DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and LOC100485356

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_031756620.1 Gene:LOC100485356 / 100485356 -ID:- Length:2087 Species:Xenopus tropicalis


Alignment Length:3450 Identity:681/3450 - (19%)
Similarity:1052/3450 - (30%) Gaps:1487/3450 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   459 VTMSSYSLYQSNNLDIV----IDKTPRPALCTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGT 519
            :|:|..|.|     ||:    ||.|  .::|::||..:.|||||::::.|.:|::.|        
 Frog    20 LTLSFSSAY-----DIIPGRPIDHT--KSICSSWGNFHYKTFDGVIYQFPGTCNYNL-------- 69

  Fly   520 FDIILKACPYGSGYGCAHTLKILWQ-----------SVLYTFENLNGTMQLTTPIKKL-----PM 568
                  |...|..|   |...:..|           .:|...:::  |::|....||:     ..
 Frog    70 ------ASHCGDSY---HEFSVHIQRAIEDGDPVIHQILIQIKDV--TLELKRDAKKVNGEIFES 123

  Fly   569 PVQVMGMKVMPVAQHVQIDLESVGLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSR 633
            |....|:.:.....:.::..: :||.|.|:....|.::...:...|:.||||..:|.|.::....
 Frog   124 PYFNYGVSITKKDGYTKVHTK-IGLTLTWNQEDSVMLEVDSKYQNKMCGLCGDYNGAPVSNEFYL 187

  Fly   634 TGKKLATVKAFADAWRVEDRSELC-QVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCI 697
            ....|..:: |.:...:.|.:..| .|:.|.:|  .:.||.|     ..|||:..|:......|.
 Frog   188 NDMPLNPIQ-FGNMQNINDPTLTCTNVDESQQM--NVSSCGQ-----YYSVCKSYLSQSAFSSCQ 244

  Fly   698 KPFNYDALIRTCMADYCNCANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGR 762
            ..|:....:..||.|.|:|::.:  .||.|..:...:::|...| .:...||..::||..|....
 Frog   245 DLFDISDYVMACMLDVCSCSSAD--VSCLCSTLTEFSRQCTHAG-GIPQNWRTNDLCPKQCPGNM 306

  Fly   763 VYQACGPNVEPTCDSDLALPASKGACNE----GCFCPEGTV--QYKEA-CITRELCPCSLRGKEF 820
            ||:..|    ..|.|..:....|..|.|    |||||:|||  .|.:| ||:...|.|..:.:.:
 Frog   307 VYKESG----SPCISSCSHHEIKSHCEEHDVDGCFCPDGTVWDDYNKAGCISISECHCKYQDQLY 367

  Fly   821 KPESTVKKNCNTCTCKNGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKT---QN 882
            .|.|.:..:|..|:|..|:|.||...|...|...|..|::|||||.|.|.|.|.|.|.|.   :.
 Frog   368 APGSKILNDCEECSCNAGKWTCTHGICPKVCSIEGGAHFKTFDGKSYKFHGNCYYLLTKARHGET 432

  Fly   883 TSVEAENVACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLP 947
            .::.||...|:....|          :|.|  ||:| ..|...:|:.:....:.::||..|: :|
 Frog   433 HAIVAELTPCNAHSRE----------TCLK--TIQF-YTDDNKNVLSIRADGSVLLNDLKIS-IP 483

  Fly   948 KMLGLGEVLIRRASSTFLTVEFADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLT 1012
            ::.|...|:....|:.|:..:|...|:::...:.::||....|.:...:||||.||....|||.|
 Frog   484 QVTGSFSVIQPTESNIFVKTKFGLQIQIYLLPLMQLYISMDNSAKNTFEGLCGNFNYIEGDDFKT 548

  Fly  1013 PEGDVETAVEPFADKWRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWI--LQDIFQDCHFL 1075
            ..|..|:....||:.|:.:.|||...|..  ..||:.:.|.|..|||:|..:  .:..|..|||.
 Frog   549 SAGIEESTASAFANTWKIQSTCQESVEVL--IDPCSFSIETKIYAEKWCSKLRDSESPFWKCHFA 611

  Fly  1076 VEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQG-VKTGWRMSVKECAV-KCPLGQVFD 1138
            |:|.::|:.|.||||:| .....|.|..||:|...|..:| :...||..:.:..: .||..|.:.
 Frog   612 VDPVEYYKRCEYDTCSC-SHSEACMCATLSSYARACAAKGIILWDWRRGICDKEIPSCPGSQTYL 675

  Fly  1139 ECGDGCALSCDDLPSKGSCKREC------VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPG 1197
            .....|..:|..| :.|  ::||      ::||.||.|.|:||...|||...|.|...||     
 Frog   676 YNITTCQSTCRSL-ALG--EKECDSEFTPIDGCGCPDGMYLNEKDGCVPISQCSCYHQGM----- 732

  Fly  1198 YKEVRPGEKFLDL---CTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPKT 1259
              .:||.|.|..|   |.|.:|..:|                                       
 Frog   733 --YLRPNEVFYKLDERCHCHEGKLNC--------------------------------------- 756

  Fly  1260 CKNMDKYVADS------SDCLPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDCN 1318
                :.::.:|      :.|:.||||.:| :.|.....||..::|.|.:..:.:..|.::.|:|.
 Frog   757 ----ESFINESFLYQMGAGCISGCVCPDG-LLDDGNGRCVHESSCPCSYNNEVFPHGYRLIEECK 816

  Fly  1319 LCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFDFQGACDYVLAK---GVFDNGDGFSITIQ 1380
            .|.|.:|.|.|.:..|..||:::|..|:.|||...::|.|:|::|:|:   |...:...|.|..:
 Frog   817 SCTCESGLWSCIQTPCYGTCTIYGSGHYITFDKKFYEFDGSCEFVVAQDYCGDSASNGTFKIITE 881

  Fly  1381 NVLCGTMGVTCSKSLEIALTGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNSKGHNAFHIYKAG 1445
            |:.|||.|||||||::|.| |:.|..|           .|....||..:|....   .:.|.:.|
 Frog   882 NIPCGTTGVTCSKSIKIYL-GNTELKL-----------TNSHMEKKFGESETDV---KYRIREVG 931

  Fly  1446 VFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGH 1510
            :::.:.. ...:.:.||:.|.:.::|.:.::.||.||||||:.||.:|..|..:...::.:.||:
 Frog   932 LYLAIRT-SSDISLIWDKKTSLLIRLPSSYKGKVCGLCGNYDDNSNNDFLTSQLIQASNVIPFGN 995

  Fly  1511 AWKLQPHCSAPVAPIDACKKHPERETWAQLKCGALKSDLFKECHAEVPLERFWKRCIFDTCACDQ 1575
            :||....|....:....|...|.|.:||:.||..:.:|:|:.||::|..:.|:..|:.|.|:||.
 Frog   996 SWKRSNECPDANSIPQPCLAAPHRRSWAEKKCDIITNDVFRSCHSKVDPKPFYDACVNDVCSCDT 1060

  Fly  1576 GGDCECLCTAVAAYADACAQKGINIRWRSQHFCPMQCDPHCSDYKACTPACAVETCDNFLDQGIA 1640
            ||||||.||||||||..||:..:.|.||:...||:.||                           
 Frog  1061 GGDCECFCTAVAAYAQLCAKADVCIHWRTPEICPIFCD--------------------------- 1098

  Fly  1641 ERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCV-PKAECKPVCMVRDGKTFYEGDITFTDSCATC 1704
                                   |.|....:|: ....|.|                        
 Frog  1099 -----------------------YYNTNENECMWHYFACGP------------------------ 1116

  Fly  1705 RCSKRKEICSGVKCDVPATTGLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDRDTSDKSVRL 1769
                                                    :.:.:...|::|..           
 Frog  1117 ----------------------------------------EDRSIHHITKYCHS----------- 1130

  Fly  1770 NDEEKVPRYDRMENVYGTCLKQYMTKVECRVKDTHEAPEQMDENVVCSLEEGLRCIGKCHDYELR 1834
                  |....:|..|.||                                              
 Frog  1131 ------PSVTHLEGCYPTC---------------------------------------------- 1143

  Fly  1835 AFCQCDEELEPELPKPTEKPQLGLACDAAVVEYKEFPGDCHKFLHCQPKGVEGGWIYVEKTCGEY 1899
                           |.|:|.           |.|....|  |.||              .|   
 Frog  1144 ---------------PAERPY-----------YDEIQKKC--FKHC--------------PC--- 1163

  Fly  1900 MMFNPTMLICDHIATVTEIKPNCGLKPEPEPEFEPIKQC-PPGKIKSECANQCENTCHYYGSILK 1963
            ::.|.|....:||                 |..:|...| ..||:.:: .|...:||..:|    
 Frog  1164 IINNITYSSGEHI-----------------PNSDPCLICYKKGKLFTD-FNFSFSTCDEHG---- 1206

  Fly  1964 KRGLCQVGEHCKPGCVDELRPDCPKLGKFWRDEDTCVHADECPCMDKAEHYVQPHKPVLGEFEVC 2028
                                            |.:|....||                       
 Frog  1207 --------------------------------EKSCSRNSEC----------------------- 1216

  Fly  2029 QCIDNAFTCVPNKPEPVPKDEDDDLDLVSVVPIYPVTLTPPLQCSPERLIPKIENPAHSLPDSIF 2093
             ||||..|..|:                    |:|                         ||:..
 Frog  1217 -CIDNFTTGTPS--------------------IHP-------------------------PDTTI 1235

  Fly  2094 NASSQLAPEHGPKMARLTKEQPRGSWSPSINDQMQYLELNFAKPEPFYGVVMAGSPEFDNYVTLF 2158
            :                                                                
 Frog  1236 S---------------------------------------------------------------- 1236

  Fly  2159 KILHSHDGIAYHYLVDETEKPQMFNGPLDSRAPVQTLFKIPIEASSLRIYPLKWHGSIAMRVELL 2223
              :|:..|:..|                                                     
 Frog  1237 --IHASKGLCAH----------------------------------------------------- 1246

  Fly  2224 ICGDKEEPKPVPTVSTILPITERPARLVDLECIDLMGVDEGKMYQDQVQSSSLWQQPNLGKKLQL 2288
                                         .:|::                         ||.:..
 Frog  1247 -----------------------------RKCVN-------------------------GKIITT 1257

  Fly  2289 LELLKLSTPLAWRPLANSQNEFIEFDFLEPRNISGFVTKGGPDGWVTGYKVMFSKKKPTWNTVLS 2353
            .:|..:                                                   ||..|.: 
 Frog  1258 TKLCSI---------------------------------------------------PTTTTAI- 1270

  Fly  2354 TDGQARIFEANHDAETERRHHFKNPILTQYIKIVPAYWEKNINMRIEPLGCFLPYPEIQRQVPVE 2418
                               |.                                            
 Frog  1271 -------------------HR-------------------------------------------- 1272

  Fly  2419 ESKPTKCNICDGVSTSSSTTGCQCQDQLFWDGNTCVQHNLCPCIENYVSYPIGSKFENSACEDCV 2483
                          |::.||.|.|    :::|..               |..|.:.         
 Frog  1273 --------------TTTHTTKCTC----YYNGTV---------------YTPGQEI--------- 1295

  Fly  2484 CVLGGHKNCKPKKCPPCLGGKLRPVITSDCFCKCEPCPKHQRLCPSSGDCIPEILWCNGVQDCAD 2548
                                 .|.|:...|:         :.:|                     
 Frog  1296 ---------------------TRSVVYGKCY---------KVVC--------------------- 1309

  Fly  2549 DEDASCSDSFTVEPDVSREKNETEVITCPVPVCPPQMKIRITEKKSRKMSKMFTFSKQVSIVDDG 2613
              |.:|.     ||..:.       |.|.....|.                              
 Frog  1310 --DGNCG-----EPPATE-------IPCTTTTTPT------------------------------ 1330

  Fly  2614 TTITKTKFISSKEQILAMPNRELDFQLEEQCDEFTCVPIPSKQVDKNETVTCTEPKCPEKYDVEL 2678
            ||.|.|...:|                            .:|...|:.|||              
 Frog  1331 TTHTTTNTTTS----------------------------TTKTTTKSTTVT-------------- 1353

  Fly  2679 DMSASKVGDCLRYSCVLRPNKDDVCEISGKSFTTFDGTVFKYGPCSHILARDIHSSSWSISVHQQ 2743
                                                 |:....||                    
 Frog  1354 -------------------------------------TISTTTPC-------------------- 1361

  Fly  2744 CSDETRKVCHKVITIQDTEAGNELILLPHLKLKFNGYEFTVQQLINSPICKASFVVSQPGKTLLA 2808
                                                                             
 Frog  1362 ----------------------------------------------------------------- 1361

  Fly  2809 VSTKYGFWVQLDDIGIVKVGISSKFIRTVDGLCGYYNGNQKDDKRSPDGQIIPNTEKFGDSWYDK 2873
                                                               :|:|     ||   
 Frog  1362 ---------------------------------------------------VPHT-----SW--- 1367

  Fly  2874 RIPKDQCGDLKCPREMQAKALQLCNIIHHPTFARCHKAVNYKQFLNNYCLEAACNCMMANNGDPA 2938
                                 |:||                       |.:|.||    :||.  
 Frog  1368 ---------------------QICN-----------------------CTKAVCN----SNGQ-- 1382

  Fly  2939 ACKCNILESFVKKCLSVNPLVQLTTWRAVAQCEINCPSPLVHTDCYKRRCEPSCDNVHGDDCPVL 3003
                  |:...|.|              ....||.|.:.:      |....|       ||    
 Frog  1383 ------LQIVQKSC--------------TPPPEITCANKM------KPIAVP-------DD---- 1410

  Fly  3004 PDACFPGCY---CPEGTVRKGPNCVPISECKDCVCNSLGASKYMTYDRKSFSFNGNCTYLLSRDV 3065
             |:|   |:   ||                  |:|...| ..|:|:|...:::.|:|:|:|..::
 Frog  1411 -DSC---CWHWECP------------------CMCGGWG-DHYLTFDGTYYAYQGSCSYVLMEEI 1452

  Fly  3066 VLPGVHTFQVYVSMDDCKKLGQPTPVEGGSCAKSLHILNGDHVIHVQRVPQKPKSLQVLVDGFEV 3130
            | ..|..|.:|:....|:      ...|.:|.:.|.:.:.:..|.:......|.||:..|:| ::
 Frog  1453 V-KTVDNFGIYLDNYHCE------DKTGITCPRKLTVRHKNQEITISPKTFSPISLETRVNG-DL 1509

  Fly  3131 KKIPYKDSWISLRQVVGKELVLSLPESHVELTASFEDLIFSLGVPSIKYGSKMEGLCGDCNGNAG 3195
            ..:||....|::.| .|..:|:.:||....:|  :..|.||:.:|..|:.....|.||.|..|..
 Frog  1510 VLLPYTQYGITVYQ-SGVYVVIEIPELQTNVT--YNGLTFSIMMPFGKFYKNTHGQCGTCTNNQA 1571

  Fly  3196 ND-LQPNPAKKKAGVDVIQSWQADEPKLGLVEECLSEDVPKEHCIPLPPE-----KDPCLQFYNA 3254
            :| |..|.......|.:..|:....|           |.|:  |..:||.     |.|.......
 Frog  1572 DDFLMANGKITTNAVAMADSFMVHNP-----------DKPR--CKSIPPVHPKTCKSPLCDLIMG 1623

  Fly  3255 ELFGKCPLAVDPIAYVSACQQDICKPGNTQQGVCVALAAYAKECNQHGICTNWR-RPQLCPYECP 3318
            .:|..|.....|..:..||..|.|...|: ...|.:|..||..|...|:|..|| ....||..||
 Frog  1624 PVFQNCHAFHSPEPFYQACLLDSCNKANS-NNECTSLQHYASICGDRGVCIQWRSHASTCPMTCP 1687

  Fly  3319 SDMVYEPCGCAK--NCDTIKALSEFDAVSLKNEAVVHTVKTDEMCLSSERFEGCFCPPGKV---M 3378
            ||.||..||.|.  .|.:|.|    ||:|||::..|              .|||||..|.:   |
 Frog  1688 SDKVYNACGPALPITCQSIPA----DAMSLKHDRRV--------------MEGCFCAKGSMPFSM 1734

  Fly  3379 DGGQCVPEIACTKCDDGLHLPDEKWKKDKCTECQCDSKGK-TTCVEKKC-QVEENICA-EG-YRP 3439
            ....||....|...|:......|.::.: |..|.|...|: .||..::| .|....|. || |:.
 Frog  1735 ATDVCVSSCGCVGPDNVPRKYGESFEYN-CETCTCLKGGRGITCQRQQCHHVRNEECTREGFYKV 1798

  Fly  3440 ETIVSVDECCPR--YRCVPETKDPSKLCLAPLVPICGPG-QFKKEKKDVNGCSQYICECIPKDQC 3501
            ..|.|.::||..  .||     |.|: | :...|.|||| :.|...|:.:.|..|:||  ||..|
 Frog  1799 TQISSTNKCCEETVCRC-----DLSR-C-SNTFPKCGPGFELKWGIKEGHCCPTYVCE--PKHVC 1854

  Fly  3502 EIIELRELLPGEIIVNVEEGCCPTQKIECKPETCPKAPVNCQERFYEVKTIKEPGMCCSKH---- 3562
             :....|.|||..:.:  |.|          |:|                      .|.:|    
 Frog  1855 -VSGNAEYLPGSHVYS--EKC----------ESC----------------------ICEQHKNNF 1884

  Fly  3563 --SCVPPKDLCIVQYELDEATKFTKTVGDKWTHAKEVCKQETCSYGPDGNAQVVSTLEQCLTDCA 3625
              :|.|     ||                                              |...|.
 Frog  1885 SIACHP-----IV----------------------------------------------CNIHCP 1898

  Fly  3626 PGFSYQNLDKTKCCGKCVQTSCIFE-----QKLYEVNALWKSADNCTTYSCLKKDGQFLVTTSRE 3685
            .||..:....|.|||.|.||:|:.:     :.:...:.|....||||.|.|...:.||:.|.|:.
 Frog  1899 AGFKVKKNSPTDCCGTCQQTNCVVKYGGSNRLMNPGDVLPSMNDNCTMYKCSLINDQFVTTVSQT 1963

  Fly  3686 VCPDV-------GSC-LSHLLYQDGCCKRCKSEPLVEDKSSCLPVSLAESRTKEILKFPVQGHGT 3742
            .||.:       ||. |||    :||||.|     ::.||||...::.:..|       .||   
 Frog  1964 SCPSLNEEECEPGSIQLSH----NGCCKTC-----IQKKSSCKLQAVDDYLT-------YQG--- 2009

  Fly  3743 CVNADPIQGFTDCEGACSSGSKYNTLTDMHEKFCTCCSIKSYHPISVKMICDDGHTFTQKHEVPS 3807
            |.:...:: .:.|||:|.:.|.|::......|.|:||.........|.:.|.||.....::....
 Frog  2010 CTSVTRVR-MSRCEGSCGTFSMYSSEERTMSKKCSCCQEVQTARNKVTLRCPDGTLLDHEYIDVL 2073

  Fly  3808 NCGCS 3812
            .|.|:
 Frog  2074 ECKCA 2078

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 35/166 (21%)
C8 680..754 CDD:285899 18/73 (25%)
TIL 758..811 CDD:280072 21/59 (36%)
VWD 840..1015 CDD:214566 53/177 (30%)
C8 1054..1121 CDD:214843 25/69 (36%)
TIL 1131..1185 CDD:280072 20/59 (34%)
TIL 1245..1298 CDD:280072 10/58 (17%)
VWD 1327..1498 CDD:214566 56/173 (32%)
C8 1535..1609 CDD:214843 34/73 (47%)
Mucin2_WxxW 1751..1837 CDD:290069 7/85 (8%)
TIL 1938..2005 CDD:280072 9/67 (13%)
FA58C 2089..2223 CDD:238014 5/133 (4%)
FA58C 2104..2225 CDD:214572 3/120 (3%)
FA58C <2299..2404 CDD:214572 4/104 (4%)
FA58C <2299..2403 CDD:238014 4/103 (4%)
VWD 2703..2858 CDD:295339 3/154 (2%)
C8 2893..2970 CDD:285899 12/76 (16%)
TIL 2974..3030 CDD:280072 10/58 (17%)
VWD 3035..3198 CDD:295339 43/163 (26%)
C8 3257..3313 CDD:285899 17/56 (30%)
VWC 3397..3451 CDD:302663 17/57 (30%)
GHB_like <3755..3813 CDD:304424 16/57 (28%)
LOC100485356XP_031756620.1 VWD 38..189 CDD:214566 36/172 (21%)
C8 236..298 CDD:400886 14/64 (22%)
TIL 302..358 CDD:410995 21/59 (36%)
VWD 398..551 CDD:395046 49/166 (30%)
C8 590..658 CDD:214843 25/68 (37%)
TIL 668..725 CDD:410995 20/59 (34%)
VWD 825..983 CDD:214566 56/173 (32%)
C8 1022..1094 CDD:214843 34/71 (48%)
VWD 1413..1579 CDD:214566 49/198 (25%)
C8 1617..1679 CDD:400886 17/62 (27%)
CT 1999..2081 CDD:214482 20/90 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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