DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and LOC100485197

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_031756619.1 Gene:LOC100485197 / 100485197 -ID:- Length:2165 Species:Xenopus tropicalis


Alignment Length:3500 Identity:692/3500 - (19%)
Similarity:1084/3500 - (30%) Gaps:1453/3500 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   426 YELQTERQKLLALLAKYRDLERRSE--W-WSSEETVVTMSSYSLYQSNNLDIV----IDKTPRPA 483
            |:.|..|:.....:||.:.:|.::.  | |    ..:|:|..|.|     ||:    :|.|  .:
 Frog     2 YKRQEMREASCHCMAKKQTMELQTPRIWVW----LALTLSLSSAY-----DIIPGRPVDHT--KS 55

  Fly   484 LCTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGTFDIILKACPYGSGYGCAHTLKILWQSVL- 547
            :|::||..:.|||||::::.|.:|::.|              |...|..|   |...:..|..: 
 Frog    56 ICSSWGNFHYKTFDGVIYQFPGTCNYNL--------------ASHCGDSY---HEFSVHIQRAIE 103

  Fly   548 ---------------YTFE------NLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESV 591
                           .|.|      .:||.:.:|        |....|:.:.....:.::..: :
 Frog   104 DGDPVIHQIFMQIKDVTIELKRDAAKVNGQIFVT--------PYFNYGVFINKKDGYTKVHTK-I 159

  Fly   592 GLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSEL 656
            ||.|.|:....|.::...:...|:.||||..:|.|.::........|..:: |.:...:.|.:..
 Frog   160 GLTLTWNQEDSVMLEVDAKYQNKMCGLCGDYNGAPVSNEFYLNDMPLNPIQ-FGNMKTINDPTIT 223

  Fly   657 C-QVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCNCANRE 720
            | .|:.|.:|  .:.||.|     ..|||:..|.......|...|:....:..||.|.|:|::.:
 Frog   224 CTNVDESQQM--NVSSCGQ-----YYSVCKSYLTQNAFSSCQDLFDVSDYVMACMLDVCSCSSAD 281

  Fly   721 HPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVEPTCDSDLALPASK 785
              .||.|..:...:::|...| .:...||..::||..|....:|:..|    ..|.|..:....|
 Frog   282 --ASCLCSTLTEYSRQCTHAG-GIPQNWRTNDLCPKRCPGNMIYKESG----SPCISSCSHHEVK 339

  Fly   786 GACNE----GCFCPEGTV---QYKEACITRELCPCSLRGKEFKPESTVKKNCNTCTCKNGQWRCT 843
            ..|.|    |||||:|||   .....||:...|.|..:.|.:.|.|.:..:|..|:|..|:|.||
 Frog   340 SLCEEHNIDGCFCPDGTVWDDHNNAGCISISECHCKYQEKFYAPGSKILNDCEECSCNAGKWTCT 404

  Fly   844 EDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQNTSVEAENVACSGAVSESMNFAAPDDP 908
            ...|...|...|..|::|||||.|.|.|.|.|.|.|.      .|...|:....|          
 Frog   405 HGVCPKVCSIEGGAHFKTFDGKPYKFHGNCYYLLSKA------TEMTPCNAYSRE---------- 453

  Fly   909 SCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFLTVEFADGI 973
            :|.|  .|:|...|   :|:.:....:.::||..|: ||.:.|...|:....|:.|:..:|...:
 Frog   454 TCLK--NIQFYTDD---NVLSIRADGSVLLNDLKIS-LPHVTGGFSVIQPTESNIFVKTKFGLQM 512

  Fly   974 RVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRTKDTCQFKA 1038
            :::...:.::||....|.:...:||||.||....|||:|..|..|:....||:.|:.:.|||...
 Frog   513 QIYLLPLMQLYISMDNSDKNTFEGLCGNFNYKEGDDFITSAGIEESTASAFANTWKIQSTCQDSV 577

  Fly  1039 ETHQGPHPCTLNPEKKAQAEKFCDWILQDI---FQDCHFLVEPEQFYEDCLYDTCACKDEMSKCF 1100
            |..  ..||:.:.|.|..|||:|. :|:|.   |..|||.|:|.::|:.|.||||:| .....|.
 Frog   578 EVL--IDPCSFSMETKIYAEKWCS-LLRDSESPFWKCHFAVDPSEYYKRCEYDTCSC-SHSEACM 638

  Fly  1101 CPILSAYGTECMRQG-VKTGWRMSVKECAV-KCPLGQVFDECGDGCALSCDDLPSKGSCKREC-- 1161
            |..||:|...|..:| :...|:..:.:..: .||..|::......|..:|..|..:   ::||  
 Frog   639 CATLSSYARACAAKGIILWDWKKGICDKEIPSCPASQIYLYNITTCQPTCRSLALE---EKECDS 700

  Fly  1162 ----VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQD 1222
                |:||.||.|.|:||...||||..|.|...||..||.....|..|:    |:|.:|..:| |
 Frog   701 EFTPVDGCGCPDGMYLNEKDSCVPKSQCSCYHQGMYLRPNEVFYRMDER----CSCHEGKLNC-D 760

  Fly  1223 AEPGDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYVADSSDCLPGCVCMEGYVYDT 1287
            :...|...   :.::...|.|:..:..::     .::|:.:: .....:.|:.||||.:| :.|.
 Frog   761 SFINDTCS---NGKVFLDCKKEKRSHMSR-----HRSCRTLN-IGPVGTGCISGCVCPDG-LLDD 815

  Fly  1288 SRLACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGH 1352
            ....||:.::|.|.:..|.:..|.::.|:|..|.|.:|.|.|.:..|..||:::|..|:.|||..
 Frog   816 GHGGCVVESSCPCSYNNKVFAHGSRLIEECKSCTCESGLWSCIQTPCYGTCTIYGSGHYITFDKK 880

  Fly  1353 DFDFQGACDYVLAK---GVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEESLLLSADSA 1414
            .:||.|:|::|:|:   |...:...|.|..:|:.|||.|||||||::|.| |:.|..|       
 Frog   881 FYDFDGSCEFVVAQDYCGDSASNGTFRIITENIPCGTTGVTCSKSIKIYL-GNTELKL------- 937

  Fly  1415 YSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKV 1479
                .|....||..:.....|   :.:.:.|:::.:.. ...:.:.||:.|.:.::|.:.::.||
 Frog   938 ----TNSHMEKKFGEFETEVG---YKVREVGLYLAIRT-SSDISLIWDKKTSLLIRLPSSYKGKV 994

  Fly  1480 SGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERETWAQLKCGA 1544
            .||||||:.|:.:|..|......::.|.||::||....|....:....|...|.|.:||:.||..
 Frog   995 CGLCGNYDDNANNDFLTSQSIQASNAMPFGNSWKRSNDCPDANSIPQPCLAAPHRRSWAEKKCDI 1059

  Fly  1545 LKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRWRSQHFCP 1609
            :.:::|..||::|..:.|:..|:.|.|:||.||||||.||||||||..||:..:.|.||:...||
 Frog  1060 ITNNVFARCHSKVDPKPFYDACVNDVCSCDTGGDCECFCTAVAAYAQLCAKADVCIHWRTPEICP 1124

  Fly  1610 MQCDPHCSDYKACTPACAVETCDNFLDQGIAERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCV- 1673
            :.||                                                  |.|....:|: 
 Frog  1125 IFCD--------------------------------------------------YYNTNENECMW 1139

  Fly  1674 PKAECKPVCMVRDGKTFYEGDITFTDSCATCRCSKRKEICSGVKCDVPATTGLPAPLVEGTTLPT 1738
            ....|.|                                                          
 Frog  1140 HYFACGP---------------------------------------------------------- 1146

  Fly  1739 PLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTKVECRVKDT 1803
                  :.:.:...|::|..                 |....:|..|.||               
 Frog  1147 ------EDRSIHHITKYCHS-----------------PSVTHLEGCYPTC--------------- 1173

  Fly  1804 HEAPEQMDENVVCSLEEGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQLGLACDAAVVEYK 1868
                                                          |||:|.           |.
 Frog  1174 ----------------------------------------------PTERPY-----------YD 1181

  Fly  1869 EFPGDCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLKPEPEPEFE 1933
            |....|  ..||              :|   ::.|.|..|...|             |.|||   
 Frog  1182 EINKSC--VSHC--------------SC---IINNITYSIGQQI-------------PNPEP--- 1211

  Fly  1934 PIKQCPPGKIKSECANQCENTCHYYGSILKKRGLCQVGEHCKPGCVDELRPDCPKLGKFWRDEDT 1998
                             |:              :|:.|......|..:  |.|            
 Frog  1212 -----------------CQ--------------ICECGTDLNKHCTTD--PAC------------ 1231

  Fly  1999 CVHADECPCMDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPKDEDDDLDLVSVVPIYP 2063
                                           ||      :....:|:|.:        :::..| 
 Frog  1232 -------------------------------CI------MSTTAQPIPTN--------TIISTY- 1250

  Fly  2064 VTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEHGPKMARLTKEQPRGSWSPSINDQMQ 2128
                                   :|||....:..|                              
 Frog  1251 -----------------------TLPDLCVQSKCQ------------------------------ 1262

  Fly  2129 YLELNFAKPEPFYGVVMAGSPEFDNYVTLFKILHSHDGIAYHYLVDETEKPQMFNGPLDSRAPVQ 2193
                                                                             
 Frog  1263 ----------------------------------------------------------------- 1262

  Fly  2194 TLFKIPIEASSLRIYPLKWHGSIAMRVELLICGDKEEPKPVPTVSTILPITERPARLVDLECIDL 2258
                               :|||.                  |.:|:...|              
 Frog  1263 -------------------NGSII------------------TTATLCSTT-------------- 1276

  Fly  2259 MGVDEGKMYQDQVQSSSLWQQPNLGKKLQLLELLKLSTPLAWRPLANSQNEFIEFDFLEPRNISG 2323
                                                                             
 Frog  1277 ----------------------------------------------------------------- 1276

  Fly  2324 FVTKGGPDGWVTGYKVMFSKKKPTWNTVLSTDGQARIFEANHDAETERRHHFKNPILTQYIKIVP 2388
                       ||.||:.|:.:       ..||:..|:..:...:|                   
 Frog  1277 -----------TGQKVIGSESR-------ERDGKCYIYVCDSTCQT------------------- 1304

  Fly  2389 AYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKCNICDGVSTSSSTTGCQCQDQLFWDGNTC 2453
                                  ::.:.|           |:...|:||||          ..:|.
 Frog  1305 ----------------------LKTKTP-----------CETTQTTSSTT----------TPSTT 1326

  Fly  2454 VQHNLCPCIENYVSYPIGSKFENSACEDCVCVLGGHKNCKPKKCPPCLGGKLRPVITSDCFCKCE 2518
            :....|.|..|..:|..|.:...:.      :||                            || 
 Frog  1327 IHTTKCSCYHNGKAYMPGEEITRNK------ILG----------------------------KC- 1356

  Fly  2519 PCPKHQRLCPSSGDCIPEILWCNGVQDCADDEDASCSDSFTVEPDVSREKNETEVITCPVPVCPP 2583
                ::.:|                       |.||.:...:|            ..|.:...| 
 Frog  1357 ----YKVVC-----------------------DGSCGEIPAIE------------FPCEITTTP- 1381

  Fly  2584 QMKIRITEKKSRKMSKMFTFSKQVSIVDDGTTITKTKFISSKEQILAMPNRELDFQLEEQCDEFT 2648
                                          ||...||                           |
 Frog  1382 ------------------------------TTTPTTK---------------------------T 1389

  Fly  2649 CVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISGKSFTTF 2713
            ..| .|....|:.|:|                                                 
 Frog  1390 TTP-SSTTTTKSTTIT------------------------------------------------- 1404

  Fly  2714 DGTVFKYGPCSHILARDIHSSSWSISVHQQCSDETRKVCHKVITIQDTEAGNELILLPHLKLKFN 2778
                                   |||....|                                  
 Frog  1405 -----------------------SISTTTPC---------------------------------- 1412

  Fly  2779 GYEFTVQQLINSPICKASFVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSKFIRTVDGLCGY 2843
                                                                             
 Frog  1413 ----------------------------------------------------------------- 1412

  Fly  2844 YNGNQKDDKRSPDGQIIPNTEKFGDSWYDKRIPKDQCGDLKCPREMQAKALQLCNIIHHPTFARC 2908
                            :|:|     ||                                      
 Frog  1413 ----------------VPHT-----SW-------------------------------------- 1418

  Fly  2909 HKAVNYKQFLNNYCLEAACNCMMANNGDPAACKCNILESFVKKCLSVNPLVQLTTWRAVAQCEIN 2973
                   |..|  |.:|.||    .||:        |:...|.|              ....|||
 Frog  1419 -------QIFN--CTKAVCN----GNGE--------LQIVQKSC--------------TPPPEIN 1448

  Fly  2974 CPSPLVHTDCYKRRCEPSCDNVHGDDCPVLPDACFPGCY---CPEGTVRKGPNCVPISECKDCVC 3035
            |.:.:      |....|       ||     |:|   |:   ||                  |||
 Frog  1449 CANKM------KPIAVP-------DD-----DSC---CWHWECP------------------CVC 1474

  Fly  3036 NSLGASKYMTYDRKSFSFNGNCTYLLSRDVVLPGVHTFQVYVSMDDCKKLGQPTPVEGGSCAKSL 3100
            :..|.|.|:|:|...:|:.|.|||:|..::| ..:..|.:|:...||   |..|   |.:|.:.|
 Frog  1475 SGWGDSHYLTFDGTYYSYQGRCTYVLVEEIV-KTIDNFGIYLDNYDC---GHKT---GITCPRKL 1532

  Fly  3101 HILNGDHVIHVQRVPQKPKSLQVLVDGFEVKKIPYKDSWISLRQVVGKELVLSLPESHVELTASF 3165
            .:.:....|.:......|.||:..|:| .:..:||....:::.| .|..||:.:||.|..:|  :
 Frog  1533 TVRHKTQEILISPKTSTPTSLETRVNG-NLVLLPYTKYGVTIYQ-SGVYLVVEIPELHTNVT--Y 1593

  Fly  3166 EDLIFSLGVPSIKYGSKMEGLCGDCNGNAGNDL-QPNPAKKKAGVDVIQSWQADEPKLGLVEECL 3229
            ..|.||:.:|..|:.....|.||.|..|..:|| ..|.....:...:..|:....|         
 Frog  1594 NGLTFSIMMPYGKFYKNTHGQCGTCTNNQADDLMMANGKVTTSAAAMADSFMVHNP--------- 1649

  Fly  3230 SEDVPKEHCIPLPPE-----KDPCLQFYNAELFGKCPLAVDPIAYVSACQQDICKPGNTQQGVCV 3289
              |.|:  |..:||.     |..........:|..|.....|..:..||..|.|...|: ...|.
 Frog  1650 --DKPR--CNSIPPVHHNTCKSAVCDLIMGPVFQNCHAFHSPEPFYQACLLDSCNKANS-DSECS 1709

  Fly  3290 ALAAYAKECNQHGICTNWR-RPQLCPYECPSDMVYEPCGCAK--NCDTIKALSEFDAVSLKNEAV 3351
            :|..||..|...|:|..|| ....||:.|||:.||:.||.|.  .|                   
 Frog  1710 SLQHYASICGDRGVCIQWRSHAPSCPFTCPSNKVYDACGPALPITC------------------- 1755

  Fly  3352 VHTVKTDEMCLSSER--FEGCFCPPGKV-----MDGGQCVPEIACTKCDDGLHLPDEKWKKD--- 3406
             .|..||.|.:.::|  .|||||..|.:     :|  .||.|..|...|   ::| .|:.:.   
 Frog  1756 -QTRPTDTMAMKNDRRVVEGCFCAKGSMPFSTKID--TCVSECGCVGPD---NIP-RKYGESFEF 1813

  Fly  3407 KCTECQCDSKGK-TTCVEKKCQ--VEENICAEGYRPETIVS-VDECCPR--YRCVPETKDPSKLC 3465
            .|..|:|...|. .||.:::|.  ..|....||:...|.|| .::||..  .||     |||: |
 Frog  1814 NCETCKCLEGGNGITCQKQQCHHARNEECTREGFYKVTQVSATNKCCEETVCRC-----DPSR-C 1872

  Fly  3466 LAPLVPICGPG-QFKKEKKDVNGCSQYICECIPKDQCEIIELRELLPGEIIVNVEEGCCPTQKIE 3529
             :...|.|||| :.|....:.:.|..|:||  ||..| :....|.|||..:.:            
 Frog  1873 -SNTFPKCGPGFELKGGINEGHCCPTYVCE--PKPVC-VRGNAEYLPGSHVYS------------ 1921

  Fly  3530 CKPETCPKAPVNCQERFYEVKTIKEPGMCCSKHSCVPPKDLCIVQYELDEATKFTKTVGDKWTHA 3594
               |.|.    ||               .|:::                         |..:|.|
 Frog  1922 ---ENCE----NC---------------VCAQN-------------------------GHNFTIA 1939

  Fly  3595 KEVCKQETCSYGPDGNAQVVSTLEQCLTDCAPGFSYQNLDKTKCCGKCVQTSCIFE-QKLYEV-- 3656
               |....|:                 ..|..||..:....:.|||.|.||:|:.: ...|.:  
 Frog  1940 ---CNPVVCN-----------------IHCPAGFKVKKNSPSDCCGTCQQTNCVVKYDGSYRIMN 1984

  Fly  3657 --NALWKSADNCTTYSCLKKDGQFLVTTSREVCPDVGSCLSHLLYQDGCCKRCKSEPLVEDKSSC 3719
              :.|....||||.|.|...:.||:.|.::..||.:                        ::..|
 Frog  1985 NGDVLPSMNDNCTMYKCSLINDQFITTVTQMSCPSL------------------------NEEDC 2025

  Fly  3720 LPVSLAESRTKEILKF----PVQGHGTCVNADPIQGFTDCEGACSSGSKYNTLTDMHEKFCTCCS 3780
            .|||:.:..:.::..|    ..||   |.:...|: .:.|||||...|:|:.........|:||:
 Frog  2026 EPVSIQKKDSCKVQAFDDYLSYQG---CRSVSRIK-MSRCEGACGKVSRYSAEEHTMSHTCSCCN 2086

  Fly  3781 IKSYHPISVKMICDDGHTFTQKHEVPSNCGC--SPCSEFS-DSAIDVRMQQDAQS 3832
            ........||:.|.||.....::.....|.|  :.|.::| :...:.:...||.|
 Frog  2087 EVQTKRSKVKLQCPDGTLIDHEYIDVLECKCAGTKCPDYSCEGVCEFQQPMDASS 2141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 35/172 (20%)
C8 680..754 CDD:285899 18/73 (25%)
TIL 758..811 CDD:280072 18/59 (31%)
VWD 840..1015 CDD:214566 51/174 (29%)
C8 1054..1121 CDD:214843 27/70 (39%)
TIL 1131..1185 CDD:280072 21/59 (36%)
TIL 1245..1298 CDD:280072 10/52 (19%)
VWD 1327..1498 CDD:214566 55/173 (32%)
C8 1535..1609 CDD:214843 33/73 (45%)
Mucin2_WxxW 1751..1837 CDD:290069 7/85 (8%)
TIL 1938..2005 CDD:280072 6/66 (9%)
FA58C 2089..2223 CDD:238014 6/133 (5%)
FA58C 2104..2225 CDD:214572 3/120 (3%)
FA58C <2299..2404 CDD:214572 9/104 (9%)
FA58C <2299..2403 CDD:238014 9/103 (9%)
VWD 2703..2858 CDD:295339 4/154 (3%)
C8 2893..2970 CDD:285899 11/76 (14%)
TIL 2974..3030 CDD:280072 10/58 (17%)
VWD 3035..3198 CDD:295339 48/162 (30%)
C8 3257..3313 CDD:285899 17/56 (30%)
VWC 3397..3451 CDD:302663 17/60 (28%)
GHB_like <3755..3813 CDD:304424 17/59 (29%)
LOC100485197XP_031756619.1 VWD 52..203 CDD:214566 36/178 (20%)
C8 253..312 CDD:400886 14/61 (23%)
TIL 316..372 CDD:410995 18/59 (31%)
VWD 401..554 CDD:214566 51/174 (29%)
C8 593..659 CDD:214843 26/67 (39%)
TIL 671..728 CDD:410995 21/59 (36%)
VWC 828..>874 CDD:327433 14/45 (31%)
VWD 855..1013 CDD:214566 55/173 (32%)
C8 1052..1124 CDD:214843 33/71 (46%)
VWD 1464..1631 CDD:214566 56/198 (28%)
C8 1669..1731 CDD:400886 17/62 (27%)
CT 2038..2121 CDD:214482 22/86 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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