DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hml and muc2.1

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	XP_021326446.1	Gene:	muc2.1 / 100332798	ZFINID:	ZDB-GENE-120904-2	Length:	742	Species:	Danio rerio

Alignment Length:	781	Identity:	210/781 - (26%)
Similarity:	343/781 - (43%)	Gaps:	83/781 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 EWWSSEETV---------VTMSSYSLYQSNNLDIVIDKTPRPALCTTWGGINMKTFDGLVFKAPL 505
            ||.:|  ||         :.:.|..:..||:::         ::|:.||..:.|||||.|::.|.
Zfish     2 EWRTS--TVCMLLLALSGIQVDSKKVSPSNHVN---------SICSMWGNFHFKTFDGDVYQFPG 55

  Fly   506 SCSHTLITD--KVSGTFDIILKACPYGSGYGCAHTLKILWQSVLYTFENLNGTMQLTTPIKKLPM 568
            .|.:.|::|  .:...|.|.:|.....:|...:.....:....:...||     |:.....|:.:
Zfish    56 MCEYNLVSDCQSLIRQFSIYVKRTERSTGPKISRVSITINDIAIELTEN-----QVNVNEAKVTL 115

  Fly   569 PVQVMGMKVMPVAQHVQIDLESVGLKLDWDHRQYVSVQAGPQMWGKVGGLCGTLDGDPNTDLTSR 633
            ||.|.|:.|.....:.:: ...:|:.:.|:....|.|:...:...:..||||..:|.|..:...:
Zfish   116 PVHVSGILVEENTIYTRL-YSKMGITVMWNKDDAVMVELDSKYSNRTCGLCGDFNGIPVYNEFIQ 179

  Fly   634 TGKKLATVKAFADAWRVEDRSELCQ--VENSAEMEFGMDSCEQSKLQKAVSVCERLLANEKLGDC 696
            :|:.:...: |.:..||.:.:..|:  .||..|... :|.||:.:..     |..||.:||...|
Zfish   180 SGRTVGYTE-FGNMHRVPNPTHQCEDPFENVDEQNV-VDQCEKYRAD-----CADLLEDEKWSSC 237

  Fly   697 IKPFNYDALIRTCMADYCNCANREHPESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFG 761
            ....:.:|.|:.|..|.||....:...:..|..:...:::|:..|.. ...||..:.|.:.|.:.
Zfish   238 SWVLDPEAYIKACTNDLCNRQPEDEDTTALCATLTEYSRQCSHAGGN-PPAWRTAKFCNVQCPYN 301

  Fly   762 RVYQACGPNVEPTCDSDLALPASKGACNE----GCFCPEGTVQYKE----ACITRELCPCSLRGK 818
            .|:...|.....||..    ..:...|.|    |||||.||| :.:    .||..|.|.|. ..:
Zfish   302 MVHSESGSPCMDTCSH----KDTNALCEEHNIDGCFCPPGTV-FDDISDTGCIPAEKCQCK-HDR 360

  Fly   819 EFKPESTVKKNCNTCTCKNGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKTQNT 883
            .:.....::|:...|.|:.|.|.|........|......|:.|||||.:.|.|.|:|.|.|....
Zfish   361 VYSSGEVLRKSEEECYCQEGSWVCMSIPGPGLCAVEEGSHFTTFDGKEFTFHGDCNYLLSKDCEE 425

  Fly   884 S---VEAENVACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAK 945
            |   :..:.|.|         |....| :|.|::.:.|......|..||.|   .|:.::..::
Zfish   426 SKFIILGQIVPC---------FTHETD-TCLKSIVVLFDNDKKNPLFIKAD---GTVQHNAEVS- 476

  Fly   946 LPKMLGLGEVLIRRASSTFLTVEFADGIRVWWDGV--SRVYIDAPPSLRGQTQGLCGTFNSNTQD 1008
            ||.|  ..:..:.|.||..:.::...|::|....|  .:|||....|.:|:|.||||.||....|
Zfish   477 LPYM--TADFTVFRPSSFHIILQTVFGLQVQVQLVPLMQVYITVDQSFQGKTCGLCGNFNKVLAD 539

  Fly  1009 DFLTPEGDVETAVEPFADKWRTKDTCQFKAETHQGPHPCTLNPEKKAQAEKFCDWI--LQDIFQD 1071
            |..||:|.||.....||:.|:.:..|..::|  :...||:.:.:.:..||.:|..:  .:.:|..
Zfish   540 DLKTPQGVVEGTAVSFANAWKAQSNCPDRSE--RMDDPCSYSSDSEHFAEHWCSKMKDKESLFAQ 602

  Fly  1072 CHFLVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQGV-KTGWRMSVKECAVK-CPLG 1134
            ||..|.|:.:|:.|.|.:|.| ::...|.|.:.|:|...|..:|| ..|||..|.:..:| ||..
Zfish   603 CHATVNPDSYYKRCKYSSCTC-EKSEDCLCTVFSSYARACAAKGVILEGWREVVCDKYIKDCPAS 666

  Fly  1135 QVFDECGDGCALSCDDLPS-KGSCKREC--VEGCRCPHGEYVNEDGECVPKKMCHCNFDGMSFRP 1196
            |.:......|..:|..|.| :.||..:.  |:||.||.|.|.:|:..|||.:.|.|..:|....|
Zfish   667 QSYSYELQSCQRTCVSLASERQSCNVDFVPVDGCACPDGLYQDENNLCVPMEKCPCYHNGQKIHP 731

  Fly  1197 G 1197
            |
Zfish   732 G 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339	36/152 (24%)
		C8	680..754	CDD:285899	17/73 (23%)
		TIL	758..811	CDD:280072	18/60 (30%)
		VWD	840..1015	CDD:214566	53/179 (30%)
		C8	1054..1121	CDD:214843	21/69 (30%)
		TIL	1131..1185	CDD:280072	20/56 (36%)
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339
		C8	3257..3313	CDD:285899
		VWC	3397..3451	CDD:302663
		GHB_like	<3755..3813	CDD:304424
muc2.1	XP_021326446.1	VWD	33..177	CDD:214566	36/149 (24%)
		C8	228..294	CDD:312319	16/66 (24%)
		TIL	298..354	CDD:307783	18/60 (30%)
		VWD	393..547	CDD:306577	51/169 (30%)
		C8	583..653	CDD:214843	22/70 (31%)
		TIL	663..720	CDD:307783	20/56 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12226at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010