Protein Alignment Hml and LOC100485197

DIOPT Version :10

• Sequence 1: NP_524060.2
• Gene: Hml / 39529
• FlyBaseID: FBgn0029167
• Length: 3843
• Species: Drosophila melanogaster
• Sequence 2: XP_031756619.1
• Gene: LOC100485197 / 100485197
• XenbaseID: XB-GENE-29077667
• Length: 2165
• Species: Xenopus tropicalis
• Alignment Length: 3500
• Identity: 692/3500 - (19%)
• Similarity: 1084/3500 - (30%)
• Gaps: 1453/3500 - (41%)

  Fly   426 YELQTERQKLLALLAKYRDLERRSE--W-WSSEETVVTMSSYSLYQSNNLDIV----IDKTPRPA 483
            |:.|..|:.....:||.:.:|.::.  | |    ..:|:|..|.|     ||:    :|.|  .:
 Frog     2 YKRQEMREASCHCMAKKQTMELQTPRIWVW----LALTLSLSSAY-----DIIPGRPVDHT--KS 55

  Fly   484 LCTTWGGINMKTFDGLVFKAPLSCSHTLITDKVSGTFDIILKACPYGSGYGCAHTLKILWQSVL- 547
            :|::||..:.|||||::::.|.:|::.|              |...|..|   |...:..|..:
 Frog    56 ICSSWGNFHYKTFDGVIYQFPGTCNYNL--------------ASHCGDSY---HEFSVHIQRAIE 103

  Fly   548 ---------------YTFE------NLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLESV 591
                           .|.|      .:||.:.:|        |....|:.:.....:.::..: :
 Frog   104 DGDPVIHQIFMQIKDVTIELKRDAAKVNGQIFVT--------PYFNYGVFINKKDGYTKVHTK-I 159

  Fly   592 GLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSEL 656
            ||.|.|:....|.::...:...|:.||||..:|.|.::........|..:: |.:...:.|.:..
 Frog   160 GLTLTWNQEDSVMLEVDAKYQNKMCGLCGDYNGAPVSNEFYLNDMPLNPIQ-FGNMKTINDPTIT 223

  Fly   657 C-QVENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCNCANRE 720
            | .|:.|.:|  .:.||.|     ..|||:..|.......|...|:....:..||.|.|:|::.:
 Frog   224 CTNVDESQQM--NVSSCGQ-----YYSVCKSYLTQNAFSSCQDLFDVSDYVMACMLDVCSCSSAD 281

  Fly   721 HPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVEPTCDSDLALPASK 785
              .||.|..:...:::|...| .:...||..::||..|....:|:..|    ..|.|..:....|
 Frog   282 --ASCLCSTLTEYSRQCTHAG-GIPQNWRTNDLCPKRCPGNMIYKESG----SPCISSCSHHEVK 339

  Fly   786 GACNE----GCFCPEGTV---QYKEACITRELCPCSLRGKEFKPESTVKKNCNTCTCKNGQWRCT 843
            ..|.|    |||||:|||   .....||:...|.|..:.|.:.|.|.:..:|..|:|..|:|.||
 Frog   340 SLCEEHNIDGCFCPDGTVWDDHNNAGCISISECHCKYQEKFYAPGSKILNDCEECSCNAGKWTCT 404

  Fly   844 EDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQNTSVEAENVACSGAVSESMNFAAPDDP 908
            ...|...|...|..|::|||||.|.|.|.|.|.|.|.      .|...|:....|
 Frog   405 HGVCPKVCSIEGGAHFKTFDGKPYKFHGNCYYLLSKA------TEMTPCNAYSRE---------- 453

  Fly   909 SCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFLTVEFADGI 973
            :|.|  .|:|...|   :|:.:....:.::||..|: ||.:.|...|:....|:.|:..:|...:
 Frog   454 TCLK--NIQFYTDD---NVLSIRADGSVLLNDLKIS-LPHVTGGFSVIQPTESNIFVKTKFGLQM 512

  Fly   974 RVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRTKDTCQFKA 1038
            :::...:.::||....|.:...:||||.||....|||:|..|..|:....||:.|:.:.|||...
 Frog   513 QIYLLPLMQLYISMDNSDKNTFEGLCGNFNYKEGDDFITSAGIEESTASAFANTWKIQSTCQDSV 577

  Fly  1039 ETHQGPHPCTLNPEKKAQAEKFCDWILQDI---FQDCHFLVEPEQFYEDCLYDTCACKDEMSKCF 1100
            |..  ..||:.:.|.|..|||:|. :|:|.   |..|||.|:|.::|:.|.||||:| .....|.
 Frog   578 EVL--IDPCSFSMETKIYAEKWCS-LLRDSESPFWKCHFAVDPSEYYKRCEYDTCSC-SHSEACM 638

  Fly  1101 CPILSAYGTECMRQG-VKTGWRMSVKECAV-KCPLGQVFDECGDGCALSCDDLPSKGSCKREC-- 1161
            |..||:|...|..:| :...|:..:.:..: .||..|::......|..:|..|..:   ::||
 Frog   639 CATLSSYARACAAKGIILWDWKKGICDKEIPSCPASQIYLYNITTCQPTCRSLALE---EKECDS 700

  Fly  1162 ----VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQD 1222
                |:||.||.|.|:||...||||..|.|...||..||.....|..|:    |:|.:|..:| |
 Frog   701 EFTPVDGCGCPDGMYLNEKDSCVPKSQCSCYHQGMYLRPNEVFYRMDER----CSCHEGKLNC-D 760

  Fly  1223 AEPGDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYVADSSDCLPGCVCMEGYVYDT 1287
            :...|...   :.::...|.|:..:..::     .::|:.:: .....:.|:.||||.:| :.|.
 Frog   761 SFINDTCS---NGKVFLDCKKEKRSHMSR-----HRSCRTLN-IGPVGTGCISGCVCPDG-LLDD 815

  Fly  1288 SRLACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGH 1352
            ....||:.::|.|.:..|.:..|.::.|:|..|.|.:|.|.|.:..|..||:::|..|:.|||..
 Frog   816 GHGGCVVESSCPCSYNNKVFAHGSRLIEECKSCTCESGLWSCIQTPCYGTCTIYGSGHYITFDKK 880

  Fly  1353 DFDFQGACDYVLAK---GVFDNGDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEESLLLSADSA 1414
            .:||.|:|::|:|:   |...:...|.|..:|:.|||.|||||||::|.| |:.|..|
 Frog   881 FYDFDGSCEFVVAQDYCGDSASNGTFRIITENIPCGTTGVTCSKSIKIYL-GNTELKL------- 937

  Fly  1415 YSTDPNKTPIKKLRDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKV 1479
                .|....||..:.....|   :.:.:.|:::.:.. ...:.:.||:.|.:.::|.:.::.||
 Frog   938 ----TNSHMEKKFGEFETEVG---YKVREVGLYLAIRT-SSDISLIWDKKTSLLIRLPSSYKGKV 994

  Fly  1480 SGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERETWAQLKCGA 1544
            .||||||:.|:.:|..|......::.|.||::||....|....:....|...|.|.:||:.||..
 Frog   995 CGLCGNYDDNANNDFLTSQSIQASNAMPFGNSWKRSNDCPDANSIPQPCLAAPHRRSWAEKKCDI 1059

  Fly  1545 LKSDLFKECHAEVPLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRWRSQHFCP 1609
            :.:::|..||::|..:.|:..|:.|.|:||.||||||.||||||||..||:..:.|.||:...||
 Frog  1060 ITNNVFARCHSKVDPKPFYDACVNDVCSCDTGGDCECFCTAVAAYAQLCAKADVCIHWRTPEICP 1124

  Fly  1610 MQCDPHCSDYKACTPACAVETCDNFLDQGIAERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCV- 1673
            :.||                                                  |.|....:|:
 Frog  1125 IFCD--------------------------------------------------YYNTNENECMW 1139

  Fly  1674 PKAECKPVCMVRDGKTFYEGDITFTDSCATCRCSKRKEICSGVKCDVPATTGLPAPLVEGTTLPT 1738
            ....|.|
 Frog  1140 HYFACGP---------------------------------------------------------- 1146

  Fly  1739 PLATQNQTKCVKGWTRWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTKVECRVKDT 1803
                  :.:.:...|::|..                 |....:|..|.||
 Frog  1147 ------EDRSIHHITKYCHS-----------------PSVTHLEGCYPTC--------------- 1173

  Fly  1804 HEAPEQMDENVVCSLEEGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQLGLACDAAVVEYK 1868
                                                          |||:|.           |.
 Frog  1174 ----------------------------------------------PTERPY-----------YD 1181

  Fly  1869 EFPGDCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLKPEPEPEFE 1933
            |....|  ..||              :|   ::.|.|..|...|             |.|||
 Frog  1182 EINKSC--VSHC--------------SC---IINNITYSIGQQI-------------PNPEP--- 1211

  Fly  1934 PIKQCPPGKIKSECANQCENTCHYYGSILKKRGLCQVGEHCKPGCVDELRPDCPKLGKFWRDEDT 1998
                             |:              :|:.|......|..:  |.|
 Frog  1212 -----------------CQ--------------ICECGTDLNKHCTTD--PAC------------ 1231

  Fly  1999 CVHADECPCMDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPKDEDDDLDLVSVVPIYP 2063
                                           ||      :....:|:|.:        :::..|
 Frog  1232 -------------------------------CI------MSTTAQPIPTN--------TIISTY- 1250

  Fly  2064 VTLTPPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEHGPKMARLTKEQPRGSWSPSINDQMQ 2128
                                   :|||....:..|
 Frog  1251 -----------------------TLPDLCVQSKCQ------------------------------ 1262

  Fly  2129 YLELNFAKPEPFYGVVMAGSPEFDNYVTLFKILHSHDGIAYHYLVDETEKPQMFNGPLDSRAPVQ 2193
                                                                             
 Frog  1263 ----------------------------------------------------------------- 1262

  Fly  2194 TLFKIPIEASSLRIYPLKWHGSIAMRVELLICGDKEEPKPVPTVSTILPITERPARLVDLECIDL 2258
                               :|||.                  |.:|:...|
 Frog  1263 -------------------NGSII------------------TTATLCSTT-------------- 1276

  Fly  2259 MGVDEGKMYQDQVQSSSLWQQPNLGKKLQLLELLKLSTPLAWRPLANSQNEFIEFDFLEPRNISG 2323
                                                                             
 Frog  1277 ----------------------------------------------------------------- 1276

  Fly  2324 FVTKGGPDGWVTGYKVMFSKKKPTWNTVLSTDGQARIFEANHDAETERRHHFKNPILTQYIKIVP 2388
                       ||.||:.|:.:       ..||:..|:..:...:|
 Frog  1277 -----------TGQKVIGSESR-------ERDGKCYIYVCDSTCQT------------------- 1304

  Fly  2389 AYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKCNICDGVSTSSSTTGCQCQDQLFWDGNTC 2453
                                  ::.:.|           |:...|:||||          ..:|.
 Frog  1305 ----------------------LKTKTP-----------CETTQTTSSTT----------TPSTT 1326

  Fly  2454 VQHNLCPCIENYVSYPIGSKFENSACEDCVCVLGGHKNCKPKKCPPCLGGKLRPVITSDCFCKCE 2518
            :....|.|..|..:|..|.:...:.      :||                            ||
 Frog  1327 IHTTKCSCYHNGKAYMPGEEITRNK------ILG----------------------------KC- 1356

  Fly  2519 PCPKHQRLCPSSGDCIPEILWCNGVQDCADDEDASCSDSFTVEPDVSREKNETEVITCPVPVCPP 2583
                ::.:|                       |.||.:...:|            ..|.:...|
 Frog  1357 ----YKVVC-----------------------DGSCGEIPAIE------------FPCEITTTP- 1381

  Fly  2584 QMKIRITEKKSRKMSKMFTFSKQVSIVDDGTTITKTKFISSKEQILAMPNRELDFQLEEQCDEFT 2648
                                          ||...||                           |
 Frog  1382 ------------------------------TTTPTTK---------------------------T 1389

  Fly  2649 CVPIPSKQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISGKSFTTF 2713
            ..| .|....|:.|:|
 Frog  1390 TTP-SSTTTTKSTTIT------------------------------------------------- 1404

  Fly  2714 DGTVFKYGPCSHILARDIHSSSWSISVHQQCSDETRKVCHKVITIQDTEAGNELILLPHLKLKFN 2778
                                   |||....|
 Frog  1405 -----------------------SISTTTPC---------------------------------- 1412

  Fly  2779 GYEFTVQQLINSPICKASFVVSQPGKTLLAVSTKYGFWVQLDDIGIVKVGISSKFIRTVDGLCGY 2843
                                                                             
 Frog  1413 ----------------------------------------------------------------- 1412

  Fly  2844 YNGNQKDDKRSPDGQIIPNTEKFGDSWYDKRIPKDQCGDLKCPREMQAKALQLCNIIHHPTFARC 2908
                            :|:|     ||
 Frog  1413 ----------------VPHT-----SW-------------------------------------- 1418

  Fly  2909 HKAVNYKQFLNNYCLEAACNCMMANNGDPAACKCNILESFVKKCLSVNPLVQLTTWRAVAQCEIN 2973
                   |..|  |.:|.||    .||:        |:...|.|              ....|||
 Frog  1419 -------QIFN--CTKAVCN----GNGE--------LQIVQKSC--------------TPPPEIN 1448

  Fly  2974 CPSPLVHTDCYKRRCEPSCDNVHGDDCPVLPDACFPGCY---CPEGTVRKGPNCVPISECKDCVC 3035
            |.:.:      |....|       ||     |:|   |:   ||                  |||
 Frog  1449 CANKM------KPIAVP-------DD-----DSC---CWHWECP------------------CVC 1474

  Fly  3036 NSLGASKYMTYDRKSFSFNGNCTYLLSRDVVLPGVHTFQVYVSMDDCKKLGQPTPVEGGSCAKSL 3100
            :..|.|.|:|:|...:|:.|.|||:|..::| ..:..|.:|:...||   |..|   |.:|.:.|
 Frog  1475 SGWGDSHYLTFDGTYYSYQGRCTYVLVEEIV-KTIDNFGIYLDNYDC---GHKT---GITCPRKL 1532

  Fly  3101 HILNGDHVIHVQRVPQKPKSLQVLVDGFEVKKIPYKDSWISLRQVVGKELVLSLPESHVELTASF 3165
            .:.:....|.:......|.||:..|:| .:..:||....:::.| .|..||:.:||.|..:|  :
 Frog  1533 TVRHKTQEILISPKTSTPTSLETRVNG-NLVLLPYTKYGVTIYQ-SGVYLVVEIPELHTNVT--Y 1593

  Fly  3166 EDLIFSLGVPSIKYGSKMEGLCGDCNGNAGNDL-QPNPAKKKAGVDVIQSWQADEPKLGLVEECL 3229
            ..|.||:.:|..|:.....|.||.|..|..:|| ..|.....:...:..|:....|
 Frog  1594 NGLTFSIMMPYGKFYKNTHGQCGTCTNNQADDLMMANGKVTTSAAAMADSFMVHNP--------- 1649

  Fly  3230 SEDVPKEHCIPLPPE-----KDPCLQFYNAELFGKCPLAVDPIAYVSACQQDICKPGNTQQGVCV 3289
              |.|:  |..:||.     |..........:|..|.....|..:..||..|.|...|: ...|.
 Frog  1650 --DKPR--CNSIPPVHHNTCKSAVCDLIMGPVFQNCHAFHSPEPFYQACLLDSCNKANS-DSECS 1709

  Fly  3290 ALAAYAKECNQHGICTNWR-RPQLCPYECPSDMVYEPCGCAK--NCDTIKALSEFDAVSLKNEAV 3351
            :|..||..|...|:|..|| ....||:.|||:.||:.||.|.  .|
 Frog  1710 SLQHYASICGDRGVCIQWRSHAPSCPFTCPSNKVYDACGPALPITC------------------- 1755

  Fly  3352 VHTVKTDEMCLSSER--FEGCFCPPGKV-----MDGGQCVPEIACTKCDDGLHLPDEKWKKD--- 3406
             .|..||.|.:.::|  .|||||..|.:     :|  .||.|..|...|   ::| .|:.:.
 Frog  1756 -QTRPTDTMAMKNDRRVVEGCFCAKGSMPFSTKID--TCVSECGCVGPD---NIP-RKYGESFEF 1813

  Fly  3407 KCTECQCDSKGK-TTCVEKKCQ--VEENICAEGYRPETIVS-VDECCPR--YRCVPETKDPSKLC 3465
            .|..|:|...|. .||.:::|.  ..|....||:...|.|| .::||..  .||     |||: |
 Frog  1814 NCETCKCLEGGNGITCQKQQCHHARNEECTREGFYKVTQVSATNKCCEETVCRC-----DPSR-C 1872

  Fly  3466 LAPLVPICGPG-QFKKEKKDVNGCSQYICECIPKDQCEIIELRELLPGEIIVNVEEGCCPTQKIE 3529
             :...|.|||| :.|....:.:.|..|:||  ||..| :....|.|||..:.:
 Frog  1873 -SNTFPKCGPGFELKGGINEGHCCPTYVCE--PKPVC-VRGNAEYLPGSHVYS------------ 1921

  Fly  3530 CKPETCPKAPVNCQERFYEVKTIKEPGMCCSKHSCVPPKDLCIVQYELDEATKFTKTVGDKWTHA 3594
               |.|.    ||               .|:::                         |..:|.|
 Frog  1922 ---ENCE----NC---------------VCAQN-------------------------GHNFTIA 1939

  Fly  3595 KEVCKQETCSYGPDGNAQVVSTLEQCLTDCAPGFSYQNLDKTKCCGKCVQTSCIFE-QKLYEV-- 3656
               |....|:                 ..|..||..:....:.|||.|.||:|:.: ...|.:
 Frog  1940 ---CNPVVCN-----------------IHCPAGFKVKKNSPSDCCGTCQQTNCVVKYDGSYRIMN 1984

  Fly  3657 --NALWKSADNCTTYSCLKKDGQFLVTTSREVCPDVGSCLSHLLYQDGCCKRCKSEPLVEDKSSC 3719
              :.|....||||.|.|...:.||:.|.::..||.:                        ::..|
 Frog  1985 NGDVLPSMNDNCTMYKCSLINDQFITTVTQMSCPSL------------------------NEEDC 2025

  Fly  3720 LPVSLAESRTKEILKF----PVQGHGTCVNADPIQGFTDCEGACSSGSKYNTLTDMHEKFCTCCS 3780
            .|||:.:..:.::..|    ..||   |.:...|: .:.|||||...|:|:.........|:||:
 Frog  2026 EPVSIQKKDSCKVQAFDDYLSYQG---CRSVSRIK-MSRCEGACGKVSRYSAEEHTMSHTCSCCN 2086

  Fly  3781 IKSYHPISVKMICDDGHTFTQKHEVPSNCGC--SPCSEFS-DSAIDVRMQQDAQS 3832
            ........||:.|.||.....::.....|.|  :.|.::| :...:.:...||.|
 Frog  2087 EVQTKRSKVKLQCPDGTLIDHEYIDVLECKCAGTKCPDYSCEGVCEFQQPMDASS 2141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:459671	35/172 (20%)
		C8	684..754	CDD:462584	16/69 (23%)
		TIL	758..811	CDD:410995	18/59 (31%)
		VWD	840..1015	CDD:214566	51/174 (29%)
		C8	1054..1121	CDD:214843	27/70 (39%)
		TIL	1131..1185	CDD:410995	21/59 (36%)
		TIL	1245..1298	CDD:460351	10/52 (19%)
		VWD	1327..1498	CDD:214566	55/173 (32%)
		C8	1535..1609	CDD:214843	33/73 (45%)
		TIL	1938..2005	CDD:473303	6/66 (9%)
		FA58C	2089..2223	CDD:238014	6/133 (5%)
		FA58C	<2299..2403	CDD:238014	9/103 (9%)
		VWD	2703..2858	CDD:459671	4/154 (3%)
		TIL	2974..3030	CDD:460351	10/58 (17%)
		VWD	3035..3198	CDD:459671	48/162 (30%)
		C8	3248..3313	CDD:462584	17/65 (26%)
		VWC	3397..3451	CDD:450195	17/60 (28%)
		GHB_like	<3755..3813	CDD:473907	17/59 (29%)
LOC100485197	XP_031756619.1	VWD	52..203	CDD:214566	36/178 (20%)
		C8	245..312	CDD:462584	16/69 (23%)
		TIL	316..372	CDD:410995	18/59 (31%)
		VWD	412..554	CDD:459671	47/163 (29%)
		C8	593..659	CDD:214843	26/67 (39%)
		TIL	671..728	CDD:410995	21/59 (36%)
		VWC	828..>874	CDD:450195	14/45 (31%)
		VWD	855..1013	CDD:214566	55/173 (32%)
		C8	1052..1124	CDD:214843	33/71 (46%)
		VWD	1464..1631	CDD:214566	56/198 (28%)
		C8	1670..1735	CDD:214843	17/65 (26%)
		CT	2038..2121	CDD:214482	22/86 (26%)