 487

  Fly   958 RRASSTFLTVEFADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVE 1022
            ...|:.|:..:|...|:::...:.::||....|.:...:||||.||....|||:|..|..|:...
 Frog   488 PTESNIFVKTKFNLQIQIYLLPLMQLYISMDNSDKNTFEGLCGNFNYIEGDDFITSAGIEESTAS 552

  Fly  1023 PFADKWRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWI--LQDIFQDCHFLVEPEQFYEDC 1085
            .||:.|:.:.|||...|...  .||:.:.|.|..||.:|..:  .:..|..|||.|:|.::|:.|
 Frog   553 AFANTWKIQSTCQDSVEILF--DPCSFSMETKIYAENWCSKLRDSESPFWKCHFAVDPAEYYKRC 615

  Fly  1086 LYDTCACKDEMSKCFCPILSAYGTECMRQG-VKTGWRMSVKECAV-KCPLGQVFDECGDGCALSC 1148
            .||||:| .....|.|..||:|...|..:| :...||..:.:..: .||..|::......|..||
 Frog   616 EYDTCSC-SHSEACMCATLSSYARACAAKGIILWDWRKGICDKEIPSCPASQIYLYNITTCQPSC 679

  Fly  1149 DDLPSKGSCKREC------VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKF 1207
            ..| :.|  ::||      ::||.||.|.|:||...|||...|.|...||..||.....|..|: 
 Frog   680 RSL-ALG--EKECDSEFTPIDGCGCPDGMYLNEKDGCVPISQCSCYHQGMYLRPNEVFYRRDER- 740

  Fly  1208 LDLCTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYVADS-- 1270
               |:|.:|..:|                                           |.::.||  
 Frog   741 ---CSCHEGKLNC-------------------------------------------DTFINDSKL 759

  Fly  1271 ----SDCLPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCSK 1331
                :.|:.||||.|| :.|.....||...:|.|.:..|.:..|.::.|:|..|.|.:|.|.|.:
 Frog   760 EIMGTGCISGCVCPEG-LLDDGNGGCVQERSCPCSYNNKVFAHGSRLIEECKSCTCESGLWSCIQ 823

  Fly  1332 NGCESTCSVWGDSHFTTFDGHDFDFQGACDYVLAKGVFD----NGDGFSITIQNVLCGTMGVTCS 1392
            ..|..||:::|..|:.|||...:||.|:|::|:|:...:    ||. |.:..:|:.|||.|||||
 Frog   824 TPCYGTCTIYGSGHYITFDKKFYDFDGSCEFVIAQDYCEDSASNGT-FRVITENIPCGTTGVTCS 887

  Fly  1393 KSLEIALTGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKL 1457
            ||::|.| |:.|..|           .|....||..:|     ...:.:.:.|:::.:.. ...:
 Frog   888 KSIKIYL-GNTELKL-----------TNSHMEKKFGES-----EVEYKVREVGLYLAIHT-SSDI 934

  Fly  1458 QVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPV 1522
            .:.||:.|.:.::|.:.::.||.||||||:.|:.:|..|..:...::.|.||::||....|...:
 Frog   935 SLVWDKKTSLLIRLPSSYKGKVCGLCGNYDDNANNDFLTSQLIQASNVMPFGNSWKRSNDCPDSI 999

  Fly  1523 APIDACKKHPERETWAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVA 1587
            :....|...|.|.:||:.||..:.:::|:.||::|..:.|:..|:.|.|:||.||||||.|||||
 Frog  1000 SIPQPCLAAPHRRSWAEKKCEIITNEVFRSCHSKVDPKPFYDACVNDVCSCDTGGDCECFCTAVA 1064

  Fly  1588 AYADACAQKGINIRWRSQHFCPMQCD----------------------------PHCSD-----Y 1619
            |||..|::..:.:.||:...||:.||                            .:||.     .
 Frog  1065 AYAQLCSKADVCVHWRTPEICPIFCDYYNTDENECMWHYFSCGPEDRSNHHHITKYCSSPPITHL 1129

  Fly  1620 KACTPACAVETCDNFLDQGIAERMC--------NRENCLEGCHI------KPCEDGFIYLNDTYR 1670
            :.|.|.|..|.  .|.|:  ..::|        |......|.||      :.||.|........|
 Frog  1130 EGCYPTCPTER--PFYDE--INKLCVSHCSCIINNNTYSIGQHIPNPDRCQICECGEDLQMRCSR 1190

  Fly  1671 DCVPKAECKPVCMVRDGKTFYEGDITFTDS-CATCRC-------------SKRKEICSGVKCDVP 1721
            |...| ||: ||.: .|:|:...:...:|| |..|:|             ||.|| |....|.:.
 Frog  1191 DSKEK-ECR-VCKI-SGRTYKIHEAIPSDSKCFRCKCGEDLQKQCSRISNSKEKE-CEDNVCTIN 1251

  Fly  1722 ATTGLPAPLVEGTTLPTPLATQN---QTKCVKGWTRWCDKDRDTSDKSV--------RLNDEEKV 1775
            ..|         ..:..|:.:.:   :.:|.|.....|::|.|:.::..        :....|.|
 Frog  1252 GRT---------YKVHEPIPSHHRCIRCECGKDLQMHCNRDSDSREEECNFCNIDGRKYRIHEPV 1307

  Fly  1776 PRYDRM------ENVYGTCLKQYMTKVECRVKDTHEAPEQMDENVVCSLEEGLRCIGKCHDYELR 1834
            |.:.|.      |::..:|.::...:..|.:           :.:...:.|.:....:|..    
 Frog  1308 PSHQRCMRCVCGEDLQKSCSRERQCEPLCNI-----------DGMTYRIHEPVPSHSRCFR---- 1357

  Fly  1835 AFCQCDEELEPE---LPKPTEKPQLGLACDAAVVEYK--EFPGDCHKFLHCQPKGVEGGWIYVEK 1894
              |:|.|:|:.:   :|...||..:...|.....:||  |.....|:.:.|:             
 Frog  1358 --CKCGEDLQKQCSRVPDSKEKECIEDFCTIDGKKYKIHEPIPSYHRCIRCE------------- 1407

  Fly  1895 TCGEYMMFNPTMLICDHIATVTEIKPN-CGLKP------EPEPEFEPIKQCPPGK-IKSECA--N 1949
             ||:.:..:     |...:...|.:.| |.:..      ||.|..:....|..|: ::..|:  .
 Frog  1408 -CGKDLQKH-----CSRDSDSGEEECNFCNIDGRKYRIYEPVPSHQRCMTCECGEDLQKSCSRER 1466

  Fly  1950 QCENTCHYYGSILKKRGLCQVGEH-----CKPGCVDELRPDCPKLGKFWRDEDTCVHADECPCMD 2009
            |||..|:..|...:...  .|..|     ||  |.::|:..|.::..  ..|..|:. |.| .:|
 Frog  1467 QCEPLCNIDGMTYRIHE--PVPSHSRCFRCK--CGEDLQKQCSRVPD--SKEKECIE-DFC-TID 1523

  Fly  2010 KAEHYVQPHKPVLGEFEVCQC 2030
            ..::.:....|.......|:|
 Frog  1524 GKKYKIHESIPSYQRCIRCEC 1544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 36/166 (22%)
C8 680..754 CDD:285899 17/73 (23%)
TIL 758..811 CDD:280072 21/59 (36%)
VWD 840..1015 CDD:214566 52/177 (29%)
C8 1054..1121 CDD:214843 24/69 (35%)
TIL 1131..1185 CDD:280072 21/59 (36%)
TIL 1245..1298 CDD:280072 13/58 (22%)
VWD 1327..1498 CDD:214566 55/174 (32%)
C8 1535..1609 CDD:214843 31/73 (42%)
Mucin2_WxxW 1751..1837 CDD:290069 12/99 (12%)
TIL 1938..2005 CDD:280072 18/74 (24%)
FA58C 2089..2223 CDD:238014
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
LOC100490280XP_031757167.1 VWD 32..183 CDD:214566 37/172 (22%)
C8 230..292 CDD:400886 13/64 (20%)
TIL 296..352 CDD:410995 21/59 (36%)
VWD 392..545 CDD:395046 49/166 (30%)
C8 584..652 CDD:214843 24/68 (35%)
TIL 662..719 CDD:410995 21/59 (36%)
VWC 792..>838 CDD:327433 14/45 (31%)
VWD 819..975 CDD:214566 55/174 (32%)
C8 1014..1086 CDD:214843 31/71 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D8946at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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