DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and muc5d

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_021326285.1 Gene:muc5d / 100334291 ZFINID:ZDB-GENE-121108-2 Length:2196 Species:Danio rerio


Alignment Length:2782 Identity:622/2782 - (22%)
Similarity:971/2782 - (34%) Gaps:898/2782 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   439 LAKYRDLER-RSEWWSSEETVVTMSSYSLYQSNNLDIVIDKTP--RPALCTTWGGINMKTFDGLV 500
            :..|||:|. .:..|.: ...::|:|..:       |.::..|  |..:|:|||..:.|||||..
Zfish    34 MGDYRDMENPMTPMWPT-TPAISMTSVPV-------ITVEPNPDHRSTICSTWGNFHFKTFDGHF 90

  Fly   501 FKAPLSCSHTL--ITDKVSGTFDIILKACPYGSGYGCAHTLKILWQSVLYTFENLNGTMQLTTPI 563
            |:.|.:|::.|  :.|..|..|:|.::.                        |.:||::..:|.:
Zfish    91 FQLPDTCNYVLAVMCDAASSDFNIQMQR------------------------ETVNGSISFSTVL 131

  Fly   564 KKLPMPV-------QVMGMKVMPVAQH---VQIDLESVGLKLD--------WDHRQYVSVQAGPQ 610
            .||...|       ..||.:.:.|..:   ::|:......|:.        |:....:|::...:
Zfish   132 IKLDGTVIKVTDSDITMGEETVTVPTYKNGIKIEGSPTSFKISNKHGVTVFWEEDNSLSIELPEK 196

  Fly   611 MWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSELCQVENSAEMEFGMDS---C 672
            ..|:..||||..:|:...|:|...          ..:|:|...:|:|:       |..:.|   |
Zfish   197 YQGQTCGLCGDFNGNLADDITDNG----------PASWKVSISTEICE-------EVTLPSTGPC 244

  Fly   673 EQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCNCANREHPESCNCDAIAMLAKEC 737
            ::  |.:..|.||..|.:.....|....:..:..:.|.:|.|.|...   ..|.|:.:..::::|
Zfish   245 DE--LSEQASFCEEYLISPGFSGCYDVMDMSSFEKACESDLCQCYGN---HDCLCNTLTEISQQC 304

  Fly   738 AFKGIKLEHG----WRNLEICPISCGFGRVYQACGPNVEPTCDSDLALPASKGACNEGCFCPEGT 798
            ...|     |    ||..::||.:|....:|..||...:.||.:..|.......|.:|||||||.
Zfish   305 THAG-----GQPGTWRTEQLCPKTCPLNLLYLECGGPCKSTCSAPTADLMCTDHCVDGCFCPEGM 364

  Fly   799 VQ---YKEACITRELCPCSLRGKEFKPESTVKKNCNTCTCKNGQWRCTEDKCGARCGAVGDPHYQ 860
            |:   .:..|:....|||....|.:....:..:.|.||||..|.|.|:...|...|..||..|..
Zfish   365 VEDDIGQSGCVPVNKCPCVHNNKTYFSGDSYTQACKTCTCDAGHWTCSYLDCPGICSVVGGSHVT 429

  Fly   861 TFDGKRYDFMGKCSYHLLKTQNTSVEAENVACSGAVSESMNFA-----APDDPS----CTKAVTI 916
            |:|||.:.|.|.|.|.|.|..|.|                :||     ||.:||    |..:|.:
Zfish   430 TYDGKTFTFSGNCDYILTKHYNNS----------------DFAVVGNLAPCNPSRTDICLNSVAL 478

  Fly   917 RFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKMLGLGEVLIRRASSTFLTVEF-ADGIRVWWDGV 980
            ..:   || ::.....|..|:..:.|. .||.:  :|.|.|.:.||:|:..:. :..:.:....:
Zfish   479 VLL---GT-TISFSSNGDVTLNGNSPF-NLPAV--IGPVSIFQPSSSFIIADLHSIRLEIQLAPI 536

  Fly   981 SRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRTKDTCQFKAETHQGPH 1045
            .::||.|....:|:..||||.:|....|||.|..|.:|.....|.:.|  |..|.....|..  :
Zfish   537 MQLYIVASTEEKGKMTGLCGNYNDVQTDDFKTESGIIEGTPTSFVNFW--KQNCPDLEITFD--N 597

  Fly  1046 PCTLNPEKKAQAEKFCDWILQD--IFQDCHFLVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYG 1108
            ||:||.:.:..|:.:|..:...  :|..||..:.|:.:|:.|:||||.|.| :.:|.|..||.|.
Zfish   598 PCSLNMDTEKLAKDWCSRLTNQSGVFSACHSEICPDIYYQWCVYDTCKCAD-IRQCMCAALSTYA 661

  Fly  1109 TECMRQG-VKTGWRMSVKECAVKCPLGQVFDECGDGCALSCDDLP-SKGSCKREC--VEGCRCPH 1169
            ..|..:| :..|| |..:.|...||....:......|..:|..|. .:.:|:...  |.||.|..
Zfish   662 HACAARGIILQGW-MDAEPCETNCPDNMKYSYGVTSCDNTCRSLSGQENTCQGSFTPVHGCVCSE 725

  Fly  1170 GEYVNEDGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYPPS 1234
            |.|:||:|:||...||.|.:.....:|..:..:.|.|    |||.:|..||...|    |...|.
Zfish   726 GTYLNEEGKCVHAGMCPCYYGNQVIQPSAEFNKEGAK----CTCNNGKLDCSSHE----DCVAPM 782

  Fly  1235 SELRSKCAKQPYAEFTKCAPKEPKTCKNMDKYVADSSDCLPGCVCMEGYVYDTSRLACVLPANCS 1299
            :..  ||: .|..:.|:|    .:||...|.....|:.|:.||:|.||.:.|.:. .||:..||.
Zfish   783 TFF--KCS-HPGEKGTEC----QRTCDKQDPNNCVSTGCVSGCMCPEGLLADGNG-GCVMRENCP 839

  Fly  1300 CHHAGKSYDDGEKIKEDCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFDFQGACDYVL 1364
            |.|.|.:...|:::::|||.|.|..|.|.|::..|..||:::|:.||.||||:.:.|.|.|::.|
Zfish   840 CTHNGVASSPGDQVQQDCNTCTCTNGMWICTQKACYGTCTIYGEGHFRTFDGNRYSFHGDCEHTL 904

  Fly  1365 AKGVFDN--GDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEESLLLSADSAYSTDPNKTPIKKL 1427
            |....|.  ...|.:..:|:.|.|....||||:.:....:  |.:|...|.....:.|.|..|  
Zfish   905 AHDYCDGNPSPSFRLVTENIPCATANSICSKSINLFFGRY--EMILSEDDGVKVVEGNGTEYK-- 965

  Fly  1428 RDSVNSKGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLD 1492
                       :.|...|::||:|:..| |.:.|||.|.|.::|..:.:..|.|||||::||:.:
Zfish   966 -----------YQINYGGIYVVIEIEGL-LNLIWDEKTSVMIQLHPKLKGNVCGLCGNFDGNANN 1018

  Fly  1493 DMQTPSMGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERETWAQLKCGALKSDLFKECHAEV 1557
            |....:..:.|.|..||.:||::|.|.......|.|.::|.|..|::.:|..:.||:||:||..|
Zfish  1019 DFMKHNGEVVTDPEEFGISWKVKPDCPDVTNIKDLCTENPHRSVWSEKRCSIIISDVFKDCHTLV 1083

  Fly  1558 PLERFWKRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRWRSQHFCPMQCDPH-----CS 1617
            ...:::..|..|||.|:.||||:|.||||||||..|.:||..::|||.:.||:.||.:     |.
Zfish  1084 DPNQYYDNCKRDTCGCETGGDCDCFCTAVAAYAAECRKKGACVKWRSPNTCPLFCDYYNPPGKCE 1148

  Fly  1618 -DYKACTPACAVETCDN----FLDQ------------------------GIAERMCNRENCLEGC 1653
             .|.:|.|.|. :||.|    ..||                        .:.::|....|.::||
Zfish  1149 WHYDSCGPPCP-KTCKNPTGTCSDQIPLLEGSTINQPDECYTTYCNSTCNVVQKMKFDNNTIDGC 1212

  Fly  1654 HIKPCEDGFIYLNDTYRDCVPKAEC----KPVCMVRDGKTFYEGDITFTDSCATCRCSKRKE--- 1711
            :||.|::|.:.||....|.|...:|    :||      |.:|.....|...| .|.|....:   
Zfish  1213 NIKTCKNGKLTLNPVQCDPVVVPKCVNGLQPV------KAYYNNGCCFRYEC-ECFCKAYGDPHY 1270

  Fly  1712 ------------ICSGVKCDVPATTGLPAPLVEGTTLPTPLATQNQTKCVKGWTRWCDKDR---- 1760
                        .|:.|             |:|..     :.|.|.:..:|.:  :||..:    
Zfish  1271 RTFDGQYYTFQGNCTYV-------------LMEEI-----IPTYNISVHLKNY--YCDVVKRIAC 1315

  Fly  1761 ----------------DTSDKSVR--LNDEEKVPRYDRMENVYGTCLKQYMTKVECRVKDTHEAP 1807
                            .|:||.|.  :||:.|:|.|.....:..|      |.:...|..|    
Zfish  1316 TQYAIVYYNSYKILLNSTNDKVVHVYVNDQLKIPTYITDNFIITT------TGIAATVNIT---- 1370

  Fly  1808 EQMDENVVCSLEEGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQLGLACDAAVVEYKEFPG 1872
               |.||..::.                                       |.|.:|        
Zfish  1371 ---DINVQITVS---------------------------------------AVDVSV-------- 1385

  Fly  1873 DCHKFLHCQPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLKPEPEPEFEPIKQ 1937
                                 |....|...|              .|..||.             
Zfish  1386 ---------------------KLPSSYFRKN--------------TKGQCGY------------- 1402

  Fly  1938 CPPGKIKSECANQCENTCHYYGSILKKRGLCQVGEHCKPGCVDELRPDCPKLGKFWRDEDTCVHA 2002
                     |.|...|.|.|.......                    .|.|:..||         
Zfish  1403 ---------CDNSVTNDCQYPNGTFSS--------------------SCEKVAAFW--------- 1429

  Fly  2003 DECPCMDKAEHYVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPKDEDDDLDLVSVVPIYPVTLT 2067
                                          |...|.|....|||                     
Zfish  1430 ------------------------------NVSQCTPPSTPPVP--------------------- 1443

  Fly  2068 PPLQCSPERLIPKIENPAHSLPDSIFNASSQLAPEHGPKMARLTKEQPRGSWSPSINDQMQYLEL 2132
                     .:|.:..|...|...:|.:...:.|                     ..:..|..: 
Zfish  1444 ---------TVPTVVPPCEILKSDLFKSCRDVVP---------------------FKEYYQACK- 1477

  Fly  2133 NFAKPEPFYGVVMAGSPEF-----DNYVTLFKILHSHDGIAYHYLVDETEKPQMFNGPLDSRAPV 2192
                    |.|...|:..:     ::|..|.    ....|.    ||....|:: .|..|.:.|.
Zfish  1478 --------YDVFTMGNKSYACATVESYAQLC----GQKSIC----VDWRSSPEL-KGLCDFKCPS 1525

  Fly  2193 QTLFKIPIEASSLRIYPLKWHGSIAMRVELLICGDKEEPKPVPTVSTILPITERPARLVDLECID 2257
            ..::|                          .||.|.|.....:.:|                  
Zfish  1526 SKVYK--------------------------ACGPKVEQSCSTSYNT------------------ 1546

  Fly  2258 LMGVDEGKMYQD-QVQSSSLWQQPNLGKKLQLLELLKLSTPLAWRP-----------LANSQNEF 2310
                    ||.| |.|..:..|..:.|               .:.|           |..:..:.
Zfish  1547 --------MYADTQCQGDNCNQTSSEG---------------CYCPDGQYRVNMTSNLCTAYCDC 1588

  Fly  2311 IEFDFLEPRNISGFVTKGGPDGWVTGYKVMFSKKKPTWNTVLSTDGQARIFEA-NHDAETERRHH 2374
            |                 ||||         |.:||         ||...::. |:..:.     
Zfish  1589 I-----------------GPDG---------SPRKP---------GQIWTYQCYNYTCQN----- 1613

  Fly  2375 FKNPILTQYIKIVPAYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTKCNICDGVSTSSSTTG 2439
                 ...|:|:              |:.|    |.|         ||  |.  ||..:|     
Zfish  1614 -----TGVYVKV--------------PVTC----PTI---------KP--CG--DGYKSS----- 1637

  Fly  2440 CQCQDQLFWDGNTCVQHNLCP-CIENY---------VSYPIG-SKFENSACEDC----VCVLGG- 2488
                           ..|.|| |:.:|         |.:.:| :|...|.|..|    |||... 
Zfish  1638 ---------------VENCCPTCVCDYEQCLKKKCDVGFELGLNKANGSCCPPCVRKDVCVYNNT 1687

  Fly  2489 -------HKNCKPKKCPPCLGGKLRPVITSDCFCKCEPCPKHQRLCPSSGDCIPEILWCNGVQDC 2546
                   :..|:...|....|..:..:.|:       |||     ..||.||.|...:....:||
Zfish  1688 EYKVGVYYFTCQTLNCRQVNGSFVAEMTTN-------PCP-----YMSSQDCGPGFDYVKKSEDC 1740

  Fly  2547 ADD-EDASCS---DSFTVEPDVSR-EKNETEVITCPVPVCPPQMKIRITEKKSRKMSKMFTF--- 2603
            ... ....|:   |:.|....|.. :..:.|.:||.|....|     :||:.|.|.:.:.:.   
Zfish  1741 CGTCVQTKCTYMMDNTTYTLQVGEVQSYKCENVTCSVISGSP-----VTERNSEKCTYLSSLDCK 1800

  Fly  2604 --SKQVSIVDD--GTTITK--TKFISSKEQILAMPNRELDFQLEE----QCDEFTC-----VPIP 2653
              |:.|....|  ||.:.|  |..|.|...:|         |:.|    :|:..||     .|:.
Zfish  1801 LGSEYVKKAGDCCGTCVQKNCTYMIGSTTYML---------QVGEVHSYKCENVTCSVISGSPVT 1856

  Fly  2654 SKQVDK------------NETV--------TCTEPKCPEKYDVELDMSASKVGDCLRYSCVLRPN 2698
            ::..:|            :|.|        ||.:..|  .|.|:..|:..:||:...|.|     
Zfish  1857 TRNSEKCTYLSSLDCKLGSEYVKEEGDCCGTCVQRNC--TYMVDNTMNTLQVGEVHSYKC----- 1914

  Fly  2699 KDDVCE-ISGKSFT-------TFDGTV-----FKY--------GPC------------SHIL-AR 2729
            ::..|. |||...|       |:..::     |:|        |.|            :|.| ..
Zfish  1915 ENVTCSIISGSPVTERNSEKCTYLSSLDCNLGFEYVIQEGDCCGTCVQRNCTYMVDETTHTLQVG 1979

  Fly  2730 DIHSSSWSISVHQQCSDETRKVCHKVITIQDTEAGNE-LILLPHLKLKFNGYEFTVQQLINSPIC 2793
            ::||        .:|.:.|   |..:.....||..:| ...|..|..| ..:|:..|:......|
Zfish  1980 EVHS--------YKCENVT---CSLISGSPVTERNSEKCTYLSSLDCK-PCFEYVKQEDECCGTC 2032

  Fly  2794 KASFVVSQ-PGKTLLAVSTKYGFWVQLDDIGIVKVGISSKFIRTVDGLCGYYNG---NQKDDKRS 2854
            |.:..|.: |..|...:.:...:..:.:                 .|.|...||   .:|..|..
Zfish  2033 KQTCCVYEAPDNTTHTLQSGEAYTSKCE-----------------TGTCHEVNGLFETEKKVKEC 2080

  Fly  2855 PD---GQIIPNTEKFGDSWYDKRIPKDQ----CGDLKCPREMQAKALQL--CNIIHHPTFARC-- 2908
            |.   ....|.|.|         :..||    |....|.|::....||:  |..:.:.....|  
Zfish  2081 PPFNADDCDPGTIK---------LDSDQCCYTCETRNCVRQINITRLQVKDCTSVQNVEIPSCTG 2136

  Fly  2909 HKAVNYKQFLNNYCLEAACNCMMANNGD--PAACKC-NILE-----SFVKKC 2952
            |....|..:.|..   .:|:|...:...  |...|| |..|     ::::.|
Zfish  2137 HCGSMYSLYTNQM---TSCSCCQKDKSTSLPVKLKCTNGTEIDYNYTYIQSC 2185

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 39/170 (23%)
C8 680..754 CDD:285899 16/77 (21%)
TIL 758..811 CDD:280072 17/55 (31%)
VWD 840..1015 CDD:214566 53/184 (29%)
C8 1054..1121 CDD:214843 22/69 (32%)
TIL 1131..1185 CDD:280072 17/56 (30%)
TIL 1245..1298 CDD:280072 16/52 (31%)
VWD 1327..1498 CDD:214566 54/172 (31%)
C8 1535..1609 CDD:214843 33/73 (45%)
Mucin2_WxxW 1751..1837 CDD:290069 18/107 (17%)
TIL 1938..2005 CDD:280072 9/66 (14%)
FA58C 2089..2223 CDD:238014 16/138 (12%)
FA58C 2104..2225 CDD:214572 14/125 (11%)
FA58C <2299..2404 CDD:214572 16/116 (14%)
FA58C <2299..2403 CDD:238014 16/115 (14%)
VWD 2703..2858 CDD:295339 37/196 (19%)
C8 2893..2970 CDD:285899 15/72 (21%)
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
muc5dXP_021326285.1 VWD 72..217 CDD:214566 38/168 (23%)
C8 263..320 CDD:312319 12/64 (19%)
TIL 324..380 CDD:307783 17/55 (31%)
VWD 409..571 CDD:214566 53/184 (29%)
C8 606..685 CDD:214843 25/80 (31%)
TIL 684..741 CDD:307783 17/56 (30%)
TIL 794..838 CDD:307783 15/48 (31%)
Pacifastin_I 848..>874 CDD:253170 9/25 (36%)
VWD 867..1025 CDD:214566 54/173 (31%)
C8 1063..1135 CDD:214843 33/71 (46%)
VWD 1252..1416 CDD:214566 43/301 (14%)
C8 1452..1512 CDD:312319 12/97 (12%)
CT 2116..2189 CDD:214482 15/73 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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